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Asie Shojaii et al.
Journal of basic and clinical physiology and pharmacology, 26(4), 369-374 (2014-12-24)
The importance of inflammatory diseases and side effects of conventional drugs necessitate the finding of new anti-inflammatory agents from natural sources. In this study, for the first time, the anti-inflammatory and analgesic effects of the aqueous extract of Astragalus arbusculinus
Marisa Wickerath et al.
Anticancer research, 34(7), 3399-3401 (2014-07-02)
The standard methods of chemotherapy in cancer treatment are expensive and pose serious health effects. The present study investigates an alternative chemotherapy by testing the combined treatment of two drugs on leukemia cells: dihydroartemisinin (DHA) and sodium salicylate (SS). Cells
Guang-Di Chen et al.
Brain research, 1485, 63-76 (2012-04-03)
The amygdala, important in forming and storing memories of aversive events, is believed to play a major role in debilitating tinnitus and hyperacusis. To explore this hypothesis, we recorded from the lateral amygdala (LA) and auditory cortex (AC) before and
Sandra Pereira et al.
The Journal of endocrinology, 217(1), 31-43 (2013-01-19)
We have shown in rats that sodium salicylate (SS), which inhibits IkBa kinase B (IKKB), prevents hepatic and peripheral insulin resistance caused by short-term (7  h) i.v. administration of Intralipid and heparin (IH). We wished to further determine whether this
Andreia Z Chignalia et al.
Clinical science (London, England : 1979), 129(1), 39-48 (2015-02-24)
The mechanisms whereby testosterone increases cardiovascular risk are not clarified. However, oxidative stress and inflammation seem to be determinants. Herein, we sought to determine whether exogenous testosterone, at physiological levels, induces leucocyte migration, a central feature in immune and inflammatory
Tomoka Takatani-Nakase et al.
PloS one, 7(10), e47980-e47980 (2012-10-31)
Transcutaneous immunization (TCI) is a novel vaccination strategy, which is expected to have therapeutic applications. However, to develop effective TCI systems, a simple, non-invasive and safe transdermal formulation is required. This study developed a novel TCI system utilizing the co-administration
Narges Hosseinmardi et al.
European journal of pharmacology, 670(2-3), 487-494 (2011-09-29)
Effects of morphine on synaptic transmission and plasticity in the hippocampus area CA1 following in vivo sodium salicylate and the potential molecular mechanism were investigated. Population spikes (PS) were recorded from stratum pylamidale of area CA1 following stimulation of Schaffer
Kui Wang et al.
Journal of medicinal chemistry, 52(20), 6402-6412 (2009-10-16)
Viologens are showing an increasing number of scientific and technical applications in addition to their use as herbicides. However, their high toxicity poses considerable risks to human health, society, and the environment. In this context, we propose a new therapeutic
Yanguang Cao et al.
The Journal of pharmacology and experimental therapeutics, 339(3), 896-904 (2011-09-10)
Type 2 diabetes mellitus (T2DM) arises owing to insulin resistance and β-cell dysfunction. Chronic inflammation is widely identified as a cause of T2DM. The Goto-Kakizaki (GK) rat is a spontaneous rodent model for T2DM with chronic inflammation. The purpose of
Rainer Amann et al.
European journal of pharmacology, 447(1), 1-9 (2002-07-11)
Aspirin (acetylsalicylic acid) is one of the most widely used drugs worldwide. It acetylates cyclooxygenases thereby irreversibly blocking the conversion of arachidonic acid to prostanoids. Biotransformation of aspirin yields salicylate, a compound that possesses similar anti-inflammatory potency as aspirin but
Agnieszka Sliwinska et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(5), 1116-1123 (2015-05-12)
Metformin and sitagliptin are hypoglycemic drugs with potential use in cancer treatment. Evidence indicates that metformin may inhibit the proliferation and growth of various types of cancer cells. Data regarding the relationship between sitagliptin and cancer cells is limited. Therapy
Mona T Kashif et al.
Journal of microbiological methods, 91(3), 354-357 (2012-10-13)
AmpC β-lactamases are enzymes that hydrolyze all β-lactam antibiotics except cefipime and imipenem. Currently, there is no standard phenotypic method for detection of such enzymes. This study aims to report the use of sodium salicylate for AmpC β-lactamases detection and
Xiao-Peng Liu et al.
Brain research, 1485, 88-94 (2012-05-23)
The auditory response to an acoustic stimulus will usually be suppressed, or masked, by a preceding sound. Here, we show that forward acoustic masking at a high frequency can boost the auditory brainstem response (ABR) in rats injected with a
Virginia M Klimek et al.
Leukemia research, 36(5), 570-574 (2011-12-14)
Sodium salicylate is an inexpensive, readily available anti-inflammatory agent which inhibits NF-κB in in vitro models. We examined whether it was possible to safely achieve and maintain salicylate levels known to inhibit NF-κB in vitro in 11 patients with MDS
Kyo Kobayashi et al.
Pharmaceutical development and technology, 20(2), 219-226 (2013-11-30)
Medical-grade collagen peptide is used as an additive agent in pharmaceutical formulations; however, it is unknown as to whether the compound exerts antioxidant effects in vitro. In this study, we evaluated the antioxidant effects of medical-grade collagen peptide on reactive
P Thakur et al.
