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mab3418

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Katja A Puttonen et al.
Cell transplantation, 22(10), 1753-1766 (2012-11-07)
Transplantation of human neural progenitor cells (hNPCs) is a promising therapeutic approach for various diseases of the central nervous system (CNS). Reliable testing of hNPC transplantation in animal models of neurological diseases requires that these cells can be produced in
Ethanol withdrawal influences survival and morphology of developing rat hippocampal neurons in vitro.
Tara A Lindsley, Shannon Clarke
Alcoholism, Clinical and Experimental Research null
Divya Pathak et al.
The Journal of biological chemistry, 290(37), 22325-22336 (2015-07-02)
Synaptic mitochondria are thought to be critical in supporting neuronal energy requirements at the synapse, and bioenergetic failure at the synapse may impair neural transmission and contribute to neurodegeneration. However, little is known about the energy requirements of synaptic vesicle
Cross-talk between neurons and astrocytes in response to bilirubin: early beneficial effects.
Falc?o, Ana Sofia, et al.
Neurochemical Research, 38, 644-659 (2013)
Yi Zhang et al.
Molecular neurobiology, 54(4), 2659-2673 (2016-03-20)
Treatment of brain injury with exosomes derived from mesenchymal stromal cells (MSCs) enhances neurite growth. However, the direct effect of exosomes on axonal growth and molecular mechanisms underlying exosome-enhanced neurite growth are not known. Using primary cortical neurons cultured in
Loic P Deleyrolle et al.
Methods in molecular biology (Clifton, N.J.), 549, 91-101 (2009-04-21)
During development and continuing into adulthood, stem cells function as a reservoir of undifferentiated cell types, whose role is to support cell genesis in several tissues and organs. In the adult, they play an essential homeostatic role by replacing differentiated
Igor O Nasonkin et al.
The Journal of comparative neurology, 519(10), 1914-1930 (2011-04-01)
DNA methyltransferases--DNMT1, DNMT3a, and DNMT3b--produce methylation patterns that dynamically regulate chromatin remodeling and gene expression. The vertebrate retina provides an ideal model to elucidate molecular control of neurogenesis as all neuronal cell types and Müller glia are generated in a
A G Pearson et al.
Neuroscience, 133(2), 437-451 (2005-05-10)
Activating transcription factor 2 (ATF2) is a member of the activator protein-1 family of transcription factors, which includes c-Jun and c-Fos. ATF2 is highly expressed in the mammalian brain although little is known about its function in nerve cells. Knockout
Jian-Nan Zhang et al.
Scientific reports, 6, 37050-37050 (2016-11-16)
Axonal degeneration is a key initiating event in many neurological diseases. Focal lesions to axons result in a rapid disintegration of the perilesional axon by acute axonal degeneration (AAD) within several hours. However, the underlying molecular mechanisms of AAD are
Bin Li et al.
Journal of neuropathology and experimental neurology, 67(1), 78-84 (2007-12-20)
The dentate gyrus, an important anatomic structure of the hippocampal formation, is one of the major areas in which neurogenesis takes place in the adult mammalian brain. Neurogenesis in the dentate gyrus is thought to play an important role in
Rachel A Jeffrey et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(50), 15613-15620 (2009-12-18)
Synaptic plasticity, the capacity of neurons to change the strength of their connections with experience, provides a mechanism for learning and memory in the brain. Long-term plasticity requires new transcription, indicating that synaptically generated signals must be transported to the
Lucio M Schiapparelli et al.
Cell reports, 28(7), 1935-1947 (2019-08-15)
The brain processes information and generates cognitive and motor outputs through functions of spatially organized proteins in different types of neurons. More complete knowledge of proteins and their distributions within neuronal compartments in intact circuits would help in the understanding
Morphologic and neurotoxic effects of ethanol vary with timing of exposure in vitro.
Tara A Lindsley, Laura L Comstock, Lisa J Rising
Alcohol null
Seung Tae Baek et al.
