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PHR1008

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Abdul S Qadir et al.
Journal of cellular biochemistry, 116(5), 730-742 (2014-11-27)
MicroRNAs are novel key regulators of cellular differentiation. Dlx transcription factors play an important role in osteoblast differentiation, and Dlx5 and Dlx2 are known targets of miR-124. Therefore, in the present study, we investigated the regulatory effects of miR-124 on...
Terukazu Sanui et al.
Journal of cellular biochemistry, 116(4), 628-639 (2014-11-18)
Sprouty was identified as an inhibitor of the fibroblast growth factor (FGF) receptor, and Sprouty2 (Spry2) functions as a negative regulator of receptor tyrosine kinase signaling. In this study, we investigated how inhibition of Spry2 affects osteoblasts and gingival epithelial...
Karen Pauwelyn et al.
PloS one, 6(8), e23096-e23096 (2011-08-11)
Mouse embryonic stem cells (mESC) have been used to study lineage specification in vitro, including towards a hepatocyte-like fate, and such investigations guided lineage differentiation protocols for human (h)ESC. We recently described a four-step protocol to induce hepatocyte-like cells from...
Christine M Sandiego et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(4), 623-629 (2015-01-08)
Detecting fluctuations in synaptic dopamine levels in extrastriatal brain regions with [(11)C]FLB 457 and positron emission tomography (PET) is a valuable tool for studying dopaminergic dysfunction in psychiatric disorders. The evaluation of reference region modeling approaches would eliminate the need...
Ting Chen et al.
Journal of molecular histology, 46(1), 1-11 (2014-12-04)
The adipose tissue-derived stem cells (ADSCs) represent a significant area of the cell therapy. Genetic modification of ADSCs may further improve their therapeutic potential. Here, we aimed to generate a lentiviral vector expressing insulin-like growth factor-I (IGF-1) and investigate the...
Marilena Vered et al.
BMC cancer, 15, 25-25 (2015-01-31)
Caveolin-1 (CAV1) may be upregulated by hypoxia and acts in a tumor-dependent manner. We investigated CAV1 in tongue squamous cell carcinoma (TSCC) and its association with clinical outcomes, and studied in vitro possible ways for CAV1 accumulation in the tumor...
Maria Patapia Zafiriou et al.
Stem cells (Dayton, Ohio), 32(9), 2480-2491 (2014-05-09)
The role of erythropoietin (Epo) in myocardial repair after infarction remains inconclusive. We observed high Epo receptor (EPOR) expression in cardiac progenitor cells (CPCs). Therefore, we aimed to characterize these cells and elucidate their contribution to myocardial regeneration on Epo...
Thiyagarajan Ramesh et al.
Metabolic brain disease, 30(2), 573-582 (2014-09-14)
Cigarette smoking is concerned as a major risk factor in the development of various neurological disorders. Oxidative stress is suggested as a possible contributing factor in the pathogenesis of cigarette smoking-induced toxicity. Therefore, the present study was intended to evaluate...
Karolien Hollanders et al.
Investigative ophthalmology & visual science, 56(2), 1335-1348 (2015-01-30)
Rho kinase (ROCK) is associated with VEGF-driven angiogenesis, as well as with inflammation and fibrosis. Therefore, the effect of AMA0428, a novel ROCK inhibitor, was studied in these processes, which highly contribute to the pathogenesis of neovascular AMD. The effect...
Luis E Sojo et al.
Rapid communications in mass spectrometry : RCM, 28(20), 2181-2190 (2014-09-03)
Catechols are an important class of analytes occurring in many natural and synthetic products. Electrospray ionization in negative mode is the preferred way of ion generation for these compounds; however, studies in positive ion mode can reveal their potential for...
Carl C Awh et al.
Ophthalmology, 122(1), 162-169 (2014-09-10)
To evaluate the impact of complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) risk alleles on the observed response to components of the Age-Related Eye Disease Study (AREDS) formulation. Genetic and statistical subgroup analysis of a randomized, prospective...
Nehal A Hamdy et al.
Acta poloniae pharmaceutica, 70(6), 987-1001 (2014-01-05)
2-Acetyl-5,6,7,8-tetrahydronaphthalene (1) was allowed to react with different aromatic aldehydes to produce the cyanopyridones 2a and 2b, which were treated with phosphorous pentasulfide to afford the corresponding thioxopyridine derivatives 3a and 3b, respectively. The reaction of 3a and 3b with...
Jhi Biau Foo et al.
BMC complementary and alternative medicine, 14, 197-197 (2014-06-21)
Dillenia suffruticosa root dichloromethane extract (DCM-DS) has been reported to exhibit strong cytotoxicity towards breast cancer cells. The present study was designed to investigate the cell cycle profile, mode of cell death and signalling pathways of DCM-DS-treated human caspase-3 deficient...
Sung Nam Kang et al.
Biomaterials, 44, 1-10 (2015-01-27)
A drug-eluting stent (DES) is one of the commonly used treatment techniques in percutaneous coronary intervention (PCI). Sirolimus (SRL) has been widely used for DES as a drug for suppressing neointimal hyperplasia causing restenosis. Phytoncides (PTC) are compounds released from...
Ghasem Saki et al.
Noise & health, 15(64), 194-198 (2013-05-22)
The aims of this study were to evaluate the effects of administration of Vitamins C and E on fertilization capacity in rats exposed to noise stress. 40 adult male rats were randomly divided into 5 equal groups. Group 1 as...
