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P4864

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Adnan R Khan et al.
Nature communications, 6, 5997-5997 (2015-01-23)
Specific B-cell subsets can regulate T-cell immune responses, and are termed regulatory B cells (Breg). The majority of Breg cells described in mouse and man have been identified by IL-10 production and are known to suppress allergy and autoimmunity. However...
Felicity M Davis et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(18), 5827-5832 (2015-04-23)
The nourishment of neonates by nursing is the defining characteristic of mammals. However, despite considerable research into the neural control of lactation, an understanding of the signaling mechanisms underlying the production and expulsion of milk by mammary epithelial cells during...
Zoya Cohen et al.
International journal of oncology, 46(1), 308-316 (2014-10-22)
There is a need for new options for reducing the side effects of cancer treatment, without compromising efficacy, enabling patients to complete treatment regimens. The botanical compound LCS101 exhibits inhibitory effects on cancer cell growth, and reduces chemotherapy-induced hematological toxicities....
Shengqiang Zhao et al.
Journal of experimental & clinical cancer research : CR, 33, 103-103 (2014-12-05)
Intrahepatic cholangiocarcinoma (IHCC) is the second most frequent primary malignant liver tumor following hepatocellular carcinoma. It is a highly fatal disease and has few therapeutics. The CXC chemokine ligand-12 (CXCL12)/CXC chemokine receptor type 4 (CXCR4) axis has been shown to...
Zhuo Zhang et al.
Molecular and cellular biochemistry, 392(1-2), 125-134 (2014-05-03)
Renal cell carcinoma (RCC) is the most common types among kidney cancers. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) strongly induces apoptosis in RCC. However, TRAIL therapy also leads to hepatotoxicity. To improve the biosafety, we inserted miRNA response elements (MREs)...
Hwa Jun Cha et al.
Molecular medicine reports, 10(4), 1663-1670 (2014-07-30)
Ultraviolet (UV) radiation impairs intracellular functions by directly damaging DNA and by indirectly generating reactive oxygen species (ROS), which induce cell cycle arrest and apoptosis. UV radiation can also alter gene expression profiles, including those of mRNA and microRNA (miRNA)....
Lei Shi et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(9), 7107-7119 (2015-04-17)
Temozolomide (TMZ) is widely used for treating glioblastoma (GBM), which can effectively inhibit the GBM growth for some months; however, it still could not prevent the invariable recurrence of GBM. The existence of glioma stem cells (GSCs) was considered to...
Song Xue et al.
Molecular medicine reports, 10(4), 1927-1934 (2014-08-12)
Raltitrexed is a specific inhibitor of thymidylate synthase (TS), which has been considered as a potential chemotherapeutic agent for the treatment of advanced gastric cancer. In the present study, the apoptosis mechanisms of raltitrexed in SGC7901 human gastric cancer cells...
Yang Yang et al.
PloS one, 10(7), e0133169-e0133169 (2015-07-16)
Recent research has suggested that certain plant-derived polyphenols, i.e., ursolic acid (UA), which are reported to have antitumor activities, might be used to sensitize tumor cells to radiation therapy by inhibiting pathways leading to radiation therapy resistance. This experiment was...
Lucas Daniel Trucco et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(12), 5262-5276 (2014-09-13)
KLF6 is a member of the Krüppel-like factor family of transcription factors, with diverse roles in the regulation of cell physiology, including proliferation, signal transduction, and apoptosis. Mutations or down-regulation of KLF6 have been described in several human cancers. In...
Ying Gao et al.
Journal of ethnopharmacology, 169, 24-33 (2015-04-12)
Paeonia suffruticosa Andrews (PSE) is a well-known Chinese medicine that has been widely used as an anti-tumor, anti-oxidative and anti-inflammatory agent. cis- and trans-gnetin H are two resveratrol oligomers isolated from the seeds of PSE. Although resveratrol is widely considered...
Qing Gong et al.
Biochemical pharmacology, 92(3), 425-437 (2014-09-28)
PEDF inhibits tumor growth via anti-angiogenic activity; however, the direct effect of PEDF on prostate carcinoma and its functional epitope as well as the underlying mechanism regulating the pathway from extracellular receptors to nuclear transcription factors has not been fully...
Congyu Wu et al.
ACS nano, 9(8), 7913-7924 (2015-07-25)
A deep understanding of the interaction of a graphene oxide (GO) sheet with cells at the molecular level may expedite its biomedical application and predict its new functions and adverse effects. Herein we inspect the interaction between micrometer-sized GO (mGO)...
Chin-Yu Liu et al.
European journal of medicinal chemistry, 90, 775-787 (2014-12-22)
To develop new anticancer drug candidates from 2-arylnaphthyridin-4-one (AN), we have designed and synthesized a series of 3'-hydroxy and 6-hydroxy derivatives of AN. The results of cytotoxicity screening indicated that the replacement of the 3'-methoxy moiety on the C-ring phenyl...
Y Wu et al.
Clinical and experimental immunology, 179(2), 277-293 (2014-09-18)
The role of NOD-like receptor family (NLRP3) has been confirmed in various inflammatory diseases. The association between NLRP3 and hyper-bileacidaemia during the sepsis remains unclear. We aimed to investigate whether NLRP3 silencing protects against the sepsis-induced hyper-bileacidaemia. Sepsis was induced...
