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Shanmugam Vanithamani et al.
PloS one, 10(9), e0137130-e0137130 (2015-09-05)
Leptospirosis is a re-emerging infectious disease that is under-recognized due to low-sensitivity and cumbersome serological tests. MAT is the gold standard test and it is the only serogroup specific test used till date. Rapid reliable alternative serogroup specific tests are
Noriyuki Suzuki et al.
Journal of endodontics, 41(9), 1474-1479 (2015-05-21)
Cathepsin K is highly expressed in osteoclasts and plays an essential role in bone resorption. NC-2300 is an artificially designed cathepsin K inhibitor, and its application to experimentally induced arthritis induces down-regulation of bone destruction. In this study, we evaluated
Raifish E Mendoza-Villarroel et al.
Biology of reproduction, 91(1), 26-26 (2014-06-06)
Testosterone production is dependent on cholesterol transport within the mitochondrial matrix, an essential step mediated by a protein complex containing the steroidogenic acute regulatory (STAR) protein. In steroidogenic Leydig cells, Star expression is hormonally regulated and involves several transcription factors.
Jakub Mondek et al.
Carbohydrate polymers, 129, 168-174 (2015-06-09)
The fast deprotonation of 1-naphthol was studied in aqueous solution and in polymer-cetyltrimethylammonium bromide (CTAB) mixtures using picosecond fluorescence spectroscopy to study the influence of hyaluronan hydration in polymer-surfactant interactions. The aqueous micelle solution showed the expected change of proton
Hydrogenation of 1-naphthol with rhodium catalyst.
Freifelder M and Stone GR.
Journal of Pharmaceutical Sciences, 53(9), 1134-1135 (1964)
Abhishek Chauhan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 110-118 (2015-02-11)
Nano-sized molecularly imprinted polymer (nMIP) was synthesized through precipitation polymerization method and used it as solid phase extraction (SPE) sorbent for the selective and simultaneous extraction of hydroxylated metabolites of polycyclic aromatic hydrocarbons (PAHs) from urine followed by ultra-high performance
María Asensio-Ramos et al.
Electrophoresis, 33(9-10), 1449-1457 (2012-06-01)
In this work, the use of the ionic liquid (IL) 1,3-dipentylimidazolium hexafluorophosphate ([PPIm][PF₆]) as an alternative extractant for IL dispersive liquid-liquid microextraction (IL-DLLME) of a group of pesticides and metabolites (2-aminobenzimidazole, carbendazim/benomyl, thiabendazole, fuberidazole, carbaryl, 1-naphthol, and triazophos) from soils
Jennifer J Bara et al.
Tissue engineering. Part A, 20(1-2), 147-159 (2013-07-31)
Osteochondral tissue repair requires formation of vascularized bone and avascular cartilage. Mesenchymal stem cells stimulate angiogenesis both in vitro and in vivo but it is not known if these proangiogenic properties change as a result of chondrogenic or osteogenic differentiation.
Y Zhang et al.
Oral diseases, 21(5), 583-592 (2015-02-05)
To understand the differences and similarities between immunocompetent and immunodeficient mice as ectopic transplantation animal models for bone tissue engineering. Osteogenic cells from mouse leg bones were cultured, seeded on β-TCP granules, and transplanted onto the backs of either immunocompetent
Rafael Gozalbes et al.
Bioorganic & medicinal chemistry, 18(19), 7078-7084 (2010-09-03)
Solubility plays a very important role in the selection of compounds for drug screening. In this context, a QSAR model was developed for predicting water solubility of drug-like compounds. First, a set of relevant parameters for establishing a drug-like chemical
S V B Janardhan Garikipati et al.
Journal of biotechnology, 210, 91-99 (2015-07-06)
The solvent resistance capacity of Pseudomonas putida S12 was applied by using the organism as a host for biocatalysis and through cloning and expressing solvent resistant pump genes into Escherichia coli. P. putida S12 expressing toluene ortho mononooxygenase (TOM-Green) was
Tanveer Ahmed et al.
Environmental toxicology and chemistry, 31(10), 2201-2209 (2012-07-05)
The binding interactions of 1-naphthol with effluent and whole natural dissolved organic matter (DOM) samples were analyzed by using a fluorescence quenching technique. Nonfractionated DOM samples from Lake Biwa (Japan), creek water, treated sewage effluents, and an extracted Lake Biwa
Md Abdullah Al Mamun et al.
Biological research, 48, 65-65 (2015-11-20)
Tridax procumbens flavonoids (TPFs) are well known for their medicinal properties among local natives. Besides traditionally used for dropsy, anemia, arthritis, gout, asthma, ulcer, piles, and urinary problems, it is also used in treating gastric problems, body pain, and rheumatic
Anika Kasprick et al.
European journal of immunology, 45(5), 1462-1470 (2015-02-14)
The role of mast cells (MCs) in autoimmunity is the matter of an intensive scientific debate. Based on observations in different MC-deficient mouse strains, MCs are considered as fundamental players in autoimmune diseases. However, most recent data suggest that the
Yutaro Tsubakihara et al.
Journal of biochemistry, 158(1), 61-71 (2015-03-13)
Arkadia, a positive regulator of Smad-dependent signalling via the transforming growth factor-β (TGF-β) family, is an E3 ubiquitin ligase that induces ubiquitylation and proteasome-dependent degradation of TGF-β suppressors such as Smad7, c-Ski and SnoN. In this study, we examined the
Anlong Liu et al.
