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Avisek Mahapa et al.
PloS one, 10(3), e0122168-e0122168 (2015-03-31)
SarA, a Staphylococcus aureus-specific dimeric protein, modulates the expression of numerous proteins including various virulence factors. Interestingly, S. aureus synthesizes multiple SarA paralogs seemingly for optimizing the expression of its virulence factors. To understand the domain structure/flexibility and the folding/unfolding
Ramon Weishaupt et al.
Biomacromolecules, 16(11), 3640-3650 (2015-09-29)
Controlled and efficient immobilization of specific biomolecules is a key technology to introduce new, favorable functions to materials suitable for biomedical applications. Here, we describe an innovative and efficient, two-step methodology for the stable immobilization of various biomolecules, including small
Nima Momtahan et al.
Tissue engineering. Part C, Methods, 21(11), 1148-1161 (2015-06-17)
Whole heart decellularization combined with patient-specific cells may prove to be an extremely valuable approach to engineer new hearts. Mild detergents are commonly used in the decellularization process, but are known to denature and solubilize key proteins and growth factors
Vaddi K Prasanna et al.
International immunopharmacology, 26(2), 304-313 (2015-04-19)
Onion (Allium cepa), a bulb crop of economic importance, is known to have many health benefits. The major objective of the present study is to address the immunomodulatory properties of onion lectin (A. cepa agglutinin; ACA). ACA was purified from
Yao-Tong Lai et al.
Colloids and surfaces. B, Biointerfaces, 127, 1-7 (2015-01-31)
We have developed a new type of artificial oxygen carrier composed of bovine hemoglobin (bHb) and bovine serum albumin (BSA) prepared by Shirasu porous glass (SPG) membrane emulsification technique. The resultant emulsion droplets containing 10 wt% bHb and 5-20 wt%
Manuel Ingo Günther et al.
Acta biomaterialia, 27, 140-150 (2015-09-09)
Despite recent progress in enhancing axonal growth in the injured spinal cord, the guidance of regenerating axons across an extended lesion site remains a major challenge. To determine whether regenerating axons can be guided in rostrocaudal direction, we implanted 2mm
Jiro Kitamura et al.
PloS one, 10(2), e0117986-e0117986 (2015-02-07)
Activation-induced cytidine deaminase (AID) is an enzyme required for antibody diversification, and it causes DNA mutations and strand breaks. Constitutive AID expression in mice invariably caused lung lesions morphologically similar to human atypical adenomatous hyperplasia (AAH), which can be a
Keith H Jansson et al.
PloS one, 9(6), e98408-e98408 (2014-06-04)
Prostate cancer (PCa) is believed to metastasize through the blood/lymphatics systems; however, PCa may utilize the extensive innervation of the prostate for glandular egress. The interaction of PCa and its nerve fibers is observed in 80% of PCa and is
Katherine M Murphy et al.
American journal of botany, 102(11), 1931-1937 (2015-11-04)
Although anthers of Zea mays, Oryza sativa, and Arabidopsis thaliana have been studied intensively using genetic and biochemical analyses in the past 20 years, few updates to anther anatomical and ultrastructural descriptions have been reported. For example, no transmission electron
Chiara Focaccetti et al.
PloS one, 10(2), e0115686-e0115686 (2015-02-12)
Antimetabolites are a class of effective anticancer drugs interfering in essential biochemical processes. 5-Fluorouracil (5-FU) and its prodrug Capecitabine are widely used in the treatment of several solid tumors (gastro-intestinal, gynecological, head and neck, breast carcinomas). Therapy with fluoropyrimidines is
Michelle M Naugle et al.
Neuroendocrinology, 100(4), 334-346 (2014-11-28)
Menopause is caused by changes in the function of the hypothalamic-pituitary-gonadal axis that controls reproduction. Hypophysiotropic gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus orchestrate the activity of this axis and are regulated by hormonal feedback loops. The mechanisms by which
Kuaifei Xia et al.
Plant, cell & environment, 38(12), 2662-2673 (2015-05-28)
Cuticular wax forms a hydrophobic layer covering aerial plant organs and acting as a protective barrier against biotic and abiotic stresses. Compared with well-known wax biosynthetic pathway, molecular regulation of wax biosynthesis is less known. Here, we show that rice
Rita Trumpaite-Vanagiene et al.
Dental materials journal, 34(3), 294-301 (2015-04-24)
The study aimed to 1) evaluate the cytotoxicity of luting cements: Hoffmann's Zinc Phosphate (Hoffmann's ZP), GC Fuji Plus Resin Modified Glass Ionomer (Fuji Plus RMGI) and 3M ESPE RelyX Unicem Resin Cement (RelyX Unicem RC) and 2) test if
Mengmeng Wang et al.
BMC ophthalmology, 15, 89-89 (2015-07-30)
Scleral cross-linking (CXL) is a novel attempt to slow down the axial elongation process in animal eyes. As a natural CXL reagent, genipin would be also effective for the prevention of myopia process. Thus, the present study was designed to
Neil A Eschmann et al.
The journal of physical chemistry. B, 119(45), 14421-14432 (2015-10-21)
A peptide fragment of the human tau protein which stacks to form neat cross β-sheet fibrils, resembling that found in pathological aggregation, (273)GKVQIINKKLDL(284) (here "R2/WT"), was modified with a spin-label at the N-terminus. With the resulting peptide, R2/G273C-SL, we probed
Donna V Peralta et al.
