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Yujin E Kim et al.
Nature protocols, 5(8), 1396-1405 (2010-07-31)
Applications for noninvasive real-time imaging of apoptosis and neuronal degeneration are hindered by technical limitations in imaging strategies and by existing probes. Monitoring the progression of a cell through apoptosis could provide valuable insight into the temporal events that initiate
Cedric A J Hutter et al.
Nature communications, 10(1), 2260-2260 (2019-05-23)
ABC exporters harness the energy of ATP to pump substrates across membranes. Extracellular gate opening and closure are key steps of the transport cycle, but the underlying mechanism is poorly understood. Here, we generated a synthetic single domain antibody (sybody)
S Fiorucci et al.
Gut, 38(2), 182-189 (1996-02-01)
The tumour necrosis factor alpha (TNF), has been implicated in the pathogenesis of non-steroidal anti-inflammatory drug (NSAID) induced gastropathy and Helicobacter pylori induced gastritis. Both conditions are characterised by high plasma pepsinogen concentrations, which are thought to reflect an increased
Nils Möller et al.
PloS one, 15(5), e0233854-e0233854 (2020-05-30)
Alpha-toxin (Hla) is a major virulence factor of Staphylococcus aureus (S. aureus) and plays an important role in S. aureus-induced pneumonia. It binds as a monomer to the cell surface of eukaryotic host cells and forms heptameric transmembrane pores. Sensitivities
Wei Li et al.
Cellular & molecular immunology, 13(4), 514-523 (2015-04-29)
Bacterial flagellin is a unique pathogen-associated molecular pattern (PAMP), which can be recognized by surface localized Toll-like receptor 5 (TLR5) and the cytosolic NOD-like receptor (NLR) protein 4 (NLRC4) receptors. Activation of the TLR5 and/or NLRC4 signaling pathways by flagellin
Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis
Zhang YL, et al.
The Journal of biological chemistry, 281(49), 37603-37615 (2006)
Yosuke Omae et al.
PloS one, 9(5), e97670-e97670 (2014-05-17)
Staphylococcus aureus forms giant colonies on soft-agar surfaces, which is called colony-spreading. In the present study, we searched for host factors that influence S. aureus colony-spreading activity. The addition of calf serum, porcine serum, or silkworm hemolymph to soft-agar medium
Chek K Tan et al.
Journal of the American Heart Association, 2(3), e000269-e000269 (2013-06-21)
Ninety percent of the patients carrying distinct SMAD3 mutations develop aortic aneurysms and dissections, called aneurysms-osteoarthritis syndrome (AOS). However, the etiology and molecular events downstream of SMAD3 leading to the pathogenesis of aortic aneurysms in these patients still remain elusive.
Marine omega-3 phospholipids: metabolism and biological activities
Burri L, et al.
International Journal of Molecular Sciences, 13(11), 15401-15419 (2012)
George G Schweitzer et al.
Journal of lipid research, 56(4), 848-858 (2015-02-28)
Lipin proteins (lipin 1, 2, and 3) regulate glycerolipid homeostasis by acting as phosphatidic acid phosphohydrolase (PAP) enzymes in the TG synthesis pathway and by regulating DNA-bound transcription factors to control gene transcription. Hepatic PAP activity could contribute to hepatic
Xu Hannah Zhang et al.
Journal of cell science, 120(Pt 23), 4134-4143 (2007-11-23)
The G1 phase of the cell cycle is marked by the rapid turnover of phospholipids. This turnover is regulated by CTP:phosphocholine-cytidylyltransferase (CCT) and group VIA Ca(2+)-independent-phospholipase A(2) (iPLA(2)). We previously reported that inhibition of iPLA(2) arrests cells in G1 phase
Nicole Mayer et al.
Bioorganic & medicinal chemistry, 23(12), 2904-2916 (2015-03-18)
Adipose triglyceride lipase (ATGL) catalyzes the degradation of cellular triacylglycerol stores and strongly determines the concentration of circulating fatty acids (FAs). High serum FA levels are causally linked to the development of insulin resistance and impaired glucose tolerance, which eventually
Chen-Lun Liu et al.
Chemistry and physics of lipids, 164(2), 125-130 (2010-12-22)
The amount of cholesterol (Ch) crystals formed in supersaturated taurochenodeoxycholate (TCDC) - lecithin (L) solutions of the same Ch saturation index (CSI) but at different Ch thermodynamic activities (Ch A(T)) was quantified at different time intervals. The initial Ch nucleation
Na Sun et al.
Journal of food science, 84(5), 1002-1011 (2019-04-13)
Although phosphatidylethanolamine (PE) is an important functional phospholipid, there have been very few reports on its antioxidant activity and corresponding molecular composition. Crude PE was extracted from egg yolk with various solvents, and response surface modeling was carried out to
Harald Steiner et al.
The Journal of biological chemistry, 283(50), 34677-34686 (2008-09-20)
Gamma-secretase is an intramembrane cleaving aspartyl protease complex intimately implicated in Alzheimer disease pathogenesis. The protease is composed of the catalytic subunit presenilin (PS1 or PS2), the substrate receptor nicastrin (NCT), and two additional subunits, APH-1 (APH-1a, as long and
Zachary J Smith et al.
