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Terukazu Sanui et al.
Journal of cellular biochemistry, 116(4), 628-639 (2014-11-18)
Sprouty was identified as an inhibitor of the fibroblast growth factor (FGF) receptor, and Sprouty2 (Spry2) functions as a negative regulator of receptor tyrosine kinase signaling. In this study, we investigated how inhibition of Spry2 affects osteoblasts and gingival epithelial
Ching-Chun Yang et al.
PloS one, 9(10), e106683-e106683 (2014-11-02)
Hepatitis B virus (HBV) core protein (HBc) can shuttle between nucleus and cytoplasm. Cytoplasm-predominant HBc is clinically associated with severe liver inflammation. Previously, we found that HBc arginine-rich domain (ARD) can associate with a host factor NXF1 (TAP) by coimmunoprecipitation.
Katharina Mahal et al.
Experimental cell research, 336(2), 263-275 (2015-06-24)
Histone deacetylases (HDAC) which play a crucial role in cancer cell proliferation are promising drug targets. However, HDAC inhibitors (HDACi) modelled on natural hydroxamic acids such as trichostatin A frequently lead to resistance or even an increased agressiveness of tumours.
Florencia A Ficarra et al.
PloS one, 10(5), e0125516-e0125516 (2015-05-12)
Xanthomonas citri subsp. citri colonizes its hosts through the trafficking of effector proteins to the plant cell by the type III protein secretion system. In X. citri subsp. citri, as in other plant pathogens, the hrp cluster encodes the type
Pablo Albertos et al.
Nature communications, 6, 8669-8669 (2015-10-27)
Plant survival depends on seed germination and progression through post-germinative developmental checkpoints. These processes are controlled by the stress phytohormone abscisic acid (ABA). ABA regulates the basic leucine zipper transcriptional factor ABI5, a central hub of growth repression, while the
Sang Sook Lee et al.
Plant, cell & environment, 38(10), 2071-2087 (2015-04-08)
Cyclophilin 18-2 (CYP18-2) genes, homologues of human peptidyl-prolyl isomerase-like 1 (PPiL1), are conserved across multicellular organisms and Schizosaccharomyces pombe. Although PPiL1 is known to interact with ski-interacting protein (SKIP), a transcriptional co-regulator and spliceosomal component, there have been no functional
Yanhao He et al.
Journal of physiology and biochemistry, 71(1), 69-78 (2015-01-30)
Hydroxysafflor yellow A (HSYA), the main active natural constituent extracted from Carthamus tinctorius L., has been widely used for the treatment of cerebrovascular and cardiovascular diseases. The aim of this study is to explore the effect of HSYA on alcohol-induced
Kong-Yan Wu et al.
Science signaling, 7(340), ra81-ra81 (2014-08-28)
Axon guidance (pathfinding) wires the brain during development and is regulated by various attractive and repulsive cues. Semaphorin 3A (Sema3A) is a repulsive cue, inducing the collapse of axon growth cones. In the mammalian forebrain, the corpus callosum is the
Valeria Iansante et al.
Nature communications, 6, 7882-7882 (2015-08-11)
Most tumour cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and evade apoptosis. Intriguingly, the molecular mechanisms that link the Warburg effect with the suppression of apoptosis are not well understood. In this study, using loss-of-function studies
Avnesh S Thakor et al.
Journal of pineal research, 59(1), 80-90 (2015-04-25)
Experimental studies in animal models supporting protective effects on the fetus of melatonin in adverse pregnancy have prompted clinical trials in human pregnancy complicated by fetal growth restriction. However, the effects of melatonin on the fetal defense to acute hypoxia
Stella Bernardo-García et al.
Genes & development, 28(15), 1681-1694 (2014-08-03)
Signaling by the hormones brassinosteroid (BR) and gibberellin (GA) is critical to normal plant growth and development and is required for hypocotyl elongation in response to dark and elevated temperatures. Active BR signaling is essential for GA promotion of hypocotyl
Louise Köblitz et al.
PloS one, 10(6), e0128938-e0128938 (2015-06-09)
The hypoxia inducible transcription factor (HIF) has been shown to coordinate the hypoxic response of vertebrates and is expressed in three different isoforms, HIF-1α, HIF-2α and HIF-3α. Knock down of either Hif-1α or Hif-2α in mice results in lethality in
Guanyu Chen et al.
The Journal of pharmacy and pharmacology, 67(1), 26-34 (2014-10-11)
The sublingual mucosa provides a promising route for the delivery of glutathione (GSH). However, challenges are encountered in developing sublingual mucoadhesive drug delivery formulations such as: prolonging drug retention, uniform drug content, desirable drug release profiles, adequate drug permeation and
Maria Maleva et al.
Environmental science and pollution research international, 22(17), 13556-13563 (2015-05-07)
Urea being a fertilizer is expected to be less toxic to plants. However, it was found that urea at 100 mg L(-1) caused the oxidative stress in Elodea leaves due to the formation of reactive oxygen species (ROS) and lipid peroxidation that
Shanlu Liang et al.
Nanotoxicology, 9(1), 92-105 (2014-03-14)
In the past few years, much work has been performed to explore the biomedical applications and toxicity of nano-graphene and its derivatives. However, the reproductive toxicity of those carbon nanomaterials has been rarely studied. In this study, we report on
Ning-Tian Ma et al.
