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p4394
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Yinu Wang et al.
Cancer research, 74(17), 4922-4936 (2014-07-19)
Emerging results indicate that cancer stem-like cells contribute to chemoresistance and poor clinical outcomes in many cancers, including ovarian cancer. As epigenetic regulators play a major role in the control of normal stem cell differentiation, epigenetics may offer a useful
Shenxu Wang et al.
Experimental lung research, 40(8), 404-414 (2014-08-26)
To investigate the effect of cisplatin on the growth and metastasis abilities of lung cancer stem cells (CSCs) via molecular imaging. The expression changes of lung CSCs cell marker in A549-Luc-C8 human non-small-cell lung cancer (NSCLC) cell line with or
Bapurao Surnar et al.
Nanoscale, 7(42), 17964-17979 (2015-10-16)
Platinum drug delivery against the detoxification of cytoplasmic thiols is urgently required for achieving efficacy in breast cancer treatment that is over expressed by glutathione (GSH, thiol-oligopeptide). GSH-resistant polymer-cisplatin core-shell nanoparticles were custom designed based on biodegradable carboxylic functional polycaprolactone
Yan Wang et al.
Biochemical pharmacology, 90(4), 356-366 (2014-06-15)
Ovarian cancer is commonly treated with anticancer agents; however, many tumors become resistant. Resistance is regulated, in part, by P-glycoprotein, which is encoded by the gene multiple drug resistance 1 (MDR1) and functions as a transmembrane efflux pump for the
Maire F Osborn et al.
ACS chemical biology, 9(10), 2404-2411 (2014-07-24)
With the importance of RNA-based regulatory pathways, the potential for targeting noncoding and coding RNAs by small molecule therapeutics is of great interest. Platinum(II) complexes including cisplatin (cis-diamminedichloroplatinum(II)) are widely prescribed anticancer compounds that form stable adducts on nucleic acids.
Yu-Jen Cheng et al.
Oncotarget, 5(22), 11564-11575 (2014-10-27)
Adjuvant chemotherapy is commonly given to surgically treated non-small-cell lung cancer (NSCLC) patients. However, the prerequisite for chemotherapy needs to be scrutinized in order to maximize the benefits to patients. In this study, we observed that NSCLC cells with high
Toshiaki Yasui et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 40(12), 2229-2231 (2014-01-08)
The patient was a 50-year-old man diagnosed as having a large type 3 advanced gastric cancer with para-aortic lymph node metastasis and with positive peritoneal cytology. We administered a combined systemic and intraperitoneal chemotherapy involving docetaxel, cisplatin, and S-1 (DCS).
Mariana Segovia-Mendoza et al.
BMC cancer, 15, 21-21 (2015-01-28)
Over the past few years, the concurrent use of cisplatin-based chemotherapy and radiation therapy has dramatically improved the local response and increased overall survival in early-stage cervical cancer. However, for the advanced stages of the disease this standard treatment has
Yoriko Murata et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 40(7), 933-936 (2013-07-19)
A 67-year-old woman was diagnosed as having advanced gastric cancer(poorly differentiated adenocarcinoma)with multiple liver metastases. She had received combined S-1 plus cisplatin chemotherapy as first-line treatment and weekly paclitaxel chemotherapy as second-line treatment, however, both had eventually proved ineffective. Because
Zhimin Huang et al.
Life sciences, 222, 78-87 (2019-02-25)
Acute kidney injury (AKI) can limit the clinical use of cisplatin in cancer treatment. The drivers of cisplatin-induced AKI include oxidative stress, mitochondrial dysfunction and apoptosis. Previous studies showed renalase protected cultured human renal proximal tubular cell (HK-2) against cisplatin
Daniela Tosoni et al.
The Journal of cell biology, 211(4), 845-862 (2015-11-26)
The cell fate determinant Numb orchestrates tissue morphogenesis and patterning in developmental systems. In the human mammary gland, Numb is a tumor suppressor and regulates p53 levels. However, whether this function is linked to its role in fate determination remains
Lamiaa A Ahmed et al.
PloS one, 9(10), e108889-e108889 (2014-10-02)
Mitochondrial dysfunction is a crucial mechanism by which cisplatin, a potent chemotherapeutic agent, causes nephrotoxicity where mitochondrial electron transport complexes are shifted mostly toward imbalanced reactive oxygen species versus energy production. In the present study, the protective role of tempol
Xinli Huang et al.
Molecular medicine reports, 10(4), 2153-2159 (2014-08-15)
Previous studies revealed that Kanglaite (KLT) exhibits antitumor and immunomodulatory activities. In the present study, we show that KLT treatment stimulated the immune response by increasing the number of T cells and natural killer (NK) cells in the blood of
Monica K VanKlompenberg et al.
BMC cancer, 15, 457-457 (2015-06-08)
The Adenomatous Polyposis Coli (APC) tumor suppressor is mutated or hypermethylated in up to 70% of sporadic breast cancers depending on subtype; however, the effects of APC mutation on tumorigenic properties remain unexplored. Using the ApcMin/+ mouse crossed to the
Lucie Koubkova et al.
