Showing 1-30 of 342 results for "

PHR1005

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Shao Fu et al.
AAPS PharmSciTech, 15(5), 1228-1237 (2014-06-04)
The purpose of this study is to characterize the inter-grade and inter-batch variability of sodium alginate used in the formulation of matrix tablets. Four different grades and three batches of one grade of sodium alginate were used to prepare matrix...
Jonathan S Jahr et al.
American journal of therapeutics, 20(2), 189-199 (2013-03-08)
Hospitals are subject to more economic pressures than ever before. On the one hand, cost containment or cost reduction is paramount, particularly in relation to costly branded pharmaceuticals. On the other hand, quality measures and value-based reimbursement penalizes poor patient...
Hans-Christoph Diener et al.
The journal of headache and pain, 15, 76-76 (2014-11-20)
Most patients with episodic tension-type headache treat headache episodes with over-the-counter medication. Combination analgesics containing caffeine may be more effective and as well tolerated as monotherapy. The aim of this study was to evaluate the efficacy of the combination of...
Kit Baley et al.
AANA journal, 82(1), 53-64 (2014-03-25)
Pediatric surgical patients are a population at risk of inadequate pain management. The American Society of Anesthesiologists' 2012 Practice Guidelines for Acute Pain Management in the Perioperative Setting recommend a multimodal approach as the most effective way to prevent and...
Christopher J Derry et al.
The Cochrane database of systematic reviews, 6(6), CD010210-CD010210 (2013-06-25)
Combining two different analgesics in fixed doses in a single tablet can provide better pain relief than either drug alone in acute pain. This appears to be broadly true across a range of different drug combinations, in postoperative pain and...
David R Janz et al.
Critical care medicine, 43(3), 534-541 (2014-12-05)
This trial evaluated the efficacy of acetaminophen in reducing oxidative injury, as measured by plasma F2-isoprostanes, in adult patients with severe sepsis and detectable plasma cell-free hemoglobin. Single-center, randomized, double-blind, placebo-controlled phase II trial. Medical ICU in a tertiary, academic...
Elias Begas et al.
Journal of chromatographic science, 52(7), 590-595 (2013-06-27)
Methotrexate (MTX) is a dihydrofolate reductase inhibitor that is used for the treatment of tumors and autoimmune diseases. Several automated binding assays are used in clinical practice and numerous chromatographic methods have been developed toward higher specificity and sensitivity. In...
Rodney N Nishimoto
Anesthesia progress, 61(3), 99-102 (2014-09-06)
This was judged to be the first place winning submission for the American Dental Society of Anesthesiology Student Essay Award. Acetaminophen is an old drug that is now available in an intravenous formulation. Its advantages and disadvantages are reviewed, including...
M Cheelo et al.
Archives of disease in childhood, 100(1), 81-89 (2014-11-28)
While paracetamol exposure in pregnancy and early infancy has been associated with asthma, it remains unclear whether this is confounded by respiratory tract infections, which have been suggested as an alternative explanation. We undertook a systematic review and meta-analysis of...
FDA asks physicians to stop prescribing high-dose acetaminophen products.
Mike Mitka
JAMA, 311(6), 563-563 (2014-02-13)
Mahmoud Mohammadi et al.
Indian pediatrics, 40(12), 1183-1186 (2004-01-15)
The present study was done to explore the relationship between the cerebrospinal fluid (CSF) glucose concentration, body temperature, seizure duration, and acetaminophen administration. Retrospective record review of 117 consecutive febrile convulsive infants aging 3 to 18 months admitted to Bahrami...
When is research clinical advice? Interpreting an exploratory study of paracetamol overdose.
Geoffrey K Isbister et al.
Clinical toxicology (Philadelphia, Pa.), 51(10), 1242-1242 (2013-11-14)
Hitoshi Maeda et al.
The Journal of pharmacology and experimental therapeutics, 352(2), 244-257 (2014-11-16)
Since reactive oxygen species (ROS) derived from Kupffer cells (KC), especially CD68(+) KC, play a key role in the induction of hepatic oxidative stress and injuries, we developed a polythiolated- and mannosylated human serum albumin (SH-Man-HSA), which functions as a...
Constantine J Karvellas et al.
Critical care medicine, 42(5), 1157-1167 (2013-12-20)
To determine if intracranial pressure monitor placement in patients with acute liver failure is associated with significant clinical outcomes. Retrospective multicenter cohort study. Academic liver transplant centers comprising the U.S. Acute Liver Failure Study Group. Adult critically ill patients with...
U Eranka Illangakoon et al.
