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Chun-Yan Li et al.
Analytica chimica acta, 774, 79-84 (2013-04-10)
In this paper we unveil a novel rhodamine compound based fluorescent chemosensor (1-Pb(2+)) for colormetric and fluorescent detection of citrate in aqueous solution. This is the first fluorescent chemosensor for citrate based on rhodamine compound. The comparison of this method
S K Yang et al.
Marine pollution bulletin, 74(1), 213-219 (2013-07-23)
Thorium(IV) biosorption is investigated by citric acid treated mangrove endophytic fungus Fussarium sp. #ZZF51 (CA-ZZF51) from South China Sea. The biosorption process was optimized at pH 4.5, equilibrium time 90 min, initial thorium(IV) concentration 50 mg L(-1) and adsorbent dose
Rahul D Sheth et al.
Biotechnology and bioengineering, 111(8), 1595-1603 (2014-03-07)
In this work, a proof of concept elastin-like polypeptide-Z domain fusion (ELP-Z) based affinity precipitation process is developed for monoclonal antibody (mAb) purification from industrial harvest feeds. Greater than 99% mAb recoveries are obtained during the initial binding step of
Andrew Godwin et al.
Shock (Augusta, Ga.), 43(1), 24-30 (2014-09-05)
Cold-inducible RNA-binding protein (CIRP) is a nuclear protein that has been recently identified as a novel inflammatory mediator in hemorrhagic shock and sepsis. We hypothesized that CIRP acts as a potent inflammatory mediator in hepatic ischemia-reperfusion (I/R), and thus blocking
Nataša Djordjević Filijović et al.
Drug development and industrial pharmacy, 41(3), 502-514 (2014-03-13)
Stress stability testing represents an important part of the drug development process. It is used as an important tool for the identification of degradation products and degradation pathways, as well as for the assessment of changes in physical form of
Johanna C van den Beukel et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(11), 4857-4867 (2014-08-03)
Brown adipose tissue (BAT) and brown-like cells in white adipose tissue (WAT) can dissipate energy through thermogenesis, a process mediated by uncoupling protein 1 (UCP1). We investigated whether stress hormones ACTH and corticosterone contribute to BAT activation and browning of
David S Wishart et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 871(2), 164-173 (2008-05-27)
With continuing improvements in analytical technology and an increased interest in comprehensive metabolic profiling of biofluids and tissues, there is a growing need to develop comprehensive reference resources for certain clinically important biofluids, such as blood, urine and cerebrospinal fluid
Yong Jin An et al.
International journal of cancer, 136(1), 162-171 (2014-05-07)
Leptomeningeal carcinomatosis (LC) is a metastatic cancer invading the central nervous system (CNS). We previously reported a metabolomic diagnostic approach as tested on an animal model and compared with current modalities. Here, we provide a proof of concept by applying
Guang-Na Zhang et al.
Materials science & engineering. C, Materials for biological applications, 33(7), 4039-4045 (2013-08-06)
The property changes of urinary nanocrystallites in 20 cases of uric acid (UA) stone formers after 1 week of potassium citrate (K3cit) intake were comparatively studied by X-ray diffraction analysis, Fourier transform infrared spectroscopy, nanoparticle size analysis, and transmission electron
Qi Chen et al.
Plant physiology and biochemistry : PPB, 70, 504-511 (2013-07-19)
Our previous study showed that citrate excretion coupled with a concomitant release of protons was involved in aluminum (Al) resistance in the broad bean. Furthermore, genes encoding plasma membrane (PM) H(+)-ATPase (vha2) and the 14-3-3 protein (vf14-3-3b) were up-regulated by
Krithika A Shetty et al.
Journal of pharmaceutical sciences, 104(2), 388-395 (2014-04-05)
Factor VIII (FVIII) replacement therapy in hemophilia A (HA) is complicated by a short half-life and high incidence of inhibitory antibody response against the protein. Phosphatidylinositol (PI) containing lipidic nanoparticles have previously been shown to reduce the immunogenicity and prolong
Erika Davies et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(14), E1354-E1363 (2014-04-08)
We provide evidence that citrate anions bridge between mineral platelets in bone and hypothesize that their presence acts to maintain separate platelets with disordered regions between them rather than gradual transformations into larger, more ordered blocks of mineral. To assess
B G Solheim et al.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, 29(2), 133-139 (2003-08-28)
Plasma and red blood cell quality are affected both by citrate concentration and the levels of extracellular leukocyte and platelet derived substances, accumulated during storage of blood. The effect of leukocyte filtration on the storage stability of whole blood was
Heleen Kraan et al.
Vaccine, 33(17), 2030-2037 (2015-03-17)
In the near future oral polio vaccine (OPV) will be replaced by inactivated polio vaccine (IPV) as part of the eradication program of polio. For that reason, there is a need for substantial amount of safe and more affordable IPV
Robert D McBane et al.
Thrombosis research, 113(2), 137-145 (2004-04-30)
To test the hypothesis that circulating platelets display evidence of reversible interactions with atherosclerotic lesions, platelet alpha-granule content and propensity for microaggregate formation were measured in samples from normal donors (n=65) and from patients with either peripheral arterial disease (n=47)
Philippe Icard et al.
