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Jéssica Arribas et al.
Apoptosis : an international journal on programmed cell death, 20(10), 1338-1346 (2015-07-29)
T-box genes regulate development processes, some of these genes having also a role in cell proliferation and survival. TBX15 is a T-box transcription factor that, recently, has been proposed as a marker in prostate cancer, but its function in carcinogenesis
Gulcin Tezcan et al.
Cellular and molecular neurobiology, 35(2), 175-187 (2014-09-13)
Glioblastoma multiforme (GBM) is one of the deadliest human malignancies. A cure for GBM remains elusive, and the overall survival time is less than 1 year. Thus, the development of more efficient therapeutic approaches for the treatment of these patients
David A Magee et al.
Tuberculosis (Edinburgh, Scotland), 94(4), 441-450 (2014-06-03)
Despite sharing >99.9% genome sequence similarity at the nucleotide level, Mycobacterium tuberculosis and Mycobacterium bovis-the causative agents of human and bovine tuberculosis, respectively-exhibit distinct host preferences. M. bovis can cause disease in both cattle and humans yet rarely transmits between
Liu Ying et al.
Cancer chemotherapy and pharmacology, 76(3), 641-650 (2015-08-01)
Transforming growth factor-β-activating kinase 1 (TAK1) has been implicated in promoting ovarian cancer progression. Here, we evaluated the anti-ovarian cancer effect of LYTAK1, a novel and specific TAK1 inhibitor. Established or primary human ovarian cancer cells were treated with LYTAK1
Rob S Burke et al.
Pharmaceutical research, 31(12), 3445-3460 (2014-07-02)
To develop a tool based on siRNA-mediated knockdown of hepatic P450 oxidoreductase (POR) to decrease the CYP-mediated metabolism of small molecule drugs that suffer from rapid metabolism in vivo, with the aim of improving plasma exposure of these drugs. siRNA
Jian He et al.
The American journal of Chinese medicine, 43(2), 305-317 (2015-03-27)
Ginsenoside Rg1 has been reported to possess anti-inflammatory activities, but the effects of Rg1 on the shear induced MCP-1 upregulation mechanism on endothelial cells (ECs) remain to be determined. In this study, we show that Rg1 down modulates shear induced
Zhixu Ni et al.
Analytical and bioanalytical chemistry, 407(17), 5161-5173 (2015-02-24)
Oxidized lipids play a significant role in the pathogenesis of numerous oxidative stress-related human disorders, such as atherosclerosis, obesity, inflammation, and autoimmune diseases. Lipid peroxidation, induced by reactive oxygen and nitrogen species, yields a high variety of modified lipids. Among
Yoo Suk Kim et al.
Annals of biomedical engineering, 43(9), 2153-2162 (2015-02-01)
The role of three-dimensional (3D) printing has expanded in diverse areas in medicine. As plastic surgery needs to fulfill the different demands from diverse individuals, the applications of tailored 3D printing will become indispensable. In this study, we evaluated the
Ivy Wilkinson-Ryan et al.
PloS one, 10(5), e0125851-e0125851 (2015-05-02)
One strategy in cancer immunotherapy is to capitalize on the key immunoregulatory and antigen presenting capabilities of dendritic cells (DCs). This approach is dependent on efficient delivery of tumor specific antigens to DCs, which subsequently induce an anti-tumor T-cell mediated
Senthilkumar K Sakthivel et al.
Journal of immune based therapies and vaccines, 6, 6-6 (2008-10-30)
Alterations in serum CXCR3 ligand levels were examined in interstitial cystitis (IC) patients; similar expression patterns in serum as well as CXCR3, CXCR3 ligands, and cytokines expressed by peripheral and local leukocyte subpopulations were characterized during cyclophosphamide (CYP)-induced acute cystitis
Ezgi Bayram et al.
Artificial cells, nanomedicine, and biotechnology, 42(6), 418-422 (2013-07-25)
In the biosensor construction, 3-mercaptopropionic acid (3-MPA) and 6-aminocaproic acid (6-ACA) were used for forming self-assembled monolayer (SAM) on a gold disc electrode and pyruvate oxidase was immobilized on the modified electrode surface by using glutaraldehyde. Biosensor response is linearly
Kylie A Alexander et al.
The Journal of clinical investigation, 124(10), 4266-4280 (2014-08-27)
Chronic GVHD (cGVHD) is the major cause of late, nonrelapse death following stem cell transplantation and characteristically develops in organs such as skin and lung. Here, we used multiple murine models of cGVHD to investigate the contribution of macrophage populations
Han-Ning Huang et al.
Marine drugs, 13(5), 3241-3258 (2015-05-27)
Shrimp anti-lipopolysaccharide factor (SALF) is an antimicrobial peptide with reported anticancer activities, such as suppression of tumor progression. In this study, we prepared a potential cancer vaccine comprised of SALF in conjunction with the cell lysate of inactivated murine bladder
Bryan M Hooks et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(10), 4418-4426 (2015-03-13)
Cortical cells integrate synaptic input from multiple sources, but how these different inputs are distributed across individual neurons is largely unknown. Differences in input might account for diverse responses in neighboring neurons during behavior. We present a strategy for comparing
Bo Wei et al.
Journal of biomaterials applications, 30(2), 160-170 (2015-03-15)
The goal of this study was to investigate the chondrogenic potential of three-dimensional polycaprolactone-hydroxyapatite (PCL-HA) scaffolds loaded with bone marrow cells in vitro and the effect of PCL-HA scaffolds on osteochondral repair in vivo. Here, bone marrow was added to
A L Althaus et al.