International journal of pharmaceutics, 477(1-2), 369-379 (2014-12-03)
A series of polyvinylpyrrolidone fibers loaded with paracetamol (PCM) and caffeine (CAF) was fabricated by electrospinning and explored as potential oral fast-dissolving films. The fibers take the form of uniform cylinders with smooth surfaces, and contain the drugs in the...
Yiming Jiang et al.
Toxicological sciences : an official journal of the Society of Toxicology, 143(1), 107-115 (2014-10-17)
Acetaminophen (APAP) overdose is the most frequent cause of drug-induced acute liver failure. Schisandra sphenanthera is a traditional hepato-protective Chinese medicine and Schisandrol B (SolB) is one of its major active constituents. In this study, the protective effect of SolB...
Marta Krasny et al.
Acta poloniae pharmaceutica, 70(3), 573-577 (2013-06-14)
In view of high availability and diversity of non-steroidal anti-inflammatory drugs (NSAIDs) on Polish market it is important for orthodontists to be aware of NSAID effect on the range of orthodontic tooth movement as well as the risk of root...
[Effectiveness of analgesic combinations in the self-medication].
Eve C A Morgenstern et al.
MMW Fortschritte der Medizin, 155(9), 49-51 (2013-08-21)
Huan Yang et al.
The Journal of experimental medicine, 212(1), 5-14 (2015-01-07)
Innate immune receptors for pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) orchestrate inflammatory responses to infection and injury. Secreted by activated immune cells or passively released by damaged cells, HMGB1 is subjected to redox modification that distinctly influences its...
Genetics of drug-induced hepatotoxicity toxicity in Gilbert's syndrome.
Ali Raza et al.
The American journal of gastroenterology, 108(12), 1936-1937 (2013-12-05)
The ability of a retrospective review of electronic health records to fully capture the frequency of supratherapeutic dosing of acetaminophen--reply.
Li Zhou et al.
JAMA internal medicine, 173(11), 1036-1036 (2013-06-12)
Sebastiano Mercadante et al.
Critical reviews in oncology/hematology, 87(2), 140-145 (2013-02-12)
The aim of this review was to assess the value of NSAIDs and paracetamol in patients with cancer pain to update a previous review performed ten years ago on this topic. The approach was analytic and based on clinical considerations...
Takako Ohkura et al.
Drug metabolism and pharmacokinetics, 29(5), 373-378 (2014-04-04)
We investigated the utility of three-dimensional (3D) spheroid cultures of human hepatocytes in discovering drug metabolites. Metabolites of acetaminophen, diclofenac, lamotrigine, midazolam, propranolol and salbutamol were analyzed by liquid chromatography-tandem mass spectrometry (LC/MS/MS) to measure enzyme activities in this system...
Nynke G L Jager et al.
Bioanalysis, 6(18), 2481-2514 (2014-11-12)
Dried blood spot (DBS) sampling, the collection of whole blood samples on paper, is an emerging technique used for bioanalytical methods. Several analytical challenges, such as possible effects of spotting volume, hematocrit and spot inhomogeneity are identified for these methods...
L-H Hao et al.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 18(12), 1505-1512 (2014-12-18)
The bioavailability of rifampicin (RMP) decreases by ∼30% on interaction with isoniazid (INH) in stomach acid conditions, which can result in the development of drug resistance and treatment failure. To compare the bioavailability in healthy volunteers of five anti-tuberculosis fixed-drug...
Two cases of corneal abrasions in children exposed to liquid detergent capsules.
Olivier Lasnier et al.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 48(2), e29-e30 (2013-04-09)
F Franceschi et al.
European review for medical and pharmacological sciences, 17(16), 2129-2135 (2013-07-31)
Pain is the most common reason people see doctors in developed Countries and a very common cause of access in Emergency Department (ED). The combination acetaminophen/codeine represents the standard medication in the second step of the WHO analgesic scale and...
Treatment of paracetamol overdose.
Benjamin Kessler et al.
Lancet (London, England), 383(9926), 1382-1382 (2014-04-25)
Harley T Syyong et al.
American journal of respiratory cell and molecular biology, 52(3), 304-314 (2014-07-24)
A characteristic feature of asthma is exaggerated airway narrowing, termed airway hyper-responsiveness (AHR) due to contraction of airway smooth muscle (ASM). Although smooth muscle (SM)-specific asthma susceptibility genes have been identified, it is not known whether asthmatic ASM is phenotypically...
Katarina Rubin et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(1), 119-125 (2014-11-06)
The suppression of hepatic cytochrome P450 (P450) expression during inflammatory and infectious diseases and the relief of this suppression by successful disease treatment have been previously demonstrated to impact drug disposition. To address this clinically relevant phenomenon preclinically, the effect...