Calcified tissue international, 97(6), 581-591 (2015-09-01)
Diabetic osteoporosis continues to surge worldwide, increasing the risk of fracture. We have previously demonstrated that haploinsufficiency of endogenous parathyroid hormone-related peptide (PTHrP) impairs fracture healing. However, whether an exogenous supply of PTHrP can repair bone damage and accelerate fracture
HongMoon Sohn et al.
Lasers in surgery and medicine, 47(9), 745-755 (2015-09-24)
Bone homeostasis is maintained by a balance between osteoblastic bone formation and osteoclastic bone resorption, where intracellular reactive oxygen species (ROS) are crucial mediators of osteoclastogenesis. Recently, low-level light therapy (LLLT), a form of laser medicine used in various clinical
Johannes Keller et al.
Nature communications, 5, 5215-5215 (2014-10-22)
The hormone calcitonin (CT) is primarily known for its pharmacologic action as an inhibitor of bone resorption, yet CT-deficient mice display increased bone formation. These findings raised the question about the underlying cellular and molecular mechanism of CT action. Here
Yuya Terao et al.
Cardiovascular diabetology, 14, 104-104 (2015-08-13)
Vascular calcification is an independent risk factor for cardiovascular disease. Diabetes mellitus increases the incidence of vascular calcification; however, detailed molecular mechanisms of vascular calcification in diabetes mellitus remain unknown. We recently reported that bone morphogenetic protein-binding endothelial cell precursor-derived
Leandra Naira Z Ramalho et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 74, 270-278 (2014-12-03)
Rosmarinic acid (RosmA) demonstrates antioxidant and anti-inflammatory properties. We investigated the effect of RosmA on liver ischemia/reperfusion injury. Rats were submitted to 60 min of ischemia plus saline or RosmA treatment (150 mg/kg BW intraperitoneally) followed by 6 h of reperfusion. Hepatocellular injury
Kristen W Smith et al.
Journal of exposure science & environmental epidemiology, 22(1), 35-45 (2011-11-03)
There is a potential for widespread occupational exposure to jet fuel among military and civilian personnel. Urinary metabolites of naphthalene have been suggested for use as short-term biomarkers of exposure to jet fuel (jet propulsion fuel 8 (JP8)). In this
Jia'En Jasmine Li et al.
Biomaterials, 54, 226-236 (2015-04-11)
Stem cells exist in an in vivo microenvironment that provides biological and physiochemical cues to direct cell fate decisions. How the stem cells sense and respond to these cues is still not clearly understood. Gold nanoparticles (AuNPs) have been widely used
Sandy Fillet et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(37), 15372-15377 (2011-08-31)
Members of the IclR family control bacterial genes involved in a number of physiological processes. The IclR-family member TtgV crystallizes as a tetramer, with each TtgV monomer consisting of two domains--a DNA binding domain and an effector recognition domain, which
Claudio Erratico et al.
Toxicology letters, 236(2), 98-109 (2015-05-10)
Polybrominated diphenyl ethers (PBDEs) were used worldwide as additive flame retardants and are classified as persistent, bioaccumulable and toxic environmental pollutants. In humans, the hydroxylated metabolites of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) and 2,2',4,4',5-pentabromodiphenyl ether (BDE-99) formed in vitro have also been
Yin Fan Lam et al.
International archives of allergy and immunology, 167(1), 29-40 (2015-06-27)
Shellfish hypersensitivity is among the most common food allergies. A murine model of IgE-mediated shrimp allergy has been established in our laboratory. The aim of this study is to determine the intestinal histological changes and cytokine expression profile of this
Seunghye Kim et al.
Calcified tissue international, 97(1), 80-89 (2015-04-22)
There have been many attempts to use the pulp tissue from human deciduous teeth for dentin or bone regeneration. The objective of this study was to determine the effects of odonto/osteogenic in vitro differentiation of deciduous teeth pulp stem cells
Dmitrij Hristodorov et al.
mAbs, 7(5), 853-862 (2015-07-29)
Macrophages are key players in controlling the immune response that can adapt to microenvironmental signals. This results in distinct polarization states (classical M1 or alternative M2), that play a differential role in immune regulation. In general, the M1 contribute to
Alicja Piasecka et al.
Journal of applied genetics, 56(1), 115-121 (2014-09-04)
The p53 transcription factor is a key tumor suppressor and a central regulator of the stress response, which has been a subject of intense research for over 30 years. Recently, a zebrafish line which carries splice site mutation (G>T) in intron
Yutaka Fukuma et al.
BioFactors (Oxford, England), 41(4), 222-231 (2015-07-15)
Bone homeostasis is regulated by a balance between osteoclast (OCL)-mediated bone resorption and osteoblast (OBL)-mediated bone formation. Thus, developing a compound that simultaneously inhibits OCL function and promotes OBL function would be useful as a new medical therapy for bone
Yaochao Zhao et al.
ACS applied materials & interfaces, 7(32), 17826-17836 (2015-07-24)
To simultaneously enhance the osteogenic and antibacterial properties of titanium, we introduced magnesium (Mg), silver (Ag), or both by using the plasma immersion ion implantation (PIII) technique, producing three PIII sample groups, namely, Mg-doped titanium (Mg-PIII), Ag-doped titanium (Ag-PIII), and
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