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Ya-Jian Zhang et al.
PloS one, 9(12), e116056-e116056 (2015-01-01)
A spontaneous late-ripening mutant of 'Jincheng' (C. sinensis L. Osbeck) sweet orange exhibited a delay of fruit pigmentation and harvesting. In this work, we studied the processes of orange fruit ripening through the comparative analysis between the Jincheng mutant and
J A Tree et al.
Journal of virology, 89(8), 4335-4344 (2015-02-06)
To evaluate new vaccines when human efficacy studies are not possible, the FDA's "Animal Rule" requires well-characterized models of infection. Thus, in the present study, the early pathogenic events of monkeypox infection in nonhuman primates, a surrogate for variola virus
Zhiqiang Ku et al.
Vaccine, 32(34), 4296-4303 (2014-06-21)
Enterovirus 71(EV71) and coxsackievirus A16 (CA16) are responsible for hand, foot and mouth disease which has been prevalent in Asia-Pacific regions, causing significant morbidity and mortality in young children. Co-circulation of and co-infection by both viruses underscores the importance and
Sangeeta Yadav et al.
Journal of environmental sciences (China), 25(1), 172-180 (2013-04-17)
Melanodins are amino-carbonyl complex, predominantly present in sugarcane molasses based distillery wastewater as major source of colourant. The microbial decolourisation of melanoidin is a challenge due to its binding property with other co-pollutants of distillery waste. Results revealed that the
Marie S Møller et al.
Journal of molecular biology, 427(6 Pt B), 1263-1277 (2015-01-07)
Complete hydrolytic degradation of starch requires hydrolysis of both the α-1,4- and α-1,6-glucosidic bonds in amylopectin. Limit dextrinase (LD) is the only endogenous barley enzyme capable of hydrolyzing the α-1,6-glucosidic bond during seed germination, and impaired LD activity inevitably reduces
Xin-Hua Lu et al.
Molecules (Basel, Switzerland), 19(6), 8518-8532 (2014-06-25)
The fruit physico-chemical properties, antioxidant activity and mineral contents of 26 pineapple [Ananas comosus (L.) Merr.] genotypes grown in China were measured. The results showed great quantitative differences in the composition of these pineapple genotypes. Sucrose was the dominant sugar
Jaewang Lee et al.
Theriogenology, 83(2), 285-293 (2014-12-03)
After the ovarian tissue (OT) transplantation, the ischemia-reperfusion injury causes depletion and apoptosis of follicle. Recent reports stated that simvastatin reduces ischemic damage. Therefore, we used the mouse whole ovarian vitrification and autotransplantation models to investigate the effects of simvastatin.
Yumin Wang et al.
Journal of molecular neuroscience : MN, 53(4), 537-545 (2014-01-08)
Pinocembrin (PB), the most abundant flavonoid in propolis, has been proven to have neuroprotective property against neurotoxicity in vivo and in vitro. Our recent study demonstrated the neuroprotective effect of PB against Aβ25-35-induced SH-SY5Y neurotoxicity. However, the mechanism as how
Thiago M Mello-de-Sousa et al.
Biotechnology for biofuels, 7(1), 129-129 (2014-10-25)
Rut-C30 is a cellulase-hyperproducing Trichoderma reesei strain and, consequently, became the ancestor of most industry strains used in the production of plant cell wall-degrading enzymes, in particular cellulases. Due to three rounds of undirected mutagenesis its genetic background differs from
Ting Wei et al.
PloS one, 9(12), e114447-e114447 (2014-12-06)
The eukaryotic translation factor eEF1A assists replication of many RNA viruses by various mechanisms. Here we show that down-regulation of eEF1A restricts the expression of viral genomic RNA and the release of infectious virus, demonstrating a biological requirement for eEF1A
Meidjie Ang et al.
The American journal of clinical nutrition, 100(4), 1059-1068 (2014-07-18)
Isomaltulose attenuates postprandial glucose and insulin concentrations compared with sucrose in patients with type 2 diabetes mellitus (T2DM). However, the mechanism by which isomaltulose limits postprandial hyperglycemia has not been clarified. The objective was therefore to assess the effects of
Olga S Kustikova et al.
Experimental hematology, 42(7), 505-515 (2014-03-29)
Tetracycline-regulated integrating vectors allow pharmacologically controlled genetic modification of murine and human hematopoietic stem cells and provide the opportunity for time- and dose-controlled reversible transgene expression in hematopoietic stem cells in vitro and in vivo. However, the background activity of
Julia B Cordero et al.
The EMBO journal, 33(13), 1474-1491 (2014-05-03)
The non-receptor tyrosine kinase c-Src, hereafter referred to as Src, is overexpressed or activated in multiple human malignancies. There has been much speculation about the functional role of Src in colorectal cancer (CRC), with Src amplification and potential activating mutations
Moritz Beck-Broichsitter et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 87(3), 524-529 (2014-03-25)
Manipulation of aerosol characteristics is of special interest for pulmonary therapy, as a suitable particle size optimizes pulmonary deposition. The present study investigated the impact of formulation variables on the aerodynamic particle diameter (d(a)) when nebulized by vibrating-membrane technology. Membranes
Yunbin Xiao et al.
International journal of nanomedicine, 10, 1155-1172 (2015-02-25)
Magnetic resonance imaging (MRI) contrast agents based on chitosan derivatives have great potential for diagnosing diseases. However, stable tumor-targeted MRI contrast agents using micelles prepared from high molecular weight chitosan derivatives are seldom reported. In this study, we developed a
Namon Hirun et al.
