Search Within
Applied Filters:
Keyword:'S8032'
Showing 1-30 of 1195 results for "

S8032

" within Papers
Sonam Gupta et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 778, 22-36 (2015-03-03)
The present study was conducted to investigate the effect of the neurotoxins 6-hydroxydopamine and lipopolysaccharide on astrocytes. Rat astrocyte C6 cells were treated with different concentration of 6-hydroxydopamine (6-OHDA)/lipopolysaccharides (LPS) for 24 h. Both neurotoxins significantly decreased the viability of...
Christian M Schürch et al.
Cell, 182(5), 1341-1359 (2020-08-09)
Antitumoral immunity requires organized, spatially nuanced interactions between components of the immune tumor microenvironment (iTME). Understanding this coordinated behavior in effective versus ineffective tumor control will advance immunotherapies. We re-engineered co-detection by indexing (CODEX) for paraffin-embedded tissue microarrays, enabling simultaneous...
José Patricio Casanova et al.
Behavioural brain research, 296, 70-77 (2015-09-01)
A growing body of evidence suggests that learned fear may be related to the function of the interoceptive insular cortex. Using an auditory fear conditioning paradigm in rats, we show that the inactivation of the posterior insular cortex (pIC), the...
Won-Tae Kim et al.
PloS one, 10(6), e0130670-e0130670 (2015-06-24)
When located in the endoplasmic reticulum (ER) membrane, B-cell receptor associated protein 31 (BAP31) is involved in the export of secreted proteins from the ER to the plasma membrane. In a previous study, we generated two monoclonal antibodies (mAbs), 297-D4...
Tobias Weber et al.
Journal of immunology research, 2015, 561814-561814 (2015-11-26)
Antibody-drug conjugates (ADCs) have evolved as a new class of potent cancer therapeutics. We here report on the development of ADCs with specificity for the B-cell lineage specific (surface) antigen CD22 being expressed in the majority of hematological malignancies. As...
Valéryane Dupuis-Maurin et al.
PloS one, 10(3), e0118551-e0118551 (2015-03-05)
Deregulated expression of oncogenes or transcription factors such as specificity protein 1 (Sp1) is observed in many human cancers and plays a role in tumor maintenance. Paradoxically in untransformed cells, Sp1 overexpression induces late apoptosis but the early intrinsic response...
M Miranda et al.
FEBS letters, 588(24), 4815-4824 (2014-12-03)
The post-translational palmitoylation of WNT morphogens is critical for proper signaling during embryogenesis and adult homeostasis. The addition of palmitoyl groups to WNT proteins is catalyzed by Porcupine (PORCN). However, the Wnt amino acid residues required for recognition and palmitoylation...
Leilei Wang et al.
Developmental and comparative immunology, 52(2), 202-214 (2015-06-07)
The C1q domain containing (C1qDC) proteins are a family of proteins possessing globular C1q (gC1q) domains, and they rely on this domain to recognize various ligands such as PAMPs, immunoglobulins, ligands on apoptotic cell. In the present study, a novel...
Maria K Magnusson et al.
Journal of Crohn's & colitis, 9(1), 56-65 (2014-12-18)
The cellular mechanisms leading to infliximab therapy response in patients with ulcerative colitis (UC) are incompletely known. We therefore investigated early effects of infliximab therapy on monocytes and associated chemokines linked to clinical therapy response in UC patients. Blood and...
Thais Helena Gasparoto et al.
PloS one, 9(9), e107170-e107170 (2014-10-01)
Chronic inflammation affects most stages of tumorigenesis, including initiation, promotion, malignant differentiation, invasion and metastasis. Inflammasomes have been described as involved with persistent inflammation and are known to exert both pro and antitumour effects. We evaluated the influence of apoptosis-associated...
Zulin Zhang et al.
Journal of separation science, 37(24), 3699-3705 (2014-10-02)
A simple and rapid method was developed for the simultaneous analysis of nine different pesticides in water samples by gas chromatography with mass spectrometry. A number of parameters that may affect the recovery of pesticides, such as the type of...
Wen-Cheng Huang et al.
Food & function, 6(8), 2550-2560 (2015-06-23)
Propionibacterium acnes is a key pathogen involved in acne inflammation. Wild bitter melon (WBM, Momordica charantia L. var. abbreviate Seringe) is consumed as both a vegetable and as folk medicine in Taiwan. We examined the inhibitory activity of the total...
Marie C Hogan et al.
BMC nephrology, 16, 190-190 (2015-11-19)
Glomerular diseases are potentially fatal, requiring aggressive interventions and close monitoring. Urine is a readily-accessible body fluid enriched in molecular signatures from the kidney and therefore particularly suited for routine clinical analysis as well as development of non-invasive biomarkers for...
M Jovanović Krivokuća et al.
Placenta, 36(2), 150-159 (2014-12-23)
Macrophage migration inhibitory factor (MIF) is expressed by villous and extravillous cytotrophoblast. This study was aimed to investigate functional relevance of MIF for human trophoblast. MIF mRNA and protein were documented in cytotrophoblast (CT) and extravillous trophoblast cell line HTR-8/SVneo...
Brianna Pomeroy et al.
Veterinary immunology and immunopathology, 167(1-2), 22-29 (2015-07-15)
During late gestation the bovine immune system is less capable of eliciting inflammatory responses and eliminating invading pathogens. The maternal immune system is directed toward tolerance in order to prevent fetal rejection due to recognition of paternal antigens. In humans...
Tridib K Goswami et al.