Journal of extracellular vesicles, 4, 28533-28533 (2015-12-10)
Current analysis of exosomes focuses primarily on bulk analysis, where exosome-to-exosome variability cannot be assessed. In this study, we used Raman spectroscopy to study the chemical composition of single exosomes. We measured spectra of individual exosomes from 8 cell lines.
Alexander Wacker et al.
Frontiers in plant science, 7, 264-264 (2016-03-26)
We tested the influence of two light intensities [40 and 300 μmol PAR / (m(2)s)] on the fatty acid composition of three distinct lipid classes in four freshwater phytoplankton species. We chose species of different taxonomic classes in order to
M Mari et al.
The Journal of biological chemistry, 276(45), 42501-42508 (2001-08-18)
Rabip4 is a Rab4 effector, which possesses a RUN domain, two coiled-coil domains, and a FYVE finger. It is associated with the early endosomes and leads, in concert with Rab4, to the enlargement of endosomes, resulting in the fusion of
Jeffrey W Simkins et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 293, 123-133 (2018-06-26)
19F magnetic resonance has been used in the medical field for quantifying oxygenation in blood, tissues, and tumors. The 19F NMR oximetry technique exploits the affinity of molecular oxygen for liquid fluorocarbon phases, and the resulting linear dependence of 19F
Nobuto Kakuda et al.
The Journal of biological chemistry, 281(21), 14776-14786 (2006-04-06)
We showed previously that cells expressing wild-type (WT) beta-amyloid precursor protein (APP) or coexpressing WTAPP and WT presenilin (PS) 1/2 produced APP intracellular domains (AICD) 49-99 and 50-99, with the latter predominating. On the other hand, the cells expressing mutant
Sławomir Lewicki et al.
Journal of liposome research, 27(2), 90-98 (2017-01-10)
Liposomes are used for encapsulation of the active compounds in different therapies, with the increasing frequency. The important areas of clinical applications of liposomes are cancer targeted treatment, antibiotic delivery or regenerative medicine. The liposomes can transfer both hydrophilic and
Stephan Laggai et al.
World journal of hepatology, 5(10), 558-567 (2013-11-02)
To establish a simple method to quantify lipid classes in liver diseases and to decipher the lipid profile in p62/IMP2-2/IGF2BP2-2 transgenic mice. Liver-specific overexpression of the insulin-like growth factor 2 mRNA binding protein p62/IMP2-2/IGF2BP2-2 was used as a model for
Lea M Hürlimann et al.
Antimicrobial agents and chemotherapy, 60(9), 5400-5411 (2016-07-07)
Nosocomial infections with Enterococcus faecalis are an emerging health problem. However, drug efflux pumps contributing to intrinsic drug resistance are poorly studied in this Gram-positive pathogen. In this study, we functionally investigated seven heterodimeric ABC transporters of E. faecalis that
Sarah E Stewart et al.
The Journal of biological chemistry, 290(52), 31101-31112 (2015-11-07)
Perforin is an essential component in the cytotoxic lymphocyte-mediated cell death pathway. The traditional view holds that perforin monomers assemble into pores in the target cell membrane via a calcium-dependent process and facilitate translocation of cytotoxic proteases into the cytoplasm
FTIR-spectroscopic characterization of phosphocholine-headgroup model compounds
Pohle W, et al.
Journal of Molecular Structure, 563, 463-467 (2001)
Kelly Varga et al.
Journal of neurochemistry, 152(1), 48-60 (2019-10-07)
Phosphatidylserine (PS), a negatively charged phospholipid present predominantly at the inner leaflet of the plasma membrane, has been widely implicated in many cellular processes including membrane trafficking. Along this line, PS has been demonstrated to be important for endocytosis, however
Jin Lee et al.
American journal of physiology. Gastrointestinal and liver physiology, 285(3), G630-G641 (2003-05-30)
Gallbladder epithelial cells (GBEC) are exposed to high and fluctuating concentrations of biliary cholesterol on their apical (AP) surface. GBEC absorb and efflux cholesterol, but the mechanisms of cholesterol uptake, intracellular trafficking, and efflux in these cells are not known.
Stephania Aragón-Rojas et al.
Food & function, 11(3), 2339-2348 (2020-03-03)
The goal of this study was to determine the effect of the carrier material, drying technology and dissolution media during the passage of L. fermentum K73 through a dynamic in vitro digestion system (IViDiS). The carrier materials were (i) culture
Yuan-Li Zhang et al.
The Journal of biological chemistry, 281(49), 37603-37615 (2006-09-15)
Insulin-resistant apoB/BATless mice have hypertriglyceridemia because of increased assembly and secretion of very low density apolipoprotein B (apoB) and triglycerides compared with mice expressing only apoB (Siri, P., Candela, N., Ko, C., Zhang, Y., Eusufzai, S., Ginsberg, H. N., and
Ohr plays a central role in bacterial responses against fatty acid hydroperoxides and peroxynitrite.
Thiago G P Alegria et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(2), E132-E141 (2016-12-29)
Organic hydroperoxide resistance (Ohr) enzymes are unique Cys-based, lipoyl-dependent peroxidases. Here, we investigated the involvement of Ohr in bacterial responses toward distinct hydroperoxides. In silico results indicated that fatty acid (but not cholesterol) hydroperoxides docked well into the active site
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