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L2020

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Mei-Yun Cheng et al.
Analytical biochemistry, 539, 11-21 (2017-09-26)
We report here the development of a compartmentalized culture device that allows the spatial separation of the somatodendrites and axons of central nervous system (CNS) neurons. The device consists of two compartments separated by a septum constructed by attaching a
Roberta Pereira de Melo Guimarães et al.
Frontiers in cellular neuroscience, 12, 410-410 (2018-11-30)
Degenerative retinopathies are the leading causes of irreversible visual impairment in the elderly, affecting hundreds of millions of patients. Müller glia cells (MGC), the main type of glia found in the vertebrate retina, can resume proliferation in the rodent adult
Ulf D Kahlert et al.
Journal of neuropathology and experimental neurology, 74(9), 889-900 (2015-07-30)
Wingless (Wnt) signaling is an important pathway in gliomagenesis and in the growth of stem-like glioma cells. Using immunohistochemistry to assess the translocation of β-catenin protein, we identified intranuclear staining suggesting Wnt pathway activation in 8 of 43 surgical samples
Efthymia Chantzi et al.
BMC bioinformatics, 20(1), 304-304 (2019-06-06)
Pharmacological treatment of complex diseases using more than two drugs is commonplace in the clinic due to better efficacy, decreased toxicity and reduced risk for developing resistance. However, many of these higher-order treatments have not undergone any detailed preceding in
Hong-Wei Han et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 97, 656-666 (2017-11-05)
In current study, a series of shikonin derivatives were synthesized and its anticancer activity was evaluated. As a result, PMMB232 showed the best antiproliferation activity with an IC
H Belinson et al.
Molecular psychiatry, 21(10), 1417-1433 (2016-02-03)
Social interaction is a fundamental behavior in all animal species, but the developmental timing of the social neural circuit formation and the cellular and molecular mechanisms governing its formation are poorly understood. We generated a mouse model with mutations in
Francesca Pistollato et al.
Toxicology and applied pharmacology, 280(2), 378-388 (2014-08-26)
According to the advocated paradigm shift in toxicology, acquisition of knowledge on the mechanisms underlying the toxicity of chemicals, such as perturbations of biological pathways, is of primary interest. Pluripotent stem cells (PSCs), such as human embryonic stem cells (hESCs)
Silvia Piccinotti et al.
PLoS pathogens, 12(7), e1005753-e1005753 (2016-07-28)
The single glycoprotein (G) of rabies virus (RABV) dictates all viral entry steps from receptor engagement to membrane fusion. To study the uptake of RABV into primary neuronal cells in culture, we generated a recombinant vesicular stomatitis virus in which
Monika Kustermann et al.
Autophagy, 14(11), 1911-1927 (2018-07-17)
VCP/p97 (valosin containing protein) is a key regulator of cellular proteostasis. It orchestrates protein turnover and quality control in vivo, processes fundamental for proper cell function. In humans, mutations in VCP lead to severe myo- and neuro-degenerative disorders such as
Gregory C Sartor et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(4), 612-626 (2018-12-07)
Histone deacetylase (HDAC) inhibitors may have therapeutic utility in multiple neurological and psychiatric disorders, but the underlying mechanisms remain unclear. Here, we identify BRD4, a BET bromodomain reader of acetyl-lysine histones, as an essential component involved in potentiated expression of
Marcos Rubio-Fernández et al.
Scientific reports, 8(1), 8543-8543 (2018-06-06)
Hypoglycosylation of α-dystroglycan (α-DG) resulting from deficiency of protein O-mannosyltransferase 1 (POMT1) may cause severe neuromuscular dystrophies with brain and eye anomalies, named dystroglycanopathies. The retinal involvement of these disorders motivated us to generate a conditional knockout (cKO) mouse experiencing
Taru Muranen et al.
Nature communications, 8, 13989-13989 (2017-01-11)
Extracellular matrix adhesion is required for normal epithelial cell survival, nutrient uptake and metabolism. This requirement can be overcome by oncogene activation. Interestingly, inhibition of PI3K/mTOR leads to apoptosis of matrix-detached, but not matrix-attached cancer cells, suggesting that matrix-attached cells
Georgi Dimchev et al.
Molecular biology of the cell, 28(10), 1311-1325 (2017-03-24)
Cell migration and cell-cell communication involve the protrusion of actin-rich cell surface projections such as lamellipodia and filopodia. Lamellipodia are networks of actin filaments generated and turned over by filament branching through the Arp2/3 complex. Inhibition of branching is commonly
Volker Kroehne et al.
Frontiers in cellular neuroscience, 11, 284-284 (2017-09-30)
Endogenous oligodendrocyte progenitor cells (OPCs) are a promising target to improve functional recovery after spinal cord injury (SCI) by remyelinating denuded, and therefore vulnerable, axons. Demyelination is the result of a primary insult and secondary injury, leading to conduction blocks
Jennifer A Tyson et al.
Development (Cambridge, England), 142(7), 1267-1278 (2015-03-26)
Medial ganglionic eminence (MGE)-derived GABAergic cortical interneurons (cINs) consist of multiple subtypes that are involved in many cortical functions. They also have a remarkable capacity to migrate, survive and integrate into cortical circuitry after transplantation into postnatal cortex. These features
Alejandra Orihuel et al.