Hiroka Suzuki et al.
American journal of physiology. Cell physiology, 307(4), C384-C394 (2014-06-20)
Transient receptor potential ankyrin 1 (TRPA1) is a Ca(2+)-permeable nonselective cation channel expressed in neuronal and nonneuronal cells and plays an important role in acute and inflammatory pain. Here, we show that an NADPH oxidase (NOX) inhibitor, diphenyleneiodonium (DPI), functions...
T Marchini et al.
Toxicology and applied pharmacology, 274(2), 274-282 (2013-12-11)
It is suggested that systemic oxidative stress and inflammation play a central role in the onset and progression of cardiovascular diseases associated with the exposure to particulate matter (PM). The aim of this work was to evaluate the time changes...
John P Shapiro et al.
Contraception, 91(3), 253-260 (2014-12-23)
Thrombin and hypoxia each target human endometrial stromal cells (HESCs) to mediate long-acting progestin-only contraceptive (LAPC)-induced abnormal uterine bleeding (AUB). Thus, the secretome resulting from treatment of primary cultures of HESCs with thrombin or hypoxia was screened by mass spectrometry...
Fuiyee Lee et al.
PloS one, 9(7), e103254-e103254 (2014-07-23)
Graft versus host disease (GvHD) is one of the main complications after hematological stem cell transplantation (HSCT). CAMPATH-1H is used in the pre-transplant conditioning regimen to effectively reduce GvHD by targeting CD52 antigens on T cells resulting in their depletion....
Jie Liu et al.
Psychoneuroendocrinology, 52, 130-142 (2014-12-02)
Epidemiological and experimental evidence has shown that psychological stress can propel cancer progression. However, its role in anti-angiogenic therapy is not well understood. We previously found that exogenous norepinephrine attenuated the effect of sunitinib, a multi-targeted anti-angiogenic agent, in a...
Adeline Sham et al.
Tissue engineering. Part A, 21(5-6), 1106-1115 (2014-11-06)
Clinical applications of tissue engineering are constrained by the ability of the implanted construct to invoke vascularization in adequate extent and velocity. To overcome the current limitations presented by local delivery of single angiogenic factors, we explored the incorporation of...
Stefanie B Murer et al.
The Journal of nutrition, 144(2), 193-201 (2013-12-20)
Oxidative stress and low-grade systemic inflammation may contribute to the pathogenesis of obesity-induced comorbidities, including nonalcoholic fatty liver disease. Increasing intake of dietary antioxidants might be beneficial, but there are few data in obese children. To examine the effect of...
Sooyeon Lee et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(48), 16140-16152 (2014-11-28)
Haploinsufficiency of peripheral myelin protein 22 (PMP22) causes hereditary neuropathy with liability to pressure palsies, a peripheral nerve lesion induced by minimal trauma or compression. As PMP22 is localized to cholesterol-enriched membrane domains that are closely linked with the underlying...
Visual outcome after antioxidant supplementation.
Stephen Beatty et al.
Ophthalmology, 120(3), 645-645 (2013-05-30)
Noushin Dianat et al.
Hepatology (Baltimore, Md.), 60(2), 700-714 (2014-04-10)
Cholangiocytes are biliary epithelial cells, which, like hepatocytes, originate from hepatoblasts during embryonic development. In this study we investigated the potential of human embryonic stem cells (hESCs) to differentiate into cholangiocytes and we report a new approach, which drives differentiation...
Cheng Li et al.
PloS one, 10(3), e0120585-e0120585 (2015-03-24)
Induced pluripotent stem cells (iPSCs) have tremendous potential as a tool for disease modeling, drug testing, and other applications. Since the generation of iPSCs "captures" the genetic history of the individual cell that was reprogrammed, iPSC clones (even those derived...
Soo Jung Choi et al.
Journal of medicinal food, 17(11), 1222-1231 (2014-08-19)
Alzheimer's disease (AD) is pathologically characterized by the presence of amyloid plaques in brain and the overproduction of amyloid beta (Aβ), leading to learning and memory impairment and intense oxidative stress. In this study, the protective effect of Ligularia fischeri...
Fei-Long Zhang et al.
CNS neuroscience & therapeutics, 20(12), 1036-1044 (2014-11-18)
To explore the effect of fucoidan treatment on oxidative stress-mediated dopaminergic neuronal damage and its potential mechanisms. The effect of fucoidan was investigated in a 6-hydroxydopamine (6-OHDA) rat model of PD, an animal model considered appropriate for preclinical studies of...
Ulrika Nordströma et al.
Neurobiology of disease, 73, 70-82 (2014-10-05)
Current research on Parkinson's disease (PD) pathogenesis requires relevant animal models that mimic the gradual and progressive development of neuronal dysfunction and degeneration that characterizes the disease. Polymorphisms in engrailed 1 (En1), a homeobox transcription factor that is crucial for...
Misato Kobayashi et al.
Bioscience, biotechnology, and biochemistry, 78(6), 1060-1066 (2014-07-19)
The mechanisms underlying the decrease in hepatic cytochrome P-450 (CYP) content in ascorbic acid deficiency was investigated in scurvy-prone ODS rats. First, male ODS rats were fed a diet containing sufficient ascorbic acid (control) or a diet without ascorbic acid...
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