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J A Tree et al.
Journal of virology, 89(8), 4335-4344 (2015-02-06)
To evaluate new vaccines when human efficacy studies are not possible, the FDA's "Animal Rule" requires well-characterized models of infection. Thus, in the present study, the early pathogenic events of monkeypox infection in nonhuman primates, a surrogate for variola virus
B Müller-Edenborn et al.
British journal of anaesthesia, 114(1), 143-149 (2014-07-06)
Growing evidence suggests a protective effect of volatile anaesthetics in ischaemia-reperfusion (I/R)-injury, and the accumulation of neutrophils is a crucial event. Pro-inflammatory cytokines carrying the C-X-C-motif including interleukin-8 (IL-8) and CXC-ligand 1 (CXCL1) activate CXC receptor-1 (CXCR1; stimulated by IL-8)
Karan M Shah et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(1), 114-121 (2014-09-25)
Cobalt and chromium species are released in the local tissues as a result of tribo-corrosion, and affect bone cell survival and function. However we have little understanding of the mechanisms of cellular entry, intracellular distribution, and speciation of the metals
María I Tracanna et al.
Phytotherapy research : PTR, 29(3), 393-397 (2014-11-25)
A new phenolic derivative, 2,8-dihydroxy-7H-furo[2,3-f]chromen-7-one (1), together with isoquercitrin (2), was isolated from the aerial parts of Tibouchina paratropica. Compound structures were elucidated by spectroscopic methods. Both compounds show antimicrobial activity towards a panel of bacterial and fungal pathogens, and
Qunfeng Ma et al.
Oncology reports, 33(1), 193-200 (2014-11-06)
Based on the three-dimensional modeling structure of human interleukin-24 (hIL-24) and its most likely active position predicted by solvent accessibility and apparent electrostatic properties, a novel hIL-24 peptide M1 was created by computer-guided molecular design. The cytotoxicity and cell selectivity
Takashi Nakamura et al.
Journal of cell science, 127(Pt 24), 5261-5272 (2014-10-26)
The basal layer of the epidermis contains stem cells and transit amplifying cells that rapidly proliferate and differentiate further into the upper layers of the epidermis. A number of molecules have been identified as regulators of this process, including p63
Katrien Forier et al.
Journal of controlled release : official journal of the Controlled Release Society, 195, 21-28 (2014-08-16)
Encapsulation of antibiotics into nanoparticles is a potential strategy to eradicate biofilms. To allow further optimization of nanomedicines for biofilm eradication, the influence of the nanoparticle size on the penetration into dense biofilm clusters needs to be investigated. In the
Valéryane Dupuis-Maurin et al.
PloS one, 10(3), e0118551-e0118551 (2015-03-05)
Deregulated expression of oncogenes or transcription factors such as specificity protein 1 (Sp1) is observed in many human cancers and plays a role in tumor maintenance. Paradoxically in untransformed cells, Sp1 overexpression induces late apoptosis but the early intrinsic response
K Sugimachi et al.
British journal of cancer, 112(3), 532-538 (2015-01-15)
Predictive biomarkers for the recurrence of hepatocellular carcinoma (HCC) have great benefit in the selection of treatment options, including liver transplantation (LT), for HCC. The purpose of this study was to identify specific microRNAs (miRs) in exosomes from the serum
Dan Li et al.
Applied and environmental microbiology, 80(20), 6473-6479 (2014-08-12)
This study intends to establish and apply methods evaluating both viral capsid and genome integrities of human noroviruses (NoVs), which thus far remain nonculturable. Murine norovirus 1 (MNV-1) and human NoV GII.4 in phosphate-buffered saline suspensions were treated with heat
Rahul Krishnan et al.
Transplantation, 99(4), 710-716 (2015-03-21)
Porcine islet xenotransplantation has been demonstrated in many animal studies to cure experimentally induced diabetes. However, several issues currently impede the translation of porcine islet xenotransplantation to sustained insulin independence clinically. Although adult pigs have mature islets that secrete insulin
Sushma Singh et al.
Parasitology research, 113(6), 2161-2168 (2014-04-15)
Leishmaniasis is one of the major health problems existing globally. The current chemotherapy for leishmaniasis presents several drawbacks like toxicity and increased resistance to existing drugs, and hence, there is a necessity to look out for the novel drug targets
Natasha L Williams et al.
Microbes and infection, 17(4), 311-316 (2014-12-24)
Melioidosis sepsis, caused by Burkholderia pseudomallei, is associated with high mortality due to an overwhelming inflammatory response. Plasmacytoid dendritic cells (pDC) are potent producers of type I interferons (IFN). This study investigated whether pDC and type I IFN play a
Jessica A Hall et al.
Molecular endocrinology (Baltimore, Md.), 28(6), 912-924 (2014-04-04)
Hepatic forkhead protein FoxO1 is a key component of systemic glucose homeostasis via its ability to regulate the transcription of rate-limiting enzymes in gluconeogenesis. Important in the regulation of FoxO1 transcriptional activity are the modifying/demodifying enzymes that lead to posttranslational
Fanmuyi Yang et al.
American journal of physiology. Heart and circulatory physiology, 307(10), H1529-H1538 (2014-09-23)
Bone marrow-derived inflammatory cells, including platelets, may contribute to the progression of pressure overload-induced left ventricular hypertrophy (LVH). However, the underlying mechanisms for this are still unclear. One potential mechanism is through release of granule cargo. Unc13-d(Jinx) (Jinx) mice, which
Kerstin Pohl et al.