Neuroscience, 231, 420-431 (2012-11-20)
Parkinson's disease (PD) is the second most common neurodegenerative disorder manifesting in motor, cognitive and behavioral anomalies. Loss of dopaminergic neurons in the substantia nigra region of the brain is the hallmark feature of PD, which is attributed to oxidative
Asami Yamaguchi et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 39(4), 605-611 (2012-04-17)
Our first report mentioned the analysis results of the safety and efficacy of trigger point (TP) therapy by Neovitacain® injection (NV) in the daily clinical treatment of myofascial pain in cancer patients. This time, we report additional considerations regarding the
M J Chaichi et al.
Journal of fluorescence, 22(5), 1209-1216 (2012-06-12)
Furan derivatives (synthesized and purified in organic laboratories) are a great interest as fluorescent emitters for peroxyoxalate chemiluminescence. Reaction of peroxyoxalates such as bis-(2,4,6-trichloro-phenyl) oxalate with H(2)O(2) can transfer energy to fluorophore via formation of dioxetanedione intermediate. Furan derivatives used
B Poźniak et al.
British poultry science, 53(6), 777-783 (2013-02-13)
1. Acetylsalicylic acid (ASA) and sodium salicylate (SS) are considered safe for poultry and often used in avian medicine. However, information on tolerance and specific side effects of these drugs in birds is lacking. 2. The aim of this study
John W Steinke et al.
Journal of immunology (Baltimore, Md. : 1950), 193(1), 41-47 (2014-06-04)
Reactions to aspirin and nonsteroidal anti-inflammatory drugs in patients with aspirin-exacerbated respiratory disease (AERD) are triggered when constraints upon activated eosinophils, normally supplied by PGE2, are removed secondary to cyclooxygenase-1 inhibition. However, the mechanism driving the concomitant cellular activation is
Masaichi-Chang-Il Lee et al.
Biochemistry, 53(41), 6615-6623 (2014-09-23)
The enzyme xanthine oxidoreductase (XOR) is an important source of oxygen free radicals and related postischemic injury. Xanthine dehydrogenase (XDH), the major form of XOR in tissues, can be converted to xanthine oxidase (XO) by oxidation of sulfhydryl residues or
Anders Aune Tveita et al.
Cancer research, 75(16), 3268-3278 (2015-06-04)
Tumors cells can escape cytotoxic CD8+ T cells by preventing MHC I display of tumor antigens. It is unknown how tumors evade CD4+ T-cell responses, but because many tumor cells lack MHC II expression, novel mechanisms would be required. We
Sarah L Baldridge et al.
American journal of veterinary research, 72(10), 1305-1317 (2011-10-04)
To determine the pharmacokinetic parameters of xylazine, ketamine, and butorphanol (XKB) administered IM and sodium salicylate (SAL) administered PO to calves and to compare drug effects on biomarkers of pain and distress following sham and actual castration and dehorning. 40
Yun Li et al.
Biosensors & bioelectronics, 62, 255-260 (2014-07-14)
A surface-enhanced fluorescence (SEF) immunosensor for the detection of microcystin-LR was developed using Au nano-crosses as fluorescence enhancement nanoparticles and cy5 as a fluorescence label molecule. The SEF effects of cy5 in the proximity of Au nanorods and gold nano-crosses
Darine Villela et al.
Life sciences, 94(2), 122-129 (2013-11-19)
The circadian rhythm in mammalian pineal melatonin secretion is modulated by norepinephrine (NE) released at night. NE interaction with β1-adrenoceptors activates PKA that phosphorylates the transcription factor CREB, leading to the transcription and translation of the arylalkylamine-N-acetyltransferase (AANAT) enzyme. Several
I V Petrova et al.
Farmakologiia i toksikologiia, 43(2), 184-186 (1980-03-01)
It is established in in-vitro experiments that mefenamic acid and sodium salicylate inhibit to an equal measure the cell immunity test, a reaction of blast transformation of lymphocytes. The effect increases with the higher concentration of the drugs under study
Fangfang Liu et al.
Toxicology, 315, 17-23 (2013-11-28)
Life-threatening acute lung injury potentially occurs following high-level accidental exposures to phosgene gas. This situation was mirrored in rats exposed nose-only at 900-1000 mg phosgene/m(3)min. At this exposure level, previous studies on rats demonstrated sustained reflexively induced cardiopulmonary dysfunction and
Jiadi Sun et al.
Biosensors & bioelectronics, 70, 239-245 (2015-04-02)
A novel DNA sensor for the detection of the Escherichia coli O157:H7 (E. coli O157:H7) eaeA gene was constructed using surface enhanced fluorescence (SEF). The spacing distance dependence nature of Au@Ag nanorods surface enhanced fluorescence was investigated when the cy3-labled
Qian Zhang et al.
Acta biomaterialia, 8(3), 1316-1322 (2011-12-14)
Poly(amidoamine) (PAMAM) dendrons were prepared from hollow fiber membranes (HFM) consisting of bromomethylated poly(2,6-dimethyl-1,4-phenylene oxide) (BPPO) in a stepwise manner. The prepared HFM were characterized by Fourier transform infrared spectroscopy, elemental analysis, and scanning electron microscopy. The drug loading efficiency
Kulthida Vaeteewoottacharn et al.
Anticancer research, 34(4), 1865-1871 (2014-04-03)
Primary effusion lymphoma (PEL) is a rare but aggressive form of non-Hodgkin's B-cell lymphoma in immunodeficient patients. Resistance to conventional chemotherapeutic regimens is common in PEL and contributes to a very poor prognosis; hence, novel potent anti-PEL agents are required.
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