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Katharina M Uhlig et al.
Journal of virology, 89(17), 9044-9060 (2015-06-19)
To induce and trigger innate and adaptive immune responses, antigen-presenting cells (APCs) take up and process antigens. Retroviral particles are capable of transferring not only genetic information but also foreign cargo proteins when they are genetically fused to viral structural...
Rongrong Li et al.
Anesthesiology, 122(3), 595-605 (2015-01-16)
The current study examined the role(s) of autophagy in myotoxicity induced by bupivacaine in mouse myoblast C2c12 cells. C2c12 cells were treated with bupivacaine. Myotoxicity was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (n = 3 to 30), live/dead assay (n =...
Ji Hyun Shin et al.
Biochemical and biophysical research communications, 460(2), 428-433 (2015-03-23)
Previously, we showed that BIX-01294 treatment strongly activates autophagy. Although, the interplay between autophagy and ciliogenesis has been suggested, the role of autophagy in ciliogenesis is controversial and largely unknown. In this study, we investigated the effects of autophagy induced...
Kelly E Miller et al.
The Journal of cell biology, 209(2), 211-220 (2015-04-22)
Linker histone H1 is required for mitotic chromosome architecture in Xenopus laevis egg extracts and, unlike core histones, exhibits rapid turnover on chromatin. Mechanisms regulating the recruitment, deposition, and dynamics of linker histones in mitosis are largely unknown. We found...
Rachida Mersni-Achour et al.
Microbiology (Reading, England), 161(Pt 5), 997-1007 (2015-02-24)
Vibrio tubiashii is a marine pathogen isolated from larval and juvenile bivalve molluscs that causes bacillary necrosis. Recent studies demonstrated the isolation of this species in a French experimental hatchery/nursery affecting Crassostrea gigas spat in 2007. Here, using larvae of...
Mariana Portovedo et al.
PloS one, 10(3), e0119850-e0119850 (2015-03-19)
Autophagy is an important process that regulates cellular homeostasis by degrading dysfunctional proteins, organelles and lipids. In this study, the hypothesis that obesity could lead to impairment in hypothalamic autophagy in mice was evaluated by examining the hypothalamic distribution and...
Ivana Pibiri et al.
European journal of medicinal chemistry, 101, 236-244 (2015-07-06)
Premature stop codons are the result of nonsense mutations occurring within the coding sequence of a gene. These mutations lead to the synthesis of a truncated protein and are responsible for several genetic diseases. A potential pharmacological approach to treat...
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
U K Laemmli
Nature, 227(5259), 680-685 (1970-08-15)
Ricardo Rodríguez-Calvo et al.
Thrombosis and haemostasis, 113(6), 1323-1334 (2015-03-27)
Matrix metalloproteinases (MMPs) are associated with tissue remodelling and repair. In non-vascular tissues, NR4A receptors have been involved in the regulation of MMPs by transcriptional repression mechanisms. Here, we analyse alternative mechanisms involving NR4A receptors in the modulation of MMP...
Y-Y Hou et al.
Oral diseases, 21(2), 195-206 (2014-04-03)
To investigate the association of miR-499a genetic polymorphism with the risk of oral leukoplakia, oral submucous fibrosis (OSF), oral squamous cell carcinoma (OSCC), and clinicopathological outcomes of OSCC. The genotyping of miR-499a T>C (rs3746444) using TagMan assay was conducted in...
Jianjun Ma et al.
The Biochemical journal, 469(3), 399-408 (2015-07-25)
Excessive osteoclast formation and bone resorption are key causes of osteoporosis. Natural compounds can serve as alternative therapeutic agents for the prevention and treatment of osteoporosis, and some natural compounds may have advantages over traditional drugs. In the present paper...
D R P Sauter et al.
Pflugers Archiv : European journal of physiology, 467(7), 1495-1508 (2014-08-29)
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst survival rates of all cancers. ANO1 (TMEM16A) is a recently identified Ca(2+)-activated Cl(-) channel (CaCC) that is upregulated in several tumors. Although ANO1 was subject to extensive studies in the recent...
Jing Wan et al.
Acta physiologica (Oxford, England), 214(2), 189-199 (2015-04-09)
Opioids are the most prescribed analgesics for moderate and severe pain management; however, chronic use impairs host innate immune response and increases susceptibility to infection. Recently, autophagy has been shown to be an innate defence mechanism against bacterial infection. The...
Min-Je Kim et al.
Journal of microbiology and biotechnology, 25(5), 648-657 (2015-02-03)
H9, a novel herbal extract, demonstrated cytotoxicity in A549 non-small cell lung cancer (NSCLC) cell lines. In this study, we investigated whether H9, and/or co-treatment with an anticancer drug, pemetrexed (PEM), inhibited tumor growth in BALB/c nude mice models bearing...
Bernardo Nuche-Berenguer et al.
Journal of cellular biochemistry, 116(1), 22-36 (2014-08-01)
Recent studies report the Src-family kinases (SFK's) are important in a number of physiological and pathophysiological responses of pancreatic acinar cells (pancreatitis, growth, apoptosis); however, the role of SFKs in various signaling cascades important in mediating these cell functions is...
Thomas B Lentz et al.
