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Sujan Badal et al.
The Journal of biological chemistry, 290(36), 22287-22297 (2015-07-25)
Fluoroquinolones (FQ) are powerful broad-spectrum antibiotics whose side effects include renal damage and, strangely, tendinopathies. The pathological mechanisms underlying these toxicities are poorly understood. Here, we show that the FQ drugs norfloxacin, ciprofloxacin, and enrofloxacin are powerful iron chelators comparable
Zilu Li et al.
ACS nano, 9(11), 10778-10789 (2015-10-06)
We have optimized mesoporous silica nanoparticles (MSNs) functionalized with pH-sensitive nanovalves for the delivery of the broad spectrum fluoroquinolone moxifloxacin (MXF) and demonstrated its efficacy in treating Francisella tularensis infections both in vitro and in vivo. We compared two different
Jakub Mondek et al.
Carbohydrate polymers, 129, 168-174 (2015-06-09)
The fast deprotonation of 1-naphthol was studied in aqueous solution and in polymer-cetyltrimethylammonium bromide (CTAB) mixtures using picosecond fluorescence spectroscopy to study the influence of hyaluronan hydration in polymer-surfactant interactions. The aqueous micelle solution showed the expected change of proton
Amie J Moyes et al.
The Journal of clinical investigation, 124(9), 4039-4051 (2014-08-12)
The endothelium plays a fundamental role in maintaining vascular homeostasis by releasing factors that regulate local blood flow, systemic blood pressure, and the reactivity of leukocytes and platelets. Accordingly, endothelial dysfunction underpins many cardiovascular diseases, including hypertension, myocardial infarction, and
Jiadi Sun et al.
Biosensors & bioelectronics, 70, 239-245 (2015-04-02)
A novel DNA sensor for the detection of the Escherichia coli O157:H7 (E. coli O157:H7) eaeA gene was constructed using surface enhanced fluorescence (SEF). The spacing distance dependence nature of Au@Ag nanorods surface enhanced fluorescence was investigated when the cy3-labled
Jung-Hoon Lee et al.
Nature communications, 6, 7571-7571 (2015-06-27)
Much of the interest in noble metal nanoparticles is due to their plasmonic resonance responses and local field enhancement, both of which can be tuned through the size and shape of the particles. However, both properties suffer from the loss
A Stančić et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 27(10), 1432-1445 (2015-08-01)
G protein-coupled receptor 55 (GPR55) is a lysophospholipid receptor responsive to certain cannabinoids. The role of GPR55 in inflammatory processes of the gut is largely unknown. Using the recently characterized GPR55 inhibitor CID16020046, we determined the role of GPR55 in experimental
S A Hassanzadeh-Tabrizi et al.
Materials science & engineering. C, Materials for biological applications, 58, 737-741 (2015-10-20)
In the present study, forsterite nanoparticles were synthesized via surfactant-assisted sol-gel method using cetyltrimethyl ammonium bromide (CTAB) as a surfactant. The effects of CTAB contents and heat treatment on the textural properties and drug release from nanoparticles were investigated. The
Karina Lopes Dornelas et al.
Analytica chimica acta, 858, 82-90 (2015-01-20)
This paper presents a simple and low-cost method for patterning poly(dimethylsiloxane) (PDMS) barriers in porous support such as paper for the construction of flexible microfluidic paper-based analytical devices (μPADs). The fabrication method consisted of contact-printing a solution of PDMS and
Nabanita Chatterjee et al.
Journal of leukocyte biology, 96(2), 325-336 (2014-04-04)
The use of live, attenuated, or genetically modified microbes or their cellular component(s) or metabolites has begun to emerge as a potential new approach in medicinal research to deliver biologically active entities. Thus, advancing our knowledge of such microbe-mediated therapy
Yiye Li et al.
ACS nano, 8(11), 11529-11542 (2014-11-07)
Near-infrared plasmonic nanoparticles demonstrate great potential in disease theranostic applications. Herein a nanoplatform, composed of mesoporous silica-coated gold nanorods (AuNRs), is tailor-designed to optimize the photodynamic therapy (PDT) for tumor based on the plasmonic effect. The surface plasmon resonance of
Sergio Berdún et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(10), G801-G806 (2015-09-26)
Stabilization of mast cell (MC) degranulation has been proposed to prevent postoperative ileus (POI). Nerve growth factor (NGF) mediates MC degranulation. The aim of the study was to evaluate whether NGF receptor antagonist K252a acts as a MC stabilizer in
S R Kim et al.
Cell death & disease, 5, e1498-e1498 (2014-10-31)
Abnormality in mitochondria has been suggested to be associated with development of allergic airway disorders. In this study, to evaluate the relationship between mitochondrial reactive oxygen species (ROS) and NLRP3 inflammasome activation in allergic asthma, we used a newly developed
Ayse Nur Aksoy et al.
Indian journal of pharmacology, 46(6), 622-626 (2014-12-30)
To explore the protective effect of progesterone on inflammation and oxidative stress in a rat model of sepsis created by cecal ligation and puncture (CLP). Rats were randomly divided into 4 groups: Overiectomy group (OVX), sham operated (control), sepsis (CLP)
Design of nanoparticles for generation and stabilization of CO2-in-brine foams with or without added surfactants
Worthen AJ, et al.
arXiv (2018)
Kamil Wojciechowski et al.
