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Tumor necrosis factor alpha: a link between neuroinflammation and excitotoxicity
Olmos G and Llado J
Mediators of Inflammation (2014)
Zhaogang Yang et al.
Theranostics, 9(21), 6269-6283 (2019-09-20)
Sepsis is a major cause of patient mortality and morbidity from bacterial infections. Although neutrophils are known to be important in the development of sepsis, how distinctive neutrophil subtypes regulate inflammatory processes involved in septicemia remains unclear. Preconditioning protects organisms...
Wei-wei Zhou et al.
Free radical biology & medicine, 74, 50-63 (2014-06-25)
Alzheimer disease (AD) is characterized by extracellular senile plaques, intracellular neurofibrillary tangles, and memory loss. Aggregated amyloid-β (Aβ), oxidative stress, and inflammation have pivotal roles in the pathogenesis of AD. Therefore, the inhibition of Aβ-induced neurotoxicity, oxidative stress, and inflammation...
Ismail M Meraz et al.
PloS one, 9(4), e94703-e94703 (2014-04-17)
Porous silicon (pSi) microparticles, in diverse sizes and shapes, can be functionalized to present pathogen-associated molecular patterns that activate dendritic cells. Intraperitoneal injection of MPL-adsorbed pSi microparticles, in contrast to free MPL, resulted in the induction of local inflammation, reflected...
Yue Hou et al.
Progress in neuro-psychopharmacology & biological psychiatry, 54, 92-102 (2014-04-09)
The present study aims to evaluate the effects of pterostilbene on lipopolysaccharide (LPS)-induced learning and memory impairment as well as the possible changes of microglia and neurons. Firstly, learning and memory function was investigated by behavioral tests. Pterostilbene attenuated LPS-induced...
Jing Zhao et al.
Investigative ophthalmology & visual science, 55(6), 3375-3384 (2014-05-09)
To evaluate the effects of the σ 1 receptor (σR1) agonist, (+)-pentazocine, on lipopolysaccharide (LPS)-induced inflammatory changes in retinal microglia cells. Retinal microglia cells were isolated from Sprague-Dawley rat pups. Cells were treated with LPS with or without (+)-pentazocine and...
Yuan Gao et al.
PloS one, 9(5), e96741-e96741 (2014-05-08)
Genkwanin is one of the major non-glycosylated flavonoids in many herbs with anti-inflammatory activities. Although its anti-inflammatory activity in vivo has been reported, the potential molecular mechanisms remain obscure. In this study, by pharmacological and genetic approaches, we explore the...
M Pesce et al.
Brain, behavior, and immunity, 41, 251-260 (2014-05-06)
Recent lines of research have boosted awareness of the immunological facets of schizophrenia. However, associations with protein tyrosine phosphatase regulators have never been reported. The aim of our study was to investigate the expression and promoter status methylation of phosphatase...
Reem N El-Naga et al.
Neurotoxicology, 44, 48-57 (2014-06-01)
The relationship between inflammation, oxidative stress and the incidence of depression had been well studied. Indole-3-carbinol (I3C), a natural active compound found in cruciferous vegetables, was shown to have anti-oxidant and anti-inflammatory activities. Therefore, the aim of this study was...
Lihong Fan et al.
Cellular and molecular neurobiology, 34(7), 999-1010 (2014-06-18)
This study evaluated whether bone marrow-derived mesenchymal stem cells (BM-MSCs) combined with xenogeneic acellular nerve grafts (xANGs) would reduce the inflammation reaction of xANGs transplantation. BM-MSCs were extracted, separated, purified, and cultured from the bone marrow of rats. Then BM-MSCs...
Ahmed El Marghani et al.
The Science of the total environment, 488-489, 228-235 (2014-05-20)
The increasing contamination of freshwater with pharmaceuticals, surfactants, pesticides and other organic compounds are of major concern. As these contaminants are detected at trace levels in the environment it is important to determine if they elicit biological responses at the...
Anna Neve et al.
Clinical and experimental medicine, 14(3), 275-283 (2013-07-05)
1,25-Dihydroxyvitamin D (1,25(OH)2D3), the active form of vitamin D, modulates both innate and adaptive immune responses. Emerging epidemiological data has also demonstrated disease-modifying and immunomodulatory effects of vitamin D in a wide range of human autoimmune diseases, including rheumatoid arthritis...
Andreas Schwingshackl et al.
Critical care medicine, 42(11), e692-e701 (2014-08-16)
We previously reported the expression of the two-pore-domain K channel TREK-1 in lung epithelial cells and proposed a role for this channel in the regulation of alveolar epithelial cytokine secretion. In this study, we focused on investigating the role of...
Kyung-mi Choi et al.
Biomaterials, 35(25), 7121-7132 (2014-05-24)
Anticancer therapeutics delivering exogenous siRNA have been explored to suppress the tumor-associated genes, but several limitations of siRNA delivery such as tumor-targeted delivery, controlled siRNA release at the sites of interest, or instabilities of siRNA in physiological fluids should be...
Gaozhi Chen et al.
Drug design, development and therapy, 8, 1869-1892 (2014-11-08)
Sepsis, a typically acute inflammatory disease, is the biggest cause of death in ICU (intensive care unit). Novel anti-inflammatory alternatives are still in urgent need. In this study, we designed and synthesized 30 indole-2-one and 7-aza-2-oxindole derivatives based on the...
Li Zuo et al.