Valeria Iansante et al.
Nature communications, 6, 7882-7882 (2015-08-11)
Most tumour cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and evade apoptosis. Intriguingly, the molecular mechanisms that link the Warburg effect with the suppression of apoptosis are not well understood. In this study, using loss-of-function studies...
Scott McComb et al.
Journal of immunology (Baltimore, Md. : 1950), 192(12), 5671-5678 (2014-05-07)
It has recently been shown that programmed necrosis, necroptosis, may play a key role in the development of inflammation. Deciphering the regulation of this pathway within immune cells may therefore have implications in pathology associated with inflammatory diseases. We show...
Sean P Sherman et al.
PloS one, 8(1), e54948-e54948 (2013-02-06)
Differentiated cells from human embryonic stem cells (hESCs) provide an unlimited source of cells for use in regenerative medicine. The recent derivation of human induced pluripotent cells (hiPSCs) provides a potential supply of pluripotent cells that avoid immune rejection and...
EpCAM induction functionally links to the Wnt-enhanced cell proliferation in human keratinocytes.
Shen CI, Lee HC, Kao YH, et al.
Cell Transplantation, 23(8), 1031-1044 (2014)
Sean M Howard et al.
PLoS genetics, 11(1), e1004943-e1004943 (2015-01-30)
Alternative end joining (Alt-EJ) chromosomal break repair involves bypassing classical non-homologous end joining (c-NHEJ), and such repair causes mutations often with microhomology at the repair junction. Since the mediators of Alt-EJ are not well understood, we have sought to identify...
Elisa Ceccherini et al.
Journal of cellular biochemistry, 116(5), 856-863 (2014-12-19)
Glioblastoma (GB) is the most common and aggressive primary tumor of the central nervous system. The current standard of care for GB consists of surgical resection, followed by radiotherapy combined with temozolomide chemotherapy. However, despite this intensive treatment, the prognosis...
Ke Fang et al.
Human molecular genetics, 23(12), 3278-3288 (2014-02-04)
Long non-coding RNAs (lncRNAs) have been recently found to be pervasively transcribed in human genome and link to diverse human diseases. However, the expression patterns and regulatory roles of lncRNAs in hematopoietic malignancies have not been reported. Here, we carried...
Kejian Zhang et al.
Molecular medicine reports, 11(1), 639-644 (2014-10-22)
Survivin is a promising anticancer therapeutic target due to its important role in the inhibition of apoptosis of tumor cells. However, little is currently known about its role in non small cell lung cancer (NSCLC). The present study evaluated whether...
Anuja Chattopadhyay et al.
Molecular cancer research : MCR, 12(9), 1283-1291 (2014-07-19)
A subset of acute promyelocytic leukemia (APL) cases has been characterized by the t(5;17)(q35;q21) translocation variant, which fuses nucleophosmin (NPM) to retinoic acid receptor α (RARA). The resultant NPM-RAR fusion protein blocks myeloid differentiation and leads to a leukemic phenotype...
Antonella Cusimano et al.
Oncotarget, 6(3), 1707-1722 (2015-01-19)
Hepatocellular carcinoma (HCC) is characterized by limited response to current drug therapies. Here, we report that SC66, a novel AKT inhibitor, reduced cell viability in a dose- and time-dependent manner, inhibited colony formation and induced apoptosis in HCC cells. SC66...
Junping Zhong et al.
Nanomedicine : nanotechnology, biology, and medicine, 11(6), 1499-1509 (2015-05-03)
Photoacoustic therapy using the large photoacoustic effect of agents for selectively killing cancer cells is demonstrated. Herein, a highly efficient photoacoustic treatment using gold nanorods (AuNRs) and its antitumor effect are reported. Folic acid conjugated AuNRs are designed to specifically...
Eiji Kotani et al.
The Journal of general virology, 96(Pt 7), 1947-1956 (2015-04-03)
Previous reports have indicated that the Bombyx mori nucleopolyhedrovirus (BmNPV) nucleic acid binding proteins BRO-B and BRO-E are expressed during the early stage of infection and that the BRO family likely supports the regulation of mRNA; however, no study has...
Seung Woo Lee et al.
Cancer letters, 360(2), 195-204 (2015-02-15)
Temozolomide (TMZ) is an alkylating agent used for the treatment of glioblastoma. The late autophagy inhibitor chloroquine (CQ) inhibits glioblastoma tumors in a p53-independent and p53-dependent manner. We addressed a possible beneficial effect of combination treatment with TMZ and CQ...
Donato Cosco et al.
International journal of pharmaceutics, 489(1-2), 1-10 (2015-04-23)
Ultradeformable liposomes represent useful formulations able to increase the skin permeation of drug compounds. In this study, resveratrol- and 5-fluorouracil-loaded ultradeformable liposomes were investigated for the potential treatment of non-melanoma skin cancer. The in vitro anticancer activity of ultradeformable liposomes...
Wei Liu et al.
Oncology reports, 32(5), 1853-1860 (2014-08-15)
Hiwi, also named PiwiL1, is a human homologue of the Piwi family which is associated with stem cells and is overexpressed in several types of cancers. In the present study, we aimed to investigate the role of Hiwi in cervical...
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