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Miki Terakata et al.
The Journal of nutrition, 143(7), 1046-1051 (2013-05-24)
In mammals, nicotinamide (Nam) is biosynthesized from l-tryptophan (l-Trp). The enzymes involved in the initial step of the l-Trp→Nam pathway are l-Trp-2,3-dioxygenase (TDO) and indoleamine-2,3-dioxygenase (IDO). We aimed to determine whether tdo-knockout (tdo(-/-)) mice fed a diet without preformed niacin
Michael E Rybak et al.
Analytical biochemistry, 333(2), 336-344 (2004-09-29)
A reversed-phase high-performance liquid chromatography (HPLC) method with fluorometric detection was developed for the routine determination of pyridoxal 5'-phosphate (PLP) and 4-pyridoxic acid (4-PA) in serum. Chlorite postcolumn derivatization was used to oxidize PLP to a more fluorescent carboxylic acid
Robert J Motzer et al.
The Lancet. Oncology, 14(6), 552-562 (2013-04-20)
In a phase 3 trial comparing the efficacy and safety of axitinib versus sorafenib as second-line treatment for metastatic renal cell carcinoma, patients given axitinib had a longer progression-free survival (PFS). Here, we report overall survival and updated efficacy, quality
Shinji Kitamura et al.
Stem cells (Dayton, Ohio), 33(3), 774-784 (2014-11-26)
The kidneys are formed during development from two distinct primordial tissues, the metanephric mesenchyme and the ureteric bud. The metanephric mesenchyme develops into the kidney nephron, the minimal functional unit of the kidney. A nephron consists of several segments and
New options for second-line therapy of advanced renal cancer.
Axel Bex
The Lancet. Oncology, 14(6), 450-451 (2013-04-20)
Thomas J Herzog et al.
Gynecologic oncology, 130(1), 25-30 (2013-04-18)
Sorafenib, an oral multikinase inhibitor of the VEGFR/PDGFR/Raf/MEK/ERK pathway, has shown potential activity in patients with recurrent ovarian cancer (OC). One strategy to prolong disease control and survival in patients with OC is maintenance therapy after achieving a complete response.
Gloria Uccello-Barretta et al.
Journal of pharmaceutical and biomedical analysis, 107, 7-10 (2015-01-07)
In total parenteral nutrition (TPN), especially in the case of preterm infants, simultaneous administration of vitamins and trace elements is still a problematic issue: guidelines put in evidence the lack of specific documentation. In this work NMR spectroscopy was applied
Donald L Bissett et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 31(7 Pt 2), 860-865 (2005-07-21)
In multiple chronic clinical studies, topical niacinamide (vitamin B3) has been observed to be well tolerated by skin and to provide a broad array of improvements in the appearance of aging facial skin (eg, reduction in the appearance of hyperpigmentated
Thomas E Hutson et al.
The Lancet. Oncology, 14(13), 1287-1294 (2013-11-12)
In previous clinical trials of patients with metastatic renal-cell carcinoma, patients treated with axitinib as second-line therapy had longer median progression-free survival than those treated with sorafenib. We therefore undertook a phase 3 trial comparing axitinib with sorafenib in patients
Yan-Jie Tian et al.
The British journal of nutrition, 111(9), 1594-1601 (2014-02-11)
Recent evidence shows that excess nicotinamide can cause epigenetic changes in developing rats. The aim of the present study was to investigate the effects of maternal nicotinamide supplementation on the fetus. Female rats were randomised into four groups fed a
Berenice Ovalle-Magallanes et al.
Phytochemistry, 110, 111-119 (2014-12-24)
An aqueous extract from the seeds of Swietenia humilis (31.6-100mg/kg bw) lowered (p<0.05) blood glucose levels in normal and nicotinamide-streptozotocin (NA-STZ)-induced hyperglycemic mice. Furthermore, when administered to fructose-fed rats with metabolic syndrome, the decoction showed significant antihyperglycemic, hypoglycemic and hypolipidemic
Nathalie Zatula et al.
Oncotarget, 5(16), 6770-6787 (2014-08-26)
The majority of human breast cancers express estrogen receptor alpha (ER), which is important for therapy with anti-estrogens. Here we describe the role of BCL9-2, a proto-oncogene previously characterized as co-activator of Wnt/ß-catenin signaling, for mammary tumorigenesis in mice and
Rajesh Ramanathan et al.
Transplantation, 98(1), 100-106 (2014-02-08)
Hepatocellular carcinoma is a major cause of death among patients with cirrhosis. A standardized approach of multimodality therapy with intent-to-treat by transplantation for all patients with hepatocellular carcinoma was instituted at our transplant center in 1997. Data were prospectively collected
Tolerability of single-agent sorafenib in the treatment of elderly patients with hepatocellular carcinoma (HCC).
Edoardo Francini et al.
Hepatology (Baltimore, Md.), 60(2), 764-765 (2014-09-05)
Clare F Megarity et al.
FEBS letters, 588(9), 1666-1672 (2014-03-19)
There are two common forms of NRH-quinone oxidoreductase 2 (NQO2) in the human population resulting from SNP rs1143684. One has phenylalanine at position 47 (NQO2-F47) and the other leucine (NQO2-L47). Using recombinant proteins, we show that these variants have similar
Takeshi Ueda et al.
