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N5535

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Mitchell E Horwitz et al.
The Journal of clinical investigation, 124(7), 3121-3128 (2014-06-10)
Delayed hematopoietic recovery is a major drawback of umbilical cord blood (UCB) transplantation. Transplantation of ex vivo-expanded UCB shortens time to hematopoietic recovery, but long-term, robust engraftment by the expanded unit has yet to be demonstrated. We tested the hypothesis
Marc Ferrer et al.
Stem cells translational medicine, 3(8), 911-922 (2014-05-31)
There is continuing interest in the development of lineage-specific cells from induced pluripotent stem (iPS) cells for use in cell therapies and drug discovery. Although in most cases differentiated cells show features of the desired lineage, they retain fetal gene
Gerardo D Anaya-Eugenio et al.
Journal of ethnopharmacology, 155(1), 416-425 (2014-06-04)
Artemisia ludoviciana, commonly known as "estafiate", plays an important role in contemporary Mexico for treating several diseases including diabetes. To establish the preclinical efficacy of Artemisia ludoviciana as hypoglycemic and/or antihyperglycemic agent using well-known animal models. Acute hypoglycemic as well
Mohsen Mohammadi Sartang et al.
Journal of diabetes research, 2015, 696372-696372 (2015-09-09)
The aim of the present study was to evaluate the effects of probiotic soymilk fortified with omega-3 in diabetic rats. Soymilk (SM), fermented soymilk (FSM), and fermented soymilk fortified with omega-3 (FSM + omega-3) were prepared. Rats were randomly assigned
[Niacin, niacinamide and blood sugar].
L Mainardi
Acta vitaminologica et enzymologica, 21(4), 139-159 (1967-01-01)
Nian-Cun Qiu et al.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 18(11), 1957-1964 (2014-09-04)
The purpose of this study is to investigate the impact of the hepatic branch of the vagus and Roux-en-Y gastric bypass (RYGB) on the level of fasting and postprandial serum glucagon-like peptide-1 (GLP-1) in type 2 diabetic mellitus rats. Randomized
Yao Li et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(9), 1688-1697 (2014-06-05)
Defects in Membrane Frizzled-related Protein (MFRP) cause autosomal recessive retinitis pigmentosa (RP). MFRP codes for a retinal pigment epithelium (RPE)-specific membrane receptor of unknown function. In patient-specific induced pluripotent stem (iPS)-derived RPE cells, precise levels of MFRP, and its dicistronic
Mark T Duncan et al.
Biotechnology and bioengineering, 111(10), 2082-2094 (2014-05-24)
The directed differentiation toward erythroid (E) or megakaryocytic (MK) lineages by the MK-E progenitor (MEP) could enhance the ex vivo generation of red blood cells and platelets for therapeutic transfusions. The lineage choice at the MEP bifurcation is controlled in
S Karovic et al.
Clinical pharmacology and therapeutics, 96(1), 27-35 (2014-03-19)
Hypertension after treatment with vascular endothelial growth factor (VEGF) receptor inhibitors is associated with superior treatment outcomes for advanced cancer patients. To determine whether increased sorafenib doses cause incremental increases in blood pressure (BP), we measured 12-h ambulatory BP in
Saeyoung Park et al.
Cytotechnology, 67(5), 851-860 (2014-07-07)
Although stem cells are promising candidates for cell replacement therapies, the vast majority are derived using animal sera, which has risk of being contaminated by animal viruses or toxins. To overcome these potential problems, we initially established multiple lines of
Koigoora Srikanth et al.
Journal of applied toxicology : JAT, 35(10), 1133-1140 (2015-04-16)
Aluminium oxide nanoparticles (Al2 O3 NPs) are increasingly used in diverse applications that has raised concern about their safety. Recent studies suggested that Al2 O3 NPs induced oxidative stress may be the cause of toxicity in algae, Ceriodaphnia dubia, Caenorhabditis
Wei Jiang et al.
Scientific reports, 4, 7456-7456 (2014-12-17)
SIRT1 could protect degenerative human NP cells against apoptosis, and there were extensive and intimate connection between apoptosis and autophagy. Up to now, the role of autophagy in the process of human IVD degeneration is unclear. We sought to explore
Feng Wang et al.
Drug design, development and therapy, 9, 575-601 (2015-01-30)
Pancreatic cancer is the most aggressive cancer worldwide with poor response to current therapeutics. Alisertib (ALS), a potent and selective Aurora kinase A inhibitor, exhibits potent anticancer effects in preclinical and clinical studies; however, the effect and underlying mechanism of
Daisuke Irikura et al.
PloS one, 10(11), e0138183-e0138183 (2015-11-20)
There is a strain of Clostridium perfringens, W5052, which does not produce a known enterotoxin. We herein report that the strain W5052 expressed a homologue of the iota-like toxin components sa and sb of C. spiroforme, named Clostridium perfringens iota-like
Katrina L Bogan et al.
