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Julia C Frei et al.
Virology, 485, 371-382 (2015-09-05)
Here we investigated the binding of Dengue virus envelope glycoprotein domain III (DIII) by two broadly neutralizing antibodies (bNAbs), 4E11 and 4E5A. There are four serotypes of Dengue virus (DENV-1 to -4), whose DIII sequences vary by up to 49%.
Shang-Xiong Huang-Fu et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(27), 9809-9815 (2015-05-20)
A novel type of supertetrahedral connectivity is exhibited by the 72-atom discrete supercubooctahedron in (Cs6Cl)2Cs5[Ga15Ge9Se48] (1), which undergoes both cation and anion exchange, as revealed by unambiguous single-crystal X-ray diffraction data. Electronic-structure studies helped to understand the Ge/Ga distribution.
Pierre-André Billat et al.
Analytical and bioanalytical chemistry, 407(12), 3449-3456 (2015-02-24)
Ganciclovir (GCV) is prescribed for cytomegalovirus infection which is a major issue in immunodepressed patients. It is however characterized by hematological toxicity. A better understanding of GCV concentration-effects relationships implies the measurement of intracellular forms. The objective of this study
D Joon et al.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 19(8), 986-991 (2015-07-15)
The main challenge in combatting extra-pulmonary tuberculosis (EPTB) is the lack of a rapid, reliable and inexpensive diagnostic test for the detection of Mycobacterium tuberculosis. To evaluate the diagnostic potential of an L-serine dehydratase gene (sdaA) loop-mediated isothermal amplification (LAMP)
Xiaoning Li et al.
Bioconjugate chemistry, 26(3), 520-528 (2015-02-26)
Subcutaneous delivery is one of the preferred administration routes for therapeutic monoclonal antibodies (mAbs). High antibody dosing requirements and small injection volumes necessitate formulation and delivery of highly concentrated mAb solutions. Such elevated antibody concentrations can lead to undesirable solution
Pelin Onsekizoglu Bagci et al.
Journal of food science, 80(9), N2071-N2078 (2015-08-05)
Gold nanoparticles (AuNPs) were synthesized at room temperature following a simple, rapid, and green route using fresh-squeezed apple juice as a reducing reagent. The optimal AuNPs, based on the particle color, stability, and color change suitable for colorimetric detection of
Gerson F Duarte Junior et al.
Electrophoresis, 36(16), 1935-1940 (2015-03-27)
This paper describes the use of ionic solutions as sensing electrodes for capacitively coupled contactless conductivity detection on electrophoresis microchips. Initially, two channels were engraved in a PMMA holder by using a CO2 laser system and sealed with a thin
Algis Grybauskas et al.
Molecular vision, 21, 201-212 (2015-03-25)
The aqueous humor nourishes the avascular tissues of the anterior segment, and the trabecular meshwork (TM) plays a role in the efflux of endogenous substances and xenobiotics from the aqueous humor. ATP (ATP)-binding cassette (ABC) transporter superfamily members respond to
Common sense medicine and cerebrospinal lavage.
B C Tsui
Anaesthesia, 69(8), 936-937 (2014-07-22)
Leilei Wang et al.
Developmental and comparative immunology, 52(2), 202-214 (2015-06-07)
The C1q domain containing (C1qDC) proteins are a family of proteins possessing globular C1q (gC1q) domains, and they rely on this domain to recognize various ligands such as PAMPs, immunoglobulins, ligands on apoptotic cell. In the present study, a novel
Alec N Salt et al.
The Journal of the Acoustical Society of America, 133(3), 1561-1571 (2013-03-08)
Responses of the ear to low-frequency and infrasonic sounds have not been extensively studied. Understanding how the ear responds to low frequencies is increasingly important as environmental infrasounds are becoming more pervasive from sources such as wind turbines. This study
R Freiry et al.
Bulletin of environmental contamination and toxicology, 93(4), 442-445 (2014-08-30)
The sensitivity of Danio rerio to three chemicals was compared at two growth stages [larval (10 ± 2 after hatching) and post-larval (60 ± 4 days after hatching)] based on acute toxicity tests. Thirty-nine 48 h acute toxicity tests were
D Draganescu et al.
International journal of biological macromolecules, 72, 614-623 (2014-09-23)
Flaxseed lignans are a natural source of useful biologically active components that show a diverse spectrum of health-promoting properties. The valuable effects of the phenolic molecules are mainly due to their antioxidant activity by preventing oxidative stress and stimulate collagen
Qamar Zia et al.
International journal of nanomedicine, 10, 1769-1790 (2015-03-19)
In the present study, we developed a self-assembled biodegradable polyglutamic acid (PGA)-based formulation of amphotericin B (AmB) and evaluated its in vitro antifungal potential against Candida albicans. The AmB-loaded PGA nanoparticles were prepared in-house and had a mean size dimension
Glen S Patten et al.
Digestive diseases and sciences, 60(6), 1624-1632 (2015-01-27)
Dietary fiber shortens gut transit time, but data on the effects of fiber components (including resistant starch, RS) on intestinal contractility are limited. We have examined RS effects in male Sprague-Dawley rats fed either a high-amylose maize starch (HAMS) or
Franziska Mohr et al.
PloS one, 10(10), e0141136-e0141136 (2015-10-28)
The muscarinic M2 receptor (M2R) acts as a negative feedback regulator in central cholinergic systems. Activation of the M2 receptor limits acetylcholine (ACh) release, especially when ACh levels are increased because acetylcholinesterase (AChE) activity is acutely inhibited. Chronically high ACh
Izabela Tuleta et al.
Atherosclerosis, 236(2), 400-410 (2014-08-26)
Obstructive sleep apnoea (OSA) has been implicated as a risk factor for atherosclerosis. The aim of our study was to examine the effects of chronic intermittent hypoxia in apoE-/- mice serving as model of OSA on endothelial dysfunction and oxidative
Taylor B Groom et al.
Molecules (Basel, Switzerland), 24(22) (2019-11-14)
A significant drawback to ammonia borane as a hydrogen storage material is the production of ammonia gas during hydrolysis. As a possible solution, maleic acid is shown to be capable of fully promoting hydrolysis of ammonia borane while also preventing
Chunfeng Wang et al.
Pharmaceutical biology, 53(3), 451-456 (2014-12-05)
Given that Pinus massoniana Lamb (Pinaceae) bark extract (PMBE) is a safe and non-toxic flavonoid found abundantly in nature, it was considered a promising novel candidate agent in the treatment of virus infection. Experiments were conducted to assay the antiviral
Bita Bayatsarmadi et al.
Chemistry, an Asian journal, 10(7), 1546-1553 (2015-04-22)
The development of ordered mesoporous carbon materials with controllable structures and improved physicochemical properties by doping heteroatoms such as nitrogen into the carbon framework has attracted a lot of attention, especially in relation to energy storage and conversion. Herein, a
Hou-Yu Wang et al.
Analytica chimica acta, 774, 92-99 (2013-04-10)
A visual electrophoretic titration method was firstly developed from the concept of moving reaction boundary (MRB) for protein content analysis. In the developed method, when the voltage was applied, the hydroxide ions in the cathodic vessel moved towards the anode
Jérémy Carlier et al.
Journal of analytical toxicology, 38(9), 619-627 (2014-07-06)
Atractyloside (ATR) and carboxyatractyloside (CATR) are diterpene glycosides that are responsible for the toxicity of several Asteraceae plants around the world. Mediterranean gum thistle (Atractylis gummifera L.) and Zulu impila (Callilepis laureola DC.), in particular, are notoriously poisonous and the
Landi Cheng et al.
Current drug delivery, 12(3), 351-357 (2015-06-10)
The objective of this research project was to develop a nanoparticle drug delivery system using the biopolymer chitosan as the base component. The nanoparticles were produced through ionotropic gelation by flush mixing chitosan with counterions carrageenan and alginate. The nanoparticles
Gregory Saia et al.
Journal of neurochemistry, 129(4), 743-752 (2014-01-31)
The regulation of transcription factor function in response to neuronal activity is important for development and function of the nervous system. The transcription factor Sp4 regulates the developmental patterning of dendrites, contributes to complex processes including learning and memory, and
Wei Liu et al.
Scientific reports, 5, 12723-12723 (2015-07-30)
In this study, we report a novel isothermal nucleic acid amplification method only requires one pair of primers and one enzyme, termed Polymerase Spiral Reaction (PSR) with high specificity, efficiency, and rapidity under isothermal condition. The recombinant plasmid of blaNDM-1
Jingyi Chen et al.
The Analyst, 140(16), 5578-5584 (2015-06-27)
A novel glucose biosensor was developed by immobilizing glucose oxidase (GOD) on a three-dimensional (3D) porous kenaf stem-derived carbon (3D-KSC) which was firstly proposed as a novel supporting material to load biomolecules for electrochemical biosensing. Here, an integrated 3D-KSC electrode
Zohra Madani et al.
Molecular medicine reports, 12(5), 7017-7026 (2015-09-24)
The current study investigated whether sardine protein mitigates the adverse effects of fructose on plasma glucagon‑like peptide-1 (GLP-1) and oxidative stress in rats. Rats were fed casein (C) or sardine protein (S) with or without high‑fructose (HF) for 2 months.
Douglas Roberto Monteiro et al.
Medical mycology, 52(6), 627-635 (2014-06-22)
Our aim in this study was to evaluate how the chemical stability of silver nanoparticles (SNs) influences their efficacy against Candida albicans and C. glabrata biofilms. Several parameters of SN stability were tested, namely, temperature (50ºC, 70ºC, and 100ºC), pH
Tristan H Coady et al.
Genes & development, 29(16), 1696-1706 (2015-08-08)
Amyotrophic lateral sclerosis (ALS) is caused by mutations in a number of genes, including the gene encoding the RNA/DNA-binding protein translocated in liposarcoma or fused in sarcoma (TLS/FUS or FUS). Previously, we identified a number of FUS target genes, among
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