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N6639

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Pan Yongming et al.
Cardiovascular diabetology, 14, 6-6 (2015-01-17)
A long-term high-fat/cholesterol (HFC) diet leads to insulin resistance (IR), which is associated with inflammation, atherosclerosis (AS), cardiac sympathovagal imbalance, and cardiac dysfunction. Peroxisome proliferator-activated receptors (PPARs) and nuclear factor ĸB (NF-κB) are involved in the development of IR-AS. Thus...
Noritoshi Inagaki et al.
PloS one, 10(8), e0135408-e0135408 (2015-08-14)
Accurate regulation of chlorophyll synthesis is crucial for chloroplast formation during the greening process in angiosperms. In this study, we examined the role of phytochrome B (phyB) in the regulation of chlorophyll synthesis in rice seedlings (Oryza sativa L.) through...
Qingxia Yuan et al.
Carbohydrate polymers, 128, 52-62 (2015-05-26)
Extraction optimization, characterization and antioxidant activity in vitro of polysaccharides from mulberry leaves (MLP) were investigated in the present study. The optimal extraction conditions with an extraction yield of 10.0 ± 0.5% for MLP were determined as follows: extraction temperature...
Chihiro Yamada et al.
Psychoneuroendocrinology, 55, 81-93 (2015-03-04)
The combination of depression and anorexia may influence morbidity and progressive physical disability in the elderly. Gender differences exist in hypothalamic-pituitary-adrenal axis activation following stress exposure. The objective of this study was to investigate gender differences in feeding behavior under...
T-Y Renn et al.
Vox sanguinis, 109(2), 138-147 (2015-04-23)
Recent clinical data suggested that platelet materials used in regenerative medicine exert anti-inflammatory effects. One must understand whether functionality varies among platelet preparations and also the role of the various protein compartments. Platelet-poor-plasma (PPP), platelet lysate with cell debris (PL)...
Raffaella Alò et al.
Brain research bulletin, 118, 65-77 (2015-09-27)
Recent evidences indicate that cerebral neurotrophic factors like vascular endothelial growth factor plus signaling pathways of the glutamatergic neuroreceptor system (L-Glu) are determinant modulators of depression-like states. In the present study, the type of interaction(s) exerted by the AMPAergic antagonist...
Weimei Ou et al.
PloS one, 9(12), e113852-e113852 (2014-12-04)
The study aimed to investigate the prevalence and epidemiological characteristics of blaNDM-1 (encoding New Delhi metallo-β-lactamase 1) in Enterobacteriaceae and the Acinetobacter calcoaceticus-Acinetobacter baumannii complex (ABC) in China from July 2011 to June 2012. PCR was used to screen for...
Masanori Noguchi et al.
Cancer immunology, immunotherapy : CII, 64(4), 493-505 (2015-02-11)
The heterogeneity expression of tumor-associated antigens (TAA) and variability of human T cell repertoire suggest that effective cancer vaccine requires induction of a wide breadth of cytotoxic T lymphocyte (CTL) specificities. This can be achieved with vaccines targeting multiple TAA....
Y N Lin et al.
The Journal of steroid biochemistry and molecular biology, 154, 85-93 (2015-07-03)
Ruscogenin, a natural steroidal sapogenin, presents in both food and medicinal plants. It has been found to exert significant anti-inflammatory activities. Considering that activation of neutrophil is a key feature of inflammatory diseases, this study was performed to investigate the...
Valentina Tassinari et al.
Journal of cell science, 132(5) (2019-02-13)
Ataxia telangiectasia is a rare, multi system disease caused by ATM kinase deficiency. Atm-knockout mice recapitulate premature aging, immunodeficiency, cancer predisposition, growth retardation and motor defects, but not cerebellar neurodegeneration and ataxia. We explored whether Atm loss is responsible for...
Lisbeth R Poulsen et al.
Nature communications, 6, 7649-7649 (2015-07-28)
Plants use solar energy to produce lipids directly from inorganic elements and are not thought to require molecular systems for lipid uptake from the environment. Here we show that Arabidopsis thaliana Aminophospholipid ATPase10 (ALA10) is a P4-type ATPase flippase that...
Ramón Martínez et al.
BMC cancer, 15, 839-839 (2015-11-05)
Kv10.1, a voltage-gated potassium channel only detected in the healthy brain, was found to be aberrantly expressed in extracerebral cancers. Investigations of Kv10.1 in brain metastasis and glioblastoma multiforme (GBM) are lacking. We analyzed the expression of Kv10.1 by immunohistochemistry...
Lukasz Szoka et al.
Molecular and cellular biochemistry, 403(1-2), 51-60 (2015-01-30)
The oxythiamine (OXY) is antivitamin of thiamine. The finding that OXY increases the cytoplasmic concentration of pyruvate, known to enhance collagen biosynthesis, led us to investigate the mechanism of this antivitamin action on collagen biosynthesis in cultured human skin fibroblasts....
Jingyi Tu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(44), 14727-14739 (2015-11-06)
The current study examined efficacy of a small Tat (trans-activator of transcription)-conjugated peptide activator of the Nrf2 (nuclear factor-E2-related factor-2) antioxidant/cell-defense pathway as a potential injury-specific, novel neuroprotectant against global cerebral ischemia (GCI). A competitive peptide, DEETGE-CAL-Tat, was designed to...
Fan Yang et al.
Cell death & disease, 10(6), 388-388 (2019-05-19)
CUL4A and CUL4B are closely related members in Cullin family and can each assemble a Cullin-RING E3 ligase complex (Cullin-RING Ligase 4A or 4B, CRL4A, or CRL4B) and participate in a variety of biological processes. Previously we showed that zebrafish...
Shi Tian et al.
Biochimica et biophysica acta, 1850(4), 708-721 (2014-12-09)
To study the role of miR-143 during embryo implantation in rat. MiR-143 expression in rat early pregnancy was detected by Northern blot. The relation between miR-143 and Lifr predicted and confirmed by bioinformatics method, dual-luciferase activity assay, Western blot and...
G Budziński et al.
Transplantation proceedings, 46(8), 2548-2551 (2014-11-09)
An insufficient number of organs for transplantation shows the need for the development of new technologies. Xenotransplantation might be the answer. To determine if the type of transgenesis influences the level of CYP3A4, which takes an active part in xenobiotics...
Kirsten O Hannesson et al.
Fish physiology and biochemistry, 41(4), 1029-1051 (2015-05-13)
In the present study, the distribution of sulphated glycosaminoglycans (GAGs) in the developing vertebral column of Atlantic salmon (Salmo salar) at 700, 900, 1100 and 1400 d° was examined by light microscopy. The mineralization pattern was outlined by Alizarin red S...
Ya-Nan Gao et al.
Biochemical and biophysical research communications, 454(2), 275-281 (2014-12-03)
Thymic involution is evolutionarily conserved and occurs early in life. However, the physiological significance remains elusive of this seemingly detrimental process. The present study investigated the potential impact of altered thymic output on T cell memory using ovalbumin (OVA) expressed...
Rashmi Tupe et al.
International journal of biological macromolecules, 79, 601-610 (2015-06-02)
The present work aims to investigate the concentration and time dependant effect of zinc on the in vitro non enzymatic modifications of albumin by diabetic levels of glucose. Further, preventive and curative effect of zinc was studied by adding zinc...
Paula Armesto et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 184, 6-19 (2015-02-04)
In this work, the complete cDNA sequence encoding angiotensinogen (agt) in the euryhaline flatfish Senegalese sole was obtained. Additionally, putative coding sequences belonging to other renin-angiotensin system (RAS) genes including renin (ren), angiotensin-converting enzyme (ace), angiotensin-converting enzyme 2 (ace2), as...
Liang-Yo Yang et al.
Journal of ethnopharmacology, 156, 61-72 (2014-08-17)
Phellinus linteus (Berkeley & Curtis), a well-known medical fungus, has long been used as a traditional medicine in Oriental countries to treat various diseases, and hispolon (HIS) is one of its bioactive components. HIS is known to possess potent antineoplastic...
William A Rose et al.
Scientific reports, 5, 13146-13146 (2015-08-15)
Human vaccines have used aluminium-based adjuvants (alum) for >80 years despite incomplete understanding of how alum enhances the immune response. Alum can induce the release of endogenous danger signals via cellular necrosis which elicits inflammation-associated cytokines resulting in humoral immunity....
Zhong-ping Ma et al.
Cell and tissue research, 361(2), 467-476 (2015-03-07)
Osteoporosis (OP) often increases the risk of bone fracture and other complications and is a major clinical problem. Previous studies have found that high blood pressure is associated with bone formation abnormalities, resulting in increased calcium loss. We have investigated...
Ronghua Wu et al.
PloS one, 10(5), e0127940-e0127940 (2015-05-30)
The 27.8 kDa membrane protein from flounder (Paralichthys olivaceus) gill (FG) cells was previously identified as a putative cellular receptor involved in lymphocystis disease virus (LCDV) infection. In this paper, the expression of receptor-27.8 kDa (27.8R) and LCDV loads in...
Jian-Ming Li et al.
Oncotarget, 6(13), 10772-10785 (2015-04-15)
Microbleeds are a common finding in aged human brains. In Alzheimer's disease (AD), neuritic plaques composed of β-amyloid (Aβ) deposits and dystrophic neurites occur frequently around cerebral vasculature, raising a compelling question as to whether, and if so, how, microvascular...
F Mastrangelo et al.
Journal of biological regulators and homeostatic agents, 28(4), 767-773 (2015-01-27)
Nitric Oxide (NO) has been linked to several cardiovascular, neurological and immunological physiological and pathological functions. Several studies have shown that the eNOS, nNOS and iNOS effects on cancer cell growth and proliferation are related to the upregulation of the...
Gang Yang et al.
Fish & shellfish immunology, 45(2), 800-807 (2015-06-09)
Probiotics have positive effects on the nutrient digestibility and absorption, immune responses, and growth of aquatic animals, including the sea cucumber (Apostichopus japonicus Selenka). A 60-day feeding trial was conducted to evaluate the effects of Bacillus cereus G19, B. cereus...
Ramamoorthy M Kalidas et al.
Cellular & molecular biology letters, 20(2), 294-309 (2015-07-24)
Lamin A is an intermediate filament protein which is cleaved by the enzyme, FACE 1 at VTRSY↓L. The cleavage is the final step in the production of the mature lamin A protein. The mature lamin A protein localizes in the...
Shaoxuan Yu et al.
Nanotechnology, 26(14), 145703-145703 (2015-03-19)
Selenium nanoparticles (Se NPs) possess well-known excellent biological activities and low toxicity, and have been employed for numerous applications except as inhibitors to protein glycation. Herein, the present study is carried out to investigate the inhibitory effect of Se NPs...
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