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Developmental toxicity assessment of common excipients using a stem cell-based in vitro morphogenesis model.
Yuan J C and Marikawa Y.
Food And Chemical Toxicology, 109, 376-385 (2017)
Gabriela Oliveira et al.
International journal of pharmaceutics, 435(1), 38-49 (2012-05-29)
Simple topical formulations which include volatile components, such as gels or sprays, are appealing from a cosmetic perspective. However, complex formulation effects may result from the use of volatile excipients in topical formulations, particularly when applied at clinically relevant doses
Superbug hideout: finding MRSA in U.S.wastewater treatment plants.
Rebecca Kessler
Environmental health perspectives, 120(11), A437-A437 (2012-11-03)
M G Soni et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 40(10), 1335-1373 (2002-10-22)
Methyl paraben (CAS No. 99-76-3) is a methyl ester of p-hydroxybenzoic acid. It is a stable, non-volatile compound used as an antimicrobial preservative in foods, drugs and cosmetics for over 50 years. Methyl paraben is readily and completely absorbed through
Ismail I Hewala et al.
Talanta, 88, 623-630 (2012-01-24)
Simple methods for HPTLC peak purity assessment and identification of the HPTLC peaks were presented. The spectrodensitograms - selected at different time intervals across the elution time of the HPTLC peak - were extracted and digital algorithms for manipulating the
Kayo Alves Figueiredo et al.
Pharmacology, biochemistry, and behavior, 131, 6-12 (2015-01-27)
This study aimed to evaluate a microemulsion system (ME) containing phenobarbital in epilepsy model induced by pilocarpine in rats and to oxidative stress and histologic lesions in hippocampus. The microemulsion was applied to the shaved back of Wistar rats. The
Rong-Li Qiu et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 34(8), 1211-1213 (2012-01-12)
To study the chemical constituents of Psoralea corylifolia. Column chromatography was used in the isolation procedure. The structures of isolated compounds were elucidated by spectral data. Seven compounds were isolated and their structures were identified as isopsoralen (1), psoralen (2)
Marina Gorga et al.
Journal of chromatography. A, 1352, 29-37 (2014-06-10)
A novel fully automated method based on dual column switching using turbulent flow chromatography followed by liquid chromatography coupled to tandem mass spectrometry (TFC-LC-MS/MS) was applied for the determination of endocrine disruptors (EDCs) and related compounds in sediment and sewage
Laura San Segundo et al.
Environmental toxicology and chemistry, 32(9), 2018-2025 (2013-05-03)
In the present study, the authors investigated the effects of bisphenol A, chlorpyrifos, methylparaben, and 2 effluent samples from wastewater treatment plants located in the province of Madrid, Spain, on the messenger RNA expression of specific genes involved in early
Mari Egawa et al.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 47(3), 196-204 (2012-03-02)
Alkyl esters of p-hydroxybenzoic acids (parabens), an endocrine disrupter, are used as preservatives in cosmetics and foods. In this study, to understand the relationship between parabens and differentiation in infants, the effects of parabens on apoptosis induced by serum deprivation
S A Moosavian Kalat et al.
Experimental parasitology, 143, 5-10 (2014-05-02)
Treatment of cutaneous leishmaniasis (CL) is a dream for the patients, health care authorities and scientists. The aim of this study was to develop a topical liposomal meglumine antimoniate (MA, Glucantime™) (Lip-MA) formulation and evaluate the therapeutic effects of the
Marisa H Miceli et al.
Antimicrobial agents and chemotherapy, 56(1), 148-153 (2011-10-12)
Infections and thromboses are the most common complications associated with central venous catheters. Suggested strategies for prevention and management of these complications include the use of heparin-coated catheters, heparin locks, and antimicrobial lock therapy. However, the effects of heparin on
James J Connell et al.
Analytical and bioanalytical chemistry, 407(8), 2245-2253 (2014-11-27)
The spatial distribution of an anticancer drug and its intended target within a tumor plays a major role on determining how effective the drug can be at tackling the tumor. This study provides data regarding the lateral distribution of sunitinib
Antonis Myridakis et al.
Analytical and bioanalytical chemistry, 407(9), 2509-2518 (2015-02-04)
Phthalates, bisphenol A (BPA) and parabens (PBs), organic chemicals widely used in everyday products, are considered to be endocrine disruptors. We propose a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of seven phthalate metabolites, six PBs and BPA
Mohammed Al Za'abi et al.
Journal of chromatographic science, 51(1), 40-43 (2012-06-22)
A sensitive and reproducible high-performance liquid chromatography-fluorescence method was developed and validated for quantitative determination of indoxyl sulfate in plasma using methyl paraben as an internal standard. The separation was carried out on an OSD-2 C18 Spherisorb column by isocratic
A novel gradient HPLC method for simultaneous determination of ranitidine, methylparaben and propylparaben in oral liquid pharmaceutical formulation
Kokoletsi XM, et al.
