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P7280

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Yusuke Goto et al.
Oncogene, 39(20), 4014-4027 (2020-03-25)
Prostate cancer (PCa) innervation contributes to the progression of PCa. However, the precise impact of innervation on PCa cells is still poorly understood. By focusing on muscarinic receptors, which are activated by the nerve-derived neurotransmitter acetylcholine, we show that muscarinic
Faping Shen et al.
Brain research, 1704, 174-186 (2018-10-23)
Neural stem cells (NSCs) give rise to the central nervous system (CNS) and persist in certain areas of adult brains for replenishing damaged differentiated cells. The loss of the balance between NSC self-renewal and differentiation could lead to tumor formation
Peter James O'Brien et al.
Chemical research in toxicology, 30(3), 804-829 (2017-02-06)
A multiparametric, live-cell, high-content-screening (HCS) cytotoxicity assay was first demonstrated in 2006 ( Arch. Toxicol. 2006 , 80 , 580 - 604 ) to be highly concordant with human hepatotoxicity, including idiosyncratic hepatotoxicities and other target organ toxicities in contrast
Hongqiang Ma et al.
Biophysical journal, 112(10), 2196-2208 (2017-05-26)
High-precision fluorescence microscopy such as superresolution imaging or single-particle tracking often requires an online drift correction method to maintain the stability of the three-dimensional (3D) position of the sample at a nanometer precision throughout the entire data acquisition process. Current
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Zikai Zhou et al.
Nature neuroscience, 21(1), 50-62 (2017-12-13)
Long-term potentiation (LTP) and depression (LTD) at glutamatergic synapses are intensively investigated processes for understanding the synaptic basis for learning and memory, but the underlying molecular mechanisms remain poorly understood. We have made three mouse lines where the C-terminal domains
Mireia Nàger et al.
Autophagy, 14(4), 619-636 (2018-01-10)
WNT-CTNN1B signaling promotes cancer cell proliferation and stemness. Furthermore, recent evidence indicates that macroautophagy/autophagy regulates WNT signaling. Here we investigated the impact of inhibiting WNT signaling on autophagy in glioblastoma (GBM), a devastating brain tumor. Inhibiting TCF, or silencing TCF4
Kara McNair et al.
Cancer biology & therapy, 20(3), 349-367 (2018-11-08)
Expression of the tumour suppressor Deleted in Colorectal Cancer (DCC) and the related protein neogenin is reduced by the mammalian serine protease chymotrypsin or the bacterial serine protease subtilisin, with increased cell migration. The present work examines whether these actions
Farhan Basit et al.
Frontiers in immunology, 9, 2489-2489 (2018-11-21)
Toll-like receptor (TLR) agonists induce metabolic reprogramming, which is required for immune activation. We have investigated mechanisms that regulate metabolic adaptation upon TLR-stimulation in human blood DC subsets, CD1c+ myeloid DCs (mDCs) and plasmacytoid DCs (pDCs). We show that TLR-stimulation
Soledad Acuna-Mendoza et al.
Stem cells and development, 26(23), 1682-1694 (2017-09-20)
Neural crest (NC) cells are a migratory, multipotent population giving rise to numerous lineages in the embryo. Their plasticity renders attractive their use in tissue engineering-based therapies, but further knowledge on their in vivo behavior is required before clinical transfer
Li Wang et al.
Neuroscience letters, 661, 63-70 (2017-10-02)
The abnormal expression of the autophagy-related protein Beclin 1 has been implicated in Alzheimer's disease (AD) brains, whereas the precise involvement of Caspase-mediated Beclin 1 cleavage in AD neurons has not yet been fully clarified. In this study, we investigated
Meghan Kerrisk Campbell et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(23), 5289-5301 (2018-05-08)
Mutations or altered protein levels of SHANK3 are implicated in neurodevelopmental disorders such as Phelan-McDermid syndrome, autism spectrum disorders, and schizophrenia (Guilmatre et al., 2014). Loss of SHANK3 in mouse models results in decreased synapse density and reduction in the
Diana Zatreanu et al.
Molecular cell, 76(1), 57-69 (2019-09-15)
Although correlations between RNA polymerase II (RNAPII) transcription stress, R-loops, and genome instability have been established, the mechanisms underlying these connections remain poorly understood. Here, we used a mutant version of the transcription elongation factor TFIIS (TFIISmut), aiming to specifically
Roberto de la Rica et al.
Analytical chemistry, 81(24), 10167-10171 (2009-11-17)
While cancer is still an implacable disease, many cancers can be cured if they are diagnosed in an early stage. Recently, it was reported that the transformation from normal cells to cancer cells can change their mechanoelastic properties to become
Bing-Ling Peng et al.
Theranostics, 10(8), 3451-3473 (2020-03-25)
While protein arginine methyltransferases (PRMTs) and PRMT-catalyzed protein methylation have been well-known to be involved in a myriad of biological processes, their functions and the underlying molecular mechanisms in cancers, particularly in estrogen receptor alpha (ERα)-positive breast cancers, remain incompletely
Seonju Choi et al.
