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Olga I Kahn et al.
Molecular biology of the cell, 26(1), 66-77 (2014-10-31)
Kinesin-5 is a slow homotetrameric motor protein best known for its essential role in the mitotic spindle, where it limits the rate at which faster motors can move microtubules. In neurons, experimental suppression of kinesin-5 causes the axon to grow
Jeffrey S Derrick et al.
Journal of the American Chemical Society, 137(46), 14785-14797 (2015-11-18)
Chemical reagents targeting and controlling amyloidogenic peptides have received much attention for helping identify their roles in the pathogenesis of protein-misfolding disorders. Herein, we report a novel strategy for redirecting amyloidogenic peptides into nontoxic, off-pathway aggregates, which utilizes redox properties
Yu Du et al.
ACS chemical neuroscience, 6(6), 871-878 (2015-04-17)
Ion channels are critical for life, and they are targets of numerous drugs. The sequencing of the human genome has revealed the existence of hundreds of different ion channel subunits capable of forming thousands of ion channels. In the face
Ying-hui Chen et al.
Chinese journal of integrative medicine, 20(8), 624-632 (2013-04-02)
To evaluate apoptotic effects of cisplatin and cordycepin as single agent or in combination with cytotoxicity in oral cancer cells. The influences of cisplatin (2.5 μg/mL) and/or cordycepin treatment (10 or 100 μmol/L) to human OC3 oral cancer cell line
James T Earnest et al.
Journal of virology, 89(11), 6093-6104 (2015-04-03)
Coronaviruses (CoVs) and low-pathogenicity influenza A viruses (LP IAVs) depend on target cell proteases to cleave their viral glycoproteins and prime them for virus-cell membrane fusion. Several proteases cluster into tetraspanin-enriched microdomains (TEMs), suggesting that TEMs are preferred virus entry
Luce Farine et al.
Scientific reports, 5, 16787-16787 (2015-11-19)
Phosphatidylethanolamine (PE) and phosphatidylcholine (PC) are among the most abundant phospholipids in biological membranes. In many eukaryotes, the CDP-ethanolamine and CDP-choline branches of the Kennedy pathway represent major and often essential routes for the production of PE and PC, with
J A Tree et al.
Journal of virology, 89(8), 4335-4344 (2015-02-06)
To evaluate new vaccines when human efficacy studies are not possible, the FDA's "Animal Rule" requires well-characterized models of infection. Thus, in the present study, the early pathogenic events of monkeypox infection in nonhuman primates, a surrogate for variola virus
B Müller-Edenborn et al.
British journal of anaesthesia, 114(1), 143-149 (2014-07-06)
Growing evidence suggests a protective effect of volatile anaesthetics in ischaemia-reperfusion (I/R)-injury, and the accumulation of neutrophils is a crucial event. Pro-inflammatory cytokines carrying the C-X-C-motif including interleukin-8 (IL-8) and CXC-ligand 1 (CXCL1) activate CXC receptor-1 (CXCR1; stimulated by IL-8)
Karan M Shah et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(1), 114-121 (2014-09-25)
Cobalt and chromium species are released in the local tissues as a result of tribo-corrosion, and affect bone cell survival and function. However we have little understanding of the mechanisms of cellular entry, intracellular distribution, and speciation of the metals
María I Tracanna et al.
Phytotherapy research : PTR, 29(3), 393-397 (2014-11-25)
A new phenolic derivative, 2,8-dihydroxy-7H-furo[2,3-f]chromen-7-one (1), together with isoquercitrin (2), was isolated from the aerial parts of Tibouchina paratropica. Compound structures were elucidated by spectroscopic methods. Both compounds show antimicrobial activity towards a panel of bacterial and fungal pathogens, and
Gamma Chi et al.
European biophysics journal : EBJ, 44(7), 589-598 (2015-08-04)
The mechanosensitive channel of large conductance MscL is a well-characterized mechanically gated non-selective ion channel, which often serves as a prototype mechanosensitive channel for mechanotransduction studies. However, there are some discrepancies between MscL constructs used in these studies, most notably
Y Mei et al.
Oncogene, 33(29), 3839-3850 (2013-08-27)
Podoplanin is highly expressed in human cancers. However, mechanisms regulating podoplanin expression remain elusive. Here we show that podoplanin promotes tumorigenesis of oral squamous cell carcinoma (OSCC) and precancerous cells both in vitro and in vivo, and the ErbB3-binding protein-1
Jon M Resch et al.
Synapse (New York, N.Y.), 0 (2014-07-30)
In the central nervous system, cystine import in exchange for glutamate through system x
Yijie Zhang et al.
Cardiovascular diabetology, 14, 69-69 (2015-06-04)
Fatty acid (FA) catabolism abnormality has been proved to play an important role in obesity-related cardiomyopathy. We hypothesized that cardiospecific suppression of CD36, the predominant membrane FA transporter, would protect against obesity-related cardiomyopathy. Four-wk-old male C57BL/6 J mice were fed
Thabe M Matsebatlela et al.
Chemico-biological interactions, 233, 95-105 (2015-04-07)
Didox (3,4-dihydroxy-benzohydroxamic acid), is a synthetic ribonucleotide reductase (RR) inhibitor derived from polyhydroxy-substituted benzohydroxamic acid, and originally developed as an anti-cancer agent. Some studies indicate that didox may have anti-oxidative stress-like properties, while other studies hint that didox may have
S Pandolfi et al.