Dalton transactions (Cambridge, England : 2003), 43(31), 11988-11999 (2014-06-28)
Ferrocene-conjugated copper(ii) complexes [Cu(Fc-aa)(aip)](ClO4) () and [Cu(Fc-aa)(pyip)](ClO4) () of l-amino acid reduced Schiff bases (Fc-aa), 2-(9-anthryl)-1H-imidazo[4,5-f][1,10]phenanthroline (aip) and 2-(1-pyrenyl)-1H-imidazo[4,5-f][1,10]phenanthroline (pyip), where Fc-aa is ferrocenylmethyl-l-tyrosine (Fc-Tyr in , ), ferrocenylmethyl-l-tryptophan (Fc-Trp in , ) and ferrocenylmethyl-l-methionine (Fc-Met in , ), were...
Md Shahinoor Islam et al.
The Science of the total environment, 541, 238-246 (2015-09-28)
Naphthenic acids (NAs) found in oil sands process-affected waters (OSPW) have known environmental toxicity and are resistant to conventional wastewater treatments. The granular activated carbon (GAC) biofilm treatment process has been shown to effectively treat OSPW NAs via combined adsorption/biodegradation...
Ana Moraga et al.
Journal of neuroinflammation, 12, 87-87 (2015-05-11)
Aging is not just a risk factor of stroke, but it has also been associated with poor recovery. It is known that stroke-induced neurogenesis is reduced but maintained in the aged brain. However, there is no consensus on how neurogenesis...
Albert T Hsu et al.
Shock (Augusta, Ga.), 44(2), 128-136 (2015-05-27)
Primed neutrophils that are capable of releasing matrix metalloproteinases (MMPs) into the circulation are thought to play a significant role in the pathophysiology of acute respiratory distress syndrome (ARDS). We hypothesized that direct measurement of plasma MMP-9 activity may be...
André R Fajardo et al.
Biomacromolecules, 15(7), 2691-2700 (2014-05-27)
Despite a growing interest in amphiphilic polysaccharide-based diblock copolymers as functional polymeric drug delivery nanosystems, biologically relevant sulfated glycosaminoglycan systems were not yet investigated. Here, we report the synthesis and the self-assembly properties in water of chondroitin sulfate-b-poly(lactic acid) (CS-b-PLA(n))....
A S Duarte et al.
Letters in applied microbiology, 60(3), 288-297 (2014-12-03)
The aim of this study was to investigate the presence and the phenotypic expression of a gene coding for a putative collagenase. This gene (AHA_0517) was identified in Aeromonas hydrophila ATCC 7966 genome and named colAh. We constructed and characterized...
Sébastien A Felt et al.
Virology, 474, 163-173 (2014-12-03)
Effective oncolytic virus (OV) therapy is dependent on the ability of replication-competent viruses to kill infected cancer cells. We previously showed that human pancreatic ductal adenocarcinoma (PDAC) cell lines are highly heterogeneous in their permissiveness to vesicular stomatitis virus (VSV)...
J A D Dela Cruz et al.
Journal of chemical neuroanatomy, 61-62, 64-71 (2014-07-16)
Hypoxia has been proposed as a mechanism underlying gene-environment interactions in the neurodevelopmental model of schizophrenia, and hypoxia-inducible factor 1 (HIF-1) could mediate the interactions. In the current study, we analyzed the HIF-1 beta subunit, as formed by aryl hydrocarbon...
Matthew R Olson et al.
Journal of immunology (Baltimore, Md. : 1950), 193(11), 5420-5433 (2014-10-24)
Although CD4(+) T cell help (Th) is critical for inducing optimal B cell and CD8(+) T cell responses, it remains unclear whether induction of CD4(+) Th responses postinfection are also dependent on CD4(+) T cell help. In this study, we...
Macarena P Quintana-Hayashi et al.
Infection and immunity, 83(4), 1610-1619 (2015-02-04)
Brachyspira hyodysenteriae colonizes the pig colon, resulting in mucohemorrhagic diarrhea and growth retardation. Fecal mucus is a characteristic feature of swine dysentery; therefore, we investigated how the mucin environment changes in the colon during infection with B. hyodysenteriae and how...
R Marino et al.
Journal of animal science, 93(3), 1376-1387 (2015-05-29)
The aim of this study was to understand the relationship between changes in postmortem degradation of myofibrillar proteins and tenderness development in 3 different muscles from 10 Podolian young bulls aged 1, 7, 14, and 21 d. Psoas major (PM)...
Barbora Vorlová et al.
European journal of medicinal chemistry, 89, 189-197 (2014-12-03)
Overactivation of NMDA receptors has been implicated in various neuropathological conditions, including brain ischaemia, neurodegenerative disorders and epilepsy. Production of d-serine, an NMDA receptor co-agonist, from l-serine is catalyzed in vivo by the pyridoxal-5'-phosphate (PLP)-dependent enzyme serine racemase. Specific inhibition of...
Eva Wattrang et al.
Journal of immunological methods, 419, 35-47 (2015-03-07)
The study aimed to evaluate cell surface mobilisation of CD107a as a general activation marker on chicken cytotoxic T cells (CTL). Experiments comprised establishment of an in vitro model for activation-induced CD107a mobilisation and design of a marker panel for...
Rashmi Tupe et al.
International journal of biological macromolecules, 79, 601-610 (2015-06-02)
The present work aims to investigate the concentration and time dependant effect of zinc on the in vitro non enzymatic modifications of albumin by diabetic levels of glucose. Further, preventive and curative effect of zinc was studied by adding zinc...
Keigo Hikishima et al.
Radiology, 275(2), 430-437 (2015-01-21)
To investigate the use of diffusion-tensor imaging (DTI) to detect denervation of the nigrostriatal pathway in a nonhuman primate model of Parkinson disease (PD) after treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). This study was approved by the institutional committee for animal experiments....
Page 1 of 40
Page 1 of 40