Biomolecules & therapeutics, 29(3), 311-320 (2021-01-08)
Accumulation of reactive oxygen species (ROS) is associated with the development of various diseases. However, the molecular mechanisms underlying oxidative stress that lead to such diseases like autosomal dominant polycystic kidney disease (ADPKD) remain unclear. Here, we observed that oxidative
Lisa J Clark et al.
Nature chemical biology, 16(10), 1096-1104 (2020-07-08)
Peptide ligands of class B G-protein-coupled receptors act via a two-step binding process, but the essential mechanisms that link their extracellular binding to intracellular receptor-arrestin interactions are not fully understood. Using NMR, crosslinking coupled to mass spectrometry, signaling experiments and
Nana Takenaka-Ninagawa et al.
PloS one, 9(8), e104462-e104462 (2014-08-12)
We recently characterized DahlS.Z-Leprfa/Leprfa (DS/obese) rats, derived from a cross between Dahl salt-sensitive rats and Zucker rats, as a new animal model of metabolic syndrome (MetS). Although the phenotype of DS/obese rats is similar to that of humans with MetS
Peng Wang et al.
International journal of molecular medicine, 43(5), 2005-2014 (2019-03-14)
The thoracic ossification of the posterior longitudinal ligament (T‑OPLL) can cause thoracic spinal stenosis, which results in intractable myelopathy and radiculopathy. Our previous whole‑genome sequencing study first reported rs199772854 in the interleukin 17 receptor C (IL17RC) gene as a potentially
Pauline Vaur et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(12), 5440-5452 (2017-08-27)
NAD
Csaba Forró et al.
Biosensors & bioelectronics, 122, 75-87 (2018-09-23)
Theoretical and in vivo neuroscience research suggests that functional information transfer within neuronal networks is influenced by circuit architecture. Due to the dynamic complexities of the brain, it remains a challenge to test the correlation between structure and function of
José A Jiménez-Torres et al.
EBioMedicine, 42, 408-419 (2019-03-25)
Anti-angiogenic treatment failure is often attributed to drug resistance, unsuccessful drug delivery, and tumor heterogeneity. Recent studies have speculated that anti-angiogenic treatments may fail due to characteristics inherent to tumor-associated blood vessels. Tumor-associated blood vessels are phenotypically different from their
Diana Fernández-Suárez et al.
Cell death & disease, 10(10), 732-732 (2019-10-02)
MAG (Myelin-associated glycoprotein) is a type I transmembrane glycoprotein expressed by Schwann cells and oligodendrocytes, that has been implicated in the control of axonal growth in many neuronal populations including cerebellar granule neurons (CGNs). However, it is unclear whether MAG
Zhimin Ou et al.
Cell reports, 26(11), 2984-2997 (2019-03-14)
The CNS plays a pivotal role in energy homeostasis, but whether oligodendrocytes are involved has been largely unexplored. Here, we show that signaling through GPR17, a G-protein-coupled receptor predominantly expressed in the oligodendrocyte lineage, regulates food intake by modulating hypothalamic neuronal
Caitlin C Murdoch et al.
PLoS pathogens, 15(3), e1007381-e1007381 (2019-03-08)
The intestinal microbiota influences the development and function of myeloid lineages such as neutrophils, but the underlying molecular mechanisms are unresolved. Using gnotobiotic zebrafish, we identified the immune effector Serum amyloid A (Saa) as one of the most highly induced
Daniel J Shiwarski et al.
Molecular biology of the cell, 30(5), 680-690 (2019-01-03)
The delta opioid receptor (DOR), a physiologically relevant prototype for G protein-coupled receptors, is retained in intracellular compartments in neuronal cells. This retention is mediated by a nerve growth factor (NGF)-regulated checkpoint that delays the export of DOR from the
Karine Laulagnier et al.
Cellular and molecular life sciences : CMLS, 75(4), 757-773 (2017-09-29)
Amyloid beta peptide (Aβ), the main component of senile plaques of Alzheimer's disease brains, is produced by sequential cleavage of amyloid precursor protein (APP) and of its C-terminal fragments (CTFs). An unanswered question is how amyloidogenic peptides spread throughout the
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Stephanie E Crilly et al.
eLife, 10 (2021-05-21)
The prevailing model for the variety in drug responses is that different drugs stabilize distinct active states of their G protein-coupled receptor (GPCR) targets, allowing coupling to different effectors. However, whether the same ligand generates different GPCR active states based
Valentina Cigliola et al.
PloS one, 11(3), e0150880-e0150880 (2016-03-10)
Signalling through gap junctions contributes to control insulin secretion and, thus, blood glucose levels. Gap junctions of the insulin-producing β-cells are made of connexin 36 (Cx36), which is encoded by the GJD2 gene. Cx36-null mice feature alterations mimicking those observed
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