Showing 1-30 of 389 results for "

PHR1353

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Hey-Yon Kim et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(1), 300-313 (2014-10-30)
Polycomb protein chromobox homolog 7 (CBX7) is involved in several biologic processes including stem cell regulation and cancer development, but its roles in breast cancer remain unknown. Here, we demonstrate that CBX7 negatively regulates breast tumor initiation. CD44(+)/CD24(-)/ESA(+) breast stem-like...
Jamie L Rhudy et al.
Pain, 155(10), 2144-2152 (2014-08-21)
In healthy individuals, emotions modulate pain and spinal nociception according to a valence linear trend (ie, pain/nociception is highest during negative emotions and lowest during positive emotions). However, emerging evidence suggests that emotional modulation of pain (but not spinal nociception)...
Michihiro Kawano et al.
Toxicology letters, 228(3), 235-240 (2014-05-09)
Di-(2-ethylhexyl)-phthalate (DEHP) is a phthalate ester that binds peroxisome proliferator-activated receptor α (PPARα) to induce proliferation of peroxisomes and regulate the expression of specific target genes. The question of whether the effect of DEHP on female reproductive processes is mediated...
Suzana S Jovanović-Šanta et al.
Steroids, 97, 45-53 (2014-09-11)
Since many estrogen derivatives exhibit anti-hormone or enzyme inhibition potential, a large number of steroidal derivatives have been synthesised from appropriate precursors, in order to obtain potential therapeutics for the treatment of hormone-dependent cancers. In molecular docking studies, based on...
Sherry A Ferguson et al.
Toxicological sciences : an official journal of the Society of Toxicology, 140(2), 374-392 (2014-05-07)
The developing central nervous system may be particularly sensitive to bisphenol A (BPA)-induced alterations. Here, pregnant Sprague Dawley rats (n = 11-12/group) were gavaged daily with vehicle, 2.5 or 25.0 μg/kg BPA, or 5.0 or 10.0 μg/kg ethinyl estradiol (EE2)...
Astrid M Pedersen et al.
International journal of oncology, 45(5), 2167-2175 (2014-09-02)
Tamoxifen‑resistant breast cancer is a major clinical problem and new treatment strategies are highly warranted. In this study, the multitargeting kinase inhibitors sorafenib and nilotinib were investigated as potential new treatment options for tamoxifen‑resistant breast cancer. The two compounds inhibited...
Coadministrating luteolin minimizes the side effects of the aromatase inhibitor letrozole.
Li F, Wong TY, Lin SM, et al.
Journal of Pharmacology and Experimental Therapeutics, 351(2), 270-277 (2014)
Qian Gao et al.
Biochemical and biophysical research communications, 453(1), 37-42 (2014-09-24)
Beta-B2-crystallin (CRYBB2), encoded by Crybb2 gene, is a major protein in the mammalian eye lens that plays an important role in maintaining the transparency of the ocular lens. However, CRYBB2 also plays important roles in many extra-lenticular tissues and organs...
Elizabeth E Sweeney et al.
Cancer research, 74(23), 7060-7068 (2014-10-12)
Hormone replacement therapy (HRT) is widely used to manage menopausal symptoms in women and can be comprised of an estrogen alone or an estrogen combined with a progestin. The Women's Health Initiative demonstrated in their randomized trials that estrogen alone...
17 beta-estradiol/levonorgestrel transdermal system. A viewpoint by Lee P. Shulman.
Lee P Shulman
Treatments in endocrinology, 3(5), 325-326 (2004-08-28)
Bong-Wook Park et al.
Stem cells and development, 23(14), 1647-1658 (2014-03-07)
Reduction of estradiol production and high serum concentrations of follicular stimulating hormone (FSH) are endocrine disorders associated with premature ovarian failure. Here, we report that transplantation of ovarian-like cells differentiated from stem cells restored endogenous serum estradiol levels. Stem cells...
Xiao-Jun Yang et al.
Journal of cellular and molecular medicine, 19(2), 452-462 (2014-11-13)
Women with endometriosis (EMs) have unexplained infertility. The recently identified telocytes (TCs) might participate in the maintenance of structural and functional integrity of oviduct tissue, but so far the involvement of TCs in EMs-affected oviduct tissue and potential impact on...
Indu Upadhyaya et al.
Applied and environmental microbiology, 81(9), 2985-2994 (2015-02-25)
Salmonella enterica serovar Enteritidis is a major foodborne pathogen in the United States, causing gastroenteritis in humans, primarily through consumption of contaminated eggs. Chickens are the reservoir host of S. Enteritidis. In layer hens, S. Enteritidis colonizes the intestine and...
Weisheng Wu et al.
Genome research, 24(12), 1945-1962 (2014-10-17)
We used mouse ENCODE data along with complementary data from other laboratories to study the dynamics of occupancy and the role in gene regulation of the transcription factor TAL1, a critical regulator of hematopoiesis, at multiple stages of hematopoietic differentiation....
Xiaoyong Fu et al.
Breast cancer research : BCR, 16(5), 430-430 (2014-09-13)
Activation of the phosphatidylinositol 3-kinase (PI3K) pathway in estrogen receptor α (ER)-positive breast cancer is associated with reduced ER expression and activity, luminal B subtype, and poor outcome. Phosphatase and tensin homolog (PTEN), a negative regulator of this pathway, is...