Blood, 124(7), 999-1009 (2014-06-18)
Studies have endeavored to reconcile whether dysfunction of neutrophils in people with cystic fibrosis (CF) is a result of the genetic defect or is secondary due to infection and inflammation. In this study, we illustrate that disrupted function of the
Renuka Kadirvelraj et al.
Biochemistry, 53(51), 8043-8051 (2014-12-06)
Human UDP-α-d-glucose-6-dehydrogenase (hUGDH) displays hysteresis because of a slow isomerization from an inactive state (E*) to an active state (E). Here we show that the structure of E* constrains hUGDH in a conformation that favors feedback inhibition at physiological pH.
Chathurini V Fernando et al.
Stem cells and development, 23(17), 1991-2003 (2014-05-08)
During development of the central nervous system, trophic, together with genetic, cues dictate the balance between cellular proliferation and differentiation. Subsequent to the birth of new neurons, additional intrinsic and extrinsic signals regulate the connectivity of these cells. While a
John Mac Sharry et al.
PloS one, 9(6), e98648-e98648 (2014-06-27)
Varying concentrations of lipopolysaccharide (LPS) in ovalbumin (OVA) may influence the airway response to allergic sensitization and challenge. We assessed the contribution of LPS to allergic airway inflammatory responses following challenge with LPS-rich and LPS-free commercial OVA. BALB/c mice were
Md Mesbah Uddin Ansary et al.
Inflammatory bowel diseases, 20(12), 2308-2320 (2014-10-31)
Apoptosis is a programmed physiological death of unwanted cells, and handling of apoptotic cells (ACs) is thought to have profound effects on immune-mediated disorders. However, there is scant information regarding the role of ACs in intestinal inflammation, in which immune
Yang Liu et al.
PloS one, 9(8), e103938-e103938 (2014-08-02)
The chemokine CXCL12 regulates multiple cell functions through its receptor, CXCR4. However, recent studies have shown that CXCL12 also binds a second receptor, CXCR7, to potentiate signal transduction and cell activity. In contrast to CXCL12/CXCR4, few studies have focused on
Rui Liu et al.
Rheumatology (Oxford, England), 54(2), 332-342 (2014-08-30)
The aim of this study was to investigate the effect of umbilical cord mesenchymal stem cells (UC-MSCs) on circulating T follicular helper (cTfh) cells in primary SS (pSS) patients. The percentage of CXCR5(+)PD-1(+)CD4(+) T cells in peripheral blood mononuclear cells
Prajwal Gurung et al.
The Journal of clinical investigation, 125(3), 1329-1338 (2015-02-18)
Leishmaniasis is a major tropical disease that can present with cutaneous, mucocutaneous, or visceral manifestation and affects millions of individuals, causing substantial morbidity and mortality in third-world countries. The development of a Th1-adaptive immune response is associated with resistance to
Lidiya Luzhna et al.
Oncotarget, 6(3), 1678-1694 (2015-02-16)
Endocrine therapy agents (the selective estrogen receptor (ER) modulators such as tamoxifen or the selective ER down-regulators such as ICI 182,780) are key treatment regimens for hormone receptor-positive breast cancers. While these drugs are very effective in controlling ER-positive breast
Shyamasree Laskar et al.
Molecular and cellular biology, 35(2), 437-450 (2014-11-12)
The epigenetic writer Sir2 maintains the heterochromatin state of chromosome in three chromosomal regions, namely, the silent mating type loci, telomeres, and the ribosomal DNA (rDNA). In this study, we demonstrated the mechanism by which Sir2 is regulated under heat
Li-Jin Chen et al.
Experimental neurology, 266, 86-98 (2015-02-25)
Compression causes the reduction of dendritic spines of underlying adult cortical pyramidal neurons but the mechanisms remain at large. Using a rat epidural cerebral compression model, dendritic spines on the more superficial-lying layer III pyramidal neurons were found quickly reduced
Sun-Young Kong et al.
PloS one, 10(2), e0118188-e0118188 (2015-02-24)
Neural stem cells (NSCs) have the ability to proliferate and differentiate into neurons and glia. Regulation of NSC fate by small molecules is important for the generation of a certain type of cell. The identification of small molecules that can
Virginie Vives et al.
Nature communications, 6, 6218-6218 (2015-02-04)
Osteoporosis is caused by excessive activity of bone-degrading osteoclasts over bone-forming osteoblast. Standard antiosteolytic treatments inhibit bone resorption by inducing osteoclast loss, with the adverse effect of hindering also bone formation. Formation of the osteoclast sealing zone requires Dock5, a
Claire D Bourke et al.
International journal for parasitology, 45(4), 215-224 (2015-01-13)
Keratinocytes constitute the majority of cells in the skin's epidermis, the first line of defence against percutaneous pathogens. Schistosome larvae (cercariae) actively penetrate the epidermis to establish infection, however the response of keratinocytes to invading cercariae has not been investigated.
Fernando P Conte et al.
Molecules (Basel, Switzerland), 20(2), 2636-2657 (2015-02-06)
Gedunin, a natural limonoid from Meliaceae species, has been previously described as an antiinflammatory compound in experimental models of allergic inflammation. Here, we report the antiinflammatory and antinociceptive effects of gedunin in an acute model of articular inflammation induced by
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