Biochimica et biophysica acta, 1838(7), 1931-1940 (2014-04-22)
The interactions between a model phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and a biosurfactant Quillaja Bark Saponin (QBS) obtained from the bark of Quillaja saponaria Molina were studied using simple models of biological membranes. QBS is known to interact strongly with the latter
Connor A Wathen et al.
Contrast media & molecular imaging, 10(3), 188-193 (2014-08-30)
Gold nanomaterials (AuNPs) represent a promising new class of contrast agents for X-ray computed tomographic (CT) imaging in both research and clinical settings. These materials exhibit superior X-ray absorption properties compared with other iodinated agents, and thus require lower injection
José Fernando Bastos Moura et al.
International journal of radiation biology, 91(6), 500-509 (2015-03-12)
To design a novel model to study Cobalt-60 (Co-60)-induced radiation mucositis and to describe the pathways involved in its development. Hamsters' cheeks were treated with Co-60 radiation (10, 20, 30 or 35 Gy). Three days later, oral mucosa scarification was
Ángel Martínez et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(44), 15651-15666 (2015-09-12)
A novel nanosystem based on mesoporous silica nanoparticles covered with carbosilane dendrons grafted on the external surface of the nanoparticles is reported. This system is able to transport single-stranded oligonucleotide into cells, avoiding an electrostatic repulsion between the cell membrane
A T Nasr et al.
Physics in medicine and biology, 60(12), 4685-4704 (2015-05-29)
In this study, recipe optimization of Leuco Crystal Violet (LCV) micelle gels made with the surfactant Cetyl Trimethyl Ammonium Bromide (CTAB) and the chemical sensitizer 2,2,2-trichloroethanol (TCE) was aided by a two-level three-factor designed experiment. The optimized recipe contains 0.75
Trinidad Montero-Melendez et al.
The American journal of pathology, 184(8), 2333-2341 (2014-07-01)
Because there is clinical evidence for an association between periodontal disease and rheumatoid arthritis, it is important to develop suitable experimental models to explore pathogenic mechanisms and therapeutic opportunities. The K/BxN serum model of inflammatory arthritis was applied using distinct
Chao Ran et al.
PloS one, 10(7), e0132049-e0132049 (2015-07-07)
A novel Acinetobacter lipase gene lipG1 was cloned from DNA extracted from intestinal sample of common carp (Cyprinus carpio), and expressed in E. coli BL21. The encoded protein was 406 amino acids in length. Phylogenetic analysis indicated that LipG1 and
Maha M Eissa et al.
PloS one, 10(11), e0141788-e0141788 (2015-11-18)
Miltefosine (MFS) is an alkylphosphocholine used for the local treatment of cutaneous metastases of breast cancer and oral therapy of visceral leishmaniasis. Recently, the drug was reported in in vitro and preclinical studies to exert significant activity against different developmental
Lei Wu et al.
Biosensors & bioelectronics, 62, 13-18 (2014-06-29)
As thiocyanate (SCN(-)) acts as an important biomarker in human health assessment, there remains an urgent need to realize rapid and reproducible analysis of SCN(-) in body fluids. Here, a droplet microfluidic device has been designed and fabricated for SCN(-)
Mateus Fortes Rossato et al.
Inflammation, 38(2), 606-615 (2014-08-15)
Vitamin E (vit-E) is a lipophilic antioxidant, and its anti-inflammatory activity is still not full characterized. Thus, our goal was to investigate the anti-inflammatory effect of repeated vit-E treatment in the arthritis induced by the intraplantar injection of complete Freund's
Xiaoqian Chu et al.
PloS one, 10(11), e0143022-e0143022 (2015-11-13)
WRKY transcription factors constitute a very large family of proteins in plants and participate in modulating plant biological processes, such as growth, development and stress responses. However, the exact roles of WRKY proteins are unclear, particularly in non-model plants. In
Paul J Ackerman et al.
Nature communications, 6, 6012-6012 (2015-01-22)
Some of the most exotic condensed matter phases, such as twist grain boundary and blue phases in liquid crystals and Abrikosov phases in superconductors, contain arrays of topological defects in their ground state. Comprised of a triangular lattice of double-twist
J Freise et al.
Zeitschrift fur Rheumatologie, 74(9), 824-828 (2015-07-15)
No standardized polymerase chain reaction (PCR) assay is available for detection of Chlamydia trachomatis (C. tr.) in synovial fluid (SF) for diagnostic use in clinical practice. This study tested the performance of two optimized molecular biology methods, to determine which
Yunyun Xie et al.
Journal of hazardous materials, 297, 66-73 (2015-05-06)
Fibrous cyano-modified mesoporous SiO2 microspheres with specific surface area of ca. 300 m(2) g(-1) have been successfully fabricated respectively by in-situ synthesis and post-modification methods, based on the hydrolysis of ethyl silicate in the presence of (2-cyanoethyl)triethoxysilane at a certain
Yanjuan Huang et al.
Chemico-biological interactions, 232, 38-48 (2015-03-18)
Down-regulation of some hepatic cytochrome P450s (CYP450s) was observed in patients and animals with ulcerative colitis (UC). This study examined changes of CYP450s activities in microsomes of liver (RLMs), intestine (RIMs) and kidney (RRMs) from rats with experimental acute colitis
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