Investigational new drugs, 33(5), 1123-1132 (2015-07-25)
Ovarian cancer is the seventh-most common cancer amongst women and the most deadly gynecologic cancer. Cisplatin based drugs are used in first line therapy, but resistance represents a major obstacle for successful treatment. In this study, we investigated the anticancer
Jolanta Saczko et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 68(5), 573-580 (2014-07-01)
High electric field, applied to plasma membrane, affects organization of the lipid molecules, generating transient hydrophilic electropores. The application of the cell membrane electroporation in combination with cytotoxic drugs could increase the drug transport into cells. This approach is known
Jin Gu Lee et al.
Respiratory research, 16, 138-138 (2015-11-11)
The development of chemo-resistance in non-small lung cancer is a major obstacle in treating patients. Hypoxia is a commonly faced microenvironment in solid tumor and suggested to be related to both autophagy and chemo-resistance. In this study, we investigated the
Guillaume Luc et al.
American journal of surgery, 210(1), 15-23 (2015-05-10)
The aim of this study was to determine the clinical impact of postoperative chemotherapy (POC) in patients with locally advanced gastroesophageal adenocarcinoma and determine the predictors of delivery of planned POC. All consecutive patients with locally advanced gastroesophageal adenocarcinoma treated
Zhongwu Li et al.
Laboratory investigation; a journal of technical methods and pathology, 94(12), 1431-1445 (2014-10-07)
The polycomb complex protein Bmi1 (B lymphoma Mo-MLV insertion region 1 homolog) mediates epigenetic transcriptional silencing by modifying chromatin structure and is critical for stem cell homeostasis and tumorigenesis. Bmi1 is frequently overexpressed in human malignancies and therefore has key
Szu-Jung Chen et al.
Biochemical pharmacology, 95(1), 28-37 (2015-03-25)
The platinum-based regimen is the front-line treatment of chemotherapy. However, development of platinum resistance often causes therapeutic failure in this disease. We previously have generated an oxaliplatin-resistant subline, named S3, from human cervical carcinoma SiHa cells, and its resistant phenotype
Jau-Ling Huang et al.
Mutagenesis, 30(4), 475-485 (2015-03-07)
The human JC virus (JCV) is potentially carcinogenic to humans as a Group 2B carcinogen, and it is ubiquitous in human populations. To investigate whether the small tumour (ST) antigen of the JCV contributes to genomic instability, we established cell
Wolfgang Hohenforst-Schmidt et al.
Journal of Cancer, 5(5), 344-350 (2014-04-12)
Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local
Christopher G England et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 92, 120-129 (2015-03-11)
Gold nanoparticles functionalized with biologically compatible layers may achieve stable drug release while avoiding adverse effects in cancer treatment. We study cisplatin and paclitaxel release from gold cores functionalized with hexadecanethiol (TL) and phosphatidylcholine (PC) to form two-layer nanoparticles, or
Jong-Lyel Roh et al.
Apoptosis : an international journal on programmed cell death, 19(11), 1594-1602 (2014-08-13)
Head and neck cancer (HNC), one of the most common cancers worldwide, frequently involves mutation of the TP53 gene and dysregulation of the p53 pathway. Overexpression of MDM2 or MDM4 inactivates the tumor-suppressive function of p53. Restoration of p53 function
Akiko Morimoto et al.
Oncotarget, 5(17), 7776-7787 (2014-10-04)
Platinum resistance has long been a major issue in the treatment of various cancers. We previously reported that enhanced annexin A4 (ANXA4) expression, a Ca2+-regulated phospholipid-binding protein, induces chemoresistance to platinum-based drugs. In this study, we investigated the role of
Sayo Horibe et al.
Life sciences, 124, 31-40 (2015-01-28)
Cisplatin (CDDP) is a platinum-based drug that is widely used in cancer chemotherapy, but the development of resistance in tumor cells is a major weakness of these treatments. Several mechanisms have been proposed to explain cisplatin resistance, and disruption of
Ken Fujimura et al.
Cancer research, 74(22), 6671-6681 (2014-09-28)
Deregulation of protein synthesis is a hallmark of cancer cell proliferation, survival, and metastatic progression. eIF5A1 and its highly related isoform eIF5A2 are translation initiation factors that have been implicated in a range of human malignancies, but how they control
E2F1-regulated DROSHA promotes miR-630 biosynthesis in cisplatin-exposed cancer cells.
Cao JX, Li SY, An GS, et al.
Biochemical and Biophysical Research Communications, 450(1), 470-475 (2014)
Lin-Hai Yan et al.
American journal of cancer research, 5(1), 321-332 (2015-01-30)
Modulator of multidrug resistance (MDR) gene is a direct transcriptional target of CDX2. However, we still speculate whether CDX2 affects MDR through other ways. In this study, a cisplatin-resistant (SGC7901/DDP) and a 5-fluoro-2, 4(1h,3h)pyrimidinedione-resistant (BGC823/5-FU) gastric cancer cell line with
R A Singh et al.
Biochimica et biophysica acta, 1405(1-3), 171-179 (1998-10-24)
Cisplatin [cis-dichlorodiammine platinum (II)], a potent chemoimmunotherapeutic drug, activates macrophages to tumoricidal state which is inhibited by protein tyrosine kinase(s) inhibitor. Cisplatin induces protein tyrosine phosphorylation of a number of cellular proteins suggesting the involvement of protein tyrosine kinase(s) in
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