Drug development and industrial pharmacy, 41(2), 194-200 (2013-11-16)
Tamarind seed xyloglucan (TSX) is generally used for drug delivery systems. Gallic acid (GA) possesses various pharmacological activities. It has a good solubility and bioavailability but short half-life. To prepare a sustained-release of GA to overcome its relatively short half-life.
Yang Zhang et al.
The International journal of oral & maxillofacial implants, 29(5), 1137-1142 (2014-09-13)
This study investigated whether the nonincision placement of miniscrews could lead to ectopic implantation of epithelium at the bone-implant interface and, if so, whether the epithelial cells could survive. The fate of grafted epithelial cells was also investigated. Ten healthy
P B Marangon et al.
Journal of neuroendocrinology, 26(11), 796-804 (2014-08-13)
In addition to its action in the control of the hypothalamic-pituitary-adrenal axis, corticotrophin-releasing factor (CRF) has been described as an anorexigenic neuropeptide, modulating food intake and energy expenditure. CRF synthesis is influenced by leptin, which would act to increase CRF
Robert H Behal et al.
Methods in enzymology, 524, 171-194 (2013-03-19)
Intraflagellar transport (IFT) involves the movement of large proteinaceous particles or trains along the length of ciliary and flagellar axonemal microtubules. The particles contain multiple copies of two protein complexes. As isolated from the flagellated model organism, Chlamydomonas reinhardtii, IFT
Nicolas Salez et al.
The Journal of infection, 69(2), 182-189 (2014-04-08)
The epidemiology of Influenza C virus (FLUCV) infections remains poorly characterised. Here, we have examined the age- and location-specific seroprevalence of antibodies against FLUCV in 1441 sera from metropolitan continental France (Marseille), South-West Indian Ocean French territories (Reunion Island) and
Spela Može Bornšek et al.
Food chemistry, 173, 61-69 (2014-12-04)
Bilberries processed into spreads represent an important source of anthocyanins if these remain rich in the final product. The effects of thermal processing were studied with non-ground and ground bilberries processed into spreads according to industrial and home-made procedures. Samples
M Miranda et al.
FEBS letters, 588(24), 4815-4824 (2014-12-03)
The post-translational palmitoylation of WNT morphogens is critical for proper signaling during embryogenesis and adult homeostasis. The addition of palmitoyl groups to WNT proteins is catalyzed by Porcupine (PORCN). However, the Wnt amino acid residues required for recognition and palmitoylation
Ahmed Abdeen et al.
American journal of physiology. Renal physiology, 307(11), F1227-F1237 (2014-10-24)
Urinary exosomes are nano-sized vesicles secreted into urine from all types of renal epithelial cells and are known to contain possible biomarker proteins for renal diseases. Gentamicin has been reported to decrease the level of renal aquaporin (AQP)2, which is
Kihoon Han et al.
Human molecular genetics, 24(7), 1813-1823 (2014-11-30)
Silencing of fragile X mental retardation 1 (FMR1) gene and loss of fragile X mental retardation protein (FMRP) cause fragile X syndrome (FXS), a genetic disorder characterized by intellectual disability and autistic behaviors. FMRP is an mRNA-binding protein regulating neuronal
Brian L Weiss et al.
Journal of immunology (Baltimore, Md. : 1950), 193(2), 773-782 (2014-06-11)
The insect gut is lined by a protective, chitinous peritrophic matrix (PM) that separates immunoreactive epithelial cells from microbes present within the luminal contents. Tsetse flies (Glossina spp.) imbibe vertebrate blood exclusively and can be exposed to foreign microorganisms during
Lihong Zhu et al.
Molecular and cellular neurosciences, 64, 74-83 (2014-05-28)
In our previous study, we reported that luteolin might exert neuroprotective functions by inhibiting the production of proinflammatory mediators, thereby suppressing microglial activation. In this study, we used two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS) to study the effect
Jeremy Sanborn et al.
Faraday discussions, 161, 167-176 (2013-06-29)
We report the experimental observation of osmotically induced transient pearling instabilities in vesicular membranes. Giant phospholipid vesicles subjected to negative osmotic gradient, which drives the influx of water in to the vesicular interior, produces transient cylindrical protrusions. These protrusions exhibit
Bamaprasad Dutta et al.
Molecular & cellular proteomics : MCP, 13(9), 2183-2197 (2014-05-17)
The chromatin-associated proteome (chromatome) regulates cellular gene expression by restricting access of transcriptional machinery to template DNA, and dynamic re-modeling of chromatin structure is required to regulate critical cell functions including growth and replication, DNA repair and recombination, and oncogenic
Shunlin Ren et al.
PloS one, 9(7), e103621-e103621 (2014-07-30)
Oxysterol sulfation plays an important role in regulation of lipid metabolism and inflammatory responses. In the present study, we report the discovery of a novel regulatory sulfated oxysterol in nuclei of primary rat hepatocytes after overexpression of the gene encoding
Luan Zhang et al.
Ecotoxicology and environmental safety, 104, 278-284 (2014-04-15)
In the current study, we hypothesize that mine (metallicolous) populations of metallophytes form a trade-off between the roots and shoots when under copper (Cu) stress to adapt themselves to heavy metal contaminated habitats, and thus, differ from normal (non-metallicolous) populations
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