Journal of Pharmaceutical and Biomedical Analysis, 38(4), 763-767 (2005)
Yoshiki Asakawa et al.
Journal of separation science, 37(19), 2641-2651 (2014-07-22)
A novel metal aquo-ion affinity chromatography has been developed for the analysis of basic compounds using heat-treated silica gel containing hydrated metal cations (metal aquo-ions) as the packing material. The packing materials of the metal aquo-ion affinity chromatography were prepared
Yujun Hou et al.
PloS one, 9(11), e111215-e111215 (2014-11-12)
Alzheimer's disease (AD) is a progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe disease-modifying treatment and symptomatic intervention alternatives against AD. Smart Soup (SS), a Chinese medicine formula
Anna Kulik et al.
Acta poloniae pharmaceutica, 68(4), 467-472 (2011-07-30)
The purpose of the study was to develop a simple, versatile HPLC method for the identification and quantification of praziquantel and ivermectin (in Equimax) or praziquantel and abamectin (in Abamitel Plus). A satisfactory separation was obtained using the Supelcosil LC-ABZ+
Andreas Lauterbach et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 614-624 (2014-12-03)
A novel adapalene-loaded solid lipid microparticle (SLMA) dispersion as a topical drug delivery system (TDDS) for follicular penetration has been introduced. The objective of the present study was to investigate the rheological properties, the follicular penetration with differential tape stripping
K Kannathasan et al.
Acta tropica, 120(1-2), 115-118 (2011-07-19)
The vector-borne diseases caused by mosquitoes are one of the major health problems in many countries especially in tropical and sub-tropical countries. The resistance of mosquitoes to synthetic chemicals and environmental toxicity created by the chemicals raised the demand for
M Khimani et al.
The journal of physical chemistry. B, 116(51), 14943-14950 (2012-12-06)
The influence of methyl paraben (MP) and butyl paraben (BP) on the aggregation characteristics of Pluronics in an aqueous medium has been investigated by DLS, SANS, viscometry, and fluorescence measurement techniques. Parabens are extensively used as preservatives in cosmetic, pharmaceutical
Bolaji Bosede Oluremi et al.
Pakistan journal of pharmaceutical sciences, 25(4), 773-776 (2012-09-27)
Gums are used as binders in tablets and also as emulsion stabilisers, suspending agents and thickeners in syrups. The need for other natural gums apart from the conventional gums to be employed as binding agents in tablets formulation led to
Hye-Min Kang et al.
Chemosphere, 226, 388-394 (2019-04-05)
Parabens are used as a preservative substance in a wide range of man-made products causing deleterious effects on aquatic organisms and therefore, the concern of their effects to aquatic organisms has been increased. In this study, acute toxicity of methylparaben
Christoph Tappeiner et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 249(12), 1831-1835 (2011-08-19)
Severe postoperative loss of vision has been occasionally reported as a rare complication of retrobulbar anesthesia, and several possible causes have been proposed in the literature. In this work, our own and other investigators' experiences with these complications are surveyed
Gustavo Henrique Rodriguez da Silva et al.
Journal of applied oral science : revista FOB, 20(4), 444-448 (2012-10-04)
To detect the presence and concentration of methylparaben in cartridges of commercial Brazilian local anesthetics. Twelve commercial brands (4 in glass and 8 in plastic cartridges) of local anesthetic solutions for use in dentistry were purchased from the Brazilian market
Laurie C Dolan et al.
Journal of food science, 78(1), T119-T127 (2013-01-03)
Free N Clear is a sanitizing agent composed of United States Pharmacopeial Convention grade benzalkonium chloride (BAC), acetic acid, and methylparaben. Free N Clear is proposed for use as a sanitizing agent at a 1: 50 dilution (2% solution), which
Katra Kolšek et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(1), 8-15 (2014-09-07)
A homeostasis of the glucocorticoid and androgen endocrine system is essential to human health. Their disturbance can lead to various diseases, for example cardiovascular, inflammatory and autoimmune diseases, infertility, cancer. Fifteen widely used industrial chemicals that disrupt endocrine activity were
Anna Wattanasatcha et al.
International journal of pharmaceutics, 434(1-2), 360-365 (2012-06-16)
Among thymol, carvacrol, citronellal, eugenol and terpinen-4-ol, thymol showed the highest antibacterial activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Thymol was then encapsulated into water dispersible submicron sized ethylcellulose/methylcellulose spheres, attaining the relatively high thymol loading level of
Kristen W Smith et al.
Environmental health perspectives, 120(11), 1538-1543 (2012-06-23)
Parabens are suspected endocrine disruptors and ubiquitous preservatives used in personal care products, pharmaceuticals, and foods. No studies have assessed the variability of parabens in women, including during pregnancy. We evaluated predictors and variability of urinary paraben concentrations. We measured
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