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Guangjin Li et al.
Journal of immunology (Baltimore, Md. : 1950), 195(3), 865-874 (2015-06-21)
With increasing age, naive CD4 T cells acquire intrinsic defects that compromise their ability to respond and differentiate. Type I IFNs, pervasive constituents of the environment in which adaptive immune responses occur, are known to regulate T cell differentiation and
Angela Juliette Degraaf et al.
American journal of respiratory cell and molecular biology, 51(2), 242-250 (2014-03-08)
Alveolar macrophages (AMs) represent the first line of innate immune defense in the lung. AMs use pattern recognition receptors (PRRs) to sense pathogens. The best studied PRR is Toll-like receptor (TLR)4, which detects LPS from gram-negative bacteria. The lipid mediator
Raquel Cabezón et al.
Journal of leukocyte biology, 97(4), 751-760 (2015-01-28)
The aim of this study was to test the hypothesis whether MERTK, which is up-regulated in human DCs treated with immunosuppressive agents, is directly involved in modulating T cell activation. MERTK is a member of the TAM family and contributes
David Solà-Villà et al.
PloS one, 10(8), e0136201-e0136201 (2015-08-20)
PGE2 has been implicated in abdominal aortic aneurysm (AAA) associated hypervascularization. PGE2-metabolism involves 15-hydroxyprostaglandin-dehydrogenase (15-PGDH) the expression of which in AAA is unknown. The aim of this study was to examine the expression and cell distribution of 15-PGDH in AAA.
Huaqing Liu et al.
Journal of medicinal chemistry, 51(22), 7094-7098 (2008-11-06)
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine, 4 (A-987306) is a new histamine H(4) antagonist. The compound is potent in H(4) receptor binding assays (rat H(4), K(i) = 3.4 nM, human H(4) K(i) = 5.8 nM) and demonstrated potent functional antagonism in vitro at human, rat
Anniek B van der Waart et al.
Cancer immunology, immunotherapy : CII, 64(5), 645-654 (2015-03-01)
Allogeneic stem cell transplantation (allo-SCT) can be a curative therapy for patients suffering from hematological malignancies. The therapeutic efficacy is based on donor-derived CD8(+) T cells that recognize minor histocompatibility antigens (MiHAs) expressed by patient's tumor cells. However, these responses
Sarah E Allison et al.
Biochemical pharmacology, 96(4), 306-314 (2015-06-13)
Metastasis is the major cause of death in cancer patients. Elevated expression of cyclooxygenase-2 (COX-2) is observed in many human cancers and over-production of downstream prostaglandins (PGs) has been shown to stimulate metastasis. A role for increased PGE2 production has
Clifford W Mason et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(12), 2077-2086 (2014-09-28)
Prostaglandin (PG) E2, a major product of cyclooxygenase (COX)-2, acts as an immunomodulator at the maternal-fetal interface during pregnancy. It exerts biologic function through interaction with E-prostanoid (EP) receptors localized to the placenta. The activation of the COX-2/PGE2/EP signal pathway
Jakub Piotrowski et al.
Journal of thermal biology, 45, 69-74 (2014-12-02)
Heme oxygenase-1 (HO-1) is an enzyme that catalyzes degradation of the heme and regulates its availability for newly synthetized hemeproteins such as cyclooxygenases, NO synthases and cytochrome P450. Moreover, HO-1 activity modulates synthesis of cytokines and prostaglandins. All of these
Tianxin Yang et al.
American journal of hypertension, 25(10), 1042-1049 (2012-06-15)
Prostaglandin E(2) (PGE(2)) is a major prostanoid with a wide variety of biological activities. PGE(2) can influence blood pressure (BP) both positively and negatively. In particular, centrally administered PGE(2) induces hypertension whereas systemic administration of PGE(2) produces a hypotensive effect.
Rossa E Brugha et al.
Thorax, 69(7), 654-659 (2014-02-26)
Airway macrophage (AM) phagocytosis is impaired in severe asthma. Prostaglandin (PG) E2 and D2 are increased in severe asthma and suppress AM phagocytic function in vitro. In this study, we sought evidence for PG-mediated impairment of phagocytosis of inhalable carbonaceous
Tara M Nordgren et al.
Nutrients, 6(12), 5434-5452 (2014-12-02)
Workers exposed to organic dusts from concentrated animal feeding operations (CAFOs) are at risk for developing airway inflammatory diseases. Available preventative and therapeutic measures for alleviating dust-induced lung disease are inadequate. Because omega-3 fatty acids can mitigate inflammatory processes, we
Fernando P Conte et al.
Molecules (Basel, Switzerland), 20(2), 2636-2657 (2015-02-06)
Gedunin, a natural limonoid from Meliaceae species, has been previously described as an antiinflammatory compound in experimental models of allergic inflammation. Here, we report the antiinflammatory and antinociceptive effects of gedunin in an acute model of articular inflammation induced by
Sang-Ho Choi et al.
Journal of neurochemistry, 98(3), 801-811 (2006-06-22)
We have recently reported that cyclooxygenase (COX)-2-deficiency affects brain upstream and downstream enzymes in the arachidonic acid (AA) metabolic pathway to prostaglandin E2 (PGE2), as well as enzyme activity, protein and mRNA levels of the reciprocal isozyme, COX-1. To gain
Paul D Bozyk et al.
American journal of respiratory cell and molecular biology, 45(3), 445-452 (2011-03-23)
Prostaglandin (PG)E(2) is a bioactive eicosanoid that regulates many biologically important processes in part due to its ability to signal through four distinct G-protein-coupled receptors with differential signaling activity and unique expression patterns in different cell types. Although PGE(2) has
Ya-Ling Hou et al.
BMC complementary and alternative medicine, 14, 415-415 (2014-10-26)
Ginsenosides, the major bioactive compounds in ginseng root, have been found to have antioxidant, immunomodulatory and anti-inflammatory activities. This study investigated the effects of ginsenosides on carbon tetrachloride (CCl4)-induced hepatitis and liver fibrosis in rats. Male Sprague-Dawley rats were randomly
Christina E Swan et al.
Prostaglandins & other lipid mediators, 96(1-4), 10-13 (2011-08-02)
Hypertension is a well established risk factor for cardiovascular diseases such as stroke and is the leading cause of chronic kidney failure. Although a number of pharmacologic agents are available for the treatment of hypertension including agents that affect the
Kirsten L Brown et al.
Biochimica et biophysica acta, 1831(6), 1098-1107 (2013-04-02)
Prostaglandin ethanolamides or prostamides are naturally occurring neutral lipid derivatives of prostaglandins that have been shown to be synthesised in vivo following COX-facilitated oxygenation of arachidonoyl ethanolamine (anandamide). Although the actions of prostaglandins have been extensively studied, little is known
Takashi Kondo et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 13(7), 1249-1255 (2015-01-31)
We investigated the effects of diclofenac, a nonsteroidal anti-inflammatory drug that inhibits prostaglandin production, on induction of esophageal sensation by acid perfusion in healthy men. We performed a prospective, double-blind, placebo-controlled, 2-period, cross-over study over 3 visits in 12 healthy
Antonella Conforti et al.
Stem cells and development, 23(21), 2591-2599 (2014-06-18)
Mesenchymal stromal cells (MSCs) are multipotent cells that possess broad immunomodulatory properties; the mechanisms underlying these properties have not been completely clarified. Aim of this study was to compare in vitro immunomodulatory effects of MSCs with those of microvesicles (MVs)
Antonina V Kurtova et al.
Nature, 517(7533), 209-213 (2014-12-04)
Cytotoxic chemotherapy is effective in debulking tumour masses initially; however, in some patients tumours become progressively unresponsive after multiple treatment cycles. Previous studies have demonstrated that cancer stem cells (CSCs) are selectively enriched after chemotherapy through enhanced survival. Here we
Xiaozhen Liu et al.
Environmental toxicology, 30(10), 1144-1152 (2014-03-29)
The aim of this study was to investigate the signaling pathways involved in the cyclooxygenase (COX)-2 regulation induced by nonylphenol (NP) in mouse testis Sertoli TM4 cells. Our results showed that treatment of TM4 cells with NP increased COX-2 protein
Chenggang Li et al.
PloS one, 9(10), e104809-e104809 (2014-10-28)
Tuberous sclerosis syndrome (TSC) is an autosomal dominant tumor suppressor gene syndrome affecting multiple organs, including renal angiomyolipomas and pulmonary lymphangioleiomyomatosis (LAM). LAM is a female-predominant interstitial lung disease characterized by the progressive cyst formation and respiratory failure, which is
Johanna C Sierra et al.
American journal of physiology. Gastrointestinal and liver physiology, 305(2), G196-G203 (2013-05-18)
Chronic infection of the gastric mucosa by Helicobacter pylori is associated with an increased risk of developing gastric cancer; however, the vast majority of infected individuals never develop this disease. One H. pylori virulence factor that increases gastric cancer risk
Lan Wang et al.
Nutrition research and practice, 9(6), 579-585 (2015-12-04)
Sonchus asper is used extensively as an herbal anti-inflammatory for treatment of bronchitis, asthma, wounds, burns, and cough; however, further investigation is needed in order to understand the underlying mechanism. To determine its mechanism of action, we examined the effects
Eun Hyoung Shim et al.
International journal of clinical and experimental pathology, 8(1), 458-465 (2015-03-11)
Jea-Ma-Chung-Sim-Youn-Ja-Tang (JCST), one of herbal formulae, is modified prescription base on Chung-Sim-Youn-Ja-Tang (CST) which treats cerebrovascular disease for the Tae-Eum-In (TE). This study was designed to determine the anti-inflammatory and anti-adipogenesis effect of CST and JCST in vitro. CST and
Catherine Olesch et al.
Oncotarget, 6(12), 10284-10296 (2015-04-15)
Prostaglandin E2 (PGE2) favors multiple aspects of tumor development and immune evasion. Therefore, microsomal prostaglandin E synthase (mPGES-1/-2), is a potential target for cancer therapy. We explored whether inhibiting mPGES-1 in human and mouse models of breast cancer affects tumor-associated
Emilie Bourdonnay et al.
The Journal of experimental medicine, 212(5), 729-742 (2015-04-08)
JAK-STAT signaling mediates the actions of numerous cytokines and growth factors, and its endogenous brake is the family of SOCS proteins. Consistent with their intracellular roles, SOCS proteins have never been identified in the extracellular space. Here we report that
Binsheng Wang et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 21(6), 1020-1028 (2015-02-25)
Chronic graft-versus-host disease (cGVHD) is a critical complication after allogeneic hematopoietic stem cell transplantation. The conditioning therapy has been involved in the impairment of bone marrow (BM) mesenchymal stem/stromal cells (MSCs). However, the potential implication of MSCs in the pathophysiology
J Y Westcott et al.
Prostaglandins, 34(6), 877-887 (1987-12-01)
Recent evidence has shown that a variety of prostaglandins and leukotrienes can be produced in brain tissue after injury in animals. It has also been speculated that increases in brain prostaglandins occur in humans following injury. Ventricular cerebrospinal fluid (CSF)
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