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Vimal Gangadharan et al.
American journal of physiology. Cell physiology, 308(1), C41-C50 (2014-10-16)
The synthesis of new bone in response to a novel applied mechanical load requires a complex series of cellular signaling events in osteoblasts and osteocytes. The activation of the purinergic receptor P2X(7)R is central to this mechanotransduction signaling cascade. Recently
Marco C Bottino et al.
Clinical oral investigations, 18(9), 2151-2158 (2014-02-19)
The purposes of this study were to fabricate biodegradable polydioxanone (PDS II®) electrospun periodontal drug delivery systems (hereafter referred to as matrices) containing either metronidazole (MET) or ciprofloxacin (CIP) and to investigate the effects of antibiotic incorporation on both periodontopathogens
Hilda A Ayala-Bravo et al.
Pharmaceutical research, 20(8), 1267-1273 (2003-09-02)
The purpose of this work was to 1) investigate the effect of sucrose esters (sucrose oleate and sucrose laureate in water or in Transcutol, TC) on the stratum corneum (SC) barrier properties in vivo and 2) examine the impact of
Sabine Ullrich et al.
Journal of pharmaceutical sciences, 104(1), 155-164 (2014-11-26)
An experimental technique is presented to determine independently shrinkage and cracking in lyophilized amorphous cakes based on photographic imaging of their top surface. An inverse correlation between cake shrinkage and cracking during freeze-drying is seen. Shrinkage relaxes the drying tension
Sowmya Purushothaman et al.
The journal of physical chemistry. B, 119(30), 9805-9810 (2015-07-07)
Curvature is a fundamental lipid membrane property that influences many membrane-mediated biological processes and dynamic soft materials. One of the key parameters that determines the energetics of curvature change is the membrane bending rigidity. Understanding the intrinsic effect of pressure
Neal Whitaker et al.
Journal of bacteriology, 197(14), 2335-2349 (2015-05-06)
Bacterial type IV coupling proteins (T4CPs) bind and mediate the delivery of DNA substrates through associated type IV secretion systems (T4SSs). T4CPs consist of a transmembrane domain, a conserved nucleotide-binding domain (NBD), and a sequence-variable helical bundle called the all-alpha
Afolabi Adisa et al.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 50(8), 552-559 (2015-06-13)
Twenty-eight different tea samples sold in the United States were evaluated using high-performance liquid chromatography (HPLC) with fluorescence detection (FLD) for their contamination with polycyclic aromatic hydrocarbons (PAHs). Many PAHs exhibit carcinogenic, mutagenic, and teratogenic properties and have been related
Yuhua Wang et al.
Antioxidants & redox signaling, 21(16), 2177-2191 (2014-05-03)
This study is designed to assess the protective cardiac effects after myocardial infarction (MI) of (i) cardiovascular progenitor cells (PC) differentiated directly into cardiomyocytes (CM) and endothelial cells (ECs) at the injury site, as separable from the effects of (ii)
Rebecca Klar et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(19), 7600-7615 (2015-05-15)
Of the eight metabotropic glutamate (mGlu) receptor subtypes, only mGlu7 is expressed presynaptically at the Schaffer collateral (SC)-CA1 synapse in the hippocampus in adult animals. Coupled with the inhibitory effects of Group III mGlu receptor agonists on transmission at this
Sankaralingam Saikolappan et al.
Journal of bacteriology, 197(1), 51-62 (2014-10-15)
The organic hydroperoxide stress resistance regulator (OhrR) is a MarR type of transcriptional regulator that primarily regulates the expression of organic hydroperoxide reductase (Ohr) in bacteria. In mycobacteria, the genes encoding these proteins exist in only a few species, which
Vinay Khatri et al.
Carbohydrate polymers, 109, 139-147 (2014-05-13)
Cellulose fiber sheets impregnated with saccharide capped-ZnO nanoparticles were used as bioactive materials for antibody immobilization. First, ZnO nanoparticles were synthesized in the presence of glucose (monosaccharide), sucrose (disaccharide) as well as alginic acid and starch (polysaccharides). The pine cellulose
York Rudhard et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(7), 2927-2941 (2015-02-24)
Axon degeneration is a programed process that takes place during development, in response to neuronal injury, and as a component of neurodegenerative disease pathology, yet the molecular mechanisms that drive this process remain poorly defined. In this study, we have
Talar Tokatlian et al.
Advanced healthcare materials, 4(7), 1084-1091 (2015-02-20)
The treatment of impaired wounds requires the use of biomaterials that can provide mechanical and biological queues to the surrounding environment to promote angiogenesis, granulation tissue formation, and wound closure. Porous hydrogels show promotion of angiogenesis, even in the absence
C Gröer et al.
Journal of pharmaceutical and biomedical analysis, 100, 393-401 (2014-09-15)
Cytochrome P450 (CYP) enzymes and UDP-glucuronosyltransferases (UGT) are major determinants in the pharmacokinetics of most drugs on the market. To investigate their impact on intestinal and hepatic drug metabolism, we developed and validated quantification methods for nine CYP (CYP1A2, CYP2B6
Peng Luo et al.
