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Lingyan Wang et al.
Journal of the Association for Research in Otolaryngology : JARO, 12(4), 407-421 (2011-03-15)
Scleraxis (Scx) is a basic helix-loop-helix transcription factor expressed in tendon and ligament progenitor cells and the differentiated cells within these connective tissues in the axial and appendicular skeleton. Unexpectedly, we found expression of the Scx transgenic reporter mouse, Scx-GFP...
Qiao Zhang et al.
Nature communications, 8, 15664-15664 (2017-06-02)
Although recent evidence has pointed to the existence of small open reading frame (smORF)-encoded microproteins in mammals, their function remains to be determined. Skeletal muscle development requires fusion of mononuclear progenitors to form multinucleated myotubes, a critical but poorly understood...
Tobias Winkler et al.
Journal of cachexia, sarcopenia and muscle, 9(5), 880-897 (2018-09-20)
No regenerative approach has thus far been shown to be effective in skeletal muscle injuries, despite their high frequency and associated functional deficits. We sought to address surgical trauma-related muscle injuries using local intraoperative application of allogeneic placenta-derived, mesenchymal-like adherent...
Anja Böhm et al.
Diabetes, 65(10), 2849-2861 (2016-07-01)
A substantial number of people at risk of developing type 2 diabetes could not improve insulin sensitivity by physical training intervention. We studied the mechanisms of this impaired exercise response in 20 middle-aged individuals at high risk of developing type...
Charlotte Suetta et al.
PloS one, 7(12), e51238-e51238 (2013-01-04)
Important insights concerning the molecular basis of skeletal muscle disuse-atrophy and aging related muscle loss have been obtained in cell culture and animal models, but these regulatory signaling pathways have not previously been studied in aging human muscle. In the...
Paula M Costello et al.
Reproductive sciences (Thousand Oaks, Calif.), 20(10), 1144-1155 (2013-02-20)
Suboptimal maternal nutrition and body composition are implicated in metabolic disease risk in adult offspring. We hypothesized that modest disruption of glucose homeostasis previously observed in young adult sheep offspring from ewes of a lower body condition score (BCS) would...
Yasuro Furuichi et al.
Biochimica et biophysica acta, 1837(10), 1699-1706 (2014-06-03)
Carnitine is well recognized as a key regulator of long-chain fatty acyl group translocation into the mitochondria. In addition, carnitine, as acetylcarnitine, acts as an acceptor of excess acetyl-CoA, a potent inhibitor of pyruvate dehydrogenase. Here, we provide a new...
K Nakyinsige et al.
Meat science, 108, 125-131 (2015-06-27)
This experiment aimed to determine microbial spoilage and lipid and protein oxidation during aerobic refrigerated (4°C) storage of rabbit meat. Forty male New Zealand white rabbits were slaughtered according to the Halal slaughter procedure. The hind limbs were used for...
Duo Zhang et al.
The Journal of cell biology, 207(6), 753-766 (2014-12-17)
It is known that thyroid hormone (TH) is a major determinant of muscle fiber composition, but the molecular mechanism by which it does so remains unclear. Here, we demonstrated that miR-133a1 is a direct target gene of TH in muscle....
Daisuke Matsumaru et al.
PloS one, 6(1), e16260-e16260 (2011-02-02)
An omphalocele is one of the major ventral body wall malformations and is characterized by abnormally herniated viscera from the body trunk. It has been frequently found to be associated with other structural malformations, such as genitourinary malformations and digit...
Pascal Stuelsatz et al.
The Journal of biological chemistry, 285(17), 12670-12683 (2010-02-09)
Calpain 3 is a calcium-dependent cysteine protease that is primarily expressed in skeletal muscle and is implicated in limb girdle muscular dystrophy type 2A. To date, its best characterized function is located within the sarcomere, but this protease is found...
E Sierra et al.
Scientific reports, 5, 15909-15909 (2015-10-31)
Different marine mammal species exhibit a wide range of diving behaviour based on their breath-hold diving capabilities. They are classically categorized as long duration, deep-diving and short duration, shallow-diving species. These abilities are likely to be related to the muscle...
Mark E Issa et al.
American journal of physiology. Cell physiology, 302(11), C1621-C1631 (2012-03-31)
The chemokine-like receptor-1 (CMKLR1) is a G protein-coupled receptor that is activated by chemerin, a secreted plasma leukocyte attractant and adipokine. Previous studies identified that CMKLR1 is expressed in skeletal muscle in a stage-specific fashion during embryogenesis and in adult...
Alice W Racca et al.
Human molecular genetics, 24(12), 3348-3358 (2015-03-06)
Distal arthrogryposis is the most common known heritable cause of congenital contractures (e.g. clubfoot) and results from mutations in genes that encode proteins of the contractile complex of skeletal muscle cells. Mutations are most frequently found in MYH3 and are...
Peter H Chipman et al.
The European journal of neuroscience, 31(2), 238-249 (2010-01-16)
Studies examining the etiology of motoneuron diseases usually focus on motoneuron death as the defining pathophysiology of the disease. However, impaired neuromuscular transmission and synapse withdrawal often precede cell death, raising the possibility that abnormalities in synaptic function contribute to...
Harshini Neelakantan et al.