Cell death and differentiation, 22(12), 2006-2019 (2015-05-30)
HEDGEHOG (HH) signaling is a key regulator of tissue development and its aberrant activation is involved in several cancer types, including melanoma. We and others have shown a reciprocal cross talk between HH signaling and p53, whose function is often
Daniel M Dupont et al.
PloS one, 10(3), e0119207-e0119207 (2015-03-21)
Nucleic acid aptamer selection is a powerful strategy for the development of regulatory agents for molecular intervention. Accordingly, aptamers have proven their diligence in the intervention with serine protease activities, which play important roles in physiology and pathophysiology. Nonetheless, there
Helioswilton Sales-Campos et al.
International immunopharmacology, 26(1), 13-22 (2015-03-17)
Current therapies for inflammatory bowel disease (IBD) are not totally effective, resulting in persistent and recurrent disease for many patients. Mosquito saliva contains immunomodulatory molecules and therein could represent a novel therapy for IBD. Here, we demonstrated the therapeutic activity
Virginie Vives et al.
Nature communications, 6, 6218-6218 (2015-02-04)
Osteoporosis is caused by excessive activity of bone-degrading osteoclasts over bone-forming osteoblast. Standard antiosteolytic treatments inhibit bone resorption by inducing osteoclast loss, with the adverse effect of hindering also bone formation. Formation of the osteoclast sealing zone requires Dock5, a
Claire D Bourke et al.
International journal for parasitology, 45(4), 215-224 (2015-01-13)
Keratinocytes constitute the majority of cells in the skin's epidermis, the first line of defence against percutaneous pathogens. Schistosome larvae (cercariae) actively penetrate the epidermis to establish infection, however the response of keratinocytes to invading cercariae has not been investigated.
Fernando P Conte et al.
Molecules (Basel, Switzerland), 20(2), 2636-2657 (2015-02-06)
Gedunin, a natural limonoid from Meliaceae species, has been previously described as an antiinflammatory compound in experimental models of allergic inflammation. Here, we report the antiinflammatory and antinociceptive effects of gedunin in an acute model of articular inflammation induced by
Jenny M Tam et al.
The Journal of infectious diseases, 210(11), 1844-1854 (2014-05-21)
Autophagy has been postulated to play role in mammalian host defense against fungal pathogens, although the molecular details remain unclear. Here, we show that primary macrophages deficient in the autophagic factor LC3 demonstrate diminished fungicidal activity but increased cytokine production
Mayuki Watanabe et al.
Journal of immunology (Baltimore, Md. : 1950), 193(11), 5660-5667 (2014-10-24)
Neutrophils are highly motile leukocytes that play important roles in the innate immune response to invading pathogens. Neutrophils rapidly migrate to the site of infections and kill pathogens by producing reactive oxygen species (ROS). Neutrophil chemotaxis and ROS production require
Katherine C Upchurch et al.
Immunology letters, 168(1), 89-97 (2015-09-19)
Toll-like receptor 7 (TLR7) agonists are of interest as vaccine adjuvants and cancer therapeutics. Therefore, development of new TLR7 agonists that can efficiently promote host immune responses without evoking side effects is of great importance. Here, we describe two new
Neil L Berinstein et al.
Oncoimmunology, 4(8), e1026529-e1026529 (2015-09-26)
DepoVax™ is an innovative and strongly immunogenic vaccine platform. Survivin is highly expressed in many tumor types and has reported prognostic value. To generate tumor-specific immune response, a novel cancer vaccine was formulated in DepoVax platform (DPX-Survivac) using survivin HLA
Masayuki Tsuneki et al.
Laboratory investigation; a journal of technical methods and pathology, 95(7), 765-780 (2015-05-12)
Microvascular endothelial cells cultured in three-dimensional hydrogel scaffolds form a network of microvessel structures when implanted subcutaneously in mice, inosculate with host vessels, and over time remodel into large ectatic vascular structures resembling hemangiomas. When compared with infantile hemangiomas, similarities
Samantha L Cavolo et al.
Molecular biology of the cell, 26(14), 2664-2672 (2015-05-30)
Axonal transport is critical for maintaining synaptic transmission. Of interest, anterograde and retrograde axonal transport appear to be interdependent, as perturbing one directional motor often impairs movement in the opposite direction. Here live imaging of Drosophila and hippocampal neuron dense-core
Grace Min Yi Tan et al.
Scientific reports, 5, 11046-11046 (2015-06-17)
Helicobacter pylori at multiplicity of infection (MOI ≥ 50) have been shown to cause apoptosis in RAW264.7 monocytic macrophage cells. Because chronic gastric infection by H. pylori results in the persistence of macrophages in the host's gut, it is likely
Jaroslav Lazar et al.
Macromolecular rapid communications, 36(16), 1472-1478 (2015-06-23)
Electrochemical impedance spectroscopy (EIS) is applied for investigating binding of lectins to multivalent glycopolymer brushes grafted from interdigital gold microelectrodes. By variation of the measuring frequency, EIS allows simultaneous analysis of binding at different subnanometer distances from the sensor surfaces.
Yair Botbol et al.
Autophagy, 11(10), 1864-1877 (2015-09-24)
Macroautophagy is a cellular process that mediates degradation in the lysosome of cytoplasmic components including proteins and organelles. Previous studies have shown that macroautophagy is induced in activated T cells to regulate organelle homeostasis and the cell's energy metabolism. However
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