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PHR1019

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Fatemeh Rajabi et al.
Chemistry & biodiversity, 9(9), 1823-1828 (2012-09-15)
The O-silylation of OH groups of alcohols and phenols with hexamethyldisilazane (HMDS) was achieved in high-to-excellent yields using catalytic quantities of a SBA-15-supported cobalt(II) nanocatalyst (typically 0.5 mol-%) at room temperature and under solvent-free conditions. Furthermore, the heterogeneous catalyst showed...
B Nair
International journal of toxicology, 20 Suppl 3, 23-50 (2002-01-05)
Benzyl Alcohol is an aromatic alcohol used in a wide variety of cosmetic formulations as a fragrance component, preservative, solvent, and viscosity-decreasing agent. Benzoic Acid is an aromatic acid used in a wide variety of cosmetics as a pH adjuster...
Minimizing injection pain.
Michel J Belliveau et al.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 184(15), 1715-1715 (2012-10-18)
J Scognamiglio et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50 Suppl 2, S140-S160 (2011-11-01)
A toxicologic and dermatologic review of benzyl alcohol when used as a fragrance ingredient is presented. Benzyl alcohol is a member of the fragrance structural group Aryl Alkyl Alcohols and is a primary alcohol. The AAAs are a structurally diverse...
Sonia G Parra et al.
Journal of visualized experiments : JoVE, (67)(67), e3848-e3848 (2012-10-02)
Multiphoton microscopy of intrinsic fluorescence and second harmonic generation (SHG) of whole mouse organs is made possible by optically clearing the organ before imaging.(1,2) However, for organs that contain fluorescent proteins such as GFP and YFP, optical clearing protocols that...
Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC.
Cudina OA, et al.
Chromatographia, 61(7-8), 415-418 (2005)
Maria A Cavasin et al.
Journal of translational medicine, 12, 314-314 (2014-11-27)
Patients with pulmonary arterial hypertension (PAH) are treated with vasodilators, including endothelin receptor antagonists (ERAs), phosphodiesterase-5 (PDE-5) inhibitors, soluble guanylyl cyclase activators, and prostacyclin. Despite recent advances in pharmacotherapy for individuals with PAH, morbidity and mortality rates in this patient...
Endea J Curry et al.
Dermatitis : contact, atopic, occupational, drug, 16(4), 203-208 (2006-03-16)
Benzyl alcohol is a weak sensitizer found in a wide array of plants and plant products, foods, cosmetics, and medications. Delayed contact dermatitis reactions as well as immediate, urticarial, and systemic reactions have been reported to occur with its use...
A A Melikian et al.
Carcinogenesis, 20(4), 719-726 (1999-05-01)
To investigate how various levels of exposure affect the metabolic activation pathways of benzene in humans and to examine the relationship between urinary metabolites and other biological markers, we have developed a sensitive and specific liquid chromatographic-tandem mass spectrometric assay...
Liang-Fei OuYang et al.
Journal of separation science, 36(4), 645-657 (2013-01-24)
The 0-1 model-inverse method of nonequilibrium nonlinear chromatography was developed to simultaneously determine the isotherm parameters and the lumped mass transfer coefficients of the two-component systems in RPLC. By comparing the simulated elution curves with experimental curves with regard to...
Evgeni Eltzov et al.
Analytical chemistry, 87(7), 3655-3661 (2015-03-17)
Indoor air pollution became a recent concern found to be oftentimes worse than outdoor air quality. We developed a tool that is cheap and simple and enables continuous monitoring of air toxicity. It is a biosensor with both a nondisposable...
Yuma Morimoto et al.
Inorganic chemistry, 51(18), 10025-10036 (2012-09-08)
The rate of oxidation of 2,5-dimethoxybenzyl alcohol (2,5-(MeO)(2)C(6)H(3)CH(2)OH) by [Fe(IV)(O)(N4Py)](2+) (N4Py = N,N-bis(2-pyridylmethyl)-N-bis(2-pyridyl)methylamine) was enhanced significantly in the presence of Sc(OTf)(3) (OTf(-) = trifluoromethanesulfonate) in acetonitrile (e.g., 120-fold acceleration in the presence of Sc(3+)). Such a remarkable enhancement of the...
Megan K Luther et al.
The Journal of antimicrobial chemotherapy, 69(12), 3263-3267 (2014-08-07)
Antimicrobial lock solutions are used for prevention and management of catheter-related bloodstream infections. ML8-X10 (a prototype oil-in-water micro-emulsion based on a novel free fatty acid), vancomycin/heparin and taurolidine/citrate/heparin (Taurolock™-Hep500) lock solutions were tested against biofilm-forming Staphylococcus epidermidis and methicillin-susceptible Staphylococcus...
J E Hulla et al.
Carcinogenesis, 22(1), 89-98 (2001-02-13)
Mice heterozygous for a null p53 allele were administered three well-characterized carcinogens to learn more about mechanisms of carcinogenesis and to evaluate the p53-deficient mouse as a tool for identifying potential human carcinogens. Benzene-induced sarcomas, p-cresidine-induced bladder carcinomas and phenolphthalein-induced...
Subramanian Natesan et al.
Journal of drug targeting, 22(10), 913-926 (2014-08-15)
Development and evaluation of camptothecin-loaded-microemulsion (ME) and -magnetic microemulsion (MME) for passive/active-targeted delivery to BALB/c mice-bearing breast cancer. Based on the pseudo-ternary phase diagrams camptothecin-loaded-MEs and -MMEs were developed using benzyl alcohol:Captex 300 (3:1), TPGS:Tween 80 (2:1) and water. Furthermore...
