Showing 1-11 of 11 results
M F Surace et al.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 18 Suppl 1, 122-125 (2009-04-29)
In a preliminary study, the recurrent presence of nervous terminations was demonstrated with optical microscopy in several slides of degenerative lumbar facet joints and surrounding soft tissues. The purpose of this study was to prove the presence of NGF (nerve...
R A Van Etten
Trends in cell biology, 9(5), 179-186 (1999-05-14)
c-Abl, the product of the cellular homologue of the transforming gene of Abelson murine leukaemia virus, has been a protein in search of a purpose for over two decades. Because c-Abl is implicated in the pathogenesis of several human leukaemias...
S Abrell et al.
Chromosoma, 109(5), 334-342 (2000-09-28)
Irregular facets (If) is a dominant gain-of-function allele of the Drosophila segmentation gene Krüppel (Kr) that interferes with eye development. In a search for genes that interact with Kr activity, we recently performed a systematic genetic screen to identify dominant...
Susanne Miehe et al.
The Journal of biological chemistry, 285(16), 12426-12434 (2010-02-19)
TRPC4 and TRPC5 are two closely related members of the mammalian transient receptor potential cation channel family that have been implicated in important physiological functions, such as growth cone guidance and smooth muscle contraction. To further unravel the role of...
Jaakko Lappalainen et al.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 144B(2), 183-192 (2006-10-13)
Synaptic actions of gamma-amino butyric acid (GABA) have been implicated in many facets of ethanol's effects and risk for alcoholism. We examined whether variation in glutamate decarboxylase-2 (GAD2), a gene encoding for a major enzyme in the synthesis of GABA...
Yuichi Takashi et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(23), 11418-11427 (2019-05-18)
Fibroblast growth factor (FGF) 23 produced by bone is a hormone that decreases serum phosphate (Pi). Reflecting its central role in Pi control, serum FGF23 is tightly regulated by serum Pi alterations. FGF23 levels are regulated by the transcriptional event...
Chaochao Zhou et al.
Journal of biomechanical engineering (2019-10-02)
Total disc arthroplasty (TDA) using an artificial disc (AD) is an attractive surgical technique for the treatment of spinal disorders, since it can maintain or restore spinal motion (unlike interbody fusion). However, adverse surgical outcomes of contemporary lumbar TDAs have...
Shaunna L Clark et al.
Pharmacogenetics and genomics, 23(2), 69-77 (2012-12-18)
To examine the unique and congruent findings between multiple raters in a genome-wide association study (GWAS) in the context of understanding individual differences in treatment response during antipsychotic therapy for schizophrenia. We performed GWAS to search for genetic variation affecting...
Sven-T Liffers et al.
BMC cancer, 11, 137-137 (2011-04-16)
Inactivating mutations of SMAD4 are frequent in metastatic colorectal carcinomas. In previous analyses, we were able to show that restoration of Smad4 expression in Smad4-deficient SW480 human colon carcinoma cells was adequate to suppress tumorigenicity and invasive potential, whereas in...
Michael Pfandler et al.
The spine journal : official journal of the North American Spine Society, 17(9), 1352-1363 (2017-06-03)
Virtual reality (VR)-based simulators offer numerous benefits and are very useful in assessing and training surgical skills. Virtual reality-based simulators are standard in some surgical subspecialties, but their actual use in spinal surgery remains unclear. Currently, only technical reviews of...
Vibol Chhor et al.
Brain, behavior, and immunity, 32, 70-85 (2013-03-05)
Microglia mediate multiple facets of neuroinflammation, including cytotoxicity, repair, regeneration, and immunosuppression due to their ability to acquire diverse activation states, or phenotypes. Modulation of microglial phenotype is an appealing neurotherapeutic strategy but a comprehensive study of classical and more...