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Puneet Gill et al.
Materials science & engineering. C, Materials for biological applications, 50, 37-44 (2015-03-10)
The constant demand for new implant materials and the multidisciplinary design approaches for stent applications have expanded vastly over the past decade. The biocompatibility of these implant materials is a function of their surface characteristics such as morphology, surface chemistry
Qisen Xiang et al.
International journal of food sciences and nutrition, 66(1), 76-84 (2014-09-30)
Carnosic acid (CA), a phenolic diterpene isolated from rosemary, shows potential benefits in health promotion and disease prevention. In the present study, the cytotoxic and apoptotic-inducing effects of CA on human hepatocellular carcinoma HepG2 cells were investigated. The MTT assay
Melanie M Erzinger et al.
Journal of biochemical and molecular toxicology, 29(1), 10-20 (2014-09-03)
Cellular induction of reductase enzymes can alter the susceptibility of cells toward drugs and chemicals. In this study, we compared the capacity of a single dose of sodium selenite and 3H-1,2-dithiole-3-thione (D3T) to influence the drug-relevant reducing capacity of HT29
Evelien De Waele et al.
Pancreas, 43(7), 1083-1092 (2014-07-09)
Epithelial-mesenchymal transition may interfere with the differentiation of cultured pancreatic acinar cells toward endocrine cells. Therefore, it will be important to investigate into detail the reprogramming of human pancreatic acinar cells toward a mesenchymal phenotype: the association with acinoductal transdifferentiation
Sushmita Das et al.
Journal of leukocyte biology, 97(2), 363-378 (2014-12-05)
Regulation of macrophage PCD plays an important role in pathogenesis of leishmaniasis. However, the precise involvement of any parasite molecule in this process remains uncertain. In the current study, in silico wide analysis demonstrated that genes in the Leishmania donovani
Autophagy modulates endoplasmic reticulum stress-induced cell death in podocytes: a protective role.
Yu-Chi Cheng et al.
Experimental biology and medicine (Maywood, N.J.), 240(4), 467-476 (2014-10-18)
Endoplasmic reticulum stress occurs in a variety of patho-physiological mechanisms and there has been great interest in managing this pathway for the treatment of clinical diseases. Autophagy is closely interconnected with endoplasmic reticulum stress to counteract the possible injurious effects
Changshan Wang et al.
Blood, 123(21), 3336-3343 (2014-04-17)
Numerous studies have recently reported mutations involving multiple components of the messenger RNA (mRNA) splicing machinery in patients with myelodysplastic syndrome (MDS). SF3B1 is mutated in 70% to 85% of refractory anemia with ringed sideroblasts (RARS) patients and is highly
Claire Bonneau et al.
Gynecologic oncology, 136(1), 112-120 (2014-12-03)
DNA repair mechanisms, environment-mediated drug resistance and cancer initiating cells (CIC) are three major research concepts that can explain the chemoresistance of epithelial ovarian cancer (EOC). The objective was to test if changes in the expression of potential markers associated
Isabel A C Ribeiro et al.
Journal of molecular recognition : JMR, 28(3), 155-165 (2015-02-04)
Sophorolipids (SLs) are glycolipid biosurfactants, produced as a mixture of several compounds by some nonpathogenic yeast. In the current study, separation of individual SLs from mixtures with further evaluation of their surface properties and biologic activity on MDA-MB-321 breast cancer
Fozia Shaheen et al.
Biochimica et biophysica acta, 1842(9), 1762-1769 (2014-06-28)
Telomerase reverse transcriptase (TERT) is a key component of the telomerase complex. By lengthening telomeres in DNA strands, TERT increases senescent cell lifespan. Mice that lack TERT age much faster and exhibit age-related conditions such as osteoporosis, diabetes and neurodegeneration.
Thomas Helland et al.
PloS one, 10(4), e0122339-e0122339 (2015-04-14)
Tamoxifen is an anti-estrogen drug used in treatment of Estrogen Receptor (ER) positive breast cancer. Effects and side effects of tamoxifen is the sum of tamoxifen and all its metabolites. 4-Hydroxytamoxifen (4OHtam) and 4-hydroxy-N-demethyltamoxifen (4OHNDtam, endoxifen) both have ER affinity
L Lin et al.
Cell death & disease, 5, e1488-e1488 (2014-10-24)
The CXCL12/CXCR4 axis has been posited widely to have significant roles in many primary tumors and metastases. It is known that CXCR7 can also be engaged by CXCL12, but the exact function of CXCR7 is controversial. This prompted us to
Yu Zheng et al.
Clinical & experimental metastasis, 31(8), 921-933 (2014-09-17)
In prostate cancer metastases to bone, cancer cell-derived cytokines stimulate RANKL expression by cells of the osteoblast lineage, which in turn activates osteoclastic bone resorption. However, it is unclear whether cells of the osteoblast lineage signal back to prostate cancer
Zhi-Qi Song et al.
CNS neuroscience & therapeutics, 20(8), 737-747 (2014-03-19)
Prion diseases are a group of infectious neurodegenerative diseases characterized by neuronal death and degeneration. Human leukocyte antigen-B-associated transcript 3 (BAT3) is an important apoptosis regulator. We therefore investigated the interactions between BAT3 and prion protein and the potential role
Yong Wang et al.
