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Hui-Ling Che et al.
International journal of analytical chemistry, 2015, 357609-357609 (2015-11-26)
Quantification of tocotrienols in human plasma is critical when the attention towards tocotrienols on its distinctive properties is arising. We aim to develop a simple and practical normal-phase high performance liquid chromatography method to quantify the amount of four tocotrienol
Caroline Übel et al.
Scientific reports, 4, 5865-5865 (2014-08-12)
In a murine model of allergic asthma, we found that Tyk-2((-/-)) asthmatic mice have induced peribronchial collagen deposition, mucosal type mast cells in the lung, IRF4 and hyperproliferative lung Th2 CD4(+) effector T cells over-expressing IL-3, IL-4, IL-5, IL-10 and
Jette Bork-Jensen et al.
Diabetologia, 58(2), 363-373 (2014-11-19)
We aimed to identify microRNAs (miRNAs) associated with type 2 diabetes and risk of developing the disease in skeletal muscle biopsies from phenotypically well-characterised twins. We measured muscle miRNA levels in monozygotic (MZ) twins discordant for type 2 diabetes using
M Ghosh et al.
Animal genetics, 46(3), 255-264 (2015-03-11)
This study was carried out with the objective to investigate the differentially expressed genes (DEGs) between Jeju native pig (JNP) and Berkshire piglets. The RNA-Seq technique was used to investigate the transcriptomes in the fat, liver and longissimus dorsi muscle
Yan-Ting Wu et al.
Journal of assisted reproduction and genetics, 32(3), 417-427 (2015-01-18)
To study the differences in protein expression profiles of follicular fluid (FF) between controlled ovarian hyperstimulation (COH) and natural ovulatory cycles. Twelve infertile women undergoing in vitro fertilization and embryo transfer (IVF-ET), with matched clinical information, were retrospectively recruited in
Jasmin Krismer et al.
Applied and environmental microbiology, 81(16), 5546-5551 (2015-06-07)
The consequences of cellular heterogeneity, such as biocide persistence, can only be tackled by studying each individual in a cell population. Fluorescent tags provide tools for the high-throughput analysis of genomes, RNA transcripts, or proteins on the single-cell level. However
Dorian Forte et al.
Stem cell research & therapy, 6, 170-170 (2015-09-12)
Due to their immunomodulatory properties, mesenchymal stromal cells (MSCs) have been used for auto-immune disease treatment. Crohn disease (CD) and ulcerative colitis are two major inflammatory bowel diseases (IBDs), resulting from pathological immune responses to environmental or microbial antigens. Preclinical
Xiujuan Shi et al.
Molecular medicine reports, 11(5), 3533-3538 (2015-01-13)
Spindle and kinetochore‑associated protein 1 (SKA1) is an important component of the human kinetochore, which plays a key role in mitosis. The resent study was designed to investigate the role of SKA1 in human glioblastoma. The results of the present
Arthur S Brecher et al.
Alcohol (Fayetteville, N.Y.), 26(1), 49-53 (2002-04-18)
The effect of low concentrations of acetaldehyde on activated partial thromboplastin time (APTT) and prothrombin time (PT) of Accuclot coagulation plasmas was monitored over a prolonged time to mimic effects observed in alcoholism. A prolongation of the APTT from 31.9
Sheila Inwood
British journal of nursing (Mark Allen Publishing), 16(22), 1390-1390 (2008-03-26)
The insertion of peripheral and central venous access devices carries a high risk of healthcare-associated infection. One of the main risks of this procedure is the introduction of microorganisms from the patient's own skin. To combat this, and to reduce
Olwen Domingo et al.
Nucleic acids research, 43(11), 5275-5283 (2015-05-03)
Propargyl groups are attractive functional groups for labeling purposes, as they allow CuAAC-mediated bioconjugation. Their size minimally exceeds that of a methyl group, the latter being frequent in natural nucleotide modifications. To understand under which circumstances propargyl-containing oligodeoxynucleotides preserve base
Philippe Haouzi et al.
Respiratory physiology & neurobiology, 215, 39-46 (2015-04-26)
Our study intended to determine the effects on oxygen uptake (VO2) of restoring a normal rate of O2 delivery following blood transfusion (BT) after a severe hemorrhage (H). Spontaneously breathing urethane anesthetized rats were bled by removing 20 ml/kg of
Yuko Ogaya et al.
Journal of medical microbiology, 64(Pt 1), 117-123 (2014-10-22)
The oral cavity has been implicated as a source of Helicobacter pylori infection in childhood. Various PCR methods have been used to detect H. pylori DNA in oral specimens with various detection rates reported. Such disparity in detection rates complicates
Tejia Zhang et al.
ACS chemical biology, 10(6), 1398-1403 (2015-03-31)
BCL-2 proteins are key regulators of programmed cell death. The interplay between pro and antiapoptotic BCL-2 members has important roles in many cancers. In addition to their apoptotic function, recent evidence supports key nonapoptotic roles for several BCL-2 proteins. We
Wnt-modified materials mediate asymmetric stem cell division to direct human osteogenic tissue formation for bone repair.
Okuchi, et al.
Nature Materials, 20, 108-118 (2021)
Maria Stancescu et al.
