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p21005

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Agostino Marrazzo et al.
European journal of medicinal chemistry, 46(1), 433-438 (2010-11-09)
Complex mechanisms of prostate cancer progression prompt to novel therapeutic strategies concerning a combination of drugs or of single molecules able to interact with more crucial targets. Histone deacetylase inhibitors and sigma ligands with mixed σ(1) antagonist and σ(2) agonist
Nikhil N Kulkarni et al.
Molecular immunology, 63(2), 530-539 (2014-12-03)
Antimicrobial peptides (AMPs) constitute an indispensable arm of innate immunity against infectious microbes in humans. Induction of endogenous AMPs may become an alternative therapy against infections. Our previous studies have demonstrated phenylbutyrate (PBA) as a novel inducer of the AMPs
Gulab S Zode et al.
The Journal of clinical investigation, 124(5), 1956-1965 (2014-04-03)
Administration of glucocorticoids induces ocular hypertension in some patients. If untreated, these patients can develop a secondary glaucoma that resembles primary open-angle glaucoma (POAG). The underlying pathology of glucocorticoid-induced glaucoma is not fully understood, due in part to lack of
Gamze Bora-Tatar et al.
Bioorganic & medicinal chemistry, 17(14), 5219-5228 (2009-06-13)
In the light of known HDAC inhibitors, 33 carboxylic acid derivatives were tested to understand the structural requirements for HDAC inhibition activity. Several modifications were applied to develop the structure-activity relationships of carboxylic acid HDAC inhibitors. HDAC inhibition activities were
Tae Woo Jung et al.
Molecular and cellular endocrinology, 470, 26-33 (2017-11-08)
Hepassocin (HPS) has recently been identified as a novel hepatokine that causes hepatic steatosis. However, the role of HPS in the development of insulin resistance in skeletal muscle under obesity remains unclear. The effect of hyperlipidemia on hepatic HPS expression
Anaïs Szpigel et al.
Diabetologia, 61(2), 399-412 (2017-10-11)
Obesity and type 2 diabetes are concomitant with low-grade inflammation affecting insulin sensitivity and insulin secretion. Recently, the thioredoxin interacting protein (TXNIP) has been implicated in the activation process of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome.
Audrey Roy-Lachapelle et al.
Journal of agricultural and food chemistry, 63(33), 7440-7449 (2015-07-28)
Microcystins (MCs) are cyanobacterial toxins encountered in aquatic environments worldwide. Over 100 MC variants have been identified and have the capacity to covalently bind to animal tissue. This study presents a new approach for cell-bound and free microcystin analysis in
Xiefang Yuan et al.
Scientific reports, 8(1), 7950-7950 (2018-05-23)
Constant exposure to allergen triggers destructive type 2 cell-mediated inflammation. The effect of allergen specific immunotherapy (SIT) in maintaining airway epithelial barrier function in asthma remains unknown. In the current study, we showed that SIT maintained airway epithelial homeostasis in
Angela Lombardi et al.
The Journal of clinical endocrinology and metabolism, 100(1), E1-10 (2014-10-09)
Amiodarone (AMIO) is one of the most effective antiarrhythmic drugs available; however, its use is limited by a serious side effect profile, including thyroiditis. The mechanisms underlying AMIO thyroid toxicity have been elusive; thus, identification of novel approaches in order
Hazel M Girvan et al.
Journal of inorganic biochemistry, 188, 18-28 (2018-08-18)
The CYP152 family of cytochrome P450 enzymes (P450s or CYPs) are bacterial peroxygenases that use hydrogen peroxide to drive hydroxylation and decarboxylation of fatty acid substrates. We have expressed and purified a novel CYP152 family member - CYP152K6 from the
Consuelo Amantini et al.
Oncotarget, 8(53), 90766-90780 (2017-12-07)
Autophagy and the ubiquitin-proteasome system (UPS) control thymus cell homeostasis under resting and endoplasmic reticulum (ER) stress conditions. Several evidence support a cross-talk between UPS and autophagy; abrogation of UPS responses stimulates autophagy, and vice versa the inhibition of autophagy
Ricardo Moure et al.
Antimicrobial agents and chemotherapy, 62(6) (2018-04-18)
Following antiretroviral therapy, HIV-infected patients show increased circulating levels of the antidiabetic hormone fibroblast growth factor 21 (FGF21). In contrast, the expression of the FGF21-obligatory coreceptor β-Klotho (KLB) is reduced in target tissues. This situation is comparable to the FGF21
Kyoungsub Song et al.
Hepatology (Baltimore, Md.), 58(5), 1681-1692 (2013-05-25)
MicroRNA-122 (miR-122), a pivotal liver-specific miRNA, has been implicated in several liver diseases including hepatocellular carcinoma (HCC) and hepatitis C and B viral infection. This study aimed to explore epigenetic regulation of miR-122 in human HCC cells and to examine
Luigia Cinque et al.
The Journal of clinical endocrinology and metabolism, 102(11), 3961-3969 (2017-09-25)
Familial isolated hypoparathyroidism (FIH) is a genetically heterogeneous disorder due to mutations of the calcium-sensing receptor (CASR), glial cells missing-2 (GCM2), guanine nucleotide binding protein α11 (GNA11), or parathyroid hormone (PTH) genes. Thus far, only four cases with homozygous and
Supin Chompoopong et al.
Neuromolecular medicine, 18(3), 334-346 (2016-07-20)
The effects of germinated brown rice (GBR) on the motor deficits and the dopaminergic (DA) cell death were investigated in Parkinson's-like disease (PD) rats. Reactive oxidative species generated by chronic subcutaneous injection of rotenone (RT) lead to neuronal apoptosis particularly
Qian Deng et al.