Nature medicine, 21(12), 1445-1454 (2015-11-03)
Focal malformations of cortical development (FMCDs) account for the majority of drug-resistant pediatric epilepsy. Postzygotic somatic mutations activating the phosphatidylinositol-4,5-bisphosphate-3-kinase (PI3K)-protein kinase B (AKT)-mammalian target of rapamycin (mTOR) pathway are found in a wide range of brain diseases, including FMCDs.
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Valerie T Y Tan et al.
Molecular brain, 11(1), 7-7 (2018-02-11)
Alzheimer's disease (AD) is a neurodegenerative disease driven in large part by accumulated deposits in the brain of the amyloid precursor protein (APP) cleavage product amyloid-β peptide (Aβ). However, AD is also characterised by reductions in secreted amyloid precursor protein-alpha
Postsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced A? and tau pathology in transgenic mouse models of Alzheimer's disease.
Shao, CY; Mirra, SS; Sait, HB; Sacktor, TC; Sigurdsson, EM
Acta neuropathologica null
Linyan Meng et al.
Human molecular genetics, 21(13), 3001-3012 (2012-04-12)
The Angelman syndrome gene, UBE3A, is subject to genomic imprinting controlled by mechanisms that are only partially understood. Its antisense transcript, UBE3A-ATS, is also imprinted and hypothesized to suppress UBE3A in cis. In this research, we showed that the mouse
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Expression of calcium channel CaV1.3 in cat spinal cord: light and electron microscopic immunohistochemical study.
Mengliang Zhang, Morten M?ller, Jonas Broman, Natalya Sukiasyan, Jacob Wienecke, Hans Hultborn
The Journal of Comparative Neurology null
Connor Long et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 93(1), 82-92 (2017-07-18)
Spinal cord injury (SCI) is a devastating disorder that affects humans and dogs. The prognosis of SCI depends on the severity of the injury and can include varying levels of motor and sensory deficits including devastating paraplegia and quadriplegia. Placental
Sarah E Rotschafer et al.
Frontiers in neural circuits, 10, 84-84 (2016-11-09)
Caspase-3 is a cysteine protease that is most commonly associated with cell death. Recent studies have shown additional roles in mediating cell differentiation, cell proliferation and development of cell morphology. We investigated the role of caspase-3 in the development of
Han Seok Koh et al.
Nature communications, 6, 6340-6340 (2015-03-21)
Inflammation is closely related to the extent of damage following cerebral ischaemia, and the targeting of this inflammation has emerged as a promising therapeutic strategy. Here, we present that hypoxia-induced glial T-cell immunoglobulin and mucin domain protein (TIM)-3 can function
Postnatal neural precursor cell regions in the rostral subventricular zone, hippocampal subgranular zone and cerebellum of the dog (Canis lupus familiaris).
Walton, RM; Parmentier, T; Wolfe, JH
Histochemistry and Cell Biology null
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Wai Si Chan et al.
Frontiers in molecular neuroscience, 6, 23-23 (2013-08-30)
Proliferation of endogenous neural stem/progenitor cells (NSPCs) has been identified in both normal and injured adult mammalian spinal cord. Yet the signaling mechanisms underlying the regulation of adult spinal cord NSPCs proliferation and commitment toward a neuronal lineage remain undefined.
Weikang Cai et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(29), 9887-9897 (2012-07-21)
The molecular mechanisms governing the spontaneous recovery seen following brain injury remain elusive, but recent studies indicate that injury-induced stimulation of hippocampal neurogenesis contributes to the repair process. The therapeutic potential of endogenous neurogenesis is tempered by the demonstration that
Min-Tae Jeon et al.
British journal of pharmacology, 177(3), 668-686 (2019-10-29)
We recently reported that AAV1-Rheb(S16H) transduction could protect hippocampal neurons through the induction of brain-derived neurotrophic factor (BDNF) in the rat hippocampus in vivo. It is still unclear how neuronal BDNF produced by AAV1-Rheb(S16H) transduction induces neuroprotective effects in the
Michael S Breen et al.
Molecular autism, 11(1), 53-53 (2020-06-21)
Phelan-McDermid syndrome (PMS) is a rare genetic disorder with high risk of autism spectrum disorder (ASD), intellectual disability, and language delay, and is caused by 22q13.3 deletions or mutations in the SHANK3 gene. To date, the molecular and pathway changes
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