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S6297

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Alexander Slobodkin et al.
PloS one, 10(7), e0132611-e0132611 (2015-07-08)
One of the key conditions of the lithopanspermia hypothesis is that microorganisms situated within meteorites could survive hypervelocity entry from space through the Earth's atmosphere. So far, all experimental proof of this possibility has been based on tests with sounding...
Mónica Boj et al.
Biology of reproduction, 93(2), 40-40 (2015-07-03)
In marine teleosts, such as the gilthead seabream, several aquaporin paralogs are known to be expressed during the hyperosmotic induction of spermatozoon motility in seawater. Here, we used immunological inhibition of channel function to investigate the physiological roles of Aqp1aa...
Juan Li et al.
Virology, 478, 86-98 (2015-03-03)
Porcine reproductive and respiratory syndrome virus (PRRSV) is a positive-sense ssRNA virus whose envelope contains four glycoproteins and three nonglycosylated proteins. Glycans of major envelope glycoprotein 5 (GP5) are proposed as important for virus assembly and entry into permissive cells....
Changik Lee et al.
Journal of neuroscience research, 93(9), 1405-1412 (2015-05-28)
In the visual cortex, synaptic plasticity is very high during the early developmental stage known as the critical period and declines with development after the critical period. Changes in the properties of N-methyl-D-aspartate receptor (NMDAR) and γ-aminobutyric acid type A...
Ken-ichiro Kamei et al.
Biomedical microdevices, 17(2), 36-36 (2015-02-18)
Three-dimensional (3D) printing is advantageous over conventional technologies for the fabrication of sophisticated structures such as 3D micro-channels for future applications in tissue engineering and drug screening. We aimed to apply this technology to cell-based assays using polydimethylsiloxane (PDMS), the...
Y Ghinis-Hozumi et al.
Journal of animal science, 93(8), 3820-3831 (2015-10-07)
Sirtuins (Sirt) are NAD-dependent deacetylases that are activated by the antioxidants resveratrol (RSV) and lipoic acid (LA). The objective of this study was to determine in bovine liver and muscle slice cultures the effect of RSV and LA treatment on...
Clara Gallina et al.
Journal of nanobiotechnology, 13, 77-77 (2015-10-30)
Treatment of myocardial infarction with mesenchymal stem cells (MSCs) has proven beneficial effects in both animal and clinical studies. Engineered silica nanoparticles (SiO2-NPs) have been extensively used as contrast agents in regenerative medicine, due to their resistance to degradation and...
Kevin S Akers et al.
Antimicrobial agents and chemotherapy, 59(1), 46-52 (2014-10-15)
While colistin is considered a last resort for the treatment of multidrug-resistant Gram-negative bacterial infections, there has been an increase in its use due to the increasing prevalence of drug-resistant infections worldwide. The pharmacology of colistin is complex, and pharmacokinetic...
I Dransfield et al.
Cell death & disease, 6, e1646-e1646 (2015-02-20)
Billions of inflammatory leukocytes die and are phagocytically cleared each day. This regular renewal facilitates the normal termination of inflammatory responses, suppressing pro-inflammatory mediators and inducing their anti-inflammatory counterparts. Here we investigate the role of the receptor tyrosine kinase (RTK)...
Magdalena Skóra et al.
Medical mycology, 52(7), 723-727 (2014-07-23)
In humans, Scopulariopsis is mainly associated with onychomycoses, rarely with cutaneous infections or with invasive mycoses. However, during the last two decades, deep infections caused by members of this genus have been increasing. Scopulariopsis brevicaulis is the most common species...
Nimrit Goraya et al.
Clinical journal of the American Society of Nephrology : CJASN, 8(3), 371-381 (2013-02-09)
Current guidelines recommend Na(+)-based alkali for CKD with metabolic acidosis and plasma total CO2 (PTCO2) < 22 mM. Because diets in industrialized societies are typically acid-producing, we compared base-producing fruits and vegetables with oral NaHCO3 (HCO3) regarding the primary outcome...
Jocelyn E Manning Fox et al.
Diabetologia, 58(7), 1503-1512 (2015-05-02)
There are potential advantages to the low-temperature (-196 °C) banking of isolated islets, including the maintenance of viable islets for future research. We therefore assessed the in vitro and in vivo function of islets cryopreserved for nearly 20 years. Human...
Martin Skov et al.
Muscle & nerve, 51(1), 65-71 (2014-04-09)
Experimental myotonia induced in rat muscle by ClC-1 chloride channel-inhibited has been shown to be related inversely to extracellular concentrations of Mg(2+) and Ca(2+) ([Mg(2+) ]o and [Ca(2+) ]o) within physiological ranges. Because this implicates a role for [Mg(2+)]o and...
Zhushi Li et al.
Oncology research, 21(6), 325-331 (2013-01-01)
It was revealed by our previous research that sodium selenite repressed autophagy accompanied by the induction of apoptosis in human leukemia NB4 cells. The inhibition of autophagy exerted a facilitative effect on apoptosis. In the present study, we further explored...
Veerander P S Ghotra et al.
Cancer research, 75(1), 230-240 (2014-11-13)
Improved targeted therapies are needed to combat metastatic prostate cancer. Here, we report the identification of the spleen kinase SYK as a mediator of metastatic dissemination in zebrafish and mouse xenograft models of human prostate cancer. Although SYK has not...