Food research international (Ottawa, Ont.), 125, 108622-108622 (2019-09-27)
The enterohemorrhagic Escherichia (E.) coli (EHEC) is a pathogen of great concern for public health and the meat industry all over the world. The high economic losses in meat industry and the high costs of the illness highlight the necessity
Elisabeth Holen et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 224, 108560-108560 (2019-07-07)
The aim was to study the effect of resveratrol on the interplay of inflammatory signals using three different cell models; a metabolic organ (liver), an endocrine organ (visceral adipose tissue, VAT) and an immune organ (head kidney leukocytes, HKL) following
Mitogenic activity of laminin on human melanoma and melanocytes: different signal requirements and role of beta 1 integrins.
Mortarini R, et al.
Cancer Research, 55(20), 4702-4710 (1995)
Angelo G Torrente et al.
The Journal of physiology, 595(12), 3847-3865 (2017-03-28)
Repolarizing currents through K+ channels are essential for proper sinoatrial node (SAN) pacemaking, but the influence of intracellular Ca2+ on repolarization in the SAN is uncertain. We identified all three isoforms of Ca2+ -activated small conductance K+ (SK) channels in
Andrea Ommer et al.
The Journal of cell biology, 218(7), 2350-2369 (2019-06-16)
Small GTPases of the Rho and Ras families are important regulators of Schwann cell biology. The Ras-like GTPases RalA and RalB act downstream of Ras in malignant peripheral nerve sheath tumors. However, the physiological role of Ral proteins in Schwann
Benedikt Linder et al.
Cancers, 11(3) (2019-03-16)
Glioblastoma is one of the deadliest malignancies and is virtually incurable. Accumulating evidence indicates that a small population of cells with a stem-like phenotype is the major culprit of tumor recurrence. Enhanced DNA repair capacity and expression of stemness marker
Elizabeth Keramaris et al.
Muscle & nerve, 55(4), 582-590 (2016-08-16)
Mutations in the Fukutin related protein (FKRP) gene are characterized by a lack of functionally glycosylated α-dystroglycan (F-α-DG) in muscles. A small number of fibers retain the capacity to produce strong IIH6 reactive glycosylated-α-DG (g-α-DG) in muscles of both FKRP
Bo Zhou et al.
Stem cells and development, 24(18), 2114-2126 (2015-06-18)
Murine postnatal neural stem cells (NSCs) give rise to neurons, astrocytes, or oligodendrocytes (OLs); however, our knowledge of the genes that control this lineage specification is incomplete. In this study, we show that nuclear factor I X (NFIX), a transcription
Jocelynn R Pearl et al.
Cell systems, 8(2), 122-135 (2019-02-18)
Transcriptional regulatory changes in the developing and adult brain are prominent features of brain diseases, but the involvement of specific transcription factors (TFs) remains poorly understood. We integrated brain-specific DNase footprinting and TF-gene co-expression to reconstruct a transcriptional regulatory network
Nida Siddiqui et al.
Nature communications, 10(1), 2693-2693 (2019-06-21)
The kinesin-3 KIF1C is a fast organelle transporter implicated in the transport of dense core vesicles in neurons and the delivery of integrins to cell adhesions. Here we report the mechanisms of autoinhibition and release that control the activity of
Scott Dyck et al.
Glia, 67(1), 125-145 (2018-11-06)
Following spinal cord injury (SCI), the population of mature oligodendrocytes undergoes substantial cell death; promoting their preservation and replacement is a viable strategy for preserving axonal integrity and white matter repair in the injured spinal cord. Dramatic upregulation of matrix
Jan Eckhardt et al.
The Journal of general physiology, 151(7), 929-943 (2019-05-16)
Calcium is an ubiquitous second messenger mediating numerous physiological processes, including muscle contraction and neuronal excitability. Ca2+ is stored in the ER/SR and is released into the cytoplasm via the opening of intracellular inositol trisphosphate receptor and ryanodine receptor calcium
Yulei Shang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(16), 4006-4019 (2018-03-28)
NMDA receptors are critical for neuronal communication. Dysfunction in NMDA receptors has been implicated in neuropsychiatric diseases. While it is well recognized that the composition of NMDA receptors undergoes a GluN2B-to-GluN2A switch in early postnatal life, the mechanism regulating this
Qingling Xia et al.
Journal of biophotonics, 12(7), e201800403-e201800403 (2019-03-13)
The aim of the present study is to optimize parameters for inhibiting neuronal activity safely and investigating thermal inhibition of rat cortex neural networks in vitro by continuous infrared (IR) laser. Rat cortex neurons were cultured on multi-electrode arrays until
Hemant B Badgandi et al.
The Journal of cell biology, 216(3), 743-760 (2017-02-06)
The primary cilium is a paradigmatic organelle for studying compartmentalized signaling; however, unlike soluble protein trafficking, processes targeting integral membrane proteins to cilia are poorly understood. In this study, we determine that the tubby family protein TULP3 functions as a
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