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Shenghong Zhong et al.
Soft matter, 11(35), 6999-7004 (2015-08-05)
Here, we report the development of an experimental system based on liquid crystals (LCs) confined in microcapillaries for imaging interfacial phenomena. The inner surfaces of the microcapillaries were modified with octadecyltrichlorosilane to promote an escaped-radial configuration of LCs. We checked
Friedrich Finkenwirth et al.
The Journal of biological chemistry, 290(27), 16929-16942 (2015-05-21)
Energy-coupling factor (ECF) transporters for vitamins and metal ions in prokaryotes consist of two ATP-binding cassette-type ATPases, a substrate-specific transmembrane protein (S component) and a transmembrane protein (T component) that physically interacts with the ATPases and the S component. The
Francesco Cambuli et al.
Nature communications, 5, 5538-5538 (2014-11-27)
Embryonic (ES) and trophoblast (TS) stem cells reflect the first, irrevocable cell fate decision in development that is reinforced by distinct epigenetic lineage barriers. Nonetheless, ES cells can seemingly acquire TS-like characteristics upon manipulation of lineage-determining transcription factors or activation
Sonam Gupta et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 778, 22-36 (2015-03-03)
The present study was conducted to investigate the effect of the neurotoxins 6-hydroxydopamine and lipopolysaccharide on astrocytes. Rat astrocyte C6 cells were treated with different concentration of 6-hydroxydopamine (6-OHDA)/lipopolysaccharides (LPS) for 24 h. Both neurotoxins significantly decreased the viability of
Eric J Roth et al.
The Review of scientific instruments, 86(11), 113103-113103 (2015-12-03)
Colloidal phenomena in porous media, natural or engineered, are important in a breadth of science and technology applications, but fundamental understanding is hampered by the difficulty in measuring colloid deposit morphology in situ. To partially address this need, this paper
Han-Peng Jiang et al.
The Analyst, 139(19), 4940-4946 (2014-07-30)
In the current study, we developed a facile strategy for the one-pot synthesis of an aptamer-based organic-silica hybrid monolithic capillary column. A 5'-SH-modified aptamer, specifically targeting doxorubicin, was covalently modified in the hybrid silica monolithic column by a sol-gel method
Dae Heon Kim et al.
Nature communications, 6, 6843-6843 (2015-04-17)
In eukaryotic cells, organellar proteome biogenesis is pivotal for cellular function. Chloroplasts contain a complex proteome, the biogenesis of which includes post-translational import of nuclear-encoded proteins. However, the mechanisms determining when and how nascent chloroplast-targeted proteins are sorted in the
Xiaolan Deng et al.
Oncotarget, 6(34), 35173-35182 (2015-10-16)
Inner centromere protein (INCENP) is a part of a protein complex known as the chromosomal passenger complex (CPC) that is essential for correcting non-bipolar chromosome attachments and for cytokinesis. We here demonstrate that a protein arginine methyltransferase PRMT1, which are
Carla Thomas et al.
Pathology, 47(4), 349-354 (2015-05-06)
Hairy cell leukaemia (HCL) is a rare, indolent chronic B-cell leukaemia accounting for approximately 2% of all adult leukaemias. The recent association of the BRAF p.Val600Glu (V600E) mutation in HCL makes it a valuable molecular diagnostic marker. We compared the
Pratoomporn Khaokhajorn et al.
World journal of microbiology & biotechnology, 31(10), 1543-1554 (2015-07-22)
Naphthoquinones are deep red polyketide pigments produced by the ant-pathogenic fungus Ophiocordyceps sp. BCC1869. In culture, biosynthesis of these naphthoquinones remains at a low level during the first 20 days and reaches its maximum production level at approximately 50 days.
Peng Lin et al.
The Science of the total environment, 541, 1070-1082 (2015-10-17)
Despite major investments in point source reductions, portions of the Great Lakes, like Green Bay, remain hypereutrophic and are subject to persistent seasonal hypoxia. Phosphorus (P) is generally a limiting nutrient in the Great Lakes ecosystem, but not all P
Sixin Jiang et al.
Respiratory research, 16, 93-93 (2015-08-06)
Polo-like kinase 1 (Plk1) is a serine/threonine protein kinase that has been implicated in the regulation of mitosis. In addition, the activation of mitogen-activated protein kinase (MAPK) is a key event in the early stage of the growth factor response.
Amal Kamal Abdel-Aziz et al.
Basic & clinical pharmacology & toxicology, 116(1), 37-46 (2014-06-17)
Imatinib is a principal therapeutic agent for targeting colorectal tumours. However, mono-targeting by imatinib does not always achieve complete cancer eradication. Selenite, a well-known chemopreventive agent, is commonly used in cancer patients. In this study, we aimed to explore whether
Subhashchandra Naik et al.
Protein science : a publication of the Protein Society, 23(10), 1461-1478 (2014-07-22)
The ability of a GroEL-based bio-layer interferometry (BLI) assay to detect structurally altered and/or aggregated species of pharmaceutically relevant proteins is demonstrated. Assay development included optimizing biotinylated-GroEL immobilization to streptavidin biosensors, combined with biophysical and activity measurements showing native and
Armêl Millet et al.
Scientific reports, 5, 13154-13154 (2015-08-25)
The enzymatic DNA relaxation requires the DNA to be transiently nicked and rejoined, the covalent topoisomerase-DNA complex being a key intermediate of the nicking-joining reaction. Practically, this reaction is most often characterized by oligonucleotides. However, the incision-religation of an oligonucleotide
Thierry K Ngouana et al.