Biochemical pharmacology, 163, 481-492 (2019-02-13)
Aging is accompanied by progressive declines in skeletal muscle mass and strength and impaired regenerative capacity, predisposing older adults to debilitating age-related muscle deteriorations and severe morbidity. Muscle stem cells (muSCs) that proliferate, differentiate to fusion-competent myoblasts, and facilitate muscle...
Analise Z Reeves et al.
ACS synthetic biology, 4(5), 644-654 (2015-04-09)
Many Gram-negative pathogens encode type 3 secretion systems, sophisticated nanomachines that deliver proteins directly into the cytoplasm of mammalian cells. These systems present attractive opportunities for therapeutic protein delivery applications; however, their utility has been limited by their inherent pathogenicity....
Ronald W Matheny et al.
Molecular and cellular biology, 35(7), 1182-1196 (2015-01-22)
Phosphoinositide 3-OH kinase (PI3K) regulates a number of developmental and physiologic processes in skeletal muscle; however, the contributions of individual PI3K p110 catalytic subunits to these processes are not well-defined. To address this question, we investigated the role of the...
Lydia Francis et al.
Journal of biomaterials applications, 33(3), 447-465 (2018-09-19)
Three-dimensional hydrogels are ideal for tissue engineering applications due to their structural integrity and similarity to native soft tissues; however, they can lack mechanical stability. Our objective was to develop a bioactive and mechanically stable hydrogel for clinical application. Auricular...
Mattia Quattrocelli et al.
The Journal of clinical investigation, 125(12), 4463-4482 (2015-11-17)
Conditions such as muscular dystrophies (MDs) that affect both cardiac and skeletal muscles would benefit from therapeutic strategies that enable regeneration of both of these striated muscle types. Protocols have been developed to promote induced pluripotent stem cells (iPSCs) to...
Céline Ferrié et al.
Experimental and molecular pathology, 108, 42-56 (2019-03-19)
Achilles tendon rupture necessitates rapid tendon reattachment to reinstate plantar flexion before affected muscles deteriorate through muscle fiber atrophy and transformation. The implicated process may involve alterations in sarcolemmal sites of myofibril attachment (costameres), which control myofibrillogenesis via a mechano-regulated...
Wei Shen et al.
The American journal of pathology, 167(4), 1105-1117 (2005-09-30)
Nonsteroidal anti-inflammatory drugs are often prescribed after muscle injury. However, the effect of nonsteroidal anti-inflammatory drugs on muscle healing remains primarily controversial. To further examine the validity of using these drugs after muscle injury, we investigated the working mechanism of...
João Paulo L F Guilherme et al.
Journal of strength and conditioning research, 33(3), 691-700 (2019-01-30)
Guilherme, JPLF, Egorova, ES, Semenova, EA, Kostryukova, ES, Kulemin, NA, Borisov, OV, Khabibova, SA, Larin, AK, Ospanova, EA, Pavlenko, AV, Lyubaeva, EV, Popov, DV, Lysenko, EA, Vepkhvadze, TF, Lednev, EM, Govorun, VM, Generozov, EV, Ahmetov, II, and Lancha Junior, AH....
Zheng Li et al.
Food chemistry, 245, 233-239 (2017-12-31)
Protein degradation is primarily responsible for postmortem meat tenderization, which might be affected by phosphorylation. The objective of this study was to investigate the effect of phosphorylation on myofibrillar proteins degradation in muscle during postmortem. Here we modulated the phosphorylation...
Holger Greschik et al.
Cell death & disease, 8(11), e3173-e3173 (2017-11-24)
While several studies correlated increased expression of the histone code reader Spin1 with tumor formation or growth, little is known about physiological functions of the protein. We generated Spin1
M Shibata et al.
Journal of animal science, 87(8), 2700-2708 (2009-05-08)
The objective of this study was to investigate the differences in the muscle proteome of grass-fed and grain-fed cattle. Eight Japanese Black Cattle 10 mo of age were separated randomly into 2 groups: 1) grazing (grass-fed) and 2) concentrate (grain-fed)...
Osvaldo Contreras et al.
Skeletal muscle, 8(1), 5-5 (2018-02-22)
Tyrosine kinase inhibitors (TKIs) are effective therapies with demonstrated antineoplastic activity. Nilotinib is a second-generation FDA-approved TKI designed to overcome Imatinib resistance and intolerance in patients with chronic myelogenous leukemia (CML). Interestingly, TKIs have also been shown to be an...
Shuji Ueda et al.
Bioscience, biotechnology, and biochemistry, 1-11 (2018-10-20)
Progress in metabolomic analysis now allows the evaluation of food quality. This study aims to identify the metabolites in meat from livestock using a metabolomic approach. Using gas chromatography-mass spectrometry (GC/MS), many metabolites were reproducibly detected in meats, and distinct...
Kim Cluff et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 305(3), R291-R299 (2013-05-31)
Peripheral arterial disease (PAD), which affects ~10 million Americans, is characterized by atherosclerosis of the noncoronary arteries. PAD produces a progressive accumulation of ischemic injury to the legs, manifested as a gradual degradation of gastrocnemius histology. In this study, we...
S Moscato et al.
Scientific reports, 8(1), 13975-13975 (2018-09-20)
Connexins are a family of membrane-spanning proteins named according to their molecular weight. They are known to form membrane channels mediating cell-cell communication, which play an essential role in the propagation of electrical activity in the heart. Cx26 has been...
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