Showing 1-30 of 413 results for "

N0636

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Katarzyna Szkudelska et al.
International journal of experimental pathology, 95(2), 86-94 (2014-03-19)
Administration of streptozotocin (STZ) and nicotinamide (NA) to adult rats allows for the induction of mild diabetes. However, this experimental model has not been fully characterized. This study was undertaken to determine the metabolic and secretory activity of adipose tissue...
Layasadat Khorsandi et al.
Cell and tissue research, 361(3), 745-753 (2015-03-22)
The aim of this study is to evaluate the collagen/hyaluronic acid (Col/HA) scaffold effect on the differentiation of insulin-producing cells (IPCs) from adipose-derived mesenchymal stem cells (ASCs). In this experimental study, ASCs were cultured and seeded in a Col/HA scaffold...
Jinshu Qiu et al.
Journal of pharmaceutical and biomedical analysis, 117, 163-172 (2015-09-12)
Monitoring amino acids and vitamins is important for understanding human health, food nutrition and the culture of mammalian cells used to produce therapeutic proteins in biotechnology. A method including ion pairing reversed-phase liquid chromatography with tandem mass spectrometry was developed...
Yu-Yun Shao et al.
Oncology, 85(5), 312-316 (2013-11-13)
A germline BIM deletion polymorphism has been proposed to predict a poor treatment efficacy of certain kinase inhibitors. The current study aimed to explore whether the BIM deletion polymorphism predicts the treatment efficacy of sorafenib for advanced hepatocellular carcinoma (HCC)....
Chung-Hwan Chen et al.
Journal of agricultural and food chemistry, 63(42), 9232-9238 (2015-08-27)
This study investigates the effects of Trametes versicolor (L.:Fr.) Pilát (TVP, also known as Yunzhi) on bone properties in diabetic rats. Forty-five male Wistar rats (8 weeks old) were fed either a chow diet (control) or a high-fat diet throughout...
T Pan et al.
Clinical radiology, 69(12), e553-e561 (2014-10-12)
To evaluate the safety and efficacy of combined therapy with transarterial chemoembolization (TACE) and sorafenib for hepatocellular carcinoma (HCC) with portal venous tumour thrombus (PVTT). This study was approved by the institutional review board. From May 2009 to May 2012...
Isabel Romero-Calvo et al.
Molecular cancer research : MCR, 17(1), 70-83 (2018-09-02)
Patient-derived pancreatic ductal adenocarcinoma (PDAC) organoid systems show great promise for understanding the biological underpinnings of disease and advancing therapeutic precision medicine. Despite the increased use of organoids, the fidelity of molecular features, genetic heterogeneity, and drug response to the...
E V Zinov'ev et al.
Eksperimental'naia i klinicheskaia farmakologiia, 76(4), 39-44 (2013-06-15)
Survival rate, average life expectancy of victims, parameters of the acid - base balance, gas composition of blood, and morphological structure of internal organs have been studied in acute experiments on a group of 120 rats with burn injury of...
Jose C Paz et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(48), 17116-17121 (2014-11-19)
In the fasted state, increases in catecholamine signaling promote adipocyte function via the protein kinase A-mediated phosphorylation of cyclic AMP response element binding protein (CREB). CREB activity is further up-regulated in obesity, despite reductions in catecholamine signaling, where it contributes...
Jun Ni et al.
Acta pharmacologica Sinica, 35(8), 1045-1054 (2014-07-01)
To explore the relationship between the signal transducer and activator of transcription 3 (STAT3) signaling and renal fibrosis. Rat renal tubular epithelial NRK-52E cells were treated with angiotesin II (Ang II), nicotinamide (an inhibitor of NAD+-dependent class III protein deacetylases...
Noriaki Kitada et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 40(4), 479-482 (2013-07-16)
The current status of treatment with sorafenib, and factors affecting the duration of treatment in patients started on sorafenib for hepatocellular carcinoma from July 2009 until April 2011 in the Department of Gastroenterology at Kobe City Medical Center General Hospital...
Virginie Bottero et al.
Virology, 392(1), 34-51 (2009-07-31)
KSHV vGPCR, a lytic cycle associated protein, induces several signaling pathways leading to the activation of various transcription factors and consequently the expression of cellular and viral genes. Though the role of vGPCR in KSHV tumorigenicity has been well studied...
Robert O'Brien et al.
The Journal of biological chemistry, 290(31), 19287-19306 (2015-05-31)
The cascade of events that lead to cognitive decline, motor deficits, and psychiatric symptoms in patients with Huntington disease (HD) is triggered by a polyglutamine expansion in the N-terminal region of the huntingtin (HTT) protein. A significant mechanism in HD...
Jerzy A Woznicki et al.
Cell death & disease, 11(1), 68-68 (2020-01-29)
Proteins of the BCL-2 family are evolutionarily conserved modulators of apoptosis that function as sensors of cellular integrity. Over the past three decades multiple BCL-2 family members have been identified, many of which are now fully incorporated into regulatory networks...
Sun Young Shin et al.
International journal of clinical pharmacology and therapeutics, 51(11), 837-846 (2013-10-01)
The purpose of this study was to identify the correlation of skin toxicity and hypertension with clinical benefit in advanced hepatocellular carcinoma (HCC) patients treated with sorafenib by analyzing medical records retrospectively. Data from medical records was statistically analyzed to...