Qiong Liu et al.
Biochimica et biophysica acta, 1828(9), 2111-2120 (2013-05-11)
The ability to adjust cell volume is required for the adaptation to osmotic stress. Plant protoplasts can swell within seconds in response to hypoosmotic shock suggesting that membrane material is released from internal stores. Since the stability of plant membranes...
Stephen T Vito et al.
Toxicology and applied pharmacology, 281(2), 185-194 (2014-12-03)
Tetramethylenedisulfotetramine (TETS) is a potent convulsant poison for which there is currently no approved antidote. The convulsant action of TETS is thought to be mediated by inhibition of type A gamma-aminobutyric acid receptor (GABAAR) function. We, therefore, investigated the effects...
Full spectrum and selected spectrum based multivariate calibration methods for simultaneous determination of betamethasone dipropionate, clotrimazole and benzyl alcohol: Development, validation and application on commercial dosage form.
Darwish HW, et al.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 169, 50-57 (2016)
D W Shaw
American journal of contact dermatitis : official journal of the American Contact Dermatitis Society, 10(4), 228-232 (1999-12-14)
A patient with allergic contact dermatitis caused by benzyl alcohol in a hearing aid impression material and in topical medications is described. In addition, the patient had topical and probably systemic corticosteroid allergy. Benzyl alcohol allergy is reviewed. allergic contact...
Wenhuai Kang et al.
Journal of food science, 77(10), C1030-C1035 (2012-09-27)
The aroma-active compounds in Chinese bayberry were identified using gas chromatography-olfactometry (GC-O) and GC-mass spectrometry techniques. The volatile compounds were extracted using Liquid-liquid extraction, solvent-assisted flavor evaporation and headspace solid-phase microextraction (HS-SPME), respectively. On the basis of odor intensity, the...
Shaoyin Wang et al.
Organic letters, 16(13), 3592-3595 (2014-06-25)
A novel Lewis acid catalyzed dehydrative [3 + 3]-annulation of readily available benzylic alcohols and propargylic alcohols was developed to give polysubstituted carbazoles and naphthalenes in moderate to good yields with water as the only byproduct. The reaction was presumed...
Thomas Pöschinger et al.
Investigative radiology, 49(7), 445-456 (2014-03-07)
Dynamic contrast-enhanced (DCE) micro-computed tomography (micro-CT) has emerged as a valuable imaging tool to noninvasively obtain quantitative physiological biomarkers of drug effect in preclinical studies of antiangiogenic compounds. In this study, we explored the ability of DCE micro-CT to assess...
Justin A Edward et al.
Biomacromolecules, 13(8), 2483-2489 (2012-08-02)
The ring-opening polymerization of substituted cyclic carbonates with 1-(3,5-bis-trifluoromethyl-phenyl)-3-cyclohexyl-thiourea (TU)/1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) organocatalysts afford highly functionalized oligocarbonates. The fluorescent alkaloid quinine can be readily incorporated into the oligocarbonates either by initiation from quinine or by ring-opening polymerization of a quinine-functionalized cyclic...
Farhaan Hafeez et al.
Drug development and industrial pharmacy, 40(6), 838-844 (2013-04-23)
Onychomycosis is a common fungal infection of the nail plate and bed that affects up to 14% of the population and can have a substantial impact on the quality of life of those affected. This study compared the onychopharmacokinetics, nail...
Kyra J Barnes et al.
European journal of clinical pharmacology, 70(9), 1097-1106 (2014-06-24)
To investigate the potential inhibitory effects of uremic toxins on the major human hepatic drug-metabolising cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes in vitro. Benzyl alcohol, p-cresol, indoxyl sulfate, hippuric acid and a combination of the four uremic toxins were...
Jinjin Zhang et al.
Inorganic chemistry, 51(24), 13380-13389 (2012-12-12)
A series of alkali metal complexes supported by two bulky tetraphenols were synthesized and characterized. The reactions of α,α,α',α'-tetra(3,5-di-tert-butyl-2-hydroxyphenyl)-p-xylene(para-tetraphenol) with (n)BuLi, sodium, and KSi(NMe(2))(3) gave bimetallic complexes 1, 2, and 3, respectively. Treatments of the α,α,α',α'-tetra(3,5-di-tert-butyl-2-hydroxyphenyl)-m-xylene(meta-tetraphenol) with 2 or 4...
Aditya M Kunjapur et al.
Journal of the American Chemical Society, 136(33), 11644-11654 (2014-07-31)
Aromatic aldehydes are useful in numerous applications, especially as flavors, fragrances, and pharmaceutical precursors. However, microbial synthesis of aldehydes is hindered by rapid, endogenous, and redundant conversion of aldehydes to their corresponding alcohols. We report the construction of an Escherichia...
Epidural administration of methylprednisolone acetate preserved with benzyl alcohol.
C C King et al.
The Annals of pharmacotherapy, 28(1), 59-60 (1994-01-01)
G Xiao et al.
Industrial health, 39(2), 206-210 (2001-05-09)
The effects on semen and the function of accessory gonad of workers after short and long term exposure to benzene, toluene, and xylene were examined. The semen and blood of 24 married workers exposed to benzene, toluene, and xylene were...
Laura A Jones et al.
The Journal of cell biology, 207(4), 499-516 (2014-11-26)
Cytoplasmic dynein 1 (dynein) is a minus end-directed microtubule motor protein with many cellular functions, including during cell division. The role of the light intermediate chains (LICs; DYNC1LI1 and 2) within the complex is poorly understood. In this paper, we...
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