European journal of pharmacology, 826, 24-30 (2018-03-05)
The aim of this study was to explore the effects of curcumin on renal cell carcinoma(RCC) through regulating autophagy. Cell viabilities were determined by MTT assay in RCC cells after treatment with curcumin at different concentrations for various durations. ATG7
Yong Wang et al.
Oncotarget, 8(44), 77685-77695 (2017-11-05)
Chronic bronchitis and emphysema are pathologic features of chronic obstructive pulmonary disease (COPD). Cigarette smoke (CS)-induced endoplasmic reticulum (ER) stress has been implicated in the COPD development, but the molecular mechanism by which it contributes to COPD etiology and the
Chan-Yen Kuo et al.
Cancer research, 77(13), 3406-3416 (2017-05-24)
Mutations and epigenetic inactivation of the tumor suppressor gene von Hippel-Lindau (VHL) are major causes of clear-cell renal cell carcinoma (ccRCC) that may originate from chronic inflammation. However, the role of VHL loss of function in the development of ccRCC
Qian Guo et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 125, 95-105 (2019-01-03)
Glucosamine (GlcN) is a dietary supplement that is widely used to promote joint health. Reports have demonstrated that oral GlcN adversely affects glucose metabolism. Here, we found that oral administration of GlcN induced insulin resistance (IR) and increased plasma glucose
J Y Chan et al.
Diabetologia, 55(11), 2999-3009 (2012-08-16)
Pancreatic beta cell destruction in type 1 diabetes may be mediated by cytokines such as IL-1β, IFN-γ and TNF-α. Endoplasmic reticulum (ER) stress and nuclear factor-κB (NFκB) signalling are activated by cytokines, but their significance in beta cells remains unclear.
Akhirunnesa Mily et al.
BMC pulmonary medicine, 13, 23-23 (2013-04-18)
We earlier showed that 4-phenylbutyrate (PB) can induce cathelicidin LL-37 expression synergistically with 1,25-dihydroxyvitamin D3 in a lung epithelial cell line. We aimed to evaluate a therapeutic dose of PB alone or in combination with vitamin D3 for induction of
Dong Hee Kim et al.
Biochemical and biophysical research communications, 488(3), 477-482 (2017-05-20)
In obese patients, free fatty acids ectopically accumulated in non-adipose tissues cause cell death. Saturated fatty acids are more deleterious to non-adipose cells, and supplementation with monounsaturated fatty acids has been proposed to rescue cells from saturated fatty acid-induced cytotoxicity;
Yasir Alhamdi et al.
PLoS pathogens, 11(5), e1004836-e1004836 (2015-05-15)
Streptococcus pneumoniae accounts for more deaths worldwide than any other single pathogen through diverse disease manifestations including pneumonia, sepsis and meningitis. Life-threatening acute cardiac complications are more common in pneumococcal infection compared to other bacterial infections. Distinctively, these arise despite
Junli Chang et al.
Molecular medicine reports, 18(1), 945-957 (2018-05-31)
Prostate cancer is the second most commonly diagnosed malignancy and the sixth global primary cause of malignancy‑associated fatality. Increased invasiveness and motility in prostate cancer cells are associated with ubiquitin proteasome system‑regulated epithelial to mesenchymal transition (EMT). Impairment of the
Xin Chou et al.
Archives of toxicology, 93(4), 965-986 (2019-02-24)
Cadmium (Cd), an occupational and environmental pollutant, induces nephrotoxicity by primarily damaging renal proximal tubular cells. In this study, we hypothesized that pyroptosis, a caspase-1-dependent inflammatory programmed cell death mechanism, mediates Cd-induced nephrotoxicity. Human proximal tubular epithelial HK-2 cells were
Dmitriy I Dovzhanskiy et al.
Oncology research, 20(2-3), 103-111 (2012-12-01)
Histone deacetylase inhibitors are a new and promising drug family with a strong anticancer activity and potent modulation of connexin expression. The restoration of connexins in cancer cells has been suggested as a possible mechanism to control tumor progression. The
Wei Zeng et al.
Life sciences, 103(1), 15-24 (2014-03-22)
Endoplasmic reticulum (ER) stress is involved in the pathogenesis of atherosclerosis (AS). Endothelial cell (EC) dysfunction and monocyte migration to the subendothelium are considered to be essential manifestations of AS. We conducted this study to determine whether ER stress was
Wai-Fai Tung et al.
Cellular and molecular neurobiology, 35(6), 849-859 (2015-03-18)
Hypoxia is an important cause of brain injury in ischemic stroke. It is known that endoplasmic reticulum (ER) stress is an important determinant of cell survival or death during hypoxia. However, the signaling pathways and molecular mechanisms involved remain to
Sandra Espada et al.
Biochemical and biophysical research communications, 491(2), 442-448 (2017-07-18)
Endoplasmic reticulum (ER) stress has been shown to play a key role during the initiation and clinical progression of the cardiovascular diseases, such as atherosclerosis. We have recently shown that expression of tissue factor pathway inhibitor (TFPI) in human monocyte-derived
Wendy Smith et al.
The Journal of pediatrics, 162(6), 1228-1234 (2013-01-18)
To examine ammonia levels, pharmacokinetics, and safety of glycerol phenylbutyrate (GPB; also referred to as HPN-100) and sodium phenylbutyrate (NaPBA) in young children with urea cycle disorders (UCDs). This open label switch-over study enrolled patients ages 29 days to under
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