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Kamil Wojciechowski et al.
Biochimica et biophysica acta, 1838(7), 1931-1940 (2014-04-22)
The interactions between a model phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and a biosurfactant Quillaja Bark Saponin (QBS) obtained from the bark of Quillaja saponaria Molina were studied using simple models of biological membranes. QBS is known to interact strongly with the latter
Formulation and pharmacokinetics of thermosensitive stealth® liposomes encapsulating 5-Fluorouracil.
Chantal Al Sabbagh et al.
Pharmaceutical research, 32(5), 1585-1603 (2014-11-25)
We optimize the encapsulation and investigate the pharmacokinetics of 5-Fluorouracil (5-FU) delivered by thermosensitive stealth(®) liposomes (TSLs) designed to trigger drug release upon hyperthermia using focused ultrasound (FUS). 5-FU was encapsulated into liposomes made of 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine/cholesterol/1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-PEG2000 either as a free
M A Morini et al.
Colloids and surfaces. B, Biointerfaces, 131, 54-58 (2015-05-08)
The purpose of the work is to compare the influence of the multilamellarity, phase state, lipid head groups and ionic media on the origin of the surface potential of lipid membranes. With this aim, we present a new analysis of
Matthew C Blosser et al.
Biophysical journal, 109(11), 2317-2327 (2015-12-05)
When micron-scale compositional heterogeneity develops in membranes, the distribution of lipids on one face of the membrane strongly affects the distribution on the other. Specifically, when lipid membranes phase separate into coexisting liquid phases, domains in each monolayer leaflet of
B Gumí-Audenis et al.
Journal of synchrotron radiation, 22(6), 1364-1371 (2015-11-03)
A fast atomic force microscope (AFM) has been developed that can be installed as a sample holder for grazing-incidence X-ray experiments at solid/gas or solid/liquid interfaces. It allows a wide range of possible investigations, including soft and biological samples under
R L DeAngelis et al.
Clinics in perinatology, 20(4), 697-710 (1993-12-01)
This article provided a brief overview of synthetic surfactants and DPPC metabolism, and summarized disposition data on the most widely used synthetic surfactant, CPHT (colfosceril palmitate, hexadecanol, and tyloxapol; Exosurf Neonatal, Burroughs Wellcome Co.). In separate experiments, young male rabbits
Nilesh Gupta et al.
International journal of pharmaceutics, 488(1-2), 33-43 (2015-04-19)
The present study investigated the feasibility of encapsulating two drugs, fasudil and superoxide dismutase (SOD), into liposomes for targeted and inhalational delivery to the pulmonary vasculature to treat pulmonary arterial hypertension (PAH). Nanosized liposomes were prepared by a thin-film formation
Cedar H A Boakye et al.
International journal of pharmaceutics, 489(1-2), 106-116 (2015-04-26)
The objectives of this study were to develop an innovative investigative model using doxorubicin as a fluorophore to evaluate the skin permeation of nanocarriers and the impact of size and surface characteristics on their permeability. Different doxorubicin-loaded liposomes with mean
Agustín Mangiarotti et al.
Biochimica et biophysica acta, 1838(7), 1823-1831 (2014-03-04)
For the biophysical study of membranes, a variety of model systems have been used to measure the different parameters and to extract general principles concerning processes that may occur in cellular membranes. However, there are very few reports in which
Ekaterina L Nemashkalova et al.
Biochemistry, 52(36), 6286-6299 (2013-08-21)
HAMLET is a complex of human α-lactalbumin (hLA) with oleic acid (OA) that kills various tumor cells and strains of Streptococcus pneumoniae. More potent protein-OA complexes were previously reported for bovine α-lactalbumin (bLA) and β-lactoglobulin (bLG), and pike parvalbumin (pPA)
Colfosceril in an infant with adult respiratory distress syndrome.
C Y Chan et al.
Clinical pharmacy, 11(10), 880-882 (1992-10-01)
Alex J Sodt et al.
The Journal of chemical physics, 132(20), 205103-205103 (2010-06-03)
We develop a coarse-grained parametrization strategy for lipid membranes that we illustrate for a dipalmitoylphosphatidylcholine bilayer. Our coarse-graining approach eliminates the high cost of explicit solvent but maintains more lipid interaction sites. We use a broad attractive tail-tail potential and
Xu Hannah Zhang et al.
Journal of cell science, 120(Pt 23), 4134-4143 (2007-11-23)
The G1 phase of the cell cycle is marked by the rapid turnover of phospholipids. This turnover is regulated by CTP:phosphocholine-cytidylyltransferase (CCT) and group VIA Ca(2+)-independent-phospholipase A(2) (iPLA(2)). We previously reported that inhibition of iPLA(2) arrests cells in G1 phase
R H Pfister et al.
The Cochrane database of systematic reviews, (3)(3), CD006069-CD006069 (2007-07-20)
Respiratory distress syndrome (RDS) is a significant cause of morbidity and mortality in preterm infants. RDS is caused by a deficiency, dysfunction, or inactivation of pulmonary surfactant. Numerous surfactants of either animal extract or synthetic design have been shown to
H M Bryson et al.
