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phr1125

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Md Nabiul Hasan et al.
Oncotarget, 6(3), 1382-1395 (2015-02-16)
Despite increasingly successful treatment of pediatric ALL, up to 20% of patients encounter relapse. By current biomarkers, the majority of relapse patients is initially not identified indicating the need for prognostic and therapeutic targets reflecting leukemia biology. We previously described
Mohammed Ghonime et al.
Immunological investigations, 44(3), 237-252 (2015-01-08)
A group of 11 medicinal plants, including Lavandula pubescens, Trigonella foenugricium, Salsola schweinforthi, Calligonum comosum, Silene succulenta, Silene villosa, Bogonvillea glabra, Cakile maritime, Gomphrene celesoids, Mirabilis jalaba, and Silene nocturna growing in Egypt, were extracted and examined for their immunomodulatory
Radoslaw Kwapiszewski et al.
Analytica chimica acta, 853, 702-709 (2014-12-04)
Lysosomal storage diseases are chronic, progressive and typically have a devastating impact on the patient and the family. The diagnosis of these diseases is still a challenge, however, even for trained specialists. Accurate diagnostic methods and high-throughput tools that could
B Kristensen et al.
Clinical and experimental immunology, 180(1), 58-69 (2014-11-22)
T helper type 17 (Th17) cells play a pathogenic role in autoimmune disease, while interleukin (IL)-10-producing Th10 cells serve a protective role. The balance between the two subsets is regulated by the local cytokine milieu and by the relative expression
Yinu Wang et al.
Cancer research, 74(17), 4922-4936 (2014-07-19)
Emerging results indicate that cancer stem-like cells contribute to chemoresistance and poor clinical outcomes in many cancers, including ovarian cancer. As epigenetic regulators play a major role in the control of normal stem cell differentiation, epigenetics may offer a useful
A U Lekmanov et al.
Anesteziologiia i reanimatologiia, (1)(1), 49-51 (2013-07-03)
Comparing analysis of randomized study was conducted. 40 Pediatric patients (2-15 years old) with heavy thermic burns and concomitant injuries were recruited into the study to assess the glutamine solution intravenous use efficiency. Parenteral feeding and feeding with glutamine solution
Florian Arnhold et al.
PeerJ, 3, e754-e754 (2015-02-24)
Mercury (Hg) is a bioaccumulating trace metal that globally circulates the atmosphere and waters in its elemental, inorganic and organic chemical forms. While Hg represents a notorious neurotoxicant, the underlying cellular pathways are insufficiently understood. We identify amyloid protein aggregation
María I Tracanna et al.
Phytotherapy research : PTR, 29(3), 393-397 (2014-11-25)
A new phenolic derivative, 2,8-dihydroxy-7H-furo[2,3-f]chromen-7-one (1), together with isoquercitrin (2), was isolated from the aerial parts of Tibouchina paratropica. Compound structures were elucidated by spectroscopic methods. Both compounds show antimicrobial activity towards a panel of bacterial and fungal pathogens, and
Rafat M Mohareb et al.
Steroids, 86, 45-55 (2014-05-06)
The reaction of androstenedione with either malononitrile or ethyl cyanoacetate and aromatic aldehydes 2a-c gave the pyran derivatives 4a-f, respectively. On the other hand, the reaction of androstenedione with thiourea and the aromatic aldehydes 2a-c gave the pyrimidine derivatives 6a-c
Daniel M Dupont et al.
PloS one, 10(3), e0119207-e0119207 (2015-03-21)
Nucleic acid aptamer selection is a powerful strategy for the development of regulatory agents for molecular intervention. Accordingly, aptamers have proven their diligence in the intervention with serine protease activities, which play important roles in physiology and pathophysiology. Nonetheless, there
Reshmi Parameswaran et al.
Molecular cancer therapeutics, 13(6), 1567-1577 (2014-05-16)
B-cell activating factor receptor (BAFF-R) is expressed on precursor B acute lymphoblastic leukemia (pre-B ALL) cells, but not on their pre-B normal counterparts. Thus, selective killing of ALL cells is possible by targeting this receptor. Here, we have further examined
Blessing Okai et al.
Infection and immunity, 83(4), 1523-1535 (2015-02-04)
Avoidance of innate immune defense is an important mechanism contributing to the pathogenicity of microorganisms. The fungal pathogen Candida albicans undergoes morphogenetic switching from the yeast to the filamentous hyphal form following phagocytosis by macrophages, facilitating its escape from the
Alba Juanes-Garcia et al.
The Journal of cell biology, 209(1), 23-32 (2015-04-15)
In this study, we show that the role of nonmuscle myosin II (NMII)-B in front-back migratory cell polarity is controlled by a short stretch of amino acids containing five serines (1935-1941). This motif resides near the junction between the C
Nikki van Bel et al.
PloS one, 9(7), e103552-e103552 (2014-07-30)
The viral integrase (IN) is an essential protein for HIV-1 replication. IN inserts the viral dsDNA into the host chromosome, thereby aided by the cellular co-factor LEDGF/p75. Recently a new class of integrase inhibitors was described: allosteric IN inhibitors (ALLINIs).
Nina V Kraguljac et al.
JAMA psychiatry, 70(12), 1294-1302 (2013-10-11)
Alterations in glutamatergic neurotransmission have been postulated to be a key pathophysiologic mechanism in schizophrenia. To evaluate hippocampal volumetric measures and neurometabolites in unmedicated patients with schizophrenia and the correlations between these markers. Our a priori hypothesis was that glutamate
Julie Bolcaen et al.
