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Donatella Ponti et al.
BMC cell biology, 16, 27-27 (2015-11-19)
The nucleolus is a multi-domain enriched with proteins involved in ribosome biogenesis, cell cycle and apoptosis control, viral replication and differentiation of stem cells. Several authors have suggested a role for the nucleolus also in malignant transformation. We have recently
Yusuke Hatanaka et al.
Scientific reports, 5, 16102-16102 (2015-11-05)
Late-onset neurodegenerative diseases are characterized by neurological symptoms and progressive neuronal death. Accumulating evidence suggests that neuronal dysfunction, rather than neuronal death, causes the symptoms of neurodegenerative diseases. However, the mechanisms underlying the dysfunction that occurs prior to cell death
Philip B Kidd et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(46), E6284-E6292 (2015-11-19)
All known circadian clocks have an endogenous period that is remarkably insensitive to temperature, a property known as temperature compensation, while at the same time being readily entrained by a diurnal temperature oscillation. Although temperature compensation and entrainment are defining
Agnieszka Konopacka et al.
eLife, 4 (2015-11-13)
In response to an osmotic challenge, the synthesis of the antidiuretic hormone arginine vasopressin (AVP) increases in the hypothalamus, and this is accompanied by extension of the 3' poly(A) tail of the AVP mRNA, and the up-regulation of the expression
Masahito Horiguchi et al.
Matrix biology : journal of the International Society for Matrix Biology, 43, 61-70 (2015-03-26)
Latent transforming growth factor-β binding protein-1 (LTBP-1) is an extracellular protein that is structurally similar to fibrillin and has an important role in controlling transforming growth factor-β (TGF-β) signaling by storing the cytokine in the extracellular matrix and by being
Lee W Goneau et al.
mBio, 6(2) (2015-04-02)
The capacity of subinhibitory levels of antibiotics to modulate bacterial virulence in vitro has recently been brought to light, raising concerns over the appropriateness of low-dose therapies, including antibiotic prophylaxis for recurrent urinary tract infection management. However, the mechanisms involved
Dominik Stammler et al.
Journal of immunology (Baltimore, Md. : 1950), 195(11), 5421-5431 (2015-11-01)
Histone deacetylase (HDAC) inhibitors (HDACi) are clinically approved anticancer drugs that have important immune-modulatory properties. We report the surprising finding that HDACi promote LPS-induced IL-1β processing and secretion in human and murine dendritic cells and murine macrophages. HDACi/LPS-induced IL-1β maturation
Gang Liu et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(11), 8553-8558 (2015-06-04)
Aberrant expression of the Cullin 4A (CUL4A) is found in many tumor types, but the functions and mechanism of CUL4A in prostate cancer (PCa) development and progression remain largely unknown. The aim of this study was to investigate the possible
Anne-Marie Byrne et al.
British journal of cancer, 113(9), 1332-1342 (2015-10-16)
The aetiology of Barrett's oesophagus (BO) and oesophageal cancer is poorly understood. We previously demonstrated that Golgi structure and function is altered in oesophageal cancer cells. A Golgi-associated protein, GOLPH2, was previously established as a tissue biomarker for BO. Cellular
Romain Simon et al.
Journal of pharmaceutical and biomedical analysis, 94, 84-91 (2014-02-21)
Glomeruli play a major role in the kidney function since they are involved in primary urine formation. It is then crucial to dispose of methods to monitor glomerular injury, especially in drug development. In this context, quantification of podocin could
Andrew Godwin et al.
Shock (Augusta, Ga.), 43(1), 24-30 (2014-09-05)
Cold-inducible RNA-binding protein (CIRP) is a nuclear protein that has been recently identified as a novel inflammatory mediator in hemorrhagic shock and sepsis. We hypothesized that CIRP acts as a potent inflammatory mediator in hepatic ischemia-reperfusion (I/R), and thus blocking
Raifish E Mendoza-Villarroel et al.
Biology of reproduction, 91(1), 26-26 (2014-06-06)
Testosterone production is dependent on cholesterol transport within the mitochondrial matrix, an essential step mediated by a protein complex containing the steroidogenic acute regulatory (STAR) protein. In steroidogenic Leydig cells, Star expression is hormonally regulated and involves several transcription factors.
H J Liu et al.
International endodontic journal, 48(10), 976-985 (2014-10-08)
To investigate the role of p300 in the regulation of proliferation and odontogenic differentiation of human dental pulp cells (HDPCs). The recombinant lentiviral vector pshRNA-copGFP was used to knock-down p300 expression in HDPCs. Protein level of acetylated H3 was detected.
Lorine J Wilkinson et al.
Kidney international, 87(5), 975-983 (2015-01-15)
Gestational stressors, including glucocorticoids and protein restriction, can affect kidney development and hence final nephron number. Since hypoxia is a common insult during pregnancy, we studied the influence of oxygen tension on kidney development in models designed to represent a
Ji Ho Kang et al.
Experimental biology and medicine (Maywood, N.J.), 240(11), 1416-1425 (2015-02-27)
Although carboplatin is one of the standard chemotherapeutic agents for non-small cell lung cancer (NSCLC), it has limited therapeutic efficacy due to activation of a survival signaling pathway and the induction of multidrug resistance. Curcumin, a natural compound isolated from
Tingting Chai et al.