PharmacoEconomics, 6(6), 563-577 (1994-11-04)
Comprehensive clinical data provide strong evidence of the efficacy of the synthetic lung surfactant colfosceril palmitate (Exosurf Neonatal) administered as prophylaxis or rescue therapy in infants with respiratory distress syndrome (RDS). The use of rescue therapy with colfosceril palmitate is
Patrick Kee et al.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 17(3), 328-336 (2014-10-11)
Macrophage plays an important role in plaque destabilization in atherosclerosis. By harnessing the affinity of macrophages to certain phospholipid species, a liposomal contrast agent containing phosphatidylserine (PS) and X-ray computed tomographic (CT) contrast agent was prepared and evaluated for CT
Merel van Elk et al.
PloS one, 10(11), e0141626-e0141626 (2015-11-13)
The objective of this study was to develop and characterize alginate microspheres suitable for embolization with on-demand triggered doxorubicin (DOX) release and whereby the microspheres as well as the drug releasing process can be visualized in vivo using MRI. For
Tonya N Zeczycki et al.
Biochemical and biophysical research communications, 450(1), 366-371 (2014-06-07)
It is essential to understand the role of cardiolipin (CL) in mitochondrial membrane organization given that changes in CL levels contribute to mitochondrial dysfunction in type II diabetes, ischemia-reperfusion injury, heart failure, breast cancer, and aging. Specifically, there are contradictory
Mark E Lobatto et al.
ACS nano, 9(2), 1837-1847 (2015-01-27)
Atherosclerosis is a major cause of global morbidity and mortality that could benefit from novel targeted therapeutics. Recent studies have shown efficient and local drug delivery with nanoparticles, although the nanoparticle targeting mechanism for atherosclerosis has not yet been fully
Olga Wesołowska et al.
Biochimica et biophysica acta, 1838(1 Pt B), 173-184 (2013-09-26)
Common hop (Humulus lupulus) constitutes a source of numerous prenylated chalcones such as xanthohumol (XH) and flavanones such as 8-prenylnaringenin (8-PN) and isoxanthohumol (IXH). Range of their biological activities includes estrogenic, anti-inflammatory, anti-infective, anti-cancer, and antioxidant activities. The aim of
Edyta Paszko et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(1-2), 202-210 (2012-11-20)
Photodynamic therapy (PDT) is based on the delivery of photocytotoxic agents to a target tissue, followed by irradiation. In order to increase the efficiency of PDT in oesophageal cancer therapy, polyethylene glycol (PEG)-grafted, transferrin (Tf)-conjugated liposome formulations of 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (Foscan)
Anthony Novell et al.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 31(4), 349-358 (2015-02-14)
Focused ultrasound (FUS) is a versatile technology for non-invasive thermal therapies in oncology. Indeed, this technology has great potential for local heat-mediated drug delivery from thermosensitive liposomes (TSLs), thus improving therapeutic efficacy and reducing toxicity profiles. In the present study
Lu Zhang et al.
ACS nano, 9(10), 9912-9921 (2015-10-09)
The functionalized lipid shell of hybrid nanoparticles plays an important role for improving their biocompatibility and in vivo stability. Yet few efforts have been made to critically examine the shell structure of nanoparticles and its effect on cell-particle interaction. Here
Sangmin Lee et al.
ACS nano, 8(5), 4257-4267 (2014-04-24)
In general, traditional gene carriers contain strong cationic charges to efficiently load anionic genes, but this cationic character also leads to destabilization of plasma membranes and causes severe cytotoxicity. Here, we developed a PCR-based nanofactory as a safe gene delivery
Ioannis G Theodorou et al.
Environmental science & technology, 49(13), 8048-8056 (2015-06-11)
The increase of production volumes of silver nanowires (AgNWs) and of consumer products incorporating them may lead to increased health risks from occupational and public exposures. There is currently limited information about the putative toxicity of AgNWs upon inhalation and
Feng Yi et al.
Journal of pharmaceutical sciences, 103(11), 3442-3447 (2014-09-27)
The phase transition evolution with hydration of a model system, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), was investigated with a fast nanocalorimetry system. Using nanocalorimetry, it is possible to measure the gel to liquid phase transitions that occur on millisecond to second time scales
Hussaini Syed Sha Qhattal et al.
ACS nano, 8(6), 5423-5440 (2014-05-09)
Hyaluronan-grafted liposomes (HA-liposomes) preferentially target CD44-overexpressing tumor cells in vitro via receptor-mediated endocytosis. We investigated the pharmacokinetics and biodistribution of HA-liposomes with various sizes of HA (MW 5-8, 50-60, and 175-350 kDa) in mice. Incorporation of negatively charged HA on
Aranya Manosroi et al.
Journal of liposome research, 19(2), 131-140 (2009-06-12)
The luciferase gene expression of lipoplexes, a liposome containing luciferase plasmid (pCMVLuc), in HeLa cell lines, was investigated. Cationic liposomes were prepared by the chloroform film method with sonication. The lipoplex was formed by loading the liposome with pCMVLuc. The
Maayke M P Kuijten et al.
Scientific reports, 5, 17220-17220 (2015-11-28)
Liposomes are spherical, self-closed structures formed by lipid bilayers that can encapsulate drugs and/or imaging agents in their hydrophilic core or within their membrane moiety, making them suitable delivery vehicles. We have synthesized a new liposome containing gadolinium-DOTA lipid bilayer
Martta Asikainen et al.
Bioresource technology, 191, 300-305 (2015-05-26)
Bio-based fuels are becoming more and more important due to the depleting fossil resources. The production of biodiesel from algae oil is challenging compared to terrestrial vegetable oils, as algae oil consists of polar fatty acids, such as phospholipids and
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