Molecular medicine reports, 12(1), 1163-1168 (2015-03-18)
Congestive heart failure (CHF) remains the single most prevalent cause of mortality and morbidity; therefore, the identification of novel biomarkers is required for the diagnosis of CHF. The aim of the present study was to examine whether microRNA (miR)-423-5p is
Michael D McConnell et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 93(3), 199-209 (2015-01-21)
The eukaryotic green alga Chlamydomonas reinhardtii has been studied extensively within the biofuel industry as a model organism, as researchers look towards algae to provide chemical feedstocks (i.e., lipids) for the production of liquid transportation fuels. C. reinhardtii, however, is
Hans Eickhoff et al.
The Journal of endocrinology, 223(3), 255-265 (2014-10-03)
Excessive or inadequate glucagon secretion promoting hepatic gluconeogenesis and glycogenolysis is believed to contribute to hyperglycemia in patients with type 2 diabetes. Currently, metabolic surgery is an accepted treatment for obese patients with type 2 diabetes and has been shown
Shuji Sugiura et al.
The Journal of investigative dermatology, 135(3), 776-785 (2014-10-15)
Human prolactin-induced protein (PIP) is a major protein found in exocrine fluids such as saliva and sweat. Intriguingly, PIP possesses residues (human PIP (hPIP): PIP (29-63)) that display similarity to the aspartic peptidase candidapepsin. Here, we aimed to determine the
Sally-Anne Stephenson et al.
Oncotarget, 6(10), 7554-7569 (2015-04-02)
EphB4 is a membrane-bound receptor tyrosine kinase (RTK) commonly over-produced by many epithelial cancers but with low to no expression in most normal adult tissues. EphB4 over-production promotes ligand-independent signaling pathways that increase cancer cell viability and stimulate migration and
Jamie P Adams et al.
Veterinary journal (London, England : 1997), 202(3), 436-442 (2014-12-03)
Virtually all diabetic dogs require exogenous insulin therapy to control their hyperglycaemia. In the UK, the only licensed insulin product currently available is a purified porcine insulin preparation. Recombinant insulin is somewhat problematic in terms of its manufacture, since the
Leyla Zilic et al.
Journal of anatomy, 227(3), 302-314 (2015-07-23)
Current nerve tissue engineering applications are adopting xenogeneic nerve tissue as potential nerve grafts to help aid nerve regeneration. However, there is little literature that describes the exact location, anatomy and physiology of these nerves to highlight their potential as
Veronica Bianchi et al.
Reproductive biology and endocrinology : RB&E, 12, 110-110 (2014-11-26)
Human mature oocytes are very susceptible to cryodamage. Several reports demonstrated that vitrification might preserve oocyte better than slow freezing. However, this is still controversial. Thus, larger clinical, biological and experimental trials to confirm this concept are necessary. The aim
Lei Yang et al.
AMB Express, 4, 54-54 (2014-11-18)
Aspergillus carbonarius has potential as a cell factory for the production of different organic acids. At pH 5.5, A.carbonarius accumulates high amounts of gluconic acid when it grows on glucose based medium whereas at low pH, it produces citric acid.
A P S Feitosa et al.
Journal of medical entomology, 52(6), 1193-1202 (2015-09-04)
Few studies have examined the cellular immune response of ticks, and further research on the characterization of the hemocytes of ticks is required, particularly on those of Rhipicephalus sanguineus (Latreille) because of the medical and veterinary importance of this tick.
Philipp Malsch et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(30), 9845-9856 (2014-07-25)
Glycoprotein 130 (gp130) is the signal transducing receptor subunit for cytokines of the interleukin-6 (IL-6) family, and it is expressed in a multitude of cell types of the immune and nervous system. IL-6-like cytokines are not only key regulators of
Ricky Y T Chiu et al.
PloS one, 10(11), e0142654-e0142654 (2015-11-12)
The paper-based immunoassay for point-of-care diagnostics is widely used due to its low cost and portability over traditional lab-based assays. Lateral-flow immunoassay (LFA) is the most well-established paper-based assay since it is rapid and easy to use. However, the disadvantage
Edoardo Micotti et al.
Neurobiology of aging, 36(2), 776-788 (2014-12-01)
Alzheimer's disease is experimentally modeled in transgenic (Tg) mice overexpressing mutated forms of the human amyloid precursor protein either alone or combined with mutated presenilins and tau. In the present study, we developed a systematic approach to compare double (TASTPM)
María I Pozo et al.
FEMS microbiology ecology, 91(6) (2015-05-23)
Floral nectars become easily colonized by microbes, most often species of the ascomycetous yeast genus Metschnikowia. Although it is known that nectar composition can vary tremendously among plant species, most probably corresponding to the nutritional requirements of their main pollinators
Minpei Kuroda et al.
Steroids, 93, 96-104 (2014-12-03)
We have analyzed the steroidal glycosides in Allium karataviense bulbs, and isolated five new bisdesmosidic steroidal glycosides: karataviosides G-K (1-5). The structures were elucidated by extensive spectroscopic analysis, including 2D NMR and enzymatic and hydrolytic cleavage. Karatavioside G (1) is
Julie Carcaud et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(10), 4157-4167 (2015-03-13)
Neural coding of pheromones has been intensively studied in insects with a particular focus on sex pheromones. These studies favored the view that pheromone compounds are processed within specific antennal lobe glomeruli following a specialized labeled-line system. However, pheromones play
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