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Hye-Youn Cho et al.
Antioxidants & redox signaling, 22(4), 325-338 (2014-10-01)
Nrf2 is a master transcription factor for antioxidant response element (ARE)-mediated cytoprotective gene induction. A protective role for pulmonary Nrf2 was determined in model oxidative disorders, including hyperoxia-induced acute lung injury (ALI). To obtain additional insights into the function and
Pei-Wen Hsieh et al.
European journal of medicinal chemistry, 45(7), 3111-3115 (2010-04-27)
A new series of benzoxazinone analogs were designed, synthesized, and assayed to determine their effects on superoxide anion generation and neutrophil elastase (NE) release in formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP)-activated human neutrophils. Of these, compounds 6-10 showed a potent dual inhibitory effect on
Shenshen Zhu et al.
Pharmacology, 95(5-6), 258-263 (2015-05-23)
This study was conducted to explore the effect of zerumbone, isolated from Zingiberzerumbet Smith, on apolipoprotein A-I (apoA-I)-mediated cholesterol efflux from THP-1 macrophages. THP-1 macrophages were treated with different concentrations (10-100 μmol/l) of zerumbone and cholesterol efflux was measured. The
Jhi Biau Foo et al.
Journal of ethnopharmacology, 166, 270-278 (2015-03-24)
Dillenia suffruticosa (Family: Dilleniaceae) or commonly known as "Simpoh air" in Malaysia, is traditionally used for treatment of cancerous growth including breast cancer. D. suffruticosa root dichloromethane extract (DCM-DS) has been reported to induce G0/G1 phase cell cycle arrest and
Radoslaw Kwapiszewski et al.
Analytica chimica acta, 853, 702-709 (2014-12-04)
Lysosomal storage diseases are chronic, progressive and typically have a devastating impact on the patient and the family. The diagnosis of these diseases is still a challenge, however, even for trained specialists. Accurate diagnostic methods and high-throughput tools that could
Beynon, R.J. and Bond, J.S., ed.
Proteolytic Enzymes: A Practical Approach, 246-246 (1989)
Liang-Feng Liu et al.
Scientific reports, 5, 16862-16862 (2015-11-19)
Tianma Gouteng Yin (TGY) is a traditional Chinese medicine (TCM) decoction widely used to treat symptoms associated with typical Parkinson's disease (PD). In this study, the neuroprotective effects of water extract of TGY were tested on rotenone-intoxicated and human α-synuclein
Sonam Gupta et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 778, 22-36 (2015-03-03)
The present study was conducted to investigate the effect of the neurotoxins 6-hydroxydopamine and lipopolysaccharide on astrocytes. Rat astrocyte C6 cells were treated with different concentration of 6-hydroxydopamine (6-OHDA)/lipopolysaccharides (LPS) for 24 h. Both neurotoxins significantly decreased the viability of
Dong Fang et al.
Pain, 156(6), 1124-1144 (2015-03-17)
Primary and metastatic cancers that affect bone are frequently associated with severe and intractable pain. The mechanisms underlying the pathogenesis of bone cancer pain still remain largely unknown. Previously, we have reported that sensitization of primary sensory dorsal root ganglion
Kylie A MacGregor et al.
European journal of medicinal chemistry, 85, 191-206 (2014-08-02)
Virtual screening of the ChemDiversity and ChemBridge compound databases against dynamin I (dynI) GTPase activity identified 2,5-bis-(benzylamino)-1,4-benzoquinone 1 as a 273 ± 106 μM inhibitor. In silico lead optimization and focused library-led synthesis resulted in the development of four discrete benzoquinone/naphthoquinone based compound
Zongjian Zhu et al.
Cancer prevention research (Philadelphia, Pa.), 8(6), 518-527 (2015-03-26)
Metformin is a widely prescribed drug for the treatment of type II diabetes. Although epidemiologic data have provided a strong rationale for investigating the potential of this biguanide for use in cancer prevention and control, uncertainty exists whether metformin should
Lin Li et al.
Neural regeneration research, 10(10), 1617-1621 (2015-12-23)
Geniposide, a monomer extracted from gardenia and widely used in Chinese medicine, is a novel agonist at the glucagon-like peptide-1 receptor. This receptor is involved in neuroprotection. In the present study, we sought to identify an anti-apoptotic mechanism for the
Agnieszka Chabowska-Kita et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(8), 3238-3252 (2015-04-22)
The brown adipocyte phenotype (BAP) in white adipose tissue (WAT) is transiently induced in adult mammals in response to reduced ambient temperature. Since it is unknown whether a cold challenge can permanently induce brown adipocytes (BAs), we reared C57BL/6J (B6)
Francesca De Amicis et al.
Molecular cancer, 14, 130-130 (2015-07-08)
Bergapten (5-methoxypsoralen), a natural psoralen derivative present in many fruits and vegetables, has shown antitumoral effects in a variety of cell types. In this study, it has been addressed how Bergapten in breast cancer cells induces autophagic process. In MCF7
Vinicius N Motta et al.
Journal of immunology (Baltimore, Md. : 1950), 194(12), 5663-5673 (2015-05-13)
Type 1 diabetes in the NOD mouse model has been linked to >30 insulin-dependent diabetes (Idd) susceptibility loci. Idd4 on chromosome 11 consists of two subloci, Idd4.1 and Idd4.2. Using congenic analysis of alleles in NOD and NOD-resistant (NOR) mice
Wei-Dong Xu et al.