Frontiers in plant science, 6, 292-292 (2015-05-23)
Programmed cell death (PCD) in plant is triggered by abiotic and biotic stress. Light-dependent PCD is unique to plants. Light-induced PCD also requires reactive oxygen species (ROS) and salicylic acid (SA). In this study, lesion simulating disease1 (LSD1) and elongated
Hélène Bon et al.
Molecular cancer research : MCR, 13(4), 620-635 (2014-12-31)
Salt-inducible kinase 2 (SIK2) is a multifunctional kinase of the AMPK family that plays a role in CREB1-mediated gene transcription and was recently reported to have therapeutic potential in ovarian cancer. The expression of this kinase was investigated in prostate
Jie Ge et al.
PloS one, 9(10), e110293-e110293 (2014-10-21)
Autophagy-related gene-5 (ATG-5) is one of the key regulators of autophagic cell death. It has been widely regarded as a protective molecular mechanism for tumor cells during the course of chemotherapy. In the present study, we investigated the expression pattern
Yuwu Liu et al.
Experimental and therapeutic medicine, 9(4), 1247-1252 (2015-03-18)
Plexins are the primary receptors of semaphorins, and participate in the majority of intracellular pathways triggered by semaphorins, including the regulation of cell adhesion and the motility of numerous cell types. Recently, several studies have reported that plexins can significantly
Toshiyuki Tsunoda et al.
Anticancer research, 35(8), 4453-4459 (2015-07-15)
Oncogenic mutations in the KRAS gene are critically involved in many human tumors but drugs targeting oncogenic KRAS have not yet been clinically developed. Herein, we established a three-dimensional floating (3DF) culture system for screening drugs that target KRAS-mediated signaling
Shihori Takanashi et al.
Folia microbiologica, 59(4), 289-293 (2014-01-08)
Lactococcus lactis subsp. lactis has been isolated from the intestines of marine fish and is a candidate probiotic for aquaculture. In order to use the bacterium as a probiotic, properties such as bile tolerance need to be assessed. Here, we
Yeo Jin Jang et al.
Biomolecules & therapeutics, 23(5), 407-413 (2015-09-04)
Paraquat dichloride (N,N-dimethyl-4-4'-bipiridinium, PQ) is an extremely toxic chemical that is widely used in herbicides. PQ generates reactive oxygen species (ROS) and causes multiple organ failure. In particular, PQ has been reported to be an immunotoxic agrochemical compound. PQ was
L L Liu et al.
Oncogene, 33(24), 3140-3150 (2013-07-16)
Prostate tumors develop resistance to androgen deprivation therapy (ADT) by multiple mechanisms, one of which is to express constitutively active androgen receptor (AR) splice variants lacking the ligand-binding domain. AR splice variant 7 (AR-V7, also termed AR3) is the most
Ciaran A Shaughnessy et al.
The Journal of experimental biology, 218(Pt 17), 2712-2719 (2015-09-04)
Migratory fishes encounter a variety of environmental conditions, including changes in salinity, temperature and dissolved gases, and it is important to understand how these fishes are able to acclimate to multiple environmental stressors. The gill is the primary site of
Gokhan Sadi et al.
European journal of nutrition, 54(6), 895-904 (2014-09-23)
The increased consumption of high-fructose corn syrup (HFCS) may contribute to the worldwide epidemic of fatty liver. In this study, we have investigated whether HFCS intake (20% beverages) influences lipid synthesis and accumulation in conjunction with insulin receptor substrate-1/2 (IRS-1;
Cosmin A Tegla et al.
Experimental and molecular pathology, 98(3), 328-337 (2015-03-17)
We have previously shown that RGC-32 is involved in cell cycle regulation in vitro. To define the in vivo role of RGC-32, we generated RGC-32 knockout mice. These mice developed normally and did not spontaneously develop overt tumors. To assess
Shisheng Tan et al.
Oncology letters, 9(5), 2056-2062 (2015-07-03)
Oxaliplatin (OX) has been widely used in adjuvant and palliative treatments of advanced colon cancer; however, cancer cells ultimately become resistant in the majority of cases. Therefore, the development of a novel strategy to overcome this resistance is important for
Jianling Liu et al.
PloS one, 10(4), e0123109-e0123109 (2015-04-02)
As a rich natural resource for drug discovery, Traditional Chinese Medicine (TCM) plays an important role in complementary and alternative medical systems. TCM shows a daunting complexity of compounds featuring multi-components and multi-targets to cure diseases, which thus always makes
Sara M Centuori et al.
Digestive diseases and sciences, 59(10), 2367-2380 (2014-07-17)
A high-fat diet coincides with increased levels of bile acids. This increase in bile acids, particularly deoxycholic acid (DCA), has been strongly associated with the development of colon cancer. Conversely, ursodeoxycholic acid (UDCA) may have chemopreventive properties. Although structurally similar
Xuming Sun et al.
American journal of physiology. Renal physiology, 309(2), F120-F136 (2015-05-15)
We previously reported that the deletion of the pH sensor GPR4 causes a non-gap metabolic acidosis and defective net acid excretion (NAE) in the GPR4 knockout mouse (GPR4-/-) (Sun X, Yang LV, Tiegs BC, Arend LJ, McGraw DW, Penn RB
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