Adam J Wells et al.
PloS one, 10(6), e0130512-e0130512 (2015-06-30)
Malignant middle cerebral artery (MCA) stroke has a disproportionately high mortality due to the rapid development of refractory space-occupying cerebral edema. Animal models are essential in developing successful anti-edema therapies; however to date poor clinical translation has been associated with...
Pauline Luczynski et al.
Stress (Amsterdam, Netherlands), 18(6), 654-667 (2015-09-15)
We have previously reported that interhemispheric regulation of medial prefrontal cortex (PFC)-mediated stress responses is subserved by glutamate (GLU)- containing callosal neurons. Evidence of chronic stress-induced dendritic and spine atrophy among PFC pyramidal neurons led us to examine how chronic...
Amber D Stubler et al.
Global change biology, 21(11), 4006-4020 (2015-06-19)
Ocean acidification will disproportionately impact the growth of calcifying organisms in coral reef ecosystems. Simultaneously, sponge bioerosion rates have been shown to increase as seawater pH decreases. We conducted a 20-week experiment that included a 4-week acclimation period with a...
Mona Connolly et al.
International journal of environmental research and public health, 12(5), 5386-5405 (2015-05-27)
Among all classes of nanomaterials, silver nanoparticles (AgNPs) have potentially an important ecotoxicological impact, especially in freshwater environments. Fish are particularly susceptible to the toxic effects of silver ions and, with knowledge gaps regarding the contribution of dissolution and unique...
Naveen K Kaushik et al.
Malaria journal, 14, 65-65 (2015-04-17)
Development of resistance against the frontline anti-malarial drugs has created an alarming situation, which requires intensive drug discovery to develop new, more effective, affordable and accessible anti-malarial agents. Inspired by their ethnobotanical reputation for being effective against febrile diseases, antiplasmodial...
Akatsuki Nawata et al.
Diseases of aquatic organisms, 115(3), 253-262 (2015-08-21)
Soft tunic syndrome in the edible ascidian Halocynthia roretzi is caused by the kinetoplastid flagellate Azumiobodo hoyamushi, which was found to assume a fusiform cell form with 2 flagella in axenic, pure culture. When the flagellate form was incubated in...
Katrien Lowette et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(9), G905-G913 (2014-09-13)
Food intake depends on a tightly controlled interplay of appetite hormones and the enteric (ENS) and central nervous system. Corticosterone (CORT) levels, which are mainly studied with regard to stress, are also increased during fasting. However, the role of CORT...
Craig Skinner et al.
PloS one, 10(7), e0132419-e0132419 (2015-07-21)
Stx2e is a primary virulence factor in STEC strains that cause edema disease in neonatal piglets. Though Stx2a and Stx2e are similar, many antibody-based Stx detection kits are designed to detect Stx2a and do not recognize the Stx2e subtype. Four...
Guillaume Perriard et al.
Journal of neuroinflammation, 12, 119-119 (2015-06-17)
Increasing evidences link T helper 17 (Th17) cells with multiple sclerosis (MS). In this context, interleukin-22 (IL-22), a Th17-linked cytokine, has been implicated in blood brain barrier breakdown and lymphocyte infiltration. Furthermore, polymorphism between MS patients and controls has been...
Ismini E Papageorgiou et al.
Brain structure & function, 220(4), 2423-2439 (2014-06-01)
Activation of microglial cells (brain macrophages) soon after status epilepticus has been suggested to be critical for the pathogenesis of mesial temporal lobe epilepsy (MTLE). However, microglial activation in the chronic phase of experimental MTLE has been scarcely addressed. In...
Alastair D Green et al.
Pflugers Archiv : European journal of physiology, 467(10), 2219-2228 (2015-01-07)
We have studied the effects of cell communication on human beta cell function and resistance to cytotoxicity using the novel human insulin-secreting cell line 1.1B4 configured as monolayers and pseudoislets. Incubation with the incretin gut hormones GLP-1 and GIP caused...
Ryutaro Kotaki et al.
Immunobiology, 220(6), 734-743 (2015-02-02)
In the intestine, immune responses to commensal microbes should be regulated precisely. This regulation is achieved partly by dendritic cells (DCs), which recognize microbes through Toll-like receptors (TLRs). Although TLR responses have been intensely studied, cross-talk between individual TLRs remains...
Hyun Ah Jung et al.
Archives of pharmacal research, 37(6), 713-720 (2013-09-10)
Fucosterol is a sterol metabolite of brown algae and regulates genes involved with cholesterol homeostasis. As a part of our continuous search for anti-obesity agents from natural marine sources, the anti-adipogenic activities of Ecklonia stolonifera and its sterol, fucosterol, were...
R Wulff et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 77, 246-253 (2015-06-21)
The objective of this study was to investigate the suitability of "Eudragit® RL/Eudragit® L55" (RL/L55) blend coatings for a pH-independent release of acidic drugs. A coating for ketoprofen and naproxen mini tablets was developed showing constant drug release rate under...
U Ozgul et al.
Anaesthesia and intensive care, 41(4), 501-504 (2013-07-03)
The aim of this study was to determine whether pretreatment with alkalinised lignocaine reduced the incidence and severity of pain during propofol injection. This prospective, randomised, double-blind study included 300 adult, American Society of Anesthesiologists physcial status I to II...
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