Journal of natural medicines, 69(4), 575-583 (2015-07-06)
Aloperine (ALO), one of the alkaloids isolated from Sophora alopecuroides L., is traditionally used for various diseases including neuronal disorders. This study investigated the protective effects of ALO on neonatal rat primary-cultured hippocampal neurons injured by oxygen-glucose deprivation and reperfusion
Abbas Güngördü et al.
Environmental toxicology, 30(9), 1091-1101 (2014-03-13)
The toxic effects of Gusathion (GUS), which is a commercial organophosphate (OP) pesticide, and also its active ingredient, azinphos methyl (AzM), are evaluated comparatively with in vitro and in vivo studies. Initially, the 96-h LC50 values of AzM and GUS
Thiyagarajan Ramesh et al.
Metabolic brain disease, 30(2), 573-582 (2014-09-14)
Cigarette smoking is concerned as a major risk factor in the development of various neurological disorders. Oxidative stress is suggested as a possible contributing factor in the pathogenesis of cigarette smoking-induced toxicity. Therefore, the present study was intended to evaluate
Sonja Stojković et al.
Experimental cell research, 335(2), 248-257 (2015-06-01)
Chemoresistance is a severe limitation to glioblastoma (GBM) therapy and there is a strong need to understand the underlying mechanisms that determine its response to different chemotherapeutics. Therefore, we induced resistance in C6 rat glioma cell line, which considerably resembles
Human islet isolation processing times shortened by one hour: minimized incubation time between tissue harvest and islet purification.
Magnus Ståhle et al.
Transplantation, 96(12), e91-e93 (2013-12-18)
Jeannette Boutter et al.
Oncotarget, 5(22), 11501-11512 (2014-11-22)
Interactions with the bone marrow microenvironment are essential for leukemia survival and disease progression. We developed an imaging-based RNAi platform to identify protective cues from bone marrow derived mesenchymal stromal cells (MSC) that promote survival of primary acute lymphoblastic leukemia
Pingping Wu et al.
Food chemistry, 173, 194-202 (2014-12-04)
This study investigated the in vitro and in vivo antioxidant activities of the flavonoids rich extract from Rhodomyrtus tomentosa Hassk (R. tomentosa) berries. The in vitro antioxidant assay demonstrated that the flavonoids rich extract (62.09% rutin equivalent) extracted by ethanol
Yiming Jiang et al.
Chemico-biological interactions, 231, 83-89 (2015-03-11)
Acetaminophen (APAP) overdose is the most frequent cause of drug-induced acute liver failure. Schisandra fructus is widely-used traditional Chinese medicine which possesses hepato-protective potential. Schisandrin A (SinA), Schisandrin B (SinB), Schisandrin C (SinC), Schisandrol A (SolA), Schisandrol B (SolB), and
Colby A Souders et al.
International journal of molecular sciences, 16(6), 12436-12453 (2015-06-05)
Angiogenic biomarkers, including soluble fms-like tyrosine kinase 1 (sFlt1), are thought to be predictors of preeclampsia onset; however, improvement is needed before a widespread diagnostic test can be utilized. Here we describe the development and use of diagnostic monoclonal antibodies
Yuexia Zhang et al.
Environmental science and pollution research international, 22(16), 12450-12457 (2015-04-24)
The main aim of the present study was to examine in vitro responses of rat alveolar macrophages (AMs) exposed to coarse chalk dust particles (particulate matter in the size range 2.5-10 μm, PM(coarse)) by respiratory burst and oxidative stress. Chalk
Rajapaksha Gedara Prasad Tharanga Jayasooriya et al.
Environmental toxicology and pharmacology, 38(3), 959-967 (2014-12-03)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in various types of malignant cancer cells, but several cancers have acquired potent resistance to TRAIL-induced cell death by unknown mechanisms. Camptothecin (CPT) is a quinolone alkaloid that induces cytotoxicity in a
Ole Lagatie et al.
Viral immunology, 28(7), 405-409 (2015-06-16)
JC Polyomavirus (JCPyV) is a widespread polyomavirus that usually resides latently in its host. As reactivation of the virus upon immune-modulating conditions holds serious risk, it is of importance to properly determine who is infected with this virus. Assessment of
H Guedouari et al.
Biochimica et biophysica acta, 1842(9), 1855-1869 (2014-07-16)
Candida albicans is an opportunist pathogen responsible for a large spectrum of infections, from superficial mycosis to systemic diseases called candidiasis. Its ability to grow in various morphological forms, such as unicellular budding yeast, filamentous pseudohyphae and hyphae, contributes to
A L Shtroblia et al.
Vestnik Rossiiskoi akademii meditsinskikh nauk, (3)(3), 68-72 (2013-07-03)
The results of the pharmacological investigation of the properties of apricot leaves dry extract are indicated in the article. It is proved that the extract belongs to the group of "relatively harmless" substances, exclusion of the ulcerogenic effect on the
Amal J Fatani et al.
Drug development research, 76(4), 204-214 (2015-06-26)
Preclinical Research This study evaluated the effects of the carvedilol, a nonselective β-adrenoceptor anatgonist with α1-adrenoceptor antagonist activity, in a rat model of experimentally induced ulcerative colitis (UC). UC was produced using acetic acid (AA) in animals previously treated with
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