The Journal of urology, 191(6), 1906-1912 (2014-02-13)
We developed an in vitro system composed of renal tubular cells, adipocytes and macrophages to simulate metabolic syndrome conditions. We investigated the molecular communication mechanism of these cells and their involvement in kidney stone formation. Mouse renal tubular cells (M-1) were...
Yutao Yan et al.
Molecules and cells, 37(5), 418-425 (2014-05-23)
Extracellular hypotonic stress can affect cellular function. Whether and how hypotonicity affects immune cell function remains to be elucidated. Macrophages are immune cells that play key roles in adaptive and innate in immune reactions. The purpose of this study was...
Hyo Geun Kim et al.
Canadian journal of physiology and pharmacology, 92(6), 429-437 (2014-05-14)
Microglia-mediated inflammation is a major pathological mechanism contributing to Alzheimer's disease (AD), and has been proposed as a potential therapeutic target. Chunghyuldan (CHD; Qingxue-dan in Chinese and Daio-Orengedokuto in Japanese) possesses wide-ranging biological effects, including anti-hyperlipidemic, anti-stroke, anti-inflammatory, and antioxidant...
Jianmin Chen et al.
PloS one, 9(6), e100631-e100631 (2014-06-20)
Development of cardiac dysfunction is associated with increased morbidity and mortality in patients with sepsis. Increasing evidence shows that gender determines the degree of inflammatory response of the host and that females tolerate sepsis better than males. It is unknown...
Christopher L Daige et al.
Molecular cancer therapeutics, 13(10), 2352-2360 (2014-07-24)
miR34a is a tumor-suppressor miRNA that functions within the p53 pathway to regulate cell-cycle progression and apoptosis. With apparent roles in metastasis and cancer stem cell development, miR34a provides an interesting opportunity for therapeutic development. A mimic of miR34a was...
Wei Dou et al.
The Journal of nutritional biochemistry, 25(9), 923-933 (2014-06-11)
Isorhamnetin is an O-methylated flavonol present in fruit and vegetables. We recently reported the identification of isorhamnetin as an activator of the human pregnane X receptor (PXR), a known target for abrogating inflammation in inflammatory bowel disease (IBD). The current...
Simone Kern et al.
Brain, behavior, and immunity, 41, 82-89 (2014-06-01)
Psychosocial stress has frequently been associated with disease activity and acute exacerbations in multiple sclerosis (MS). Despite this well established finding, strikingly little is known about the acute hypothalamic-pituitary-adrenal (HPA) and sympathetic-adrenal-medullary (SAM) stress response in MS. Twenty-six early relapsing-remitting...
Maria Ruweka Fernando et al.
PloS one, 9(4), e94188-e94188 (2014-04-17)
Macrophages are important innate immune cells that are associated with two distinct phenotypes: a pro-inflammatory (or classically activated) subset with prototypic macrophage functions such as inflammatory cytokine production and bactericidal activity, and an anti-inflammatory (or alternatively activated (AAM)) subset linked...
Lu Huang et al.
Journal of biomedical materials research. Part A, 102(10), 3369-3378 (2013-10-30)
Bulk metallic glasses (BMGs) are considered to be a competitive candidate of biomedical materials, owing to their appealing mechanical properties and high thermal processability. Based on the established biosafety of the Zr-based BMGs, macrophage responses to (Zr₅₅ Al₁₀ Ni₅ Cu₃₀)₉₉...
William R Proctor et al.
Hepatology (Baltimore, Md.), 60(5), 1741-1752 (2014-04-12)
Liver eosinophilia has been associated with incidences of drug-induced liver injury (DILI) for more than 50 years, although its role in this disease has remained largely unknown. In this regard, it was recently shown that eosinophils played a pathogenic role...
Joanna Koziel et al.
Journal of immunology (Baltimore, Md. : 1950), 192(11), 5363-5372 (2014-04-29)
Cathelicidin LL-37 plays an essential role in innate immunity by killing invading microorganisms and regulating the inflammatory response. These activities depend on the cationic character of the peptide, which is conferred by arginine and lysine residues. At inflammatory foci in...
Elena Moretti et al.
Fertility and sterility, 102(2), 354-360 (2014-05-17)
To explore the relationships between resistin, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) and semen parameters, sperm apoptosis, and necrosis in infertile patients and in control subjects with unknown reproductive potential with/without smoking habits, leukocytospermia, and varicocele. Prospective study. Sperm...
Natalí N Guerrero-Vargas et al.
Journal of neuroimmunology, 273(1-2), 22-30 (2014-06-12)
Several studies have shown circadian variations in the response of the immune system suggesting a role of the suprachiasmatic nucleus (SCN). Here we show that lipopolysaccharide (LPS) administration in the beginning of the active period induced more severe responses in...
Chan Chen et al.
Acta pharmacologica Sinica, 35(11), 1428-1438 (2014-09-30)
Fasudil, a selective Rho kinase (ROCK) inhibitor, has been shown to alleviate the severity of experimental autoimmune encephalomyelitis (EAE) via attenuating demyelination and neuroinflammation. The aim of this study was to investigate the effects of fasudil on interactions between macrophages/microglia...
Stephen P McAdoo et al.
Journal of the American Society of Nephrology : JASN, 25(10), 2291-2302 (2014-04-05)
Spleen tyrosine kinase (SYK) has an important role in immunoreceptor signaling, and SYK inhibition has accordingly attenuated immune-mediated injury in several in vivo models. However, the effect of SYK inhibition on autoantibody production remains unclear, and SYK inhibition has not...
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