Journal of neurophysiology, 113(4), 1184-1194 (2014-11-28)
Hilar ectopic dentate granule cells (DGCs) are a salient feature of aberrant plasticity in human temporal lobe epilepsy (TLE) and most rodent models of the disease. Recent evidence from rodent TLE models suggests that hilar ectopic DGCs contribute to hyperexcitability
G Herma Renkema et al.
European journal of human genetics : EJHG, 23(2), 202-209 (2014-05-02)
Defects in complex II of the mitochondrial respiratory chain are a rare cause of mitochondrial disorders. Underlying autosomal-recessive genetic defects are found in most of the 'SDHx' genes encoding complex II (SDHA, SDHB, SDHC, and SDHD) and its assembly factors.
Megan D Lee et al.
Molecular immunology, 63(2), 540-549 (2014-12-03)
Antigen engagement of the T-cell receptor (TCR) induces a rapid and dramatic decondensation of chromatin that is necessary for T-cell activation. This decondensation makes T-cells competent to respond to interleukin-2 providing a mechanism to ensure clonotypic proliferation during an immune
Janna Schneppenheim et al.
Biochemical and biophysical research communications, 451(1), 48-53 (2014-07-19)
The invariant chain (CD74) mediates targeting of the MHCII complex to endosomal compartments, where CD74 undergoes degradation allowing MHCII to acquire peptides. We demonstrated recently that intramembrane proteolysis of the final membrane-bound N-terminal fragment (NTF) of CD74 is catalyzed by
Philipp Müller et al.
Cancer immunology research, 2(8), 741-755 (2014-06-12)
Antibody-drug conjugates (ADC) are emerging as powerful treatment strategies with outstanding target-specificity and high therapeutic activity in patients with cancer. Brentuximab vedotin represents a first-in-class ADC directed against CD30(+) malignancies. We hypothesized that its sustained clinical responses could be related
Damián Pérez-Mazliah et al.
PLoS pathogens, 11(3), e1004715-e1004715 (2015-03-13)
Interleukin-21 signaling is important for germinal center B-cell responses, isotype switching and generation of memory B cells. However, a role for IL-21 in antibody-mediated protection against pathogens has not been demonstrated. Here we show that IL-21 is produced by T
Naveen K Jha et al.
PLoS pathogens, 7(1), e1001260-e1001260 (2011-02-02)
A large group of viruses rely on low pH to activate their fusion proteins that merge the viral envelope with an endosomal membrane, releasing the viral nucleocapsid. A critical barrier to understanding these events has been the lack of approaches
Tin Ngo et al.
BMC cell biology, 15, 30-30 (2014-07-24)
MXD3 is a basic-helix-loop-helix-leucine-zipper transcription factor involved in cellular proliferation. In previous studies we demonstrated that knock-down of MXD3 in the human medulloblastoma cell line DAOY resulted in decreased proliferation. Surprisingly, overexpression of MXD3 in DAOY cells also decreased proliferation
Masayuki Tsuneki et al.
Laboratory investigation; a journal of technical methods and pathology, 95(7), 765-780 (2015-05-12)
Microvascular endothelial cells cultured in three-dimensional hydrogel scaffolds form a network of microvessel structures when implanted subcutaneously in mice, inosculate with host vessels, and over time remodel into large ectatic vascular structures resembling hemangiomas. When compared with infantile hemangiomas, similarities
N Craig Carville et al.
Journal of biomedical materials research. Part A, 103(8), 2540-2548 (2014-12-17)
In this work, the influence of substrate surface charge on in vitro osteoblast cell proliferation on ferroelectric lithium niobate (LN) crystal surfaces is investigated. LN has a spontaneous polarization along the z-axis and is thus characterized by positive and negative
Lukasz Szoka et al.
Molecular and cellular biochemistry, 403(1-2), 51-60 (2015-01-30)
The oxythiamine (OXY) is antivitamin of thiamine. The finding that OXY increases the cytoplasmic concentration of pyruvate, known to enhance collagen biosynthesis, led us to investigate the mechanism of this antivitamin action on collagen biosynthesis in cultured human skin fibroblasts.
Yair Botbol et al.
Autophagy, 11(10), 1864-1877 (2015-09-24)
Macroautophagy is a cellular process that mediates degradation in the lysosome of cytoplasmic components including proteins and organelles. Previous studies have shown that macroautophagy is induced in activated T cells to regulate organelle homeostasis and the cell's energy metabolism. However
Helioswilton Sales-Campos et al.
International immunopharmacology, 26(1), 13-22 (2015-03-17)
Current therapies for inflammatory bowel disease (IBD) are not totally effective, resulting in persistent and recurrent disease for many patients. Mosquito saliva contains immunomodulatory molecules and therein could represent a novel therapy for IBD. Here, we demonstrated the therapeutic activity
Sally Hamour et al.
PloS one, 10(8), e0136238-e0136238 (2015-09-01)
IL-17 is a pro-inflammatory cytokine implicated in the pathogenesis of glomerulonephritis and IL-17 deficient mice are protected from nephrotoxic nephritis. However, a regulatory role for IL-17 has recently emerged. We describe a novel protective function for IL-17 in the kidney.
Thabe M Matsebatlela et al.
Chemico-biological interactions, 233, 95-105 (2015-04-07)
Didox (3,4-dihydroxy-benzohydroxamic acid), is a synthetic ribonucleotide reductase (RR) inhibitor derived from polyhydroxy-substituted benzohydroxamic acid, and originally developed as an anti-cancer agent. Some studies indicate that didox may have anti-oxidative stress-like properties, while other studies hint that didox may have
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