Laboratory investigation; a journal of technical methods and pathology, 94(12), 1312-1325 (2014-11-05)
Cigarette smoking enhances oxidative stress and airway inflammation in asthma, the mechanisms of which are largely unknown. Myeloid-derived regulatory cells (MDRC) are free radical producing immature myeloid cells with immunoregulatory properties that have recently been demonstrated as critical regulators of
Rabia T Khan et al.
PloS one, 9(2), e88009-e88009 (2014-02-08)
Experimental animal models of Salmonella infections have been widely used to identify genes important in the host immune response to infection. Using an F2 cross between the classical inbred strain C57BL/6J and the wild derived strain MOLF/Ei, we have previously
Jianjian Zheng et al.
Molecular and cellular biochemistry, 398(1-2), 1-9 (2014-08-26)
Activation of hepatic stellate cells (HSCs) is an essential event in the initiation and progression of liver fibrosis. MicroRNAs have been shown to play a pivotal role in regulating HSC functions such as cell proliferation, differentiation, and apoptosis. Recently, miR-181b
Mahdieh Mondanizadeh et al.
Journal of cellular biochemistry, 116(6), 943-953 (2015-01-07)
MicroRNAs play an important role in neuronal development and function. miR-124 is the most abundantly expressed miRNA in the nervous system. Several different mRNA targets have been proposed for miR-124, but the precise function of endogenous miR-124 and its mRNA
Dimitrios Ioannou et al.
PloS one, 10(3), e0118886-e0118886 (2015-03-11)
The higher-order organization of chromatin is well-established, with chromosomes occupying distinct positions within the interphase nucleus. Chromatin is susceptible to, and constantly assaulted by both endogenous and exogenous threats. However, the effects of DNA damage on the spatial topology of
Angelika Drynda et al.
Immunopharmacology and immunotoxicology, 36(2), 150-157 (2014-03-05)
The aim of this study was to determine the immunomodulatory activity of 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide in vitro. This compound was used for the synthesis of a series of 5-amino-3-methyl-4-isoxazolecarboxylic acid semicarbazides and thiosemicarbazides with documented immunotropic activity. The performed measurements
Huacheng Hou et al.
BioMed research international, 2015, 470934-470934 (2015-04-14)
Autologous osteochondral transplantation (AOT) is a method for articular cartilage repair. However, several disadvantages of this method have been reported, such as transplanted cartilage degeneration and the lack of a connection between the grafted and adjacent cartilage tissues. To evaluate
Man-Jung Hung et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 113(10), 704-715 (2013-06-25)
Mesh-augmented vaginal surgery for treatment of pelvic organ prolapse (POP) does not meet patients' needs. This study aims to test the hypothesis that fascia tissue engineering using adipose-derived stem cells (ADSCs) might be a potential therapeutic strategy for reconstructing the
David Cerezo et al.
Experimental cell research, 331(1), 11-20 (2014-12-17)
The acquisition of a multidrug-resistant (MDR) phenotype by tumor cells is one of the main causes of chemotherapy failure in cancer, and, usually, is due to the increased expression of P-glycoprotein (MDR-1, P-gp, ABCB1), a pump that expels chemotherapeutics from
Vinayak Khattar et al.
International journal of oncology, 46(1), 395-406 (2014-10-30)
Constitutive levels of Cks1 protein are very high in mammary carcinoma tissue and in breast tumor cell lines. However, despite being transcribed at relatively high levels, Cks1 protein is very low in normal mammary tissue. Also, basal Cks1 is barely
Vinayak Khattar et al.
Cancer chemotherapy and pharmacology, 75(2), 411-420 (2014-12-30)
Cks1, a conformationally heterogenous 9 kDa protein, is markedly overexpressed in cancer cells and contributes to tumor development. Cks1 is an essential component of the SCF-Skp2 ubiquitin ligase complex that targets the Cdk inhibitors p27(Kip1) and p21(Cip1). Cks1 is known
Kenneth K B Tan et al.
Biomaterials, 43, 32-43 (2015-01-17)
Parkinson's disease (PD) is a neurodegenerative disease attributed to the loss of midbrain dopaminergic (DA) neurons. The current lack of predictive models for this disease has been hampered by the acquirement of robust cells, posing a major barrier to drug
Zhigang Liu et al.
Neuro-oncology, 16(6), 787-799 (2014-01-29)
Supratentorial primitive neuroectodermal tumor (sPNET) is a malignant brain tumor with poor prognosis. New model systems that replicate sPNET's molecular subtype(s) and maintain cancer stem cell (CSC) pool are needed. A fresh surgical specimen of a pediatric sPNET was directly
Alvena K Kureshi et al.
Investigative ophthalmology & visual science, 55(11), 7583-7588 (2014-10-23)
To assess the suitability of human donor corneas maintained in long-term organ culture for the isolation and expansion of viable and functional corneal stromal stem cells (CSSCs). These cells display properties similar to mesenchymal stem cells and demonstrate the ability
Ayuko Imaoka et al.
Drug metabolism and pharmacokinetics, 29(5), 414-418 (2014-05-09)
The drug interaction between new quinolone antibiotics (NQs) and polyvalent metal cation products, leading to a significant decrease in the absorption of NQ, is considered to be attributable to the formation of poorly absorbable chelate and physicochemical adsorption of NQs
Gary S L Peh et al.
Cell transplantation, 24(2), 287-304 (2013-11-26)
Corneal endothelium-associated corneal blindness is the most common indication for corneal transplantation. Restorative corneal transplant surgery is the only option to reverse the blindness, but a global shortage of donor material remains an issue. There are immense clinical interests in
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