Biomaterials, 60, 20-30 (2015-05-16)
This article details the construction and testing of a phenotypic assay system that models in vivo cardiac function in a parallel in vitro environment with human stem cell derived cardiomyocytes. The major determinants of human whole-heart function were experimentally modeled by integrating
Mark A Travassos et al.
The American journal of tropical medicine and hygiene, 93(2), 416-424 (2015-06-10)
A community-based immunization coverage survey is the standard way to estimate effective vaccination delivery to a target population in a region. Accompanying serosurveys can provide objective measures of protective immunity against vaccine-preventable diseases but pose considerable challenges with respect to
Gary S L Peh et al.
Scientific reports, 5, 9167-9167 (2015-04-01)
The global shortage of donor corneas has garnered extensive interest in the development of graft alternatives suitable for endothelial keratoplasty using cultivated primary human corneal endothelial cells (CECs). We have recently described a dual media approach for the propagation of
Ryan V Tien Sing Young et al.
Biomicrofluidics, 9(4), 046501-046501 (2015-07-17)
Liposomes are currently well-established as biocompatible delivery vehicles for numerous compounds. However, conventional manufacturing tends to rely on time-consuming processes, costly equipment, unstable reaction parameters, and numerous pre- and post-processing steps. Herein, we demonstrate a microscope-slide-sized alternative: a double flow-focusing
Hatice Ceylan Koydemir et al.
Lab on a chip, 15(5), 1284-1293 (2014-12-30)
Rapid and sensitive detection of waterborne pathogens in drinkable and recreational water sources is crucial for treating and preventing the spread of water related diseases, especially in resource-limited settings. Here we present a field-portable and cost-effective platform for detection and
Piotr Luliński et al.
Talanta, 129, 155-164 (2014-08-17)
A 2-(4-methoxyphenyl)ethylamine imprinted polymer (MIP) was successfully applied for the selective separation of tyramine. A computational analysis was used to predict the affinity of the polymer matrix towards tyramine and a preliminary experimental evaluation was made for the target analyte.
Ana Penko et al.
Food chemistry, 168, 372-382 (2014-08-31)
The oxidation processes were studied in chicken patties, enriched with n-3 fatty acids, after 8days of storage at 4°C, under different aerobic conditions, and following heat treatment. Significant effects were seen on lipid and cholesterol oxidation and the sensory qualities
M N M Nogueira et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 63(9), 769-778 (2014-06-21)
Tea tree oil (TTO) is an essential oil with anti-inflammatory properties, steam distilled from the plant Melaleuca alternifolia. We investigated the immunomodulatory properties of TTO and its components (terpinen-4-ol and alpha-terpineol) using lipopolysaccharide (LPS)-stimulated macrophages. The ability of TTO, terpinen-4-ol
Kaiyu Jiang et al.
BMC medical genomics, 8, 55-55 (2015-08-28)
The transcriptional complexity of mammalian cells suggests that they have broad abilities to respond to specific environmental stimuli and physiologic contexts. These abilities were not apparent a priori from the structure of mammalian genomes, but have been identified through detailed
Anzelle Delport et al.
Life sciences, 117(2), 56-66 (2014-12-03)
The phenothiazinium compound, methylene blue (MB), possesses diverse pharmacological actions and is attracting attention for the treatment of bipolar disorder and Alzheimer's disease. MB acts on both monoamine oxidase (MAO) and the nitric oxide (NO)-cGMP pathway, and possesses antidepressant activity
Simone Wahl et al.
BMC medicine, 13, 48-48 (2015-04-11)
Excess body weight is a major risk factor for cardiometabolic diseases. The complex molecular mechanisms of body weight change-induced metabolic perturbations are not fully understood. Specifically, in-depth molecular characterization of long-term body weight change in the general population is lacking.
Sara Triñanes et al.
Talanta, 132, 433-442 (2014-12-06)
A new straightforward and inexpensive sample screening method for both EPA and EU priority polycyclic aromatic hydrocarbons (PAHs) in water has been developed. The method is based on combined direct immersion and headspace (DIHS) sorptive extraction, using low-cost disposable material
Ulrich-Christian Schröder et al.
Biomicrofluidics, 9(4), 044118-044118 (2015-09-05)
This work presents a polymeric centrifugal microfluidic platform for the rapid and sensitive identification of bacteria directly from urine, thus eliminating time-consuming cultivation steps. This "Lab-on-a-Disc" platform utilizes the rotationally induced centrifugal field to efficiently capture bacteria directly from suspension
Julie Lessard et al.
PloS one, 10(3), e0122065-e0122065 (2015-03-31)
Mature adipocytes can reverse their phenotype to become fibroblast-like cells. This is achieved by ceiling culture and the resulting cells, called dedifferentiated fat (DFAT) cells, are multipotent. Beyond the potential value of these cells for regenerative medicine, the dedifferentiation process
Lok Kumar Shrestha et al.
Journal of the American Chemical Society, 135(2), 586-589 (2013-01-02)
A new class of fullerene (C(60)) crystals with bimodal pore architectures consisting of macropores and mesopores was synthesized by using a liquid-liquid interfacial precipitation (LLIP) method involving an interface between isopropyl alcohol (IPA) and a saturated solution of C(60) in
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