Japanese journal of clinical oncology, 43(6), 616-628 (2013-05-01)
Axitinib is a potent and selective second-generation inhibitor of vascular endothelial growth factor receptors 1, 2 and 3. The efficacy and safety of axitinib in Japanese patients with metastatic renal cell carcinoma were evaluated. A subgroup analysis was conducted in
Else Driehuis et al.
Cancer discovery, 9(7), 852-871 (2019-05-06)
Previous studies have described that tumor organoids can capture the diversity of defined human carcinoma types. Here, we describe conditions for long-term culture of human mucosal organoids. Using this protocol, a panel of 31 head and neck squamous cell carcinoma
V F Patel et al.
Indian journal of pharmaceutical sciences, 76(6), 483-494 (2015-01-17)
The present study was aimed at investigating the effect of hydrotrope and surfactant on poor solubility of atorvastatin calcium. Excipients screening followed by factorial design was performed to study effect of excipients and manufacturing methods on solubility of drug. Three
ETV6-FLT3 fusion gene-positive, eosinophilia-associated myeloproliferative neoplasm successfully treated with sorafenib and allogeneic stem cell transplant.
L Falchi et al.
Leukemia, 28(10), 2090-2092 (2014-05-24)
John D Hainsworth et al.
Cancer investigation, 31(5), 323-329 (2013-04-26)
To evaluate the feasibility and efficacy of sorafenib and everolimus in renal cell carcinoma (RCC). Patients with advanced RCC and ≤ 1 previous targeted therapy were treated. Maximum tolerated doses were sorafenib 200 mg PO BID, everolimus 35 mg PO
Yan Li et al.
Cancer letters, 356(2 Pt B), 392-403 (2014-10-11)
ZLJ33, an oral active multi-kinase inhibitor, was evaluated both in vitro and in vivo against human pancreatic cancer. It could effectively inhibit cell proliferation, induce apoptosis, and cause inhibition of invasion in pancreatic cancer cells. At a dose of 15.0 mg/kg
Ehsan Taghizadeh Davoudi et al.
Pakistan journal of pharmaceutical sciences, 27(1), 203-208 (2014-01-01)
Cancer is among most important causes of death in recent decades. Whoever the renal cell carcinoma incidence is low but it seems it is more complicated than the other cancers in terms of pathophysiology and treatments. The purpose of this
Chenphop Sawangmake et al.
Biochemical and biophysical research communications, 452(3), 581-587 (2014-09-03)
Dental tissue-derived mesenchymal stem cells have been proposed as an alternative source for mesenchymal stem cells. Here, we investigated the differentiation ability toward insulin producing cells (IPCs) of human dental pulp stem cells (hDPSCs) and human periodontal ligament stem cells
C Giorgio et al.
Pharmacological research, 141, 319-330 (2019-01-10)
Eph/ephrin interactions and their bidirectional signaling are integral part of the complex communication system between β-cells, essential for glucose homeostasis. Indeed, Eph/ephrin system was shown to be directly involved in the glucose-stimulated insulin secretion (GSIS) process occurring in the pancreatic
David E Buchholz et al.
Stem cells translational medicine, 2(5), 384-393 (2013-04-20)
Controlling the differentiation of human pluripotent stem cells is the goal of many laboratories, both to study normal human development and to generate cells for transplantation. One important cell type under investigation is the retinal pigmented epithelium (RPE). Age-related macular
Robert C Neugebauer et al.
Journal of medicinal chemistry, 51(5), 1203-1213 (2008-02-14)
NAD (+)-dependent histone deacetylases (sirtuins) are enzymes that cleave acetyl groups from lysines in histones and other proteins. Potent selective sirtuin inhibitors are interesting tools for the investigation of the biological functions of those enzymes and may be future drugs
Su Cheol Park et al.
Stem cells and development, 24(13), 1506-1514 (2015-04-14)
A large number of cancer stem cells (CSCs) have been isolated and identified; however, none has been cultured in an unlimited manner in vitro without losing tumorigenicity and multipotency. In this study, we successfully clonogenically cultured a newly identified CD34+
Vincenzo Libri et al.
Lancet (London, England), 384(9942), 504-513 (2014-05-06)
Friedreich's ataxia is a progressive degenerative disorder caused by deficiency of the frataxin protein. Expanded GAA repeats within intron 1 of the frataxin (FXN) gene lead to its heterochromatinisation and transcriptional silencing. Preclinical studies have shown that the histone deacetylase
Y Gong et al.
European review for medical and pharmacological sciences, 18(19), 2808-2820 (2014-10-24)
Obesity has long been suspected to be a risk factor for cancer. The relationship between body fat deposition and the pathogenesis of cancer has been the subject of many studies, however, no clear consensus has emerged linking these two biological
Christopher M Rembold
Current diabetes reports, 4(5), 330-334 (2004-10-06)
Non-insulin-dependent diabetes mellitus (NIDDM) and the metabolic syndrome separately and additively increase the risk for atherosclerotic cardiovascular disease. Considering the high cardiovascular risk associated with NIDDM and the metabolic syndrome, aggressive therapy of dyslipidemia with tailored combination therapy should be
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