ACS applied materials & interfaces, 7(13), 7101-7111 (2015-03-15)
The use of human serum albumin nanoparticles (HSAPs) as a drug carrier system for cancer treatment has proven successful through current marketable clinical formulations. Despite this success, there is a current lack of multifunctional HSAPs, which offer combinational therapies of
Ismini E Papageorgiou et al.
Brain structure & function, 220(4), 2423-2439 (2014-06-01)
Activation of microglial cells (brain macrophages) soon after status epilepticus has been suggested to be critical for the pathogenesis of mesial temporal lobe epilepsy (MTLE). However, microglial activation in the chronic phase of experimental MTLE has been scarcely addressed. In
Junying Zheng et al.
PloS one, 9(4), e94732-e94732 (2014-04-16)
Cardiac ischemia and reperfusion (I/R) injury occurs because the acute increase in oxidative/inflammatory stress during reperfusion culminates in the death of cardiomyocytes. Currently, there is no drug utilized clinically that attenuates I/R injury in patients. Previous studies have demonstrated degranulation
Chun-Ling Chen et al.
Life sciences, 141, 25-31 (2015-09-15)
The effects of preconditioning on cardioprotection have mainly been studied in vitro. No sufficient in vivo experiments have been performed to optimize ischemic preconditioning (IPC) or hypoxic preconditioning (HPC) for clinical applications. The purpose of this study was to establish
Seon-Mi Jeon et al.
Journal of microbiology and biotechnology, 25(5), 723-731 (2015-03-05)
Microalgae hold promise as producers of sustainable biomass for the production of biofuels and other biomaterials. However, the selection of strains with efficient and robust production of desirable resources remains challenging. In this study, we isolated a green microalga from
Kaspar Broch et al.
International journal of cardiology, 179, 378-384 (2014-12-03)
Elevated levels of soluble ST2 (sST2) are associated with adverse outcome in heart failure. A change in sST2 levels has also been shown to presage outcome. In vitro, ST2 expression is induced by myocardial stress and pro-inflammatory stimuli. The determinants
Fumito Sakamoto et al.
Cytotechnology, 67(1), 75-84 (2013-12-07)
We compared the osteoblastic differentiation abilities of dedifferentiated fat cells (DFATs) and human bone marrow mesenchymal stem cells (hMSCs) as a cell source for bone regeneration therapies. In addition, the utility of DFATs in bone tissue engineering in vitro was
Sandrigo Mangini et al.
International journal of cardiology, 178, 55-62 (2014-12-03)
Clinical and experimental conflicting data have questioned the relationship between infectious agents, inflammation and dilated cardiomyopathy (DCM). The aim of this study was to determine the frequency of infectious agents and inflammation in endomyocardial biopsy (EMB) specimens from patients with
Kathy C Nguyen et al.
Toxicological sciences : an official journal of the Society of Toxicology, 146(1), 31-42 (2015-03-27)
There are an increasing number of studies indicating that mitochondria are relevant targets in nanomaterial-induced toxicity. However, the underlying mechanisms by which nanoparticles (NPs) interact with these organelles and affect their functions are unknown. The aim of this study was
Jihye Baek et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(4), 572-583 (2015-02-03)
Meniscus injury and degeneration have been linked to the development of secondary osteoarthritis (OA). Therapies that successfully repair or replace the meniscus are, therefore, likely to prevent or delay OA progression. We investigated the novel approach of building layers of
Giulia Ruozi et al.
Nature communications, 6, 7388-7388 (2015-06-13)
Functional screening of expression libraries in vivo would offer the possibility of identifying novel biotherapeutics without a priori knowledge of their biochemical function. Here we describe a procedure for the functional selection of tissue-protective factors based on the in vivo
Jingjing Li et al.
Marine drugs, 13(6), 3368-3387 (2015-05-30)
Hepatic ischemia reperfusion (IR) is an important issue in complex liver resection and liver transplantation. The aim of the present study was to determine the protective effect of astaxanthin (ASX), an antioxidant, on hepatic IR injury via the reactive oxygen
Gulay Bayramoglu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 990, 84-95 (2015-04-13)
Lysozyme is an important polypetide used in medical and food applications. We report a novel magnetic strong cation exchange beads for efficient purification of lysozyme from chicken egg white. Magnetic chitosan (MCHT) beads were synthesized via phase inversion method, and
Rong Zou et al.
Molecular medicine reports, 12(2), 2027-2034 (2015-05-06)
Disruption of the blood-brain barrier (BBB) and subsequent brain edema are major contributors to the pathogenesis of ischemic stroke, however, current clinical therapeutic methods remains unsatisfactory. Electroacupuncture (EA) pretreatment has a protective effect against cerebral ischemia/reperfusion (I/R). However, the underlying
Ke-Nan Huang et al.
The Journal of surgical research, 192(2), 621-627 (2014-09-27)
Operative stabilization is frequently used in the clinical treatment of multiple rib fractures (MRF); however, no ideal material exists for use in this fixation. This study investigates a newly developed biodegradable plate system for the stabilization of MRF. Silk fiber-reinforced
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