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P4978

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Studies on calf-intestinal alkaline phosphatase. I. Chromatographic purification, microheterogeneity and some other properties of the purified enzyme.
L ENGSTROM
Biochimica et biophysica acta, 52, 36-48 (1961-09-02)
Fabiano Ribeiro Cirano et al.
The Journal of oral implantology, 40(6), 655-659 (2014-12-17)
This study analyzed the role of recombinant human bone morphogenetic protein 2 (rhBMP-2) and recombinant human bone morphogenetic protein 7 (rhBMP-7) in the adhesion and differentiation of rat osteoblast-like (osteo-1) cells cultured on chemically modified titanium surfaces. Osteo-1 cells were
Si Chen et al.
Toxicology, 322, 78-88 (2014-05-29)
Sertraline is used for the treatment of depression, and is also used for the treatment of panic, obsessive-compulsive, and post-traumatic stress disorders. Previously, we have demonstrated that sertraline caused hepatic cytotoxicity, with mitochondrial dysfunction and apoptosis being underlying mechanisms. In
Samir K Gupta et al.
Journal of acquired immune deficiency syndromes (1999), 64(3), 279-283 (2013-11-28)
We performed a randomized controlled trial in 30 HIV-infected participants to either continue tenofovir/emtricitabine/efavirenz (Continuation Group) or switch to tenofovir/emtricitabine/raltegravir (Switch Group) for 24 weeks. There were no significant differences in the changes in flow-mediated dilation, 25(OH) vitamin D, or
Alexandra M Roch et al.
Annals of surgery, 260(4), 680-688 (2014-09-10)
As such, the natural history of MPD-involved IPMN is poorly understood. The high-risk of malignancy associated with main pancreatic duct (MPD)-involved intraductal papillary mucinous neoplasm (IPMN) has been established by surgical series. The International Consensus Guidelines recommend surgical resection of
Yuki Matsushita et al.
The Journal of biological chemistry, 288(27), 19973-19985 (2013-05-09)
CCN3, a member of the CCN protein family, inhibits osteoblast differentiation in vitro. However, the role of CCN3 in bone regeneration has not been well elucidated. In this study, we investigated the role of CCN3 in bone regeneration. We identified
L Wang et al.
Cell proliferation, 46(2), 214-222 (2013-03-21)
Stem cells from the dental apical papilla (SCAPs) can be induced to differentiate along both osteoblast and odontoblast lineages. However, little knowledge is available concerning their differentiation efficiency in osteogenic media containing additional KH2 PO4 . Stem cells from the
Xia Kang et al.
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 27(9), 1122-1127 (2013-11-28)
To investigate the role of micro RNA-451 (miRNA-451) in promoting the osteogenesis of mesenchymal stem cells (MSCs) by targeting regulatory calcium binding protein 39 (CAB39). pMIR-report and pRL-TK vectors were selected to identify the relationship between miRNA-451 and CAB39 by
Clare Wykes et al.
Annals of hematology, 93(12), 2051-2056 (2014-07-02)
Vitamin D deficiency is common in sickle cell anaemia (SCA, HbSS), although its significance and optimal means of correction are unknown. We conducted an audit to assess the clinical significance of 25-hydroxy vitamin D (25-OHD) deficiency in children with SCA
S R Pidruchna
Klinichna khirurhiia, (3)(3), 59-62 (2013-05-31)
In recent years there are intensively studied the role of hepatocytic affection in the complications progress in trauma of various genesis, including the multiple and combined. Positive correcting impact of lyophilized xenoimplants on the hepatic markers activity was demonstrated in
Ryosuke Yamaguchi et al.
Rheumatology (Oxford, England), 53(12), 2191-2195 (2014-06-25)
The aim of this study was to compare the levels of bone and cartilage metabolism markers in the synovial fluid of the hip joint between patients with secondary OA due to osteonecrosis of the femoral head (ONFH), rapidly destructive arthrosis
N Kurtoglu-Aksoy et al.
Clinical and experimental obstetrics & gynecology, 41(2), 149-153 (2014-05-02)
Premature ovarian failure (POF) is the cessation of ovarian function before the age of 40. The loss of ovarian function, whether premature or not, has an overwhelming impact on female skeletal health, leading to an increased risk of developing osteoporosis
Asim F Choudhri et al.
The Journal of nutrition, 144(12), 1920-1927 (2014-10-25)
Despite advances in nutritional support and intensive care, preterm infants are at higher risk of compromised neurodevelopment. This study evaluated the contribution of total parenteral nutrition (PN) to compromised neurodevelopment after preterm birth. Preterm pigs were provided PN or enteral
M D McKee et al.
Journal of dental research, 92(8), 721-727 (2013-05-23)
Phosphatases are involved in bone and tooth mineralization, but their mechanisms of action are not completely understood. Tissue-nonspecific alkaline phosphatase (TNAP, ALPL) regulates inhibitory extracellular pyrophosphate through its pyrophosphatase activity to control mineral propagation in the matrix; mice without TNAP
T T Yang et al.