Meiyan Sun et al.
Endocrinology, 155(8), 2787-2796 (2014-05-16)
Calcium-dependent chloride conductances have been described in chicken and human granulosa cells (GCs) and may be involved in steroidogenesis. However, the molecular identities of corresponding chloride channels remain unknown. The purpose of this study was to explore the expression and...
Yang Gao et al.
Biology of reproduction, 92(2), 34-34 (2014-12-17)
Despite increasing evidence pointing to the essential involvement of the transforming growth factor beta (TGFB) superfamily in reproduction, a definitive role of TGFB signaling in the uterus remains to be unveiled. In this study, we generated a gain-of-function mouse model...
Seiro Satohisa et al.
Endocrinology, 155(8), 3005-3016 (2014-06-01)
Adduction of a nitric oxide (NO) moiety (NO(•)) to cysteines termed as S-nitrosylation (SNO) has emerged as a crucial mechanism for NO signaling crucial for mediating the vascular effects of estrogens. Mitochondrion is a known vascular risk factor; however, the...
Kurt D Pennell et al.
Steroids, 95, 24-31 (2014-12-30)
Analytical techniques used to quantify neurosteroids in biological samples are often compromised by non-specificity and limited dynamic range which can result in erroneous results. A relatively rapid and inexpensive gas chromatography-mass spectrometry (GC-MS) was developed to simultaneously measure nine neurosteroids...
Enrique Fuentes-Mattei et al.
Journal of the National Cancer Institute, 106(7), doi:10-doi:10 (2014-06-25)
Obesity increases the risk of cancer death among postmenopausal women with estrogen receptor-positive (ER+) breast cancer, but the direct evidence for the mechanisms is lacking. The purpose of this study is to demonstrate direct evidence for the mechanisms mediating this...
J M Gámez et al.
Environmental toxicology and pharmacology, 39(1), 9-15 (2014-12-02)
The research work studies the effect of providing a low dose of bisphenol A (BPA), on the reproductive axis of prepubertal female rats. Wistar mated rats were treated with either 0.1% ethanol or BPA in their drinking water until their...
Dimitri Tränkner et al.
Cell reports, 29(4), 791-799 (2019-10-24)
Aberrant microglia activity is associated with many neurological and psychiatric disorders, yet our knowledge about the pathological mechanisms is incomplete. Here, we describe a genetically defined microglia sublineage in mice which has the ability to suppress obsessive compulsion and anxiety symptoms. These...
Kathryn J Grive et al.
Developmental biology, 392(1), 42-51 (2014-05-20)
Primary ovarian insufficiency (POI) affects 1% of women under the age of 40 and is associated with premature ovarian follicle depletion. TAF4b deficiency in adult female mouse models results in hallmarks of POI including stereotyped gonadotropin alterations indicative of early...
Zhonghua Shi et al.
Endocrinology, 155(5), 1982-1990 (2014-03-08)
Omental adipose tissue plays a central role in insulin resistance in gestational diabetes mellitus (GDM), and the molecular mechanisms leading to GDM remains vague. Evidence demonstrates that maternal hormones, such as estradiol, contribute to insulin resistance in GDM. In this...
Caroline Pinto et al.
Toxicology and applied pharmacology, 280(1), 60-69 (2014-08-12)
Zebrafish, Danio rerio, is increasingly used as an animal model to study the effects of pharmaceuticals and environmental estrogens. As most of these estrogens have only been tested on human estrogen receptors (ERs), it is necessary to measure their effects...
Shuuji Mawaribuchi et al.
Endocrinology, 155(10), 3996-4005 (2014-07-23)
The African clawed frog, Xenopus laevis, has a ZZ/ZW-type sex-determination system. We previously reported that a W-linked gene, Dm-W, can determine development as a female. However, the mechanisms of early sex differentiation remain unclear. We used microarrays to screen for...
Lina E Aguirre et al.
International journal of endocrinology, 2014, 507395-507395 (2014-08-29)
In this study, we evaluated the independent and combined effects of baseline circulating gonadal, anabolic hormones and adipokines on physical function in 107 frail, obese (BMI ≥ 30 kg/m(2)), and older (≥65 yr) subjects. Our results showed significant positive correlations between circulating...
Matthew M Roforth et al.
PloS one, 9(4), e95987-e95987 (2014-04-30)
The effects of 17-β-estradiol in osteoblasts are primarily mediated by the nuclear transcription factors, estrogen receptor (ER)α and ERβ. ERs function through three general modes of action: DNA-binding dependent through estrogen response elements (EREs; designated nuclear ERE signaling); nuclear signaling...
Hye Yeon Choi et al.
PloS one, 9(6), e99421-e99421 (2014-06-13)
Placenta, as a reservoir of nutrients, has been widely used in medical and cosmetic materials. Here, we focused on the antioxidant properties of placental extract and attempted to isolate and identify the main antioxidant factors. Porcine placental extracts were prepared...
Characterization of the zebrafish Ugt repertoire reveals a new class of drug-metabolizing UDP glucuronosyltransferases.
Wang Y, Huang H, and Wu Q
Molecular Pharmacology, 86(1), 62-75 (2014)