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Shenshen Zhu et al.
Pharmacology, 95(5-6), 258-263 (2015-05-23)
This study was conducted to explore the effect of zerumbone, isolated from Zingiberzerumbet Smith, on apolipoprotein A-I (apoA-I)-mediated cholesterol efflux from THP-1 macrophages. THP-1 macrophages were treated with different concentrations (10-100 μmol/l) of zerumbone and cholesterol efflux was measured. The
Yaqin Zhang et al.
Nutrition & metabolism, 12, 21-21 (2015-06-13)
Cytokines secreted by adipose tissue macrophages (ATMs) significantly alter adipocyte function, inducing inflammatory responses and decreasing insulin sensitivity. However, little relevant information is available regarding the role of microvesicles (MVs) derived from ATMs in macrophage-adipocyte crosstalk. MVs were generated by
Hai Huang et al.
Hepatology (Baltimore, Md.), 62(2), 600-614 (2015-04-10)
Innate immunity plays a crucial role in the response to sterile inflammation such as liver ischemia/reperfusion (I/R) injury. The initiation of liver I/R injury results in the release of damage-associated molecular patterns, which trigger an innate immune and inflammatory cascade
Ming-Tai Chen et al.
Scientific reports, 5, 16229-16229 (2015-11-07)
RNA binding proteins (RBPs)-mediated post-transcriptional control has been implicated in influencing various aspects of RNA metabolism and playing important roles in mammalian development and pathological diseases. However, the functions of specific RBPs and the molecular mechanisms through which they act
Jiabin Zhang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(31), 12825-12834 (2013-08-02)
Notch is a cell surface receptor that is known to regulate developmental processes by establishing physical contact between neighboring cells. Many recent studies show that it also plays an important role in the formation of long-term memory (LTM) in adults
J Bagnall et al.
Integrative biology : quantitative biosciences from nano to macro, 7(6), 713-725 (2015-05-21)
Live-cell imaging of fluorescent fusion proteins has transformed our understanding of mammalian cell signalling and function. However, some cellular systems such as immune cells are unsuitable or refractory to many existing transgene delivery methods thus limiting systematic analyses. Here, a
Neil L Berinstein et al.
Oncoimmunology, 4(8), e1026529-e1026529 (2015-09-26)
DepoVax™ is an innovative and strongly immunogenic vaccine platform. Survivin is highly expressed in many tumor types and has reported prognostic value. To generate tumor-specific immune response, a novel cancer vaccine was formulated in DepoVax platform (DPX-Survivac) using survivin HLA
Leo Hansmann et al.
Cancer immunology research, 3(6), 650-660 (2015-02-26)
It would be very beneficial if the status of cancers could be determined from a blood specimen. However, peripheral blood leukocytes are very heterogeneous between individuals, and thus high-resolution technologies are likely required. We used cytometry by time-of-flight and next-generation
Camilla Schinner et al.
Acta physiologica (Oxford, England), 226(2), e13242-e13242 (2018-12-26)
Mutations in desmosomal proteins can induce arrhythmogenic cardiomyopathy with life-threatening arrhythmia. Previous data demonstrated adrenergic signalling to be important to regulate desmosomal cohesion in cardiac myocytes. Here, we investigated how signalling pathways including adrenergic signalling, PKC and SERCA regulate desmosomal
Bin Zhang et al.
Autophagy, 16(7), 1262-1278 (2019-09-11)
Synovitis is implicated in the pathology of osteoarthritis (OA) and significantly contributes to the development of OA. As a noninvasive physical therapy, low-intensity pulsed ultrasound (LIPUS) has been reported to possess anti-inflammatory effect in recent years. However, the role of
S Tang et al.
Clinical and experimental immunology, 180(3), 408-418 (2015-02-04)
Increasing evidence indicates that aberrant neutrophil extracellular trap (NET) formation could contribute to the pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Recent research has provided evidence that a novel type of ANCA autoantibody, anti-lysosomal membrane protein-2 (LAMP-2) antibody, may
Kazufumi Hirano et al.
Antioxidants & redox signaling, 23(5), 358-374 (2015-07-03)
The NADPH oxidase (NOX) family of enzymes catalyzes the formation of reactive oxygen species (ROS). NOX enzymes not only have a key role in a variety of physiological processes but also contribute to oxidative stress in certain disease states. To
Lauren G Aoude et al.
Familial cancer, 14(4), 621-628 (2015-08-08)
Germline mutations in the exonuclease domain of POLE have been shown to predispose to colorectal cancers and adenomas. POLE is an enzyme involved in DNA repair and chromosomal DNA replication. In order to assess whether such mutations might also predispose
Daniella M Schwartz et al.
Immunity, 50(1), 106-120 (2019-01-17)
CD4+ T helper (Th) differentiation is regulated by diverse inputs, including the vitamin A metabolite retinoic acid (RA). RA acts through its receptor RARα to repress transcription of inflammatory cytokines, but is also essential for Th-mediated immunity, indicating complex effects
Yong Woo Ji et al.
Investigative ophthalmology & visual science, 55(10), 6829-6838 (2014-09-27)
We aimed to determine the role of CCR7+CD11b+ cell lymph node (LN) homing and T-cell differentiation in dry eye (DE)-induced immunopathogenesis and investigate the therapeutic effects of cyclooxygenase-2 (COX-2) and prostaglandin E2/eicosanoid-prostanoid (PGE2/EP) inhibitors against DE. Six-week-old female C57BL/6 mice
Themis Alissafi et al.