K Schulpis et al.
Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 17(5), 443-448 (2004-09-11)
Low folate and vitamin B(12) concentrations during pregnancy are implicated with neural tube defects (NTD) and neurological manifestations in the neonates. To compare serum concentrations of folate and vitamin B(12) in 1025 Greek mothers, 908 immigrant Albanian mothers at delivery...
Keiichi Ito et al.
Liver international : official journal of the International Association for the Study of the Liver, 34(9), 1378-1390 (2013-11-19)
Hepatoblasts are somatic progenitor cells of the foetal liver that possess high proliferative capacity and bi-potency for differentiation into both hepatocytes and cholangiocytes. Although mesenchymal cells are known to be important for liver ontogeny, current understanding of their interaction with...
Danielle L Gomez et al.
PloS one, 10(8), e0133862-e0133862 (2015-08-20)
Neurogenin 3 (NGN3) is necessary and sufficient for endocrine differentiation during pancreatic development and is expressed by a population of progenitor cells that give rise exclusively to hormone-secreting cells within islets. NGN3 protein can be detected in the adult rodent...
Makoto Shioya et al.
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 111(7), 1424-1432 (2014-07-08)
Erythema multiforme (EM) is a known side effect of sorafenib therapy in cancer patients; at onset, the causative medication should be permanently discontinued. Here we report two cases of hepatocellular carcinoma (HCC) that developed sorafenib-induced EM. In both cases, retreatment...
Faqi Li et al.
Current medicinal chemistry, 13(8), 883-895 (2006-04-14)
Nicotinamide, the amide form of niacin (vitamin B(3)), is the precursor for the coenzyme beta-nicotinamide adenine dinucleotide (NAD(+)) and plays a significant role during the enhancement of cell survival as well as cell longevity. Yet, these abilities of nicotinamide appear...
Elisabeth Smolle et al.
Anticancer research, 34(4), 1519-1530 (2014-04-03)
Ovarian cancer (OC) is ranked as the eighth most common gynecological malignancy and is the leading cause of gynecological cancer-related deaths in women worldwide. The response to platinum- and taxane-based chemotherapy is very often poor, and targeted-therapeutics are currently being...
Kai Sun et al.
Scientific reports, 4, 6494-6494 (2014-09-30)
Cell-based therapies (CBTs) are considered the effective approaches to treat liver failure. However, which cell type is the most suitable source of CBTs for acute liver failure (ALF) or chronic liver failure (CLF) remains unclear. To investigate this, mature hepatocytes...
K Maráková et al.
Die Pharmazie, 69(9), 663-668 (2014-10-03)
The advanced hyphenated method based on capillary electrophoresis (CE) on-line combined with electrospray ionization (ESI) and tandem mass spectrometry (MS/MS, here triple quadrupole, QqQ) was developed and applied in pharmaceutical analysis in this work. Under the optimized CE separation (background...
Roberto Iacovelli et al.
Cancer treatment reviews, 40(2), 271-275 (2013-09-28)
Antiangiogenic agents (AAs) have reported grater efficacy compared to interferon. Despite these advances, radiological complete response to therapy is rare. We meta-analyzed the incidence of complete response in patients treated with AAs and in controls in main randomized clinical trials...
Giampiero Colombano et al.
Journal of medicinal chemistry, 53(2), 616-623 (2009-12-08)
The inhibition of NAD synthesis or salvage pathways has been proposed as a novel target for antitumoral drugs. Two molecules with this mechanism of action are at present undergoing clinical trials. In searching for similar novel molecules, we exploited copper-catalyzed...
Weirong Wang et al.
Experimental cell research, 319(10), 1523-1533 (2013-04-23)
The ligand-activated transcription factor peroxisome proliferator-activated receptor-α (PPARα) participates in the regulation of cellular inflammation. More recent studies indicated that sirtuin1 (SIRT1), a NAD(+)-dependent deacetylase, regulates the inflammatory response in adipocytes. However, whether the role of PPARα in inflammation is...
Salvatore Simmini et al.
Nature communications, 5, 5728-5728 (2014-12-17)
The endodermal lining of the adult gastro-intestinal tract harbours stem cells that are responsible for the day-to-day regeneration of the epithelium. Stem cells residing in the pyloric glands of the stomach and in the small intestinal crypts differ in their...
Nicotinamide, a form of vitamin B3, promotes expansion of natural killer cells that display increased in vivo survival and cytotoxic activity
Frei GM, et al.
Blood, 118, 4035-4035 (2011)
Shafiq M Syed et al.
Cell stem cell, 26(1), 64-80 (2019-12-31)
The remarkable regenerative capacity of the endometrium (the inner lining of the uterus) is essential for the sustenance of mammalian life. Over the years, the role of stem cells in endometrial functions and their pathologies has been suggested; however, the...
Sina Bartfeld et al.
Gastroenterology, 148(1), 126-136 (2014-10-14)
We previously established long-term, 3-dimensional culture of organoids from mouse tissues (intestine, stomach, pancreas, and liver) and human intestine and pancreas. Here we describe conditions required for long-term 3-dimensional culture of human gastric stem cells. The technology can be applied...