Mycoses, 58(1), 33-39 (2014-10-08)
Minor species of the Candida albicans complex may cause overestimation of the epidemiology of C. albicans, and misidentifications could mask their implication in human pathology. Authors determined the occurrence of minor species of the C. albicans complex (C. africana, C.
Jingjing Wang et al.
Life sciences, 120, 31-38 (2014-12-03)
Myriocin is a fungal metabolite with antiviral activity, including influenza, hepatitis B, and hepatitis C viruses. We investigated whether myriocin has activity against human HSV-2, one of the most prevalent pathogens of sexually transmitted disease. Cell culture systems were used
Carol A Stepien et al.
PloS one, 10(8), e0135146-e0135146 (2015-08-28)
Viral Hemorrhagic Septicemia virus (VHSv) is an RNA rhabdovirus, which causes one of the world's most serious fish diseases, infecting >80 freshwater and marine species across the Northern Hemisphere. A new, novel, and especially virulent substrain-VHSv-IVb-first appeared in the Laurentian
Guizhong Zhang et al.
Biochimica et biophysica acta, 1852(8), 1574-1584 (2015-04-29)
Proliferation of vascular smooth muscle cells (VSMCs) plays an important role in restenosis, a disease characterized by smooth muscle cell hyperplasia and neointimal formation. How proliferation signals are controlled to avoid restenosis is not fully understood. Here we report that
Maasa Tsuge et al.
Cytotechnology, 67(4), 681-687 (2014-07-11)
Post-translational modifications alter protein function to mediate complex hierarchical regulatory processes that are crucial to eukaryotic cellular function. The small ubiquitin-like modifier (SUMO) is an important post-translational modification that affects transcriptional regulation, nuclear localization, and the maintenance of genome stability.
Qi Peng et al.
PloS one, 10(3), e0120683-e0120683 (2015-03-17)
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common enzymatic disorder of the erythrocytes that affects 400 million people worldwide. We developed a PCR-reverse dot blot (RDB) assay to screen twenty genotypes of seventeen Chinese G6PD mutations and investigate the spectrum of
Eduardo Cremonese Filippi-Chiela et al.
Autophagy, 11(7), 1099-1113 (2015-02-24)
Autophagy and senescence have been described as central features of cell biology, but the interplay between these mechanisms remains obscure. Using a therapeutically relevant model of DNA damage-induced senescence in human glioma cells, we demonstrated that acute treatment with temozolomide
Roberta Minotti et al.
Molecular and cellular biology, 35(18), 3189-3199 (2015-07-08)
ADP-ribosyltransferase diphtheria-toxin like 1/poly(ADP-ribose) polymerase 1 (ARTD1/PARP1) is a chromatin-associated protein in the nucleus and plays an important role in different cellular processes such as regulation of gene transcription. ARTD1 has been shown to coregulate the inflammatory response by modulating
Imma Noguerola et al.
FEMS microbiology ecology, 91(7) (2015-07-22)
Sulfidic redoxclines are a suitable niche for the growth and activity of different chemo- and photolithotrophic sulphide-oxidizing microbial groups such as the Epsilonproteobacteria and the green sulfur bacteria (GSB). We have investigated the diversity, abundance and contribution to inorganic carbon
Kayla M Harmeyer et al.
Nucleic acids research, 43(6), e38-e38 (2014-12-30)
Genome-wide chromatin immunoprecipitation (ChIP) studies have brought significant insight into the genomic localization of chromatin-associated proteins and histone modifications. The large amount of data generated by these analyses, however, require approaches that enable rapid validation and analysis of biological relevance.
Abdolvahab Moradi et al.
Iranian journal of basic medical sciences, 17(5), 370-377 (2014-06-27)
It has been reported that the mutation of the pre-core (PC) and basal-core promoter (BCP) may play an important role in the development of HBV-related hepatocellular carcinoma (HCC). In this study the PC and BCP mutations were investigated in chronic
Jia-Min B Pang et al.
Breast cancer research : BCR, 16(5), 423-423 (2014-10-22)
DNA methylation is a well-studied biomarker in invasive breast cancer, but its role in ductal carcinoma in situ (DCIS) is less well characterized. The aims of this study are to assess the methylation profile in DCIS for a panel of
Faiza Tebbji et al.
PLoS genetics, 10(11), e1004770-e1004770 (2014-11-07)
Mediator is a multi-subunit protein complex that regulates gene expression in eukaryotes by integrating physiological and developmental signals and transmitting them to the general RNA polymerase II machinery. We examined, in the fungal pathogen Candida albicans, a set of conditional
Franziska Mohr et al.
PloS one, 10(10), e0141136-e0141136 (2015-10-28)
The muscarinic M2 receptor (M2R) acts as a negative feedback regulator in central cholinergic systems. Activation of the M2 receptor limits acetylcholine (ACh) release, especially when ACh levels are increased because acetylcholinesterase (AChE) activity is acutely inhibited. Chronically high ACh
Mariane Noronha Domingues et al.
Journal of molecular biology, 427(15), 2491-2506 (2015-05-28)
Poly(A)-binding proteins (PABPs) play crucial roles in mRNA biogenesis, stability, transport and translational control in most eukaryotic cells. Although animal PABPs are well-studied proteins, the biological role, three-dimensional structure and RNA-binding mode of plant PABPs remain largely uncharacterized. Here, we
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