Journal of immunology (Baltimore, Md. : 1950), 194(12), 5812-5824 (2015-05-08)
Foxp3(+) regulatory T cell (Treg)-based immunotherapy holds promise for autoimmune diseases. However, this effort has been hampered by major caveats, including the low frequency of autoantigen-specific Foxp3(+) Tregs and lack of understanding of their molecular and cellular targets, in an
Haggai Bar-Yoseph et al.
Gastroenterology, 157(5), 1338-1351 (2019-08-12)
Some patients develop anti-drug antibodies (ADAs), which reduce the efficacy of infliximab, a monoclonal antibody against tumor necrosis factor (TNF), in the treatment of immune-mediated diseases, including inflammatory bowel diseases. ADAs arise inconsistently, and it is not clear what factors
Jaehyuk Choi et al.
Nature genetics, 47(9), 1011-1019 (2015-07-21)
Cutaneous T cell lymphoma (CTCL) is a non-Hodgkin lymphoma of skin-homing T lymphocytes. We performed exome and whole-genome DNA sequencing and RNA sequencing on purified CTCL and matched normal cells. The results implicate mutations in 17 genes in CTCL pathogenesis
Kuo-Chou Chiu et al.
Oral oncology, 51(7), 683-689 (2015-04-26)
This study investigated the potential involvement of Axl signaling in polarization of tumor-associated macrophages (TAMs) in oral squamous cell carcinoma (OSCC). Condition medium (CM) from OSCC cells (OEC-M1 and YD38) were collected and their effects on macrophage (THP-1) polarization were
Janine Beale et al.
Science translational medicine, 6(256), 256ra134-256ra134 (2014-10-03)
Rhinoviruses (RVs), which are the most common cause of virally induced asthma exacerbations, account for much of the burden of asthma in terms of morbidity, mortality, and associated cost. Interleukin-25 (IL-25) activates type 2-driven inflammation and is therefore potentially important
Y N Lin et al.
The Journal of steroid biochemistry and molecular biology, 154, 85-93 (2015-07-03)
Ruscogenin, a natural steroidal sapogenin, presents in both food and medicinal plants. It has been found to exert significant anti-inflammatory activities. Considering that activation of neutrophil is a key feature of inflammatory diseases, this study was performed to investigate the
Matyas Meggyes et al.
Placenta, 36(10), 1153-1160 (2015-08-19)
Immunoregulation implies the activation of negative pathways leading to the modulation of specific immune responses. Co-inhibitory receptors (such as PD-1 and TIM-3) represent possible tools for this purpose. PD-1 and TIM-3 have been demonstrated to be present on immune cells
Kyle P Glover et al.
Toxicology letters, 229(1), 210-219 (2014-06-25)
12-O-Tetradecanoylphorbol-13-acetate (TPA) is a non-genotoxic tumor promoter that dysregulates the protein kinase C (PKC) pathway and causes variable cellular responses to DNA damage in different experimental models. In the present study, we pretreated human lymphoblastoid TK6 cells (wild-type p53) for
Alexandra H Miller et al.
Assay and drug development technologies, 13(9), 515-528 (2015-10-28)
Severe bacterial infection can lead to inflammation, host tissue damage, and ultimately disseminated septic shock. The mammalian innate immune system responds to microbial infection through the detection of invariant pathogen-associated molecular patterns (PAMPs) by a range of pattern recognition receptors
Julia Niessl et al.
EBioMedicine, 54, 102727-102727 (2020-04-09)
Untreated HIV infection leads to alterations in HIV-specific CD4+ T cells including increased expression of co-inhibitory receptors (IRs) and skewing toward a T follicular helper cell (Tfh) signature. However, which changes are maintained after suppression of viral replication with antiretroviral
Francesca Graziano et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(25), E3265-E3273 (2015-06-10)
HIV type 1 (HIV-1) infects CD4(+) T lymphocytes and tissue macrophages. Infected macrophages differ from T cells in terms of decreased to absent cytopathicity and for active accumulation of new progeny HIV-1 virions in virus-containing compartments (VCC). For these reasons
Brian Astry et al.
Clinical immunology (Orlando, Fla.), 157(2), 228-238 (2015-02-11)
Inflammation is an integral component of autoimmune arthritis. The balance of pathogenic T helper 17 (Th17) and protective T regulatory (Treg) cells can influence disease severity, and its resetting offers an attractive approach to control autoimmunity. We determined the frequency
Marshall P Thomas et al.
Journal of immunology (Baltimore, Md. : 1950), 192(11), 5390-5397 (2014-04-29)
Killer lymphocyte granzyme (Gzm) serine proteases induce apoptosis of pathogen-infected cells and tumor cells. Many known Gzm substrates are nucleic acid binding proteins, and the Gzms accumulate in the target cell nucleus by an unknown mechanism. In this study, we
Esther Florsheim et al.
Journal of immunology (Baltimore, Md. : 1950), 194(10), 4621-4630 (2015-04-17)
Proteases are recognized environmental allergens, but little is known about the mechanisms responsible for sensing enzyme activity and initiating the development of allergic inflammation. Because usage of the serine protease subtilisin in the detergent industry resulted in an outbreak of
Esmaeil Mortaz et al.
PloS one, 10(8), e0136455-e0136455 (2015-09-01)
Chronic obstructive pulmonary disease (COPD) is a major global health problem with cigarette smoke (CS) as the main risk factor for its development. Airway inflammation in COPD involves the increased expression of inflammatory mediators such as CXCL-8 and IL-1β which
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