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Leilei Guo et al.
Materials science & engineering. C, Materials for biological applications, 108, 110403-110403 (2020-01-12)
Drug resistance is a major hindrance in the anticancer treatment, which encourages the development of effective therapeutic strategies. For the first time, MDM2-mediated p53 degradation was identified as a critical factor for developing acquired resistance of doxorubicin (DOX) in HepG2
Alice Verchère et al.
Nature communications, 6, 6890-6890 (2015-04-23)
Antibiotic resistance is a major public health issue and many bacteria responsible for human infections have now developed a variety of antibiotic resistance mechanisms. For instance, Pseudomonas aeruginosa, a disease-causing Gram-negative bacteria, is now resistant to almost every class of
Zhongxiang Liang et al.
PloS one, 11(4), e0152587-e0152587 (2016-04-02)
Peste des Petits Ruminants (PPR) is an acute, highly contagious, and febrile viral disease that affects both domestic and wild small ruminants. The disease has become a major obstacle to the development of sustainable Agriculture. Hemagglutinin (H), the envelope glycoprotein
Yoonhee Bae et al.
Mitochondrion, 37, 27-40 (2017-07-04)
Mitochondria dysfunction plays a role in many human diseases. Therapeutic techniques for these disorders require novel delivery systems that can specifically target and penetrate mitochondria. In this study, we report a novel nanosome composed of dequalinium-DOTAP-DOPE (1,2 dioleoyl-3-trimethylammonium-propane-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine) (DQA80s) as
Maitrayee Sardar Sinha et al.
Biochimica et biophysica acta. Molecular basis of disease, 1864(9 Pt B), 3060-3068 (2018-07-01)
Parkinson's disease (PD) and other synucleinopathies are characterized by accumulation of misfolded aggregates of α-synuclein (α-syn). The normal function of α-syn is still under investigation, but it has been generally linked to synaptic plasticity, neurotransmitter release and the maintenance of
Sivaramakrishnan Ramadurai et al.
Langmuir : the ACS journal of surfaces and colloids, 35(24), 8095-8109 (2019-05-24)
Many drugs have intracellular or membrane-associated targets, thus understanding their interaction with the cell membrane is of value in drug development. Cell-free tools used to predict membrane interactions should replicate the molecular organization of the membrane. Microcavity array-supported lipid bilayer
Vincent Mercier et al.
Nature cell biology, 22(8), 947-959 (2020-08-06)
The plasma membrane tension strongly affects cell surface processes, such as migration, endocytosis and signalling. However, it is not known whether the membrane tension of organelles regulates their functions, notably intracellular traffic. The endosomal sorting complexes required for transport (ESCRT)-III
Luca Digiacomo et al.
Nanoscale, 12(32), 16697-16704 (2020-08-11)
Following exposure to human plasma (HP), nanoparticles (NPs) are coated with a biomolecular layer referred to as a protein corona. We recently revealed that characterizing the protein coronas of various NPs may provide a unique opportunity for cancer identification and
Caterina Masaracchia et al.
Biochimica et biophysica acta. Proteins and proteomics, 1868(1), 140298-140298 (2019-11-05)
The misfolding and aggregation of alpha-synuclein (aSyn) are thought to be central events in synucleinopathies. The physiological function of aSyn has been related to vesicle binding and trafficking, but the precise molecular mechanisms leading to aSyn pathogenicity are still obscure.
Rossella Loria et al.
Journal of experimental & clinical cancer research : CR, 38(1), 1-1 (2019-01-05)
The possibility to combine Low Intensity UltraSound (LIUS) and Nanoparticles (NP) could represent a promising strategy for drugs delivery in tumors difficult to treat overcoming resistance to therapies. On one side the NP can carry drugs that specifically target the
Carlos Eduardo Pena et al.
Biochimica et biophysica acta. Proteins and proteomics, 1868(1), 140248-140248 (2019-07-08)
Fungi cellulases are used to degrade cellulose-containing biomass for bioethanol production. Industrial cellulases such as Cel7A from Trichoderma reesei (TrCel7A) are critical in this process. Thus, the understanding of structure and dynamics is crucial for engineering variants with improved cellulolytic
Alexander Rouvinski et al.
Nature communications, 8, 15411-15411 (2017-05-24)
A problem in the search for an efficient vaccine against dengue virus is the immunodominance of the fusion loop epitope (FLE), a segment of the envelope protein E that is buried at the interface of the E dimers coating mature
Ashutosh Prince et al.
Physical chemistry chemical physics : PCCP, 21(4), 1980-1987 (2019-01-12)
Antimicrobial peptides have been attracting significant attention as potential anti-cancer therapeutic agents in recent times. Yet most antimicrobial peptides seem to possess cytotoxic effects on non-cancerous cells. Nisin, an antimicrobial peptide and FDA approved food preservative, has recently been found
Shashank Reddy Pinnapireddy et al.
Biomaterials science, 8(1), 232-249 (2019-11-05)
Non-viral gene delivery in its current form is largely dependent upon the ability of a delivery vehicle to protect its cargo in the extracellular environment and release it efficiently inside the target cell. Also a simple delivery system is required
Catherine Suarez et al.
Nature communications, 10(1), 4041-4041 (2019-09-08)
Members of the Apicomplexa phylum, including Plasmodium and Toxoplasma, have two types of secretory organelles (micronemes and rhoptries) whose sequential release is essential for invasion and the intracellular lifestyle of these eukaryotes. During invasion, rhoptries inject an array of invasion
Farnaz Behroozi et al.
International journal of pharmaceutics, 548(1), 62-72 (2018-05-29)
Oxidative stress has been implicated in the progression of age-related macular degeneration (AMD). Treatment with antioxidants seems to delay progression of AMD. In this study, we suggested an antioxidant delivery system based on redox-sensitive liposome composed of phospholipids and a
Maria Timchenko et al.
International journal of molecular sciences, 20(20) (2019-10-23)
The nature of renal amyloidosis involving Bence-Jones proteins in multiple myeloma is still unclear. The development of amyloidosis in neurodegenerative diseases is often associated with a high content of asparagine and glutamine residues in proteins forming amyloid deposits. To estimate
Maria Luisa Moyá et al.
Pharmaceutics, 11(2) (2019-02-10)
Cefepime is an antibiotic with a broad spectrum of antimicrobial activity. However, this antibiotic has several side effects and a high degradation rate. For this reason, the preparation and characterization of new liposomes that are able to encapsulate this antibiotic
Alejandro Melero et al.
Current biology : CB, 28(12), 1950-1958 (2018-06-12)
Coat protein complex II (COPII) proteins form vesicles from the endoplasmic reticulum to export cargo molecules to the Golgi apparatus. Among the many proteins involved in this process, Sec12 is a key regulator, functioning as the guanosine diphosphate (GDP) exchange
Monika Rak et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 155, 199-209 (2020-08-05)
Lipofection is a widely used molecular biology technique and one of the most promising non-viral gene therapy strategies. However, one of the main drawbacks of using cationic lipids-based lipoplexes in DNA/RNA delivery is serum-associated inhibition of transfection. We have addressed
Randi Nordström et al.
Journal of colloid and interface science, 554, 592-602 (2019-07-23)
In the present study, we investigate degradable anionic dendritic nanogels (DNG) as carriers for antimicrobial peptides (AMPs). In such systems, the dendritic part contains carboxylic acid-based anionic binding sites for cationic AMPs, whereas linear poly(ethylene glycol) (PEG) chains form a
ShiYu Wang et al.
The Journal of cell biology, 218(8), 2600-2618 (2019-06-30)
The activities of neuronal signaling receptors depend heavily on the maturation state of the endosomal compartments in which they reside. However, it remains unclear how the distribution of these compartments within the uniquely complex morphology of neurons is regulated and
Ana Catarina Alves et al.
Biochimica et biophysica acta, 1859(5), 941-948 (2017-02-06)
The present work aimed to study the interactions between the anticancer drug daunorubicin and lipid membrane mimetic models of cancer cells composed by their most representative classes of phospholipids, with different degrees of complexity. Regarding these anticancer drug-membrane interactions, several
Natália Bueno Leite et al.
Biophysical journal, 109(5), 936-947 (2015-09-04)
Polybia-MP1 (MP1) is a bioactive host-defense peptide with known anticancer properties. Its activity is attributed to excess serine (phosphatidylserine (PS)) on the outer leaflet of cancer cells. Recently, higher quantities of phosphatidylethanolamine (PE) were also found at these cells' surface.
Shuo Qian et al.
The journal of physical chemistry letters, 9(19), 5778-5784 (2018-08-17)
The water distribution between lipid bilayers is important in understanding the role of the hydration force at different steps of the membrane fusion pathway. In this study, we used grazing-angle neutron diffraction to map out the water distribution in lipid
S Szala et al.
Gene therapy, 3(11), 1026-1031 (1996-11-01)
An attempt was made to use simple cationic liposomes DC-Chol/DOPE and DDAB/DOPE (DC-Chol is 3 beta (N(N',N-dimethylaminoethane) carbamoyl) cholesterol, DDAB is dimethyldioctadecyl ammonium bromide and DOPE is dioleoylphosphatidylethanolamine) for transfer of Escherichia coli cytosine deaminase 'suicide' gene under the control
Bertrand Z Yeung et al.
The AAPS journal, 17(6), 1475-1482 (2015-08-20)
RNAi therapeutics provide an opportunity to correct faulty genes, and several RNAi have entered clinical evaluation. The existing quantification methods typically use radioactivity- or fluorescence-labeled RNAi, require large blood volumes, and/or have a limited dynamic detection range. We established a
Preeti Choudhary et al.
BMC bioinformatics, 18(1), 583-583 (2017-12-24)
Knowledge of catalytic residues can play an essential role in elucidating mechanistic details of an enzyme. However, experimental identification of catalytic residues is a tedious and time-consuming task, which can be expedited by computational predictions. Despite significant development in active-site
Meghan A Morrissey et al.
eLife, 7 (2018-06-05)
Chimeric antigen receptors (CARs) are synthetic receptors that reprogram T cells to kill cancer. The success of CAR-T cell therapies highlights the promise of programmed immunity and suggests that applying CAR strategies to other immune cell lineages may be beneficial.
D Pozzi et al.
Nanoscale, 7(33), 13958-13966 (2015-07-30)
When nanoparticles come into contact with biological media, they are covered by a biomolecular 'corona', which confers a new identity to the particles. In all the studies reported so far nanoparticles are incubated with isolated plasma or serum that are
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