Journal of proteomics, 113, 57-72 (2014-10-05)
The present study first utilized a standardized shotgun proteomic analysis method to determine differences in protein expression of fibroblasts in the ligament between AS patients and healthy controls. Proteins extracted from primarily cultured FLLs from 35 AS patients and 10
Likui Wang et al.
Cellular immunology, 297(1), 10-18 (2015-06-11)
MAGEA10, a cancer/testis antigens expressed in tumors but not in normal tissues with the exception of testis and placenta, represents an attractive target for cancer immunotherapy. However, suppressive cytoenvironment and requirement of specific HLA-alleles presentation frequently led to immunotherapy failure.
Piia Takabe et al.
Experimental cell research, 337(1), 1-15 (2015-07-30)
Malignant skin melanoma is one of the most deadly human cancers. Extracellular matrix (ECM) influences the growth of malignant tumors by modulating tumor cells adhesion and migration. Hyaluronan is an essential component of the ECM, and its amount is altered
Yaun-Chao Huang et al.
Journal of natural products, 72(7), 1273-1278 (2009-07-09)
Eight new prenylated flavonoids, ugonins M-T (1-8), together with five known compounds, ugonins J-L (9-11), 5,4'-dihydroxy-4'',4''-dimethyl-5''-methyl-5''H-dihydrofurano[2'',3'':6,7]flavanone, and quercetin, were isolated and purified from the rhizomes of Helminthostachys zeylanica. The structures of the new isolates were elucidated by spectroscopic and chemical
Johannes Zander et al.
Infection and immunity, 76(4), 1333-1339 (2007-12-28)
Thymidine-dependent small-colony variants (SCVs) of Staphylococcus aureus are frequently associated with persistent and recurrent infections in cystic fibrosis patients. The phenotypic appearance of S. aureus SCVs or normal-colony variants (NCVs) is postulated to be affected by the intracellular amount of
N Punwani et al.
The British journal of dermatology, 173(4), 989-997 (2015-07-01)
INCB018424 is a novel, potent Janus kinase (JAK)1/JAK2 inhibitor that blocks signal transduction of multiple proinflammatory cytokines. To evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary efficacy of topical INCB018424 phosphate cream in patients with plaque psoriasis. Topical INCB018424 phosphate
Longfei Yang et al.
Neurochemical research, 40(9), 1966-1975 (2015-08-19)
CUG-binding protein 1, a member of the CELF (CUGBP and embryonic lethal abnormal vision-like factor) family of RNA-binding proteins, is shown to be multifunctional, regulating many posttranscriptional processes including alternative splicing, deadenylation, mRNA decay, and translation. Recently, CUGBP1 is found
Qing Xie et al.
Biomaterials, 66, 67-82 (2015-07-22)
Mesenchymal stem cells (MSCs) have been extensively applied in the field of tissue regeneration. MSCs derived from various tissues exhibit different characteristics. In this study, a cluster of cells were isolated from human ethmoid sinus mucosa membrane and termed as
Hefeng Zhou et al.
Aging and disease, 11(3), 559-574 (2020-06-04)
Parkinson's disease (PD), the second most common neurodegenerative disorder, is neuropathologically characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) and the presence of Lewy bodies in surviving neurons. α-synuclein (α-syn) is the major component
Tin Ngo et al.
BMC cell biology, 15, 30-30 (2014-07-24)
MXD3 is a basic-helix-loop-helix-leucine-zipper transcription factor involved in cellular proliferation. In previous studies we demonstrated that knock-down of MXD3 in the human medulloblastoma cell line DAOY resulted in decreased proliferation. Surprisingly, overexpression of MXD3 in DAOY cells also decreased proliferation
Prathab Balaji Saravanan et al.
Life sciences, 130, 88-96 (2015-03-31)
The aim of this study was to find the protective role of Telmisartan (TS) in LPS intoxicated neuronal cells and elucidate the possible neuroprotective mechanism of action. TLR4 and AT1R specific primers were designed and used in rtPCR to confirm
Marta Gritti et al.
Oncotarget, 5(22), 11252-11268 (2014-11-02)
Epidemiological and preclinical studies propose that metformin, a first-line drug for type-2 diabetes, exerts direct antitumor activity. Although several clinical trials are ongoing, the molecular mechanisms of this effect are unknown. Here we show that chloride intracellular channel-1 (CLIC1) is
Brandon J Kim et al.
The Journal of clinical investigation, 125(6), 2473-2483 (2015-05-12)
Bacterial meningitis is a serious infection of the CNS that results when blood-borne bacteria are able to cross the blood-brain barrier (BBB). Group B Streptococcus (GBS) is the leading cause of neonatal meningitis; however, the molecular mechanisms that regulate bacterial
Kenichi Kitanishi et al.
The Journal of biological chemistry, 290(33), 20466-20476 (2015-07-03)
Adenosylcobalamin-dependent isomerases catalyze carbon skeleton rearrangements using radical chemistry. We have recently demonstrated that an isobutyryl-CoA mutase variant, IcmF, a member of this enzyme family that catalyzes the interconversion of isobutyryl-CoA and n-butyryl-CoA also catalyzes the interconversion between isovaleryl-CoA and
Ziqi Zhou et al.
Fundamental & clinical pharmacology, 29(4), 371-381 (2015-05-29)
Phenytoin (PHT) is a commonly prescribed first-line antiepileptic drug. However, long-term administration of PHT can cause memory loss and balance disturbance. Gastrodin (GD) is the major bioactive component in Tianma and has sedative, anticonvulsive, memory strengthening, and neuroprotective effects. To
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