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PHG0007

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Enrique Navarro et al.
Environmental science & technology, 49(13), 8041-8047 (2015-05-29)
Various factors have been invoked to explain the toxicity of silver nanoparticles (AgNP) to microorganisms including particle size and the nature of stabilizing coatings as well as the amount of dissolved silver occurring in AgNP suspensions. In this study we...
Jing Sun et al.
Antimicrobial agents and chemotherapy, 59(3), 1627-1633 (2014-12-31)
Candida albicans persisters constitute a small subpopulation of biofilm cells and play a major role in recalcitrant chronic candidiasis; however, the mechanism underlying persister formation remains unclear. Persisters are often described as dormant, multidrug-tolerant, nongrowing cells. Persister cells are difficult...
Magdalena Skóra et al.
Medical mycology, 52(7), 723-727 (2014-07-23)
In humans, Scopulariopsis is mainly associated with onychomycoses, rarely with cutaneous infections or with invasive mycoses. However, during the last two decades, deep infections caused by members of this genus have been increasing. Scopulariopsis brevicaulis is the most common species...
E Elias et al.
The British journal of surgery, 101(12), 1566-1575 (2014-09-12)
Roux-en-Y gastric bypass may lead to impaired calcium uptake. Therefore, operation-specific effects of gastric bypass and vertical banded gastroplasty on bone mineral density (BMD) were examined in a randomized clinical trial. Bone resorption markers and mechanisms of decreased calcium uptake...
Sheri L Peterson et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(10), 4332-4349 (2015-03-13)
Traumatic injury to CNS fiber tracts is accompanied by failure of severed axons to regenerate and results in lifelong functional deficits. The inflammatory response to CNS trauma is mediated by a diverse set of cells and proteins with varied, overlapping...
Stephanie M Marshall et al.
PloS one, 9(6), e98953-e98953 (2014-06-06)
The primary risk factor for atherosclerotic cardiovascular disease is LDL cholesterol, which can be reduced by increasing cholesterol excretion from the body. Fecal cholesterol excretion can be driven by a hepatobiliary as well as a non-biliary pathway known as transintestinal...
Shota Tanaka et al.
Biological & pharmaceutical bulletin, 38(9), 1272-1279 (2015-07-17)
The effects of decitabine (DAC), a DNA methyltransferase (DNMT) inhibitor, on metastasis and exosomal expression of microRNAs were examined in SW620/OxR cells, a human colorectal cancer (CRC) cell line (SW620) with acquired resistance to oxaliplatin. This cell line shows an...
Kathy C Nguyen et al.
Toxicological sciences : an official journal of the Society of Toxicology, 146(1), 31-42 (2015-03-27)
There are an increasing number of studies indicating that mitochondria are relevant targets in nanomaterial-induced toxicity. However, the underlying mechanisms by which nanoparticles (NPs) interact with these organelles and affect their functions are unknown. The aim of this study was...
Wylly Ramsés García-Niño et al.
Biological trace element research, 167(1), 130-145 (2015-03-17)
Hexavalent chromium [Cr(VI)] compounds are extremely toxic and carcinogenic. Despite the vast quantity of reports about Cr(VI) toxicity, the information regarding its effects when it is intraperitoneally (i.p.) administered is still limited. In contrast, it has been shown that curcumin...
Olfa Tabbene et al.
FEMS yeast research, 15(4), fov022-fov022 (2015-05-10)
In the present study, the synergism of the lipopeptide bacillomycin D in combination with the polyene amphotericin B against pathogenic Candida species is described along with their potential cytotoxicity against mammalian cells. Bacillomycin D inhibited the growth of various Candida...
Nikolas Stroth et al.
Bioorganic & medicinal chemistry, 23(15), 4824-4830 (2015-06-18)
G protein-coupled receptors (GPCRs) mediate biological signal transduction through complex molecular pathways. Therapeutic effects of GPCR-directed drugs are typically accompanied by unwanted side effects, owing in part to the parallel engagement of multiple signaling mechanisms. The discovery of drugs that...
Carmen C Leitch et al.
PloS one, 9(5), e98687-e98687 (2014-05-29)
Primary cilia regulate an expanding list of signaling pathways in many different cell types. It is likely that identification of the full catalog of pathways associated with cilia will be necessary to fully understand their role in regulation of signaling...
Sudhakar Raja Subramaniam et al.
Neurobiology of disease, 70, 204-213 (2014-07-13)
Parkinson's disease (PD) is characterized by the progressive degeneration of nigrostriatal dopaminergic neurons leading to motor deficits. The mechanisms underlying the preferential vulnerability of nigrostriatal dopaminergic neurons in PD remain poorly understood. Recent evidence supports a role for mitochondrial dysfunction...
B Pippi et al.
Journal of applied microbiology, 118(4), 839-850 (2015-01-08)
To evaluate the ability of Candida parapsilosis and Candida glabrata to develop phenotypic resistance to a benzophenone enriched fraction obtained from Brazilian red propolis (BZP-BRP) as compared to fluconazole (FLC). To investigate possible synergy between BZP-BRP and FLC and anidulafungin...
Samah Kalakh et al.
Neuropathology and applied neurobiology, 41(7), 964-982 (2015-03-20)
Experimental evidence has shown that the adrenal steroid hormone, androstenediol, dampens the symptoms of demyelination. However, the cellular and molecular effects of androstenediol are not yet known. In the present study, we investigated the cellular and subcellular effects of this...
Dean-Chuan Wang et al.