BioTechniques, 23(6), 1110-1114 (1998-01-09)
The cDNA encoding secreted alkaline phosphatase (SEAP) is a useful tool for investigating the function of known or putative enhancer/promoter elements. SEAP has the unusual properties of extreme heat stability and resistance to the phosphatase inhibitor L-homoarginine. Therefore, endogenous alkaline
Kanakaraju Kaliannan et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(17), 7003-7008 (2013-04-10)
Metabolic syndrome comprises a cluster of related disorders that includes obesity, glucose intolerance, insulin resistance, dyslipidemia, and fatty liver. Recently, gut-derived chronic endotoxemia has been identified as a primary mediator for triggering the low-grade inflammation responsible for the development of
Jun Murotsuki
Clinical calcium, 23(12), 1784-1788 (2013-12-03)
Three types of fetal therapy of skeletal dysplasias, as enzyme replacement, in utero stem cell transplantation, and gene therapy, are reviewed. Clinical trial of recombinant ALP for infantile hypophosphatasia has already started in Japan. In future, such enzyme replacement therapy
Zhao Shifang et al.
Journal of biomedical nanotechnology, 10(7), 1313-1319 (2014-05-09)
The aim of this study was to deposit simvastatin-hydroxyapatite (sim-HA) coatings on titanium surfaces by an electrochemical process and evaluate osteoprogenitor cell responses to sim-HA-coated surfaces. Simvastatin was prepared onto titanium surfaces with varying concentration (10(-7), 10(-6), 10(-5) and 10(-4)
Douglas C Bauer et al.
JAMA internal medicine, 174(7), 1126-1134 (2014-05-07)
Discontinuation of bisphosphonate therapy after 3 to 5 years is increasingly considered, but methods to monitor fracture risk after discontinuation have not been established. To test methods of predicting fracture risk among women who have discontinued alendronate therapy after 4
Ilhan Bayhan et al.
The Journal of reproductive medicine, 58(7-8), 319-323 (2013-08-21)
To assess the association between leptin levels and bone mineral density (BMD) and bone metabolism markers in postmenopausal women taking strontium ranelate. In this longitudinal uncontrolled study, postmenopausal osteoporotic women were administered strontium ranelate and categorized into 1 of 2
G U Mohangi et al.
SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging, 67(7), 354-358 (2013-08-21)
Demineralised bone matrix (DBM) is an allograft material widely used as a bone filler and bone graft substitute. DBM contains bone morphogenetic proteins (BMPs), which induce and regulate bone formation during embryogenesis and in postnatal life. To investigate the osteoinductivity
Xiu-Mei Weng et al.
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 42(5), 578-582 (2013-10-30)
To evaluate the application of bone turnover markers bone alkaline phosphatase (BALP) and N-MID osteocalcin (N-MID) in monitoring of osteoporosis treatment with recombined parathyroid hormone 1-34 (rhPTH1-34). The bone mineral density (BMD) of the lumbar spine L2-L4 and the proximal
Gregory R Sondag et al.
Journal of cellular physiology, 229(7), 955-966 (2013-11-23)
Osteoactivin (OA) is a novel osteogenic factor important for osteoblast differentiation and function. Previous studies showed that OA stimulates matrix mineralization and transcription of osteoblast specific genes required for differentiation. OA plays a role in wound healing and its expression
T Guo et al.
Journal of dental research, 93(12), 1290-1295 (2014-08-21)
In previous studies, fluorapatite (FA) crystal-coated surfaces have been shown to stimulate the differentiation and mineralization of human dental pulp stem cells (DPSCs) in two-dimensional cell culture. However, whether the FA surface can recapitulate these properties in three-dimensional culture is
M R Giuca et al.
European journal of paediatric dentistry : official journal of European Academy of Paediatric Dentistry, 14(3), 175-180 (2013-12-04)
The aim of the present investigation was to analyse cephalometric skeletal structures and hormonal and enzymatic parameters in young obese subjects in comparison with those of normal weight subjects. The whole sample consisted of 50 Caucasian patients (28 males and
Eva-Maria Katzenmaier et al.
Anticancer research, 34(10), 5429-5438 (2014-10-03)
The physiological compound sodium butyrate can induce differentiation in colon cancer cells in vitro. Due to the role of galectins in growth control we explored its effect on this network beyond galectins-1 and -3, with deliberate consideration of the status
Masafumi Tomita et al.
Toxicology, 319, 63-68 (2014-03-04)
There is a close relationship between the central nervous system activity and bone metabolism. Therefore, methamphetamine (METH), which stimulates the central nervous system, is expected to affect bone turnover. The aim of this study was to investigate the role of
A Alcaraz et al.
British journal of cancer, 109(1), 121-130 (2013-06-27)
Levels of bone turnover markers (BTM) might be correlated with outcome in terms of skeletal-related events (SRE), disease progression, and death in patients with bladder cancer (BC) and renal cell carcinoma (RCC) with bone metastases (BM). We try to evaluate
Beata Augustyńska et al.
Psychiatria polska, 47(1), 17-30 (2013-07-31)
The aim of this study was the assessment to of metabolism of bone tissue as changes in concentration of biochemical markers of bone turnover in inpatient alcohol dependent women. The studied group consisted of 50 alcohol dependent female patients who
L A Alekseeva et al.
Klinicheskaia laboratornaia diagnostika, (12)(12), 3-7 (2014-04-25)
Recently, the share of children with verified neonatal hepatitis induced by genetic predisposition, malformations of biliary tracts, inborn infections with affection of hepatobiliary system increased. The comprehensive biochemical examination of 62 children aged from 1.5 months to 2 years old
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