Bulletin du cancer, 100(5), 427-433 (2013-04-26)
Cancer cells activate glycolysis, glutaminolysis and β-oxidation to promote their biosynthesis. The low activity of pyruvate kinase, reexpressed in its embryonic isoform PKM2, generates a bottleneck at the end of glycolysis, which reorients glucose catabolism towards formation of molecules implied
Lars Tatenhorst et al.
Journal of neuropathology and experimental neurology, 73(8), 770-779 (2014-07-09)
Chronic degeneration of nigrostriatal projections, followed by nigral dopaminergic cell death, is a key feature of Parkinson disease (PD). This study examines the neuroprotective potential of the rho kinase inhibitor fasudil in the 6-hydroxydopamine (6-OHDA) mouse model of PD in
Ienaka Takeda et al.
NMR in biomedicine, 22(6), 577-584 (2009-03-05)
Saliva is a readily accessible biofluid that is important for the overall health, aiding in the chewing, swallowing, and tasting of food as well as the regulation mouth flora. As a first step to determining and understanding the human saliva
Chaoying Qiu et al.
Food chemistry, 141(3), 2772-2778 (2013-07-23)
The effects of citric acid deamidation on the physiochemical properties of wheat gluten were investigated. In vitro digestion was carried out to determine changes of molecular weight distribution, amino acids composition and antioxidant efficacy of wheat gluten hydrolysates. Results indicated
Ge Liu et al.
Prostaglandins, leukotrienes, and essential fatty acids, 91(6), 251-260 (2014-12-03)
Conventional assays of omega-3 long chain polyunsaturated fatty acid (n-3 LCPUFA) status in humans involve venous blood collection and expensive, multi-step processes that limit their usefulness as screening tools. This study aimed to develop a capillary dried blood spot (DBS)
L C Costello et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 34(8), 417-424 (2002-08-29)
The control and alteration of key regulatory enzymes is a determinant of the reactions and pathways of intermediary metabolism in mammalian cells. An important mechanism in the metabolic control is the hormonal regulation of the genes associated with the transcription
Santiago González-López et al.
The journal of adhesive dentistry, 15(5), 481-489 (2013-04-18)
To compare the percentage of collagen exposed in dentin root thirds after two irrigation protocols with manual or rotary instrumentation using two methacrylate resin-based sealers. Forty-eight single-root human teeth were prepared with manual (n = 24) or nickeltitanium ProFile rotary
Elena Pérez et al.
International journal of pharmaceutics, 470(1-2), 107-119 (2014-05-13)
Environmentally sensitive hydrogels have gained considerable attention in recent years as one of the most promising drug delivery systems. In the present study, two new formulations of pH and temperature stimuli-responsive nanogels (NGs) based on poly-N-isopropylacrylamide (NIPA), N-hydroxyethyl acrylamide (HEAA)
Jingjing Du et al.
Journal of nanoscience and nanotechnology, 13(1), 690-693 (2013-05-08)
Ni-W alloy coatings were prepared by electrodeposition technique with citric acid as a complexing agent. The influence of the main technical parameters on W content in the Ni-W alloy coatings were investigated by electron dispersive spectroscopy (EDS), and the microstructure
Guan-Ming Kuang et al.
Journal of biomedical materials research. Part A, 103(5), 1613-1621 (2014-08-05)
Calcium phosphate cements (CPCs) have long been used as osteoconductive bone substitutes in the treatment of bone defects. However, the degradation rate of CPC is typically too slow to match the new bone growth rate. It is known that strontium
Yih-Loong Lai et al.
The Chinese journal of physiology, 52(5 Suppl), 332-338 (2010-04-03)
Inhalation of citric acid (CA) causes airway constriction and coughing. To investigate the role of mast cells in CA-induced airway constriction and cough, three experiments using guinea pigs were carried out. In the first experiment, we used compound 48/80 to
Xiaolin Li et al.
Nanoscale research letters, 9(1), 583-583 (2014-10-28)
We examined the toxicity of four carbon-based nanomaterials (unmodified) by using carbon quantum dots (CQDs), graphene quantum dots (GQDs), graphene oxide (GO), and single-walled carbon nanotubes (SWCNTs) to cultivate bean sprout. Results showed that the toxicity of these four carbon
Erik Olsson et al.
Carbohydrate polymers, 94(2), 765-772 (2013-04-03)
Starch films with different amounts of citric acid produced by solution casting were subjected to different curing temperatures and compared with films plasticized with glycerol. The films were tested in a controlled moisture generator, which enabled the moisture sorption to
David M Foureau et al.
Cancer immunology, immunotherapy : CII, 63(12), 1329-1340 (2014-09-11)
Interleukin-2 (IL-2) therapy leads to clinically relevant responses in 10-16 % of patients with metastatic melanoma (MMEL) or 10-30 % of patients with metastatic renal cell carcinoma (MRCC). To date, no biomarkers have been validated to identify patients who are likely to
Wolfram Gronwald et al.
Kidney international, 79(11), 1244-1253 (2011-03-11)
Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of kidney failure; however, urinary biomarkers for the disease are lacking. In a step towards identifying such markers, we used multidimensional-multinuclear nuclear magnetic resonance (NMR) spectroscopy with support vector machine-based
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