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Jinshu Qiu et al.
Journal of pharmaceutical and biomedical analysis, 117, 163-172 (2015-09-12)
Monitoring amino acids and vitamins is important for understanding human health, food nutrition and the culture of mammalian cells used to produce therapeutic proteins in biotechnology. A method including ion pairing reversed-phase liquid chromatography with tandem mass spectrometry was developed
T M Hill et al.
Journal of dairy science, 98(7), 4882-4888 (2015-04-29)
Energy demands for calves can increase during periods of heat and cold stress. One way to potentially increase energy intake is to increase the energy density of the feed with fat. Trial 1a compared a control starter with no added
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Ali M Yehia et al.
Analytica chimica acta, 1104, 95-104 (2020-02-29)
Paper-based microfluidic device was designed with wax-printing to combine potentiometric, fluorimetric and colorimetric detection zones. This newly developed trimodal paper chip has been used for on-site determination of ketamine hydrochloride (KET) as a date rape drug in beverages. The device
Eyal Zur
International journal of pharmaceutical compounding, 17(2), 113-123 (2013-05-23)
Nausea and vomiting in pregnancy can have serious adverse effects on the quality of a woman's life, affecting her occupational, social, and domestic functioning, and her general well-being; therefore, it is very important to treat this condition appropriately and effectively.
Sidney M Gospe
Current opinion in neurology, 19(2), 148-153 (2006-03-16)
Pyridoxine dependency is an uncommon but important cause of intractable seizures presenting in infancy and early childhood. This paper discusses recent clinical, biochemical and genetic studies and how the findings should change our approach in evaluating young patients with antiepileptic
Kristina M Brooks et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 67(2), 193-201 (2018-02-08)
Once-weekly isoniazid and rifapentine for 3 months is a treatment option in persons with human immunodeficiency virus and latent tuberculosis infection. This study aimed to examine pharmacokinetic drug-drug interactions between this regimen and dolutegravir, a first-line antiretroviral medication. This was
Eliana Valencia-Lozano et al.
International journal of molecular sciences, 20(21) (2019-11-14)
This report presents an efficient protocol of the stable genetic transformation of coffee plants expressing the Cry10Aa protein of Bacillus thuringiensis. Embryogenic cell lines with a high potential of propagation, somatic embryo maturation, and germination were used. Gene expression analysis
Matthias Fellner et al.
Biochemistry, 57(38), 5513-5523 (2018-08-31)
LarE from Lactobacillus plantarum is an ATP-dependent sulfur transferase that sacrifices its Cys176 sulfur atom to form a dehydroalanine (Dha) side chain during biosynthesis of the covalently linked nickel-pincer nucleotide (NPN) cofactor (pyridinium 3-thioamide-5-thiocarboxylic acid mononucleotide) of lactate racemase. Coenzyme
Yu-Jun Wan et al.
Journal of agricultural and food chemistry, 67(3), 895-904 (2019-01-05)
It has been found that probiotic-fermented carrot pulp has a beneficial effect in reducing blood glucose, more so than unfermented pulp. This paper explores the reason for this by looking at fermentation-induced changes in nutritional components and hypoglycemic effects of
Samantha F H de Witte et al.
Stem cell research & therapy, 8(1), 140-140 (2017-06-10)
Mesenchymal stromal cells (MSC) possess immunomodulatory properties and low immunogenicity, both crucial properties for their development into an effective cellular immunotherapy. They have shown benefit in clinical trials targeting liver diseases; however the efficacy of MSC therapy will benefit from
Pei Chen et al.
Fish physiology and biochemistry, 43(1), 229-244 (2016-09-14)
In this study, two isoforms slc34a2 genes (type IIb sodium-dependent phosphate cotransporter), slc34a2a2 and slc34a2b, were cloned from intestine and kidney of yellow catfish (Pelteobagrus fulvidraco), with rapid amplification of cDNA ends. The structure differences and the regulation effects of
Monika A Lesniewska et al.
Drug development and industrial pharmacy, 41(4), 663-669 (2014-03-04)
Acyclovir (ACV) belongs to a class of drugs with low bioavailability. Selected ACV esters including acetyl (Ac-), isobutyryl (iBut-), pivaloyl (Piv-), ethoxycarbonyl (Etc-) and nicotinoyl (Nic-) were synthesized, and their lipophilicity was determined by the high-performance liquid chromatography (HPLC) RP
G Tolis et al.
The Journal of clinical endocrinology and metabolism, 44(6), 1197-1199 (1977-06-01)
The acute effect of pyridoxine (B6) on serum GH and PRL levels and its chronic effects on galactorrhea in nine subjects (group I, n=4, idiopathic galactorrhea with normal PRL levels and normal menses; Group II, n=5, galactorrhea-amenorrhea with increased PRL
G S Kidd et al.