Neuroscience letters, 600, 232-237 (2015-06-28)
Lactational exposure to vanadium can reduce the locomotor activity in adult animals. In this study, we investigated whether lactational vanadium exposure impairs the motor coordination and whether exercise ameliorates this dysfunction. Sprague-Dawley dams were treated with or without vanadium during...
Maria Siopi et al.
The Journal of antimicrobial chemotherapy, 69(6), 1611-1619 (2014-02-20)
Although voriconazole reached the bedside 10 years ago and became the standard care in the treatment of invasive aspergillosis, reliable clinical breakpoints are still in high demand. Moreover, this has increased due to the recent emergence of azole resistance. Four...
Maria Teresa Montagna et al.
Journal of medical microbiology, 63(Pt 12), 1638-1643 (2014-09-12)
We determined the in vitro antifungal activity of liposomal amphotericin B (L-AmB) against 604 clinical yeast isolates. Amphotericin B deoxycholate (D-AmB) was tested in parallel against all the isolates. Susceptibility testing was performed according to the Clinical and Laboratory Standards...
Lydia K Nyasae et al.
Traffic (Copenhagen, Denmark), 15(12), 1344-1365 (2014-09-23)
Physiologic Cu levels regulate the intracellular location of the Cu ATPase ATP7B. Here, we determined the routes of Cu-directed trafficking of endogenous ATP7B in the polarized hepatic cell line WIF-B and in the liver in vivo. Copper (10 µm) caused ATP7B...
Hongying Sui et al.
Drug design, development and therapy, 9, 3183-3190 (2015-07-01)
Ovarian cancer is the leading cause of death in women with gynecological malignancy worldwide. Despite multiple new approaches to treatment, relapse remains almost inevitable in patients with advanced disease. The poor outcome of advanced ovarian cancer treated with conventional therapy...
Qian Zhang et al.
The Journal of experimental medicine, 211(13), 2549-2566 (2014-11-26)
DOCK8 mutations result in an inherited combined immunodeficiency characterized by increased susceptibility to skin and other infections. We show that when DOCK8-deficient T and NK cells migrate through confined spaces, they develop cell shape and nuclear deformation abnormalities that do...
Liam D Tryon et al.
American journal of physiology. Cell physiology, 309(4), C228-C238 (2015-06-13)
The purpose of this study was to determine how the expression of mitochondrial transcription factor A (Tfam), a protein that governs mitochondrial DNA (mtDNA) transcription and replication, is regulated during a state of reduced organelle content imposed by muscle disuse....
Min Quan et al.
Journal of cellular biochemistry, 116(8), 1574-1582 (2015-02-05)
NS5ATP9, a gene up-regulated by NS5A, plays a crucial oncogenic role in several types of human tumours. However, the underlying mechanisms remain unclear. Autophagy, an evolutionarily conserved catabolic process, maintains cellular homeostasis under stress conditions, such as starvation, and plays...
Nevin Çelebi et al.
Drug development and industrial pharmacy, 41(4), 631-639 (2014-03-01)
The purpose of this study was to prepare hydrogels and microemulsion (ME)-based gel formulations containing 1% terbinafine hydrochloride (TER-HCL) and to evaluate the use of these formulations for the antifungal treatment of fungal infections. Three different hydrogel formulations were prepared...
Jun Sasamori et al.
Biological & pharmaceutical bulletin, 38(12), 1946-1953 (2015-12-04)
This study investigated the effects of an adenosine receptor agonist, 2-octynyladenosine (YT-146), on mitochondrial function in ischemic and ischemic/reperfused hearts. Isolated rat hearts were perfused in the Langendorff manner with a constant flow rate, and exposed to 30 min of ischemia...
Vincenzo Carbone et al.
The Journal of biological chemistry, 290(35), 21690-21704 (2015-07-16)
One of the most critical events in the origins of cellular life was the development of lipid membranes. Archaea use isoprenoid chains linked via ether bonds to sn-glycerol 1-phosphate (G1P), whereas bacteria and eukaryotes use fatty acids attached via ester...
Nádia Pereira Gonçalves et al.
Journal of neuropathology and experimental neurology, 74(3), 203-217 (2015-02-11)
Familial amyloidotic polyneuropathy (FAP) is characterized by a length-dependent axonal loss in the peripheral nervous system that results from deposition of extracellular prefibrillar transthyretin (TTR) and amyloid fibrils. We have previously shown that an inflammatory stimulus in the peripheral nerve...
Na Young Yi et al.
Experimental lung research, 41(9), 499-513 (2015-10-27)
Previous studies have indicated that the sulfated polysaccharide heparin has anti-inflammatory effects. However, the mechanistic basis for these effects has not been fully elucidated. NCI-H292 (mucoepidermoid) and HBE-1 (normal) human bronchial epithelial cells were treated with LPS alone or in...
Marcin Okroj et al.
Cancer immunology, immunotherapy : CII, 64(4), 467-478 (2015-01-27)
Tumor cells often evade killing by the complement system by overexpressing membrane-bound complement inhibitors. However, production of soluble complement inhibitors in cells other than hepatocytes was rarely reported. We screened several breast cancer cell lines for expression of soluble complement...
F Romana Auciello et al.
FEBS letters, 588(18), 3361-3366 (2014-08-02)
AMPK is known to be activated by oxidative stress. Addition of glucose oxidase to cells generates H2O2 at a constant rate that is opposed by enzymic degradation, providing a good model for physiological oxidative stress. AMPK activation by glucose oxidase...
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