Journal of virology, 89(1), 181-194 (2014-10-17)
Adeno-associated virus (AAV) is a dependent virus of the family Parvoviridae. The gene expression and replication of AAV and derived recombinant AAV (rAAV) vectors are severely limited (>10-fold) by the cellular DNA damage-sensing complex made up of Mre11, Rad50, and...
Chary Marquez Batista et al.
Neural plasticity, 2014, 451639-451639 (2014-08-12)
Pigment epithelium derived factor (PEDF) exerts trophic actions to motoneurons and modulates nonneuronal restorative events, but its effects on neuroplasticity responses after spinal cord (SC) injury are unknown. Rats received a low thoracic SC photothrombotic ischemia and local injection of...
Weitao Wen et al.
The Journal of infection, 70(6), 631-640 (2014-12-17)
It has been well recognized that microRNA plays a role in the host-pathogen interaction network. The significance of microRNA in the regulation of dengue virus (DENV) replication, however, remains unknown. The objective of our study was to determine the biological...
Huifen Li et al.
Diagnostic pathology, 10, 117-117 (2015-07-22)
MicroRNAs (miRNAs) can serve as tumor suppressors and might provide an efficient strategy for annihilating tumor cells. Nevertheless, the potential role of miR-325 in hepatocellular carcinoma (HCC) is still unknown. Using RT-PCR, immunoblots invasion assays and bioinformatics strategies, we investigated...
Polina Rabinovich-Toidman et al.
PloS one, 10(11), e0143420-e0143420 (2015-11-26)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease and it is the most common adult onset neurodegenerative disorder affecting motor neurons. There is currently no effective treatment for ALS and our understanding of the pathological mechanism is still far...
Duo Zhang et al.
Molecular medicine reports, 11(1), 349-356 (2014-10-30)
Trichosanthin (TCS) is a type I ribosome--inactivating protein, which inhibits cell viability in human epithelial type 2 (HEp-2) and AMC-HN-8 human laryngeal epidermoid carcinoma cells. Although TCS is a potential chemotherapeutic agent, its mechanism of action remains to be elucidated....
Jong Hyun Lee et al.
Oncotarget, 6(8), 6386-6405 (2015-03-20)
Persistent phosphorylation of signal transducers and activators of transcription 3 (STAT3) is frequently observed in tumor cells. We found that brassinin (BSN) suppressed both constitutive and IL-6-inducible STAT3 activation in lung cancer cells. Moreover, BSN induced PIAS-3 protein and mRNA...
Shoken Lee et al.
The EMBO journal, 34(5), 669-688 (2015-01-18)
P4-ATPases translocate aminophospholipids, such as phosphatidylserine (PS), to the cytosolic leaflet of membranes. PS is highly enriched in recycling endosomes (REs) and is essential for endosomal membrane traffic. Here, we show that PS flipping by an RE-localized P4-ATPase is required...
Carine P Arnoni et al.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 16(3), 469-480 (2014-03-05)
Transformer Growth Factor (TGF-β1) and angiotensin II (AngII) induce epithelial mesenchymal transition (EMT) and myofibroblastic transdifferentiation (MFT) contributing to renal fibrosis. The present study evaluated the capacity of an AT1 receptor blocker (losartan) to induce the regression of pre-existing fibrosis...
Yongbo Yu et al.
Chemical research in toxicology, 28(3), 490-500 (2015-01-28)
The multinucleation effect of silica nanoparticles (SiNPs) had been determined in our previous studies, but the relative mechanisms of multinucleation and how the multinucleated cells are generated were still not clear. This extensional study was conducted to investigate the mechanisms...
Zhenqing Wei et al.
Pituitary, 18(5), 710-721 (2015-04-12)
Pituitary carcinomas are extremely rare neoplasms, and molecular events leading to malignant pituitary transformation are largely unknown. Enhanced understanding of molecular mechanisms driving malignant pituitary progression would be beneficial for pituitary carcinoma diagnosis and treatment. Differential microRNA expression in paired...
Xiaosong Gu et al.
Experimental physiology, 100(7), 805-817 (2015-05-07)
What is the central question of this study? What is the cardioprotective role of fractalkine neutralization in heart failure and what are the mechanisms responsible? What is the main finding and its importance? The concentration of fractalkine is increased in...
Young Min Kim et al.
International immunopharmacology, 26(1), 112-118 (2015-03-31)
High mobility group box 1 (HMGB1) is now recognized as a late mediator of sepsis. Although glycyrrhizin was known as inhibitor of HMGB1, it is not yet clear underlying mechanism(s). We found that glycyrrhizin activates translocation of Nrf2 from cytosol...
Jennifer A Fraser et al.
Journal of molecular biology, 427(8), 1728-1747 (2014-12-30)
Mouse double minute 2 (MDM2) has a phosphorylation site within a lid motif at Ser17 whose phosphomimetic mutation to Asp17 stimulates MDM2-mediated polyubiquitination of p53. MDM2 lid deletion, but not Asp17 mutation, induced a blue shift in the λ(max) of...
Pete Gagnon et al.
Journal of chromatography. A, 1374, 145-155 (2014-12-08)
Chromatin heteroaggregates comprising nucleosomal arrays, DNA, histone and non-histone host cell proteins contributed 28% of the host contaminant mass in an IgG cell culture harvest. A subset comprising soluble particles of 50-400nm was retained through its histone component by an...
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