The Journal of clinical endocrinology and metabolism, 54(4), 872-875 (1982-04-01)
Six patients with amenorrhea, five of whom had galactorrhea and elevated PRL levels, were evaluated on a metabolic ward. All had normal sella tomograms, normal thyroid functions, and routine laboratory evaluations. None of the patients had taken any medication in
Kathleen M Hayden et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association, 13(11), 1187-1196 (2017-05-23)
The Mediterranean and Dietary Approaches to Stop Hypertension diets have been associated with lower dementia risk. We evaluated dietary inflammatory potential in relation to mild cognitive impairment (MCI)/dementia risk. Baseline food frequency questionnaires from n = 7085 women (aged 65-79 years) were
Réjean M Guerriero et al.
Pediatric neurology, 76, 47-53 (2017-10-08)
Pyridoxine is converted to its biologically active form pyridoxal-5-phosphate (P5P) by the enzyme pyridox(am)ine 5'-phosphate oxidase and serves as a cofactor in nearly 200 reactions in the central nervous system. Pyridox(am)ine 5'-phosphate oxidase deficiency leads to P5P dependent epilepsy, typically
Ana Gutiérrez-Preciado et al.
PloS one, 10(5), e0126124-e0126124 (2015-05-06)
Riboflavin, the precursor for the cofactors flavin mononucleotide (FMN) and flavin adenine dinucleotide, is an essential metabolite in all organisms. While the functions for de novo riboflavin biosynthesis and riboflavin import may coexist in bacteria, the extent of this co-occurrence
Ngaire Keenan et al.
Epilepsy research, 108(6), 1087-1094 (2014-06-05)
To investigate biochemical cardiovascular risk factors and vascular endothelial function and structure in children with epilepsy on antiepileptic drugs (AEDs), particularly sodium valproate (VPA) and carbamazepine (CBZ). Individuals with epilepsy have increased risk factors for vascular disease, particularly lipid abnormalities
Clara D M van Karnebeek et al.
American journal of human genetics, 105(3), 534-548 (2019-08-20)
Early-infantile encephalopathies with epilepsy are devastating conditions mandating an accurate diagnosis to guide proper management. Whole-exome sequencing was used to investigate the disease etiology in four children from independent families with intellectual disability and epilepsy, revealing bi-allelic GOT2 mutations. In-depth
Wan-Chun Chiu et al.
Food & function, 6(5), 1692-1700 (2015-04-25)
Clinical and animal experiments indicated that gut-derived endotoxin and imbalanced intestinal microbiota contribute to the pathogenesis of alcoholic liver disease (ALD). In this study, we investigated whether synbiotic supplementation could improve ALD in rats by altering the intestinal microbial composition
Henrika Wickström et al.
AAPS PharmSciTech, 18(2), 293-302 (2016-10-16)
Printing technologies were recently introduced to the pharmaceutical field for manufacturing of drug delivery systems. Printing allows on demand manufacturing of flexible pharmaceutical doses in a personalized manner, which is critical for a successful and safe treatment of patient populations with
Sara Sanders et al.
PloS one, 13(5), e0197638-e0197638 (2018-05-18)
The in vivo microenvironment of bacterial pathogens is often characterized by nutrient limitation. Consequently, conventional rich in vitro culture conditions used widely to evaluate antibacterial agents are often poorly predictive of in vivo activity, especially for agents targeting metabolic pathways.
Paulo Rema et al.
Animals : an open access journal from MDPI, 9(4) (2019-04-26)
Insects are emerging as a sustainable alternative to fishmeal and fish oil in aquafeeds. This study assessed the effect of graded incorporation levels of defatted yellow mealworm (Tenebrio molitor) protein meal on juvenile rainbow trout (Oncorhynchus mykiss) growth performance, body
Zhichao Liu et al.
PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated
Yachana Upadhyay et al.
Colloids and surfaces. B, Biointerfaces, 185, 110624-110624 (2019-11-13)
This manuscript presents a novel bioanalytical approach for the selective ratiometric fluorescent sensing of enzymatic activity of the alkaline phosphatase (ALP) in the biological samples. The probe was designed by conjugating the pyridoxal 5'-phosphate (PLP) over the surface of bovine
Zhengyi Fu et al.
Fish & shellfish immunology, 95, 697-704 (2019-11-13)
This study evaluates the effects of different dietary sources of non-protein energy on growth performance, histological structure, antioxidant status and immune response of barramundi Lates calcarifer. Fish were fed with isoenergetic diets (18 kJ/g) with two types of non-protein energy in
Ziyi Yin et al.
Autophagy, 16(5), 900-916 (2019-07-18)
Cells are faced with various stresses during their growth and development, and autophagy is a degradative process in which cells can break down their own components to recycle macromolecules and provide energy under these stresses. For pathogenic fungi that utilize
Yijun Kang et al.
The British journal of nutrition, 118(6), 431-440 (2017-10-06)
Anaemia during pregnancy, characterised by Hb <110 g/l, is a specific risk factor for adverse maternal and perinatal outcomes in developing countries. The objective of this study was to determine the effectiveness of daily antenatal supplementation with multiple micronutrients (MMN)
Thangavelu Kokulnathan et al.
Ultrasonics sonochemistry, 44, 231-239 (2018-04-24)
In the modern world, the contamination of ecosystem by human and veterinary pharmaceutical drugs through the metabolic excretion, improper disposal/industrial waste has been subjected to a hot issue. Therefore, exploitation of exclusive structured material and reliable technique is a necessary
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