Density bottles are mainly used to determine the density of liquids of moderate viscosity. They are not volumetric instruments, however, they are calibrated 'to contain' as in the case of volumetric flasks.
Pharmaceutical products are often characterized by complex formulations. Difficulties observed during Karl Fischer determination are often caused by the limited solubility. In some cases side reactions have to be considered. In dependance of composition and properties of the formulations, various