Journal of neuro-oncology, 120(2), 257-266 (2014-07-30)
Current glioblastoma (GB) small animal models for cranial radiation therapy (RT) use simple single beam technologies, which differ from the advanced conformal image-guided radiation techniques used in clinical practice. This technological disparity presents a major disadvantage for the development of
Sirpa Rainesalo et al.
Neurochemical research, 29(1), 319-324 (2004-03-03)
Altered plasma and cerebrospinal fluid amino acid levels may be associated with human epilepsy. We studied three groups of patients, those with a generalized epileptic syndrome, juvenile myoclonic epilepsy, patients with refractory localization-related epilepsies, and patients with acute seizures (within
Damián Pérez-Mazliah et al.
PLoS pathogens, 11(3), e1004715-e1004715 (2015-03-13)
Interleukin-21 signaling is important for germinal center B-cell responses, isotype switching and generation of memory B cells. However, a role for IL-21 in antibody-mediated protection against pathogens has not been demonstrated. Here we show that IL-21 is produced by T
M I Botez et al.
Brain : a journal of neurology, 114 ( Pt 1A), 333-348 (1991-02-01)
A total of 157 epileptic patients were studied with respect to (1) biogenic amine precursors and metabolites in the CSF, (2) levels of folate and thiamine in the blood and CSF, (3) length of treatment with phenytoin (PHT), (4) PHT
Linda Ottoboni et al.
Neurology, 81(22), 1891-1899 (2013-11-01)
We set out to characterize the clinical impact and functional consequences of rs1800693(G), the multiple sclerosis (MS) susceptibility allele found in the TNFRSF1A locus. We analyzed prospectively collected data on patients with MS to assess the role of the TNFRSF1A
Cell biology. Making sense of amino acid sensing.
Robert T Abraham
Science (New York, N.Y.), 347(6218), 128-129 (2015-01-13)
Sarah L Newstead et al.
Journal of immunology research, 2014, 694717-694717 (2014-08-30)
Reactive nitrogen is critical for the clearance of Francisella tularensis infections. Here we assess the role of nitric oxide in control of intracellular infections in two murine macrophage cell lines of different provenance: the alveolar macrophage cell line, MH-S, and
Janna Schneppenheim et al.
Biochemical and biophysical research communications, 451(1), 48-53 (2014-07-19)
The invariant chain (CD74) mediates targeting of the MHCII complex to endosomal compartments, where CD74 undergoes degradation allowing MHCII to acquire peptides. We demonstrated recently that intramembrane proteolysis of the final membrane-bound N-terminal fragment (NTF) of CD74 is catalyzed by
Lidiya Luzhna et al.
Oncotarget, 6(3), 1678-1694 (2015-02-16)
Endocrine therapy agents (the selective estrogen receptor (ER) modulators such as tamoxifen or the selective ER down-regulators such as ICI 182,780) are key treatment regimens for hormone receptor-positive breast cancers. While these drugs are very effective in controlling ER-positive breast
Siyi He et al.
Tissue engineering. Part A, 21(5-6), 928-938 (2014-10-16)
Great challenges in transplantation of mesenchymal stem cells (MSCs) for treating ischemic diabetic ulcers (IDUs) are to find a suitable carrier and create a beneficial microenvironment. Brain-derived neurotrophic factor (BDNF), a member of neurotrophin family, is considered angiogenic and neuroprotective.
Violette Dirix et al.
Microbes and infection, 16(7), 562-570 (2014-05-08)
In addition to antibodies, Th1-type T cell responses are also important for long-lasting protection against pertussis. However, upon immunization with the current acellular vaccines, many children fail to induce Th1-type responses, potentially due to immunomodulatory effects of some vaccine antigens
David A Magee et al.
Tuberculosis (Edinburgh, Scotland), 94(4), 441-450 (2014-06-03)
Despite sharing >99.9% genome sequence similarity at the nucleotide level, Mycobacterium tuberculosis and Mycobacterium bovis-the causative agents of human and bovine tuberculosis, respectively-exhibit distinct host preferences. M. bovis can cause disease in both cattle and humans yet rarely transmits between
Bin Li et al.
The Journal of clinical endocrinology and metabolism, 99(9), 3363-3372 (2014-05-21)
TSH provokes expression of inflammatory genes in CD34(+) fibrocytes. These cells appear to infiltrate the orbit in Graves' disease (GD), where they putatively become the CD34(+) orbital fibroblast subset (GD-OF). This may have importance in solving the pathogenesis of thyroid-associated
Jian Yang et al.
Stem cells (Dayton, Ohio), 33(5), 1390-1404 (2014-12-30)
We previously demonstrated that coexpressing retinoic acid (RA) receptor gamma and liver receptor homolog-1 (LRH1 or NR5A2) with OCT4, MYC, KLF4, and SOX2 (4F) rapidly reprograms mouse embryonic fibroblast cells (MEFs) into induced pluripotent stem cells (iPSCs). Here, we further
Peter Vegh et al.
Tuberculosis (Edinburgh, Scotland), 95(1), 60-67 (2015-02-19)
Mycobacterium bovis, the causative agent of bovine tuberculosis, a major problem for global agriculture, spreads via an airborne route and is taken up by alveolar macrophages (AM) in the lung. Here, we describe the first next-generation sequencing (RNA-seq) approach to
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