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Hsp90 Co-chaperone p23 contributes to dopaminergic mitochondrial stress via stabilization of PHD2: Implications for Parkinson's disease.
Rane A, et al.
Neurotoxicology (2018)
Katriina Kahlos et al.
Molecular and cellular biochemistry, 254(1-2), 47-54 (2003-12-17)
We previously reported that exposure to exogenous nitric oxide (NO) causes diminished expression of thioredoxin/thioredoxin reductase, a critical component of the redox system that regulates the functions of redox-sensitive enzymes, receptors, and transcription factors. Here we examined the role of
A laboratory practical illustrating the use of the ChIP-qPCR method in a robust model: Estrogen receptor alpha immunoprecipitation using Mcf-7 culture cells
Lacazette E
BioChemistry: An Indian Journal (2017)
Fugui Zhu et al.
Nucleic acids research, 46(12), 6026-6040 (2018-05-08)
Sin3a is a core component of histone-deacetylation-activity-associated transcriptional repressor complex, playing important roles in early embryo development. Here, we reported that down-regulation of Sin3a led to the loss of embryonic stem cell (ESC) self-renewal and skewed differentiation into mesendoderm lineage.
Ricardo Rivera-Soto et al.
Journal of virology, 94(5) (2019-12-06)
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of two B-cell lymphoproliferative diseases and Kaposi's sarcoma, an endothelial-cell-driven cancer. KSHV viral interleukin-6 (vIL-6) is a viral homolog of human IL-6 (hIL-6) that is expressed in KSHV-associated malignancies. Previous studies have
Benjamin J Spears et al.
Molecular plant-microbe interactions : MPMI, 32(5), 540-549 (2018-11-28)
One layer of the innate immune system allows plants to recognize pathogen-associated molecular patterns (PAMPS), activating a defense response known as PAMP-triggered immunity (PTI). Maintaining an active immune response, however, comes at the cost of plant growth and development; accordingly
Juri Kazakevych et al.
Nucleic acids research, 45(10), 5770-5784 (2017-03-24)
Epigenetic mechanisms, including chromatin structure, chromatin dynamics and histone modifications play an important role for maintenance and differentiation of pluripotent embryonic stem cells. However, little is known about the molecular mechanisms of adult stem cell specification and differentiation. Here, we
James Matsunaga et al.
Microbiology (Reading, England), 152(Pt 12), 3777-3786 (2006-12-13)
Leptospirosis is a widespread zoonosis caused by invasive spirochaetes belonging to the genus Leptospira. Pathogenic leptospires disseminate via the bloodstream to colonize the renal tubules of reservoir hosts. Little is known about leptospiral outer-membrane proteins expressed during the dissemination stage
Donna L Cioffi et al.
Circulation research, 97(11), 1164-1172 (2005-10-29)
Store-operated calcium (SOC) entry represents the principal Ca2+ entry pathway into nonexcitable cells. Despite intensive investigation, mechanisms underlying activation of SOC entry have remained elusive. The endothelial ISOC channel is a Ca2+-selective SOC entry channel to which the transient receptor
NF-?B directly regulates ?-arrestin-1 expression and forms a negative feedback circuit in TNF-a?induced cell death
Li J, et al.
Faseb Journal (2018)
Julien Goure et al.
Infection and immunity, 72(8), 4741-4750 (2004-07-24)
Pseudomonas aeruginosa efficiently intoxicates eukaryotic cells through the activity of the type III secretion-translocation system (TTSS). Gene deletions within the translocation operon pcrGVH-popBD abolish pore-forming activity of P. aeruginosa strains with macrophages and TTSS-dependent hemolysis. Here we investigated the requirements
Yan Zeng et al.
PLoS pathogens, 17(2), e1009300-e1009300 (2021-02-13)
Influenza A virus (IAV) has evolved various strategies to counteract the innate immune response using different viral proteins. However, the mechanism is not fully elucidated. In this study, we identified the PB1 protein of H7N9 virus as a new negative
Anand Rane et al.
Neurotoxicology, 65, 166-173 (2018-02-23)
The heat shock factor 90 (hsp90) complex has long been associated with neuropathological phenotypes linked to Parkinson's disease (PD) and its inhibition is neuroprotective in disease models. Hsp90 is conventionally believed to act by suppressing induction of hsp70. Here, we
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