Annual review of nutrition, 28, 115-130 (2008-04-24)
Although baseline requirements for nicotinamide adenine dinucleotide (NAD+) synthesis can be met either with dietary tryptophan or with less than 20 mg of daily niacin, which consists of nicotinic acid and/or nicotinamide, there is growing evidence that substantially greater rates
Santosh Nagaraju et al.
Xenotransplantation, 22(4), 317-324 (2015-07-17)
Pig islet grafts have been successful in treating diabetes in animal models. One remaining question is whether neonatal pig isletlike cell clusters (NICC) are resistant to the early loss of islets from the instant blood-mediated inflammatory reaction (IBMIR). Neonatal isletlike
Axitinib in advanced renal-cell carcinoma.
Nadia Yousaf et al.
The Lancet. Oncology, 14(13), 1245-1246 (2013-11-12)
Takeshi Natori et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 40(5), 635-637 (2013-07-19)
Sorafenib is an oral multi-kinase inhibitor that targets tumor growth and angiogenesis signal transduction pathways. Two global phase III trials showed that sorafenib prolonged the survival of patients with advanced hepatocellular carcinoma (HCC). Based on the positive results of these
Geert O Janssens et al.
European journal of cancer (Oxford, England : 1990), 50(6), 1112-1119 (2014-01-16)
Retrospective studies indicate that larger tumour volume is a strong prognostic indicator for poor tumour control after (chemo)radiotherapy for laryngeal cancer. The impact of tumour volume on the outcome of patients treated within a prospective study comparing accelerated radiotherapy (AR)±carbogen
Galbha Duggal et al.
Stem cells (Dayton, Ohio), 33(9), 2686-2698 (2015-06-26)
Human embryonic stem cells (hESCs) closely resemble mouse epiblast stem cells exhibiting primed pluripotency unlike mouse ESCs (mESCs), which acquire a naïve pluripotent state. Efforts have been made to trigger naïve pluripotency in hESCs for subsequent unbiased lineage-specific differentiation, a
Marcin Imielinski et al.
The Journal of clinical investigation, 124(4), 1582-1586 (2014-02-27)
Targeted cancer therapies often induce "outlier" responses in molecularly defined patient subsets. One patient with advanced-stage lung adenocarcinoma, who was treated with oral sorafenib, demonstrated a near-complete clinical and radiographic remission for 5 years. Whole-genome sequencing and RNA sequencing of
Ruo-Lei Jian et al.
Gene, 562(1), 107-116 (2015-03-01)
Mesenchymal stem cells (MSCs) have been reported to be an attractive source for the generation of transplantable surrogate β cells. A murine embryonic mesenchymal progenitor cell line C3H10T1/2 has been recognized as a model for MSCs, because of its multi-lineage
Dan Huang et al.
Applied microbiology and biotechnology, 99(3), 1399-1413 (2014-12-10)
Lysine acetylation is a dynamic, reversible posttranslational modification that is known to play an important role in regulating the activity of many key enzymes in bacteria. Acetylproteome studies have been performed on some bacteria. However, until now, there have been
Shin-Ichiro Imai
Current pharmaceutical design, 15(1), 20-28 (2009-01-20)
New interest in NAD biology has recently been revived, and enzymes involved in NAD biosynthetic pathways have been identified and characterized in mammals. Among them, nicotinamide phosphoribosyltransferase (Nampt) has drawn much attention in several different fields, including NAD biology, metabolism
Tomasz Szkudelski
Experimental biology and medicine (Maywood, N.J.), 237(5), 481-490 (2012-05-24)
Administration of both streptozotocin (STZ) and nicotinamide (NA) has been proposed to induce experimental diabetes in the rat. STZ is well known to cause pancreatic B-cell damage, whereas NA is administered to rats to partially protect insulin-secreting cells against STZ.
Stimulatory Role of Glycated Fetal Bovine Serum Along with Iron on In Vitro Production of Insulin by Differentiated Mouse Embryonic Stem Cells
Nishigaki I, et al.
Journal of Health Science, 57(4), 356-361 (2011)
Nadiah Ghazalli et al.
Stem cells and development, 24(17), 1995-2008 (2015-05-06)
Postnatal pancreas is a potential source for progenitor cells to generate endocrine β-cells for treating type 1 diabetes. However, it remains unclear whether young (1-week-old) pancreas harbors multipotent progenitors capable of differentiating into duct, acinar, and endocrine cells. Laminin is
Manuel Chan et al.
Cancer research, 74(21), 5948-5954 (2014-08-26)
GMX1778 and its prodrug GMX1777 represent a new class of cancer drugs that targets nicotinamide phosphoribosyltransferase (NAMPT) as a new strategy to interfere with biosynthesis of the key enzymatic cofactor NAD, which is critical for a number of cell functions
Cinzia Maria Chinnici et al.
Cell transplantation, 24(6), 1139-1153 (2014-03-29)
This study was designed to assess liver-specific functions of human fetal liver cells proposed as a potential source for hepatocyte transplantation. Fetal liver cells were isolated from livers of different gestational ages (16-22 weeks), and the functions of cell preparations
Utilization of niacin and niacinamide for NAD formation in rat liver.
Nutrition reviews, 30(6), 139-141 (1972-06-01)
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