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Susanne Vetterkind et al.
Journal of cellular and molecular medicine, 13(5), 887-895 (2008-05-29)
Par-4 (prostate apoptosis response 4) is a pro-apoptotic protein and tumour suppressor that was originally identified as a gene product up-regulated during apoptosis in prostate cancer cells. Here, we show, for the first time, that Par-4 is expressed and co-localizes
Andreas H Laustsen et al.
Nature communications, 9(1), 3928-3928 (2018-10-04)
The black mamba (Dendroaspis polylepis) is one of the most feared snake species of the African savanna. It has a potent, fast-acting neurotoxic venom comprised of dendrotoxins and α-neurotoxins associated with high fatality in untreated victims. Current antivenoms are both
Aihua Tang et al.
Investigative ophthalmology & visual science, 50(8), 3794-3801 (2009-03-04)
To analyze PASP in terms of its gene distribution and expression, its corneal pathologic effects, its enzymatic properties, and the protectiveness of the immune response to this protease. Twenty-five strains of P. aeruginosa were analyzed for the PASP gene and
Falsely elevated thyroid-stimulating hormone (TSH) level due to macro-TSH
Sakai, H., et al.
Endocrine J., 56, 435-440 (2009)
Rebecca A Alyea et al.
BMC neuroscience, 10, 59-59 (2009-06-18)
Neurological diseases and neuropsychiatric disorders that vary depending on female life stages suggest that sex hormones may influence the function of neurotransmitter regulatory machinery such as the dopamine transporter (DAT). In this study we tested the rapid nongenomic effects of
Joel B Miesfeld et al.
Scientific reports, 8(1), 10195-10195 (2018-07-07)
In vertebrate retinal progenitor cells, the proneural factor Atoh7 exhibits a dynamic tissue and cellular expression pattern. Although the resulting Atoh7 retinal lineage contains all seven major cell types, only retinal ganglion cells require Atoh7 for proper differentiation. Such specificity
Steffen Krauss et al.
Journal of virology, 83(24), 12854-12870 (2009-10-09)
Our previous work has shown that efficient evasion from type I interferon responses by human cytomegalovirus (hCMV) requires expression of the 72-kDa immediate-early 1 (IE1) protein. It has been suggested that IE1 inhibits interferon signaling through intranuclear sequestration of the
Michael J Law et al.
G3 (Bethesda, Md.), 7(3), 1001-1010 (2017-02-02)
In the budding yeast
Fang Liu et al.
Neoplasia (New York, N.Y.), 10(11), 1275-1284 (2008-10-28)
Accumulating evidence suggests that multiple complex mechanisms may be involved, simultaneously or complementarily, in the emergence and development of multidrug resistance (MDR) in various cancers. Cell adhesion-mediated MDR is one such mechanism. In the present study, we initially observed increased
John Collins et al.
Liver, 22(6), 501-506 (2002-11-26)
Persistent elevation of aspartate aminotransferase (AST) activity in serum due to the presence of a macroenzyme form of AST (macro-AST) may lead to diagnostic confusion in many clinical conditions, particularly those associated with chronic liver disease. We describe a case
André-Patrick Arrigo
Methods in molecular biology (Clifton, N.J.), 787, 105-119 (2011-09-08)
Human HspB1 (also denoted Hsp27) is a well-known member, together with alphaB-crystallin, of the small heat-shock (or stress) proteins (sHsps) (20-40 kDa). In this chapter, I describe procedures for testing the oligomeric and phosphorylation patterns of HspB1 as well as
Barbara Weicht et al.
Journal of cellular biochemistry, 102(5), 1300-1307 (2007-10-25)
Platelets induce osteoclastogenesis in total bone marrow cultures where hematopoietic cells can interact with stromal cells. Whether or not activated platelets directly act on hematopoietic cells to promote their differentiation into osteoclasts remains unknown. Here we report that platelet releasates
Sai Kiran Sharma et al.
EJNMMI research, 4(1), 60-60 (2015-06-28)
Epithelial ovarian cancer (EOC) is characterized by the overexpression of cancer antigen 125 (CA125), a mucinous glycoprotein that serves as a tumor biomarker. Early diagnosis of EOC is plagued by its asymptomatic nature of progression and the limitations of currently
María Pía Negroni et al.
Journal of clinical immunology, 30(3), 474-484 (2010-02-17)
Muscarinic acetylcholine receptors (mAChR) belong to the G-protein-coupled receptor family and are extensively expressed in most cells in mammals. We had reported the expression of mAChR in murine and human breast tumors. The presence of antibodies in the sera of
J W Priest et al.
Molecular and biochemical parasitology, 113(1), 117-126 (2001-03-20)
Cryptosporidium parvum is a protozoan parasite of the intestinal epithelium that has caused numerous outbreaks of diarrheal illness in humans. During our studies of the host immune response to C. parvum infection, we noted that two of the immunodominant surface
Hiroshi Hirai et al.
Investigational new drugs, 29(4), 534-543 (2010-01-20)
Deregulation of cell-cycle control is a hallmark of cancer. Thus, cyclin-dependent kinases (Cdks) are an attractive target for the development of anti-cancer drugs. Here, we report the biological characterization of a highly potent pan-Cdk inhibitor with a macrocycle-quinoxalinone structure. Compound
Michelle E LeBlanc et al.
The Journal of experimental medicine, 214(4), 1029-1047 (2017-03-24)
Diabetic retinopathy (DR) is a leading cause of vision loss with retinal vascular leakage and/or neovascularization. Current antiangiogenic therapy against vascular endothelial growth factor (VEGF) has limited efficacy. In this study, we applied a new technology of comparative ligandomics to
Young-Ho Lee et al.
Molecular and cellular biology, 22(11), 3621-3632 (2002-05-09)
Hormone-activated nuclear receptors (NR) bind to specific regulatory DNA elements associated with their target genes and recruit coactivator proteins to remodel chromatin structure, recruit RNA polymerase, and activate transcription. The p160 coactivators (e.g., SRC-1, GRIP1, and ACTR) bind directly to
Yucheng Xu et al.
The Journal of biological chemistry, 281(23), 16090-16098 (2006-04-06)
Amelogenin is the major protein component of the forming enamel matrix. In situ hybridization revealed a periodicity for amelogenin mRNA hybridization signals ranging from low to high transcript abundance on serial sections of developing mouse teeth. This in vivo observation
Boaz O Owuor et al.
Journal of immunological methods, 352(1-2), 192-194 (2009-11-07)
Attempts have been made at finding ways of cleaning used protein G agarose to revive their efficiency and make them reusable for purifying immunoglobulin G (IgG) in affinity column chromatography. A successful cleaning procedure that involved the use of 4-mol/L
C Wang et al.
Blood, 85(9), 2570-2578 (1995-05-01)
The activity of hemolytically inactive C5b67, designated iC5b67, was evaluated as an agonist for functional responses of human polymorphonuclear leukocytes (PMN). C5b67 was formed from purified human complement components and decayed in phosphate-buffered saline (PBS) until it had no lytic
Carl F Fortin et al.
International immunology, 22(8), 637-649 (2010-05-27)
Polymorphonuclear neutrophils (PMNs) are the first line of defense against invading organisms in humans; in addition, PMNs contribute to the linking of innate and adaptive immunity. To fulfill their biological behavior, PMNs utilize an arsenal of proteolytic enzymes, including members
Lylla Ngo et al.
Acta histochemica, 105(1), 21-28 (2003-04-02)
This study describes a novel rapid histochemical method to survey surface properties of sperm in a model system, the sea urchin. Surface properties of live and fixed sea urchin sperm of 2 species (Strongylocentrotus purpuratus and Lytechinus pictus) in seawater
Human Embryonic Stem Cells Suffer from Centrosomal Amplification.
Holubcova, Z., et